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Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

Acta Pharmaceutica Sinica B 2022年第2期12卷 708-722页

作者： Xiang Wang Xinxin Chen Wenqian z.ou Hongbo Men Terigen Bao yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang z.eng Lu Cai Pediatric Research Institute Department of PediatricsUniversity of Louisville School of MedicineLouisvilleKY 40202USA Department of Cardiovascular Disease the First Hospital of Jilin UniversityChangchun 130021China Department of Burn Surgery First Hospital of Jilin UniversityJilin UniversityChangchun 130021China Department of Pharmacology and Toxicology University of Louisville School of MedicineLouisvilleKY 40202USA Pediatric Heart Research Program Cardiovascular Innovation InstituteUniversity of Louisville School of MedicineLouisvilleKY 40202USA Cincinnati Children’s Heart Institute Greater Louisville and Western Kentucky PracticeLouisvilleKY 40202USA

Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM *** glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 *** morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron *** of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and *** was also evidenced in the heart of type 2 diabetic mice with *** of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of *** factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 *** protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-*** findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 *** suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM.

关键词： Advanced glycation end-products AMPK Cell death Diabetic cardiomyopathy Engineered cardiac tissue Ferroptosis Lipid peroxidation NRF2

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Research on Rotation Technique of Single-axis Rotary SINS

Research on Rotation Technique of Single-axis Rotary SINS

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第37届中国控制会议

作者： Jun Shen yike Cai Junwei Wu School of Automation Beijing Institute of Technology Beijing Automation Control Equipment Institute

Rotary modulation and control algorithms are the key technologies of the rotating strapdown inertial navigation system. The complex rotation scheme earns limited accuracy, while causing larger siz., lower reliability and higher additional cost. This paper analyz.d the sources of inertial sensors’ errors, compared similarities and differences, and evaluated the performance of all kinds of single-axis rotation modulation schemes. Initial alignment requires transposition in high accuracy and the rotary motor needs to stay a steady pace in actual practice under multiple interferences, so this paper designed a dual closed-loop controller for all concerned, with an ordinary PID in the position loop and ADRC controller in the speed loop,ensuring the modulation runs smoothly. The simulation results show that the system has some good characteristics such as fast response, no overshoot and good robustness. Compared with the original PID control, the new control algorithm helps rotary motor improve its anti-jamming performance.

关键词： Rotary Inertial Navigation System Single-axis Rotation Error Mitigation Active Disturbance Rejection Control

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CeO2-z.O2固相溶液的制备和贮氧能力的研究

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离子交换与吸附 2007年第4期23卷 322-329页

作者：袁文辉罗仡科华南理工大学化工学院广东省绿色化学品技术重点实验室华南理工大学化工学院广东省绿色化学品技术重点实验室广州510640

二氧化铈(CeO2)是优良的催化剂和催化剂促进剂,通过引入二氧化锆(z.O2)可以提高其热稳定性及贮氧能力。研究以硝酸铈(IV)和氯氧锆为原料,用均相沉淀法制备CeO2-z.O2固相溶液。用X光衍射(XRD)、差热-热重分析(DSC-TGA)、BET测定法和贮氧... 详细信息

二氧化铈(CeO2)是优良的催化剂和催化剂促进剂,通过引入二氧化锆(z.O2)可以提高其热稳定性及贮氧能力。研究以硝酸铈(IV)和氯氧锆为原料,用均相沉淀法制备CeO2-z.O2固相溶液。用X光衍射(XRD)、差热-热重分析(DSC-TGA)、BET测定法和贮氧能力测定法对制备的CeO2-z.O2进行了表征。BET测定制备的样品比表面积可达114m2/g;XRD结果表明,均相沉淀法制备样品具有萤石结构,Ce/z.为3:1,450℃时即可制备出Ce0.75z.0.25O2,800℃时,相结构稳定,TGA-DSC热分析没有出现热峰,说明样品热稳定性优良;通过100℃、200℃、400℃和800℃的氧贮存能力测定,实验结果表明,CeO2-z.O2固体溶液的氧贮存能力随温度的升高而降低,在高温下的氧贮存能力随z.含量的增加而增大,z.O2的引入不但改进了CeO2的热稳定性,而且提高CeO2样品高温下的氧贮存能力。

关键词： CeO2-z.O2 均相沉淀法结构表征贮氧能力

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A Pulse Phase Estimation Method Based on Improved Particle Swarm Optimiz.tion

A Pulse Phase Estimation Method Based on Improved Particle S...

