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Combined chemo-endocrine therapy as a potential new option for HR+/HER2−advanced breast cancer:a prospective study of fulvestrant plus oral vinorelbine

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Cancer Biology & Medicine 2023年第4期20卷 287-296页

作者： Xue Wang Jian Yue Yikun Kang Zhong Dai Jie Ju Jiayu Wang Pin Zhang Fei Ma Binghe Xu Peng Yuan Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Oncology Huanxing Cancer HospitalBeijing 100026China Department of Medical Oncology and Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:Endocrine therapy with fulvestrant has shown synergistic antitumor effects with some chemotherapy drugs in vitro.This study evaluated the efficacy and safety of fulvestrant with vinorelbine in patients with hormone receptor positive(HR+)/human epidermal growth factor receptor-2-negative(HER2−)recurrent or metastatic breast cancer.Methods:Patients were intramuscularly administered fulvestrant 500 mg(day 1 per cycle for 28 days)and oral vinorelbine(60 mg/m2 on days 1,8,and 15 of each cycle).The primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival,objective response rate,disease control rate,duration of response,and safety.Results:A total of 38 patients with HR+/HER2−advanced breast cancer included in the study were followed up for a median time of 25.1 months.The overall median PFS was 9.86 months[95%confidence interval(CI)7.2-23.13],and the median PFS of the first-line and the second-line treatment population was 20.73 months(95%CI 9.82 to NR)and 4.27 months(95%CI 3.68 to NR),respectively.Most adverse events reported were of grade 1/2,and none were of grade 4/5.Conclusions:This is the first exploratory study of a fulvestrant and oral vinorelbine regimen in the treatment of HR+/HER2−recurrent and metastatic breast cancer.The combination chemo-endocrine therapy was efficacious,safe,and promising for patients with HR+/HER2−advanced breast cancer.

关键词： HR+/HER2−breast cancer recurrence metastasis fulvestrant oral vinorelbine

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Tuning Atomically Dispersed Fe Sites in Metal–Organic Frameworks Boosts Peroxidase‑Like Activity for Sensitive Biosensing

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Nano-Micro Letters 2020年第12期12卷 392-403页

作者： Weiqing Xu Yikun Kang Lei Jiao Yu Wu Hongye Yan Jinli Li Wenling Gu Weiyu Song Chengzhou Zhu Key Laboratory of Pesticide and Chemical Biology of Ministry of Education International Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079People’s Republic of China State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249People’s Republic of China

Although nanozymes have been widely developed,accurate design of highly active sites at the atomic level to mimic the electronic and geometrical structure of enzymes and the exploration of underlying mechanisms still face significant challenges.Herein,two functional groups with opposite electron modulation abilities(nitro and amino)were introduced into the metal–organic frameworks(MIL-101(Fe))to tune the atomically dispersed metal sites and thus regulate the enzymelike activity.Notably,the functionalization of nitro can enhance the peroxidase(POD)-like activity of MIL-101(Fe),while the amino is poles apart.Theoretical calculations demonstrate that the introduction of nitro can not only regulate the geometry of adsorbed intermediates but also improve the electronic structure of metal active sites.Benefiting from both geometric and electronic effects,the nitro-functionalized MIL-101(Fe)with a low reaction energy barrier for the HO*formation exhibits a superior POD-like activity.As a concept of the application,a nitro-functionalized MIL-101(Fe)-based biosensor was elaborately applied for the sensitive detection of acetylcholinesterase activity in the range of 0.2–50 mU mL−1 with a limit of detection of 0.14 mU mL−1.Moreover,the detection of organophosphorus pesticides was also achieved.This work not only opens up new prospects for the rational design of highly active nanozymes at the atomic scale but also enhances the performance of nanozyme-based biosensors.

