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The Research of Project Quality Management Model Based on Lean Construction

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The Research of Project Quality Management Model Based on Le...

Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats

2015 International Conference on Management Science,Education Technology,Arts,Social Science and Economics(MSETASSE 2015)

作者： Han yike Wang Jianbin School of management Xi'an University of Architecture and Technology

Derived from the manufacturing, lean construction is a new kind of project management model. Lean thinking is built into the in the process of construction quality management, the difference between the traditional construction mode and lean construction are analyz.d. From two aspects of external control and internal management, a new project quality management model based on lean construction is built.

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 143-152页

作者： Wenna Li Ting Li Leilei Liu Qi Han Hairong z.ang yike Sun Ruisen Hao Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Community Health Service Center of Hailar East Road Office Hohhotthe Inner Mongolia Autonomous Region010015China School of Medicine Henan Polytechnic UniversityJiaozuo454000China

Background: Based on the effect of seasonal changes on human visceral function, this study investigated the impact of seasonal photoperiod of the pineal body on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in rats, aiming to reveal the mechanism by which pineal gland melatonin regulates the seasonal secretion of hippocampal ***: Vernal equinox, summer solstice, autumn equinox, and winter solstice were selected as four experimental time points, and rats were randomly divided into normal control group, sham operation group, and pinealectomiz.d group. The seasonal changes in corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH), corticosterone, hypothalamic melatonin receptor(MTR), and hippocampal corticosterone receptor(CORTR) were examined by enz.me-linked immunosorbent ***: Comparing the same group between different seasons, we showed that in the normal control group, CRH, ACTH, corticosterone, and MTR were higher, while CORTR was lower in autumn and winter than in spring(all P z.d group showed higher levels of corticosterone(P =.01), MTR(P =.01), and CORTR(P =.03) during spring;reduced levels of MTR and CORTR(both P <.001) during summer;higher levels of ACTH(P =.001) and MTR(P <.001),and lower levels of CRH(P =.001), corticosterone(P <.001), and CORTR(P =.003) during autumn;and lower levels of CRH(P <.001) and MTR(P =.004), and higher level of ACTH(P <.001) in ***: Seasonal photoperiod acts on the pineal gland to secrete different levels of melatonin,resulting in seasonal changes in the hypothalamic-pituitary-adrenal axis-hippocampal-receptor, which may be the pathophysiological basis for the onset of seasonal affective disorder.

关键词： Pineal gland Melatonin Hippocampus Seasonal photoperiod Hypothalamic-pituitary-adrenal axis Receptor

Effects of seasonal changes on T-helper 1/T-helper 2 immune balance and ecz.ma onset in rats

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 64-72页

作者： Hairong z.ang Leilei Liu yike Sun Wenna Li Ruochong Wang Xiao Sun Guangqin z.u Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Department of Acupuncture and Minimally Invasive Oncology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China

Objective: To explore the impact of seasonal changes on the T-helper 1(Th1)/T-helper 2(Th2) immune balance of the body in order to elucidate the internal immunological mechanisms underlying seasonal ***: Eighty 4-week-old male Sprague-Dawley rats were divided into 5 season groups kept in corresponding season simulation environments, and subdivided into the model group and the control group. The Ecz.ma Area and Severity Index(EASI) and scratching frequency were evaluated. The serum levels of immunoglobulin E(IgE), interleukin-2(IL-2), interleukin-12(IL-12), and interferon-gamma(IFN-γ), interleukin-4(IL-4), interleukin-25(IL-25), and interleukin-31(IL-31), and melatonin(MT), as well as the MT receptor(MTR) levels in the spleen, were detected by enz.me-linked immunosorbent assay analysis. The mRNA expression levels of T-bet and GATA3 were detected by quantitative real-time polymerase chain ***: EASI scores and the scratching frequency of the model group were higher in the long summer than in the other 4 seasons. Meanwhile, the serum levels of IgE and the Th2 cytokines IL-4, IL-25, and IL-31, as well as GATA3 mRNA expression levels, were high during the long summer in both groups. However, the serum levels of the Th1 cytokines IL-2, IL-12, and IFN-γ, as well as MT, MTR, and T-bet mRNA levels, were lower during the long summer. In all 5 seasonal groups(spring, summer, long summer, autumn, and winter), the levels of all immune factors, especially IL-4 and IL-31, were higher in the model group than those in the control group,while the concentrations of MT and MTR were ***: Under long light, hot, and humid conditions in the long summer, the body is more likely to suffer from Th2-dominated immune imbalance. This is the internal mechanism behind the high incidence and severity of ecz.ma during the long summer. MT and MTR play a key role in the seasonal onset of ecz.ma.

关键词： Ecz.ma Seasonality Long summer Immuniz.tion Th1/Th2 Melatonin Immunoglobulin E

Analysis of Detection and Treatment Schemes of Highway Tunnel Lining Cracks

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Journal of Architectural Research and Development 2021年第1期5卷 4-7页

作者： yike Wei Lingfeng Yu China Merchants Chongqing Testing Center for Highway Engineering CO. LTDChongqing 400060China Chongqing Jiaotong University Chongqing 400074China

Highway tunnels play a very important role in people's daily *** them,lining is an essential part of tunnel engineering,and the quality of lining greatly affects the overall quality of the *** this basis,the causes of lining cracks and the detection methods of existing highway tunnel lining cracks are analyz.d,and the treatment countermeasures for highway tunnel lining cracks are proposed.

关键词： Highway tunnel Lining Crack detection Treatment

Design of metal-organic frameworks for improving pseudo-solid-state magnesium-ion electrolytes:Open metal sites,isoreticular expansion,and framework topology

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Journal of Materials Science & Technology 2023年第13期144卷 15-27页

作者： Yun z.eng Junpo Guo De Ning yike Huang Wen Lei Jing Li Jianding Li Götz.Schuck Jingjun Shen Yan Guo Qi z.ang Hao Tian Hou Ian Huaiyu Shao Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeMacao 999078China Centre for Photonics Information and Energy Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China School of Science Huzhou UniversityHuzhou 313000China Helmholtz.Center Berlin for Materials and Energy Albert-Einstein-StreetBerlin 1512489Germany Cancer Center and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China

The design criteria for metal-organic frameworks(MOFs)have been established by evaluating the rela-tionship between their key characteristics and magnesium-ion conductivity based on three types of sec-ondary building blocks(z._(4)O(CO_(2))_(6):MOF-5 and MOF-177;Cu_(2)(CO_(2))4:MOF-199,MOF-143,MOF-14,and MOF-399;Cu_(2)O_(2)(CO_(2))2:Cu-MOF-74)to achieve pseudo-solid-state magnesium-ion *** found that open-metal sites and channel layouts play a pivotal role in promoting magnesium-ion transport dy-namics at reduced activation energy,transforming MOF scaffolds into ionic-channel analogs.X-ray ab-sorption spectroscopy combined with Raman and Fourier-transform infrared spectroscopy predicted the chemical environment,solvents,and anions that occupied coordinatively unsaturated metal *** chemical compositions of electrolytes determined by^(1)H-NMR(nuclear magnetic resonance)and organic elemental analysis confirmed that isoreticular expansion increases the molar percentage of charge carri-ers,providing high *** current research systematically reveals the impacts of different MOF characteristics on ionic conduction performance,paving the way for the construction of a new class of fast and selective multivalent-ion pseudo-solid electrolytes.

关键词： Magnesium conduction Magnesium battery Metal-organic frameworks Solid-state electrolytes Reticular chemistry

Capsid destabiliz.tion and epitope alterations of human papillomavirus 18 in the presence of thimerosal

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Journal of Pharmaceutical Analysis 2021年第5期11卷 617-627页

作者： Xiaofen Huang yike Li Meifeng Nie Mingxi Yue Yufang Li z.ijie Lin Huirong Pan Mujin Fang Ting Wu Shaowei Li Jun z.ang Ningshao Xia Qinjian z.ao State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Public HealthXiamen UniversityXiamenFujian361102China School of Public Health Xiamen UniversityXiamenFujian361102China School of Life Science Xiamen UniversityXiamenFujian361102China Xiamen Innovax Biotech Company XiamenFujian361005China

Thimerosal has been widely used as a preservative in drug and vaccine products for *** to the strong propensity to modify thiols in proteins,conformational changes could occur due to covalent bond formation between ethylmercury(a degradant of thimerosal)and *** a conformational change could lead to partial or even complete loss of desirable protein *** study aims to investigate the effects of thimerosal on the capsid stability and antigenicity of recombinant human papillomavirus(HPV)18 virus-like particles(VLPs).Dramatic destabiliz.tion of the recombinant viral capsid upon thimerosal treatment was *** a negative effect on the thermal stability of VLPs preserved with thimerosal was shown to be dependent on the thimerosal *** highly neutraliz.ng antibodies,13H12 and 3C3,were found to be the most sensitive to thimerosal *** kinetics of antigenicity loss,when monitored with 13H12 or 3C3 as probes,yielded two distinctly different sets of kinetic parameters,while the data from both monoclonal antibodies(mAbs)followed a biphasic exponential decay *** potential effect of thimerosal on protein function,particularly for thiolcontaining proteinaceous active components,needs to be comprehensively characteriz.d during formulation development when a preservative is necessary.

关键词： Thiol-modifying agent Monoclonal antibody Antigenicity loss Epitope-specific Conformational stability

In silico off-target profiling for enhanced drug safety assessment

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2927-2941页

作者： Jin Liu yike Gui Jingxin Rao Jingjing Sun Gang Wang Qun Ren Ning Qu Buying Niu z.iyi Chene Xia Sheng Yitian Wang Mingyue z.eng Xutong Li College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Nanjing University of Chinese Medicine Nanjing 210023China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyHangzhou 330106China

Ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent ***,the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screening and animal testing is *** off-target interactions,along with the adverse drug reactions they induce,are significant factors affecting drug *** assess the liability of candidate drugs,we developed an artificial intelligence model for the precise prediction of compound off-target interactions,leveraging multi-task graph neural *** outcomes of off-target predictions can serve as representations for compounds,enabling the differentiation of drugs under various ATC codes and the classification of compound ***,the predicted off-target profiles are employed in adverse drug reaction(ADR)enrichment analysis,facilitating the inference of potential ADRs for a *** the withdrawn drug Pergolide as an example,we elucidate the mechanisms underlying ADRs at the target level,contributing to the exploration of the potential clinical relevance of newly predicted off-target ***,our work facilitates the early assessment of compound safety/toxicity based on off-target identification,deduces potential ADRs of drugs,and ultimately promotes the secure development of drugs.

关键词： Drug safety Off-target prediction Adverse drug reactions Toxicity Molecular representation Artificial intelligence

Lightweight hydrides nanocomposites for hydrogen storage: Challenges, progress and prospects

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Science China Materials 2019年第11期62卷 1597-1625页

作者： Li Li yike Huang Cuihua An Yijing Wang School of Materials Science and Engineering University of JinanJinan 250022China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China Tianjin Key Laboratory of Advanced Functional Porous Materials Institute for New Energy Materials&Low-Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

As typical high-capacity complex hydrides,lightweight hydrides have attracted intensive attention due to their high gravimetric and volumetric energy densities of hydrogen ***,lightweight hydrides also have high thermodynamic stability and poor kinetics,so they ususally require high hydrogen desorption temperature and show inferior reversibility under mild *** review summariz.s recent progresses on the endeavor of overcoming thermodynamic and kinetic challenges for Mg based hydrides,lightweight metal borohydrides and ***,the current state,advantages and challenges for Mg-based hydrides and lightweight metal hydrides are ***,alloying,nanoscaling and appropriate doping techniques are demonstrated to decrease the hydrogen desorption temperature and promote the reversibility behavior in lightweight *** scaffolds materials,approaches for synthesis of nanoconfined systems and hydriding-dehydriding properties are *** addition,the evolution of various dopants and their effects on the hydrogen storage properties of lightweight hydrides are investigated,and the relevant catalytic mechanisms are ***,the remaining challenges and the sustainable research efforts are discussed.

关键词： hydrogen storage Mg-based materials borohydrides alanates nanoscaling

Bioinspired porous microspheres for sustained hypoxic exosomes release and vasculariz.d bone regeneration

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Bioactive Materials 2022年第8期7卷 377-388页

作者： yike Gao z.oying Yuan Xiaojing Yuan z.uo Wan Yingjie Yu Qi z.an Yuming z.ao Jianmin Han Jianyong Huang Chunyang Xiong Qing Cai Department of Pediatric Dentistry Peking University School and Hospital of StomatologyNational Center of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing100081China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300072China Dental Medical Devices Testing Center Dental Materials LaboratoryPeking University School and Hospital of StomatologyBeijing100081China Wenz.ou Institute University of Chinese Academy of SciencesOujiang LaboratoryWenzhouZhejiang325000China

Exosomes derived from mesenchymal stem cells(MSCs)have demonstrated regenerative potential for cell-free bone tissue engineering,nevertheless,certain challenges,including the confined therapeutic potency of exosomes and ineffective delivery method,are still ***,we confirmed that hypoxic precondition could induce enhanced secretion of exosomes from stem cells from human exfoliated deciduous teeth(SHEDs)via comprehensive proteomics analysis,and the corresponding hypoxic exosomes(H-Exo)exhibited superior potential in promoting cellular angiogenesis and osteogenesis via the significant up-regulation in focal adhesion,VEGF signaling pathway,and thyroid hormone ***,we developed a platform technology enabling the effective delivery of hypoxic exosomes with sustained release kinetics to irregular-shaped bone defects via *** platform is based on a simple adsorbing technique,where exosomes are adsorbed onto the surface of injectable porous poly(lactide-co-glycolide)(PLGA)microspheres with bioinspired polydopamine(PDA)coating(PMS-PDA microspheres).The PMS-PDA microspheres could effectively adsorb exosomes,show sustained release of H-Exo for 21 days with high bioactivity,and induce vasculariz.d bone regeneration in 5-mm rat calvarial *** findings indicate that the hypoxic precondition and PMS-PDA porous microsphere-based exosome delivery are efficient in inducing tissue regeneration,hence facilitating the clinical translation of exosome-based therapy.

关键词： Hypoxic exosomes Stem cells from human exfoliated deciduous teeth Porous microsphere Sustained release Vasculariz.d bone regeneration