检索结果-南通市图书馆

Maternal High-Fat Diet Impairs Offspring Glucose Metabolism and Programs Hepatic DNA Methylation linked to NK Cell-Mediated Cytotoxicity Signaling Pathway at Weaning

引用

Food Science and Human Wellness 2024年

作者： Sheng Zheng ling Zhang Shixuan Zhang Guanyu Hu yikai li Jia Zheng Department of Traditional Chinese Orthopedics and Traumatology Center for Orthopedic Surgery The Third Affiliated Hospital of Southern Medical University Department of Endocrinology Peking University First Hospital

Maternal consumption of a high-fat diet has been linked to increased risks of obesity and impaired glucose metabolism in offspring. However， the precise epigenetic mechanisms governing these intergenerational effects， particularly during the early stages of offspring development， remain poorly understood. In this study， female C57BL/6J mice were randomly assigned to either a high-fat diet or normal chow diet throughout gestation and lactation. Methylated DNA immunoprecipitation (MeDIP) coupled with microarray analysis was employed to identify differentially methylated genes in the livers of offspring at weaning age. We found that maternal high-fat diet feeding predisposes offspring to obesity and impaired glucose metabolism as early as the weaning period. DNA methylation profile analysis unveiled a significant enrichment of differentially methylated genes within the natural killer (NK) cell-mediated cytotoxicity pathway. MeDIP-PCR validated reduced methylation levels of specific genes within this pathway， including TNFα， PI3K， and SHC1. Consistently， the expressions of TNFα， PI3K， and SHC1 were significantly upregulated， accompanied by elevated serum TNFα and IL-6 levels in offspring from dams fed with high-fat diet. Moreover， we assessed the expressions of genes associated with NK cell activities， uncovering a notable rise in hepatic granzyme B levels and a trend towards increased CD107a expression in offspring from dams fed a high-fat diet. In addition， methylation levels of TNFα， PI3K， and SHC1 promoters were inversely correlated with glucose response during glucose tolerance testing. In conclusion， our findings underscore the critical role of the NK cell-mediated cytotoxicity signaling pathway in mediating DNA methylation patterns， thereby contributing to the programming effects of maternal high-fat diet consumption on offspring glucose metabolism as early as the weaning period.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Value Evaluation Method for Pumped Storage in the New Power System

引用

Chinese Journal of Electrical Engineering 2023年第3期9卷 26-38页

作者： Yumin Peng Ying Yang Man Chen Xuelin Wang Yijun Xiong Mu Wang yikai li Bushi Zhao CSG PGC Power Storage Research Institute Guangzhou 510635China Sichuan Energy Internet Research Institute Tsinghua UniversityChengdu 610213China

When integrating the generation of large-scale renewable energy,such as wind and solar energy,the supply and demand sides of the new power system will exhibit high uncertainty.Pumped storage power stations can improve flexible resource supply regulation in the power system,which is the key support and important guarantee for building low-carbon,safe,and efficient new power systems.limited by the current operation mode and electricity price mechanism,the pumped storage power station cost cannot be effectively recovered,and the value cannot be reasonably compensated,resulting in difficult return on investment,single investment subjects,and notable industry development difficulties.According to the operational requirements of the new power system,combined with the various functions of pumped storage power stations,the value of pumped storage power stations in the new power system was analyzed.Based on the equivalent value substitution principle and system operation simulation,a pumped storage value evaluation method for the new power system was proposed.The new power system operation was simulated considering the dispatching model of wind and photovoltaic power abandonment penalties.Under the same dispatching objectives,the output of various power sources and power generation operating costs with and without pumped storage power stations in the system were compared.From economic,safety,social,and environmental benefit perspectives,a quantitative model of the pumped storage power station value was established,covering seven dimensions:asset investment savings,power generation operating cost reduction,flexible adjustment capability improvement,system resilience enhancement,power outage loss reduction,renewable energy consumption,and emission reduction promotion.Based on the new power system operation and planning data for southern China,the value of typical pumped storage power stations was analyzed,and the results showed that with new power system’s construction and development,the value of pumped storage power stati

关键词： Pumped storage new power system evaluation method value substitution operation simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rising grain prices in response to phased climatic change during 1736–1850 in the North China Plain

引用

Science China Earth Sciences 2019年第11期62卷 1832-1844页

作者： Yanjun WEN Xiuqi FANG Yang liU yikai li Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China School of Geography and Environment Baoji University of Arts and SciencesBaoji 721013China Institute for Atmospheric and Earth System Research University of HelsinkiHelsinki 00014Finland

Grain price volatility during historical periods is regarded as an important indicator of the impact of climate change on economic system, as well as a key link to adjust food security and social stability. The present study used the wheat prices in Baoding Prefecture, China, during 1736–1850 to explore connections between climatic transition and grain price anomalies in the North China Plain. The main findings were as follows:(1) The grain price change showed an apparent correspondence with climatic transition. The period 1781–1820 was a transition phase, with more extremes and decreased precipitations when the climate shifted from a warm phase to a cold one. Corresponding with the climatic transition, the grain price during 1781–1820 was characterized by that the mean of the original grain price series was significantly higher(lower) than the previous(later)phase, and the variance and anomaly amplitude of the detrended grain price series was the highest during 1736–1850.(2) The correspondence between grain price extremes and drought events occurred in phases. Five grain price extremes occurred following drought events during 1781–1810, while extreme droughts were the direct cause of the grain price spike during 1811–1820.(3) Social stability affected by climate change also played an important role in the grain price spike between 1811 and 1820. Paralleling the pathway of "precipitation-grain production-grain price", climate change could have an impact on grain price via the pathway of "precipitation-grain production-grain price-famine-uprising-grain price", as shown during the Tianli Uprising in 1813. These findings could contribute to an improved understanding of the interaction between climate change and human society during the historical period.

关键词： 18–19th century Climate change Grain price anomalies North China Plain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

俯仰式播种单体仿形性能检测试验台设计与试验

引用

农业机械学报 2024年第2期55卷 90-100页

作者：衣淑娟李怡凯陈继国王淞赵斌黑龙江八一农垦大学工程学院大庆163319

为解决播种单体仿形机构性能难以检测的问题,设计了俯仰式播种单体仿形性能检测试验台。阐述了试验台组成结构与工作原理,对其高速传动系统、液压升降系统、监控系统以及关键部件参数进行设计。应用ANSYS软件对台架整体和关键部件进行... 详细信息

为解决播种单体仿形机构性能难以检测的问题,设计了俯仰式播种单体仿形性能检测试验台。阐述了试验台组成结构与工作原理,对其高速传动系统、液压升降系统、监控系统以及关键部件参数进行设计。应用ANSYS软件对台架整体和关键部件进行静力学分析和模态分析,验证结构设计的合理性。为检验俯仰式播种单体仿形性能检测试验台的实际检测效果,以德邦大为1205型牵引式免耕精量播种机播种单体为研究对象,先以液压杆伸出量与传送带速度为试验因素,以监控系统误差为评价指标进行试验。试验得出,在液压杆伸出量为0~200 mm范围内,监控系统角度传感器最大误差为0.69 mm;在传送带速度8~19 km/范围内,光电编码器最大误差为0.18 km/h。确认监控系统准确性后,再以单体速度为试验因素,采集速度8、10、12 km/h下地块的起伏数据为目标曲线,以地形起伏模拟曲线的绝对误差平均值为指标进行单因素试验,试验得出,所设计的试验台可有效模拟田间地面的起伏频率与起伏量,绝对误差平均值为1.86 mm,满足播种单体仿形性能检测需求。

关键词：高速播种机仿形机构试验台架农田地形液压系统

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国膏摩疗法与膏摩文化的过去、现在和将来

引用

中华中医药杂志 2024年第3期39卷 1419-1422页

作者：钟伟兴谌祖江李义凯南方医科大学中医药学院广州510515

中国膏摩疗法是最古老的医疗实践技术之一,最早的文字记载出现于《五十二病方》中。后世历代医家对膏摩疗法的膏摩方及主治病症不断发展和扩大。作为体表刺激疗法中的一种,膏摩疗法具备中药与按摩的双重功效,曾与针灸、导引、吐纳等疗... 详细信息

中国膏摩疗法是最古老的医疗实践技术之一,最早的文字记载出现于《五十二病方》中。后世历代医家对膏摩疗法的膏摩方及主治病症不断发展和扩大。作为体表刺激疗法中的一种,膏摩疗法具备中药与按摩的双重功效,曾与针灸、导引、吐纳等疗法并列,广泛应用于临床,但在近现代中逐渐淡出医生与科研工作者的视野,临床上少见应用,也鲜见有相关重要研究,并未得到充分的发展和推广,只留下大量的经验膏摩方。文章试从膏摩疗法的起源、历史发展、现代研究进展和展望等方面展开论述,以期探索膏摩疗法在现代医疗体系中的应用可能性,引起科研工作者和临床医生的兴趣,促进相关研究,为膏摩疗法的现代转型和发展提供基础。

关键词：膏摩疗法医学史体表刺激疗法膏摩文化膏摩方

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

喷油压力对柴油喷雾两阶段着火的影响

引用

内燃机学报 2024年第3期42卷 193-202页

作者：黎一锴娄悦杨子明王东方孙成瀚北京理工大学机械与车辆学院北京100081 北京理工大学重庆创业中心重庆401120 昆明理工大学云南省内燃机重点实验室云南昆明650500

基于流动式定容燃烧试验装置以及CONVERGE三维仿真模型,研究了冷起动工况对应缸内上止点环境下喷射压力对柴油自由射流的喷雾宏观特性及两阶段着火转化过程的影响.结果表明:在冷起动工况条件下,低喷射压力(20 MPa)条件下的液相贯穿距略... 详细信息

基于流动式定容燃烧试验装置以及CONVERGE三维仿真模型,研究了冷起动工况对应缸内上止点环境下喷射压力对柴油自由射流的喷雾宏观特性及两阶段着火转化过程的影响.结果表明:在冷起动工况条件下,低喷射压力(20 MPa)条件下的液相贯穿距略大;随着喷射压力的增加,气相喷雾贯穿距增大,气/液相喷雾锥角增大,表明在喷雾体头部区域形成较大的混合气区域;不同喷射压力条件下,喷雾内的局部温度及局部当量比分布规律相似;但随着喷射压力的增大,高温低当量比区域面积增大,促进了低温反应的进行.另一方面,较高的喷射压力使得喷雾流速增大,抑制了喷雾低温核心区域CH_(2)O和热量的累积,进而恶化了低温反应阶段向高温反应阶段的过渡,使高温着火准备过程延长.最终导致高温着火滞燃期随喷射压力升高呈现先减小后增大的变化趋势.

关键词：柴油喷雾低温环境喷射压力滞燃期

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Survival outcomes of conversion surgery for metastatic pancreatic ductal adenocarcinoma after neoadjuvant therapy

引用

Journal of Pancreatology 2023年第3期6卷 110