关键词： Nanozymes Metal–organic frameworks Atomically dispersed sites Peroxidase-like activity Biosensors

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Experimental Study on Insulation Properties of Epoxy Casting Resins Using High-frequency Square Waveforms

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CSEE Journal of Power and Energy Systems 2021年第6期7卷 1227-1237页

作者： yikun Zhao Guoqiang Zhang Dong Han kang Li Zongjia Qiu Fuyao Yang the Institute of Electrical Engineering Chinese Academy of Sciencesand University of Chinese Academy of SciencesBeijing 100190China the Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China the Global Energy Interconnection Research Institute Beijing 102209China

Although the transmission efficiency of high-voltage high-frequency transformers improve as the rated frequency increases,their insulation performance is severely affected.Through a high-frequency experimental platform,insulation tests on epoxy casting resins are carried out using high-frequency square wave signals.Subsequently,the variations of discharge inception and flashover voltages with frequency were analyzed based on the Secondary Electron Emission Avalanche(SEEA)model.The breakdown characteristics of epoxy casting resins are studied based on the Weibull distribution analysis and inverse power function model.Finally,an insulation test standard is proposed based on the breakdown characteristics of epoxy casting resins for dry-type HV-HF transformers.The results show that,the flashover voltages are noticeably reduced with the increase of frequency while the discharge inception is hardly affected by frequency.Moreover,the drop in breakdown voltages and insulation lifetime shortening are caused by high-frequency thermal effects.Also,the applied voltages of epoxy resin cast dry-type HV-HF transformers are recommended to be 3.27 to 3.49 times their maximum operating voltages in 1min applied withstand tests.The applied voltages of the induced withstand tests should be 2.20 to 2.52 times their maximum operating voltages.

关键词： Breakdown characteristics HV-HF transformer insulation test standard surface discharge

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《铂类药物晚期乳腺癌应用专家共识(2020版)》解读

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中国肿瘤临床 2022年第6期49卷 271-274页

作者：康一坤袁芃国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院内科北京市10021 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院特需医疗部北京市10021

铂类药物是乳腺癌化疗中的常用药物,通过规范化疗方案和合理优化治疗策略,可延长晚期患者的生存时间,改善预后。中国医师协会肿瘤医师分会乳腺癌学组为指导铂类药物在晚期乳腺癌中的临床应用,制定了《铂类药物晚期乳腺癌应用专家共识(2... 详细信息

铂类药物是乳腺癌化疗中的常用药物,通过规范化疗方案和合理优化治疗策略,可延长晚期患者的生存时间,改善预后。中国医师协会肿瘤医师分会乳腺癌学组为指导铂类药物在晚期乳腺癌中的临床应用,制定了《铂类药物晚期乳腺癌应用专家共识(2020版)》。本文针对该共识进行解读,为晚期乳腺癌个体化诊疗提供科学依据。

关键词：晚期乳腺癌铂类药物临床应用专家共识

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三阴性乳腺癌的治疗进展

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肿瘤防治研究 2022年第8期49卷 812-819页

作者：康一坤袁芃国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院特需医疗部北京100021

三阴性乳腺癌(TNBC)是一类临床病理相对独立的乳腺癌类型,具有侵袭性强、预后差的特点。由于内分泌治疗和针对HER-2的靶向治疗效果差,化疗仍是TNBC主要的治疗手段。然而TNBC具有较强的异质性,对其进行精细分型,探索新的精准治疗方法成... 详细信息

三阴性乳腺癌(TNBC)是一类临床病理相对独立的乳腺癌类型,具有侵袭性强、预后差的特点。由于内分泌治疗和针对HER-2的靶向治疗效果差,化疗仍是TNBC主要的治疗手段。然而TNBC具有较强的异质性,对其进行精细分型,探索新的精准治疗方法成为当务之急。本文将整理重要的临床试验结果,分析TNBC的治疗策略,包括手术治疗、放射治疗、化疗、靶向治疗以及免疫治疗等,为TNBC的临床治疗提供参考。

关键词：三阴性乳腺癌 BRCA基因化疗免疫治疗

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Ultra-small hollow ternary alloy nanoparticles for efficient hydrogen evolution reaction

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National Science Review 2021年第7期8卷 185-197页

作者： Zhenxing Li Chengcheng Yu Yikun Kang Xin Zhang Yangyang Wen Zhao-Kui Wang Chang Ma Cong Wang Kaiwen Wang Xianlin Qu Miao He Ya-Wen Zhang Weiyu Song State Key Laboratory of Heavy Oil Processing College of New Energy and Materials Beijing Key Laboratory of Biogas Upgrading Utilization China University of Petroleum (Beijing) College of Science China University of Petroleum (Beijing) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University Beijing Key Laboratory and Institute of Microstructure and Property of Advanced Materials Beijing University of Technology Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and Applications PKU–HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry College of Chemistry and Molecular Engineering Peking University

Hollow nanoparticles with large specific surface area and high atom utilization are promising catalysts for the hydrogen evolution reaction(HER). We describe herein the design and synthesis of a series of ultra-small hollow ternary alloy nanostructures using a simple one-pot strategy. The same technique was demonstrated for hollow PtNiCu nanoparticles, hollow PtCoCu nanoparticles and hollow CuNiCo nanoparticles. During synthesis, the displacement reaction and oxidative etching played important roles in the formation of hollow structures. Moreover, our hollow PtNiCu and PtCoCu nanoparticles were single crystalline, with an average diameter of 5 nm. Impressively, ultra-small hollow PtNiCu nanoparticles,containing only 10% Pt, exhibited greater electrocatalytic HER activity and stability than a commercial Pt/C catalyst. The overpotential of hollow Pt Ni Cu nanoparticles at 10 mA cm-2was 28 mV versus reversible hydrogen electrode(RHE). The mass activity was 4.54 A mg Pt-1at-70 mV versus RHE, which is 5.62-fold greater than that of a commercial Pt/C system(0.81 A mg Pt-1). Through analyses of bonding and antibonding orbital filling, density functional theory calculations demonstrated that the bonding strength of different metals to the hydrogen intermediate(H*) was in the order of Pt > Co > Ni > Cu. The excellent HER performance of our hollow PtNiCu nanoparticles derives from moderately synergistic interactions between the three metals and H*. This work demonstrates a new strategy for the design of low-cost and high-activity HER catalysts.

关键词： ultra-small hollow nanostructure hydrogen evolution reaction density functional theory

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Experimental evaluation of thermolysis-driven gas emissions from LiPF6-carbonate electrolyte used in lithium-ion batteries

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Journal of Energy Chemistry 2020年第10期29卷 124-135页

作者： Zhenghai Liao Shen Zhang yikun Zhao Zongjia Qiu kang Li Dong Han Guoqiang Zhang Thomas G.Habetler Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100039China School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332United States

This paper performs an experimental evaluation of thermolysis-driven gases generated by the thermal decomposition of 1 M LiPF6+EC/DMC=1/1 v/v electrolytes at various decomposition temperatures,pyrolysis durations,and oxygen concentrations.Carried out in a home-built autoclave filled with pure helium,the experiment reveals that as the decomposition temperature increases,more types and larger quantities of gases will be released.Specifically,the experimental results demonstrate trends of logistic growth in the volume concentration of CO2,C2H6O,C2H4,CO,and C2H4O2 with the increase of decomposition temperature.With a prolonged pyrolysis duration,while volume concentrations of certain gases,such as CO2,C2H6O,C2H5F,and CO would increase,the concentration of C2H4O2 actually decreases.Moreover,concentrations of both C2H4 and C2H5F will first decrease and reach their minimum values at 1%v/v oxygen concentration,and then they would quickly climb back at higher oxygen concentrations,while the concentrations of C2H6 and C2H3F would decrease monotonically.It is envisioned that the detailed experimental results and findings on the gas generation pattern of 1 M LiPF6+EC/DMC=1/1 v/v electrolytes can facilitate the development of an early warning mechanism of thermal runaway based on gas sensing technology,which can be effectively applied to monitor the potential thermal failures of lithium-ion batteries with the same type of electrolyte and thus promote the thermal safety of battery packs in safety-critical applications.

关键词： LiPF6-carbonate electrolyte Thermal decomposition Gas analysis Lithium-ion battery Thermal safety

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Chemical Compositions,Microstructure and Mechanical Properties of Roll Core used Ductile Iron in Centrifugal Casting Composite Rolls

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Journal of Materials Science & Technology 2012年第9期28卷 853-858页

作者： Yunlong Bai yikun Luan Nannan Song Xiuhong kang Dianzhong Li Yiyi Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The industrial manufacture processes of three kinds of roll core used ductile irons have been investigated via systematical experiments. EfFects of the ratio of C/Si, pig iron, nodularizer and alloying method on the microstructure and mechanical properties of the heavy section ductile iron have been analyzed. It has been found that when treated with RE-Mg plus Sb, high quality nodular castings can be produced even if much anti spheroidizing alloy elements are included in the pig iron. The alloy element Sb played an important role in the control of graphite morphology.

关键词： Centrifugal casting Roll Heavy section ductile iron Micro-alloying with Sb

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Atomically dispersed N-coordinated Fe-Fe dual-sites with enhanced enzyme-like activities

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Nano Research 2022年第2期15卷 959-964页

作者： Lei Jiao Wei Ye Yikun Kang Yu Zhang Weiqing Xu Yu Wu Wenling Gu Weiyu Song Yujie Xiong Chengzhou Zhu Key Laboratory of Pesticide and Chemical Biology of Ministry of Education International Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Hefei National Laboratory for Physical Sciences at the Microscale Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)School of Chemistry and Materials Scienceand National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China

Replacement of enzymes with nanomaterials such as atomically dispersed metal catalysts is one of the most crucial steps in addressing the challenges in biocataiysis.Despite the breakthroughs of single-atom catalysts in enzyme-mimicking,a fundamental investigation on the development of an instructional strategy is still required for mimicking biatomic/multiatomic active sites in natural enzymes and constructing synergistically enhanced metal atom active sites.Herein,Fe_(2)NC catalysts with atomically dispersed Fe-Fe dual-sites supported by the metal-organic frameworks-derived nitrogen-doped carbon are employed as biomimetic catalysts to perform proof-of-concept investigation.The effect of Fe atom number toward typical oxidase(cytochrome C oxidase,NADH oxidase,and ascorbic acid oxidase)and peroxidase(NADH peroxidase and ascorbic acid peroxidase)activities is systematically evaluated by experimental and theoretical investigations.A peroxo-like O_(2) adsorption in Fe_(2)NC nanozymes could accelerate the O-O activation and thus achieve the enhanced enzyme-like activities.This work achieves the vivid simulation of the enzyme active sites and provides the theoretical basis for the design of high-performance nanozymes.As a concept application,a colorimetric biosensor for the detection of S^(2-) in tap water is established based on the inhibition of enzyme-like activity of Fe_(2)NC nanozymes.

关键词： nanozymes atomically dispersed dual-metal sites oxidase-like activities single-atom catalysis sensors

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Aerosol characteristics and impacts on weather and climate over the Tibetan Plateau

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National Science Review 2020年第3期7卷 492-495页

作者： Chuanfeng Zhao yikun Yang Hao Fan Jianping Huang Yunfei Fu Xiaoye Zhang Shichang kang Zhiyuan Cong Husi Letu Massimo Menenti State Key Laboratory of Earth Surface Processes and Resource Ecology and College of Global Change and Earth System Science Beijing Normal University Collaborative Innovation Center for Western Ecological Safety College of Atmospheric Sciences Lanzhou University School of Earth and Space Sciences University of Science and Technology of China Institute of Atmospheric Composition Chinese Academy of Meteorological Sciences State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences

With the most massive snow and ice globally between 60°S and 60°N, the Tibetan Plateau (TP), also called the third pole of the world, plays significant roles in the weather, climate and lives in South Asia and East Asia and even the world [1–3].Investigating the variation of weather and the climate system over the TP has long been carried out, which is signif-

关键词： Aerosol characteristics and impacts on weather and climate over the Tibetan Plateau

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