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第十三届中国卫星导航年会

作者： yike Qiao Yusong Wang Wei z.eng College of Aerospace Science and Engineering National University of Defense Technology

X-ray pulsar-based navigation（XPNAV） is a celestial autonomous navigation method based on X-ray pulsar observation. The pulse phase estimation has been the key point of XPNAV because the balance of accuracy and efficiency in pulse phase estimation is difficult to obtain. In response to this problem, a pulse phase estimation method based on improved particle swarm optimiz.tion is proposed. Experiments were conducted based on simulation data and real data. The results demonstrate that the proposed method significantly reduces the CPU time cost of pulse estimation on the premise of guaranteeing high reliability and accuracy.

关键词： x-ray pulsar-based navigation signal processing improved particle swarm optimiz.tion

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The Architecture Design Based on the Landscape Conditions: Taking the Architectural Design of Subsidence Area for Example

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Journal of Landscape Research 2014年第5期6卷 3-6页

作者： HU yike LUAN Tianhao SHAO Di School of Civil Engineering Tianjin University

The relationship between architecture and people, architecture and city, architecture and nature has always been the soul of architectural design. In the architectural design, study on the relationship between architecture and nature needs "site analysis"(mapping), and "natural environment" tends to affect the design results[1]. In many special areas, the design needs analysis of geology, geomorphology, hydrology, vegetation and other landscape elements. Coal mining subsidence area is the product of the conf licts between human activities and natural environment in the process of industrializ.tion. As the research object, coal mining subsidence area can be a good study object to demonstrate architectural design strategies and methods based on landscape, and fi eld defects of the site may be the origin of architectural space organiz.tion: architectural concept, structure, morphology, spatial organiz.tion are all from the landscape elements.

关键词： Landscape architecture Landscape elements Coal mining subsidence area

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Ovalbumin-loaded paramagnetic nano-triangles for enhanced dendritic cell stimulation,T_(1)-MR imaging,and antitumor immunity

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Journal of Materials Science & Technology 2023年第17期148卷 123-137页

作者： yike Hou z.e Tang Jabeen Farheen Madiha Saeed Lijia Luo Wenz. Ren Dandan Luo Asim Mushtaq Ruibo z.ao Jian Ge z.angsen Yu Yao Li M.z.bair Iqbal Xiangdong Kong Institute of Smart Biomedical Materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Cixi Institute of Biomedical Engineering CAS Key Laboratory of Magnetic Materials and DevicesKey Laboratory of Additive Manufacturing Materials of Zhejiang ProvinceNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Department of Materials Imperial College LondonLondon SW72AZUK College of Life Sciences China Jiliang UniversityHangzhou 310018China Laboratory of Nanomedicine Medical Science Research CenterSchool of MedicineShaoxing UniversityShaoxing 312000China

Vaccine-based cancer immunotherapy has demonstrated a significant potential for cancer treatment in *** the efficiencies of vaccines are limited,they can be enhanced by a well-designed antigen delivery system that promotes sufficient antigen presentation of dendritic cells(DCs)for initiating high T cell ***,antigen-loaded manganese oxide(Mn_(3)O_(4))triangular-shaped ultrasmall nanoparti-cles were prepared to stimulate DC-based immunotherapy under the guidance of T_(1)magnetic resonance *** FDA-approved triblock copolymer Pluronic^(■)F-68 wasused not onlyto transferthe phase from hydrophobic to hydrophilic but also to enrich antigen loading and improve the biocompatibility of the prepared ***(OVA),a model antigen,was adsorbed on the surface of polymer-coated nanoparticles through electrostatic interaction to form Mn_(3)O_(4)@PF68-OVA nanoparticle-antigen complexes to stimulate DC-based immuniz.tion and antigen-specific T cell *** Mn_(3)O_(4)@PF68-OVA nanovaccine(NV)induces negligible toxicity effects against 4T1 and bone marrow-derived dendritic cells(BMDCs)by conventional methods supports the proliferation of intestine organoids,which are an innovative three-dimensional cytotoxicity evaluation system,thereby indicating their potential safety for in vivo cancer *** designed paramagnetic nanovaccine possessed excellent OVA delivery to dendritic-regulated antigen-specific T cells in vitro by stimulating the maturation level of *** ad-dition,Mn_(3)O_(4)@PF68-OVA NVs enhance immunity in vivo by increasing the T-cells and M1 macrophages,which suggests improved ***,vaccination with Mn_(3)O_(4)@PF68-OVA offer complete pro-tection in the prophylactic group and significant tumor inhibition in the therapeutic group against B16-OVA *** addition,the designed nanovaccine demonstrated high T_(1)-MR imaging in the tumor,fur-ther justifying enhanced tumor accumulation and capability to

关键词： Ovalbumin Nanovaccine Antigen delivery Magnetic resonance imaging Contrast agent Cancer immunotherapy

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Research on the Long Lifetime of LEO Remote Sensing Satellites

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Aerospace China 2013年第2期14卷 11-12页

作者： Yang yike Chen Saiqi Li Tan China Aerospace Science and Technology Corporation

To increase the efficiency of satellite,reduce the average R&Dcost of satellite,and promote the stable and continuous development of satellite remote sensing application,the main constraints on

关键词：遥感卫星长寿命低轨中国制造

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Molecular mechanisms of seasonal photoperiod effects of the pineal gland on the hippocampus in rats

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Journal of Traditional Chinese Medical Sciences 2021年第2期8卷 135-144页

作者： Qi Han Guowen Du Leilei Liu Lepeng Wang Wenna Li Hairong z.ang yike Sun Pei z.u Ruisen Hao Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Background:Based on the theory of“five z.ng-organs corresponding to the seasons”in traditional Chinese medicine(TCM),physiological functions including emotions vary with the *** aimed to investigate the seasonal photoperiod effects of melatonin(MT)released from the pineal gland on the MT receptor(MTR)-Gs/Gi-cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)-cAMP response element-binding protein(CREB)signaling pathway in the ***:Rats were divided into three groups:control,operation(surgery with pineal gland removal),and pseudo-operation groups(same surgery as operation group but without removing pineal gland),and fed at specific time across the four *** levels of MTR,adenylate cyclase(AC),cAMP,PKA,and CREB in the hippocampus were analyz.d using *** concentrations of Gs and Gi were analyz.d using Western *** expression of CREB mRNA was detected by ***:For intragroup comparisons,compared with spring,the levels of Gs/Gi in the control group were higher in summer,autumn,and winter(P=.009 in summer;P z.ng-organs corresponding to the seasons”.

关键词： Pineal gland Melatonin Hippocampus Photoperiod Signaling pathway

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康熙未年的内“面谕”与与第三次立储计划——以《本朝题驳公案》新见史料为中心

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清史研究 2023年第5期139卷 73-84页

作者：毛亦可北京大学历史学系北京100871

《本朝题驳公案》是康熙末年根据邸报编辑的坊刻本书籍,其中收录了康熙五十六、五十七年之际的长篇“面谕”,以及与康熙朝第三次立储计划相关的上谕、题本等罕见史料。该书与《实录》《起居注》中的相关记载有着微妙的差别,提示《实录... 详细信息

《本朝题驳公案》是康熙末年根据邸报编辑的坊刻本书籍,其中收录了康熙五十六、五十七年之际的长篇“面谕”,以及与康熙朝第三次立储计划相关的上谕、题本等罕见史料。该书与《实录》《起居注》中的相关记载有着微妙的差别,提示《实录》《起居注》中的记载可能经过雍正朝的篡改。从该书的记载看来,康熙帝于五十六、五十七年之际一度重病不起,并长期不能理政,因而在五十六年底发布了长篇“面谕”,预备当做遗诏,并有第三次立储计划,且立储人选很可能仍是胤,但因康熙帝对胤初及其周围小集团的不满而中止。

关键词：《本朝题驳公案》康熙面谕立储

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论新中国民族政策的合法性

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广西民族研究 2011年第3期 27-31页

作者：欧以克广西民族大学教育科学学院研究员南宁530006

新中国民族政策的合法性主要来源于意识形态、法理和绩效基础。当前中国民族政策的合法性正面临着新的挑战,应从推进民族理论创新、加强马克思主义民族观教育、完善民族政策、将民族政策提升为民族法规等方面入手,巩固民族政策的合法性... 详细信息

新中国民族政策的合法性主要来源于意识形态、法理和绩效基础。当前中国民族政策的合法性正面临着新的挑战,应从推进民族理论创新、加强马克思主义民族观教育、完善民族政策、将民族政策提升为民族法规等方面入手,巩固民族政策的合法性基础,使民族政策赢得社会的共同认可和广泛支持。

关键词：新中国民族政策合法性基础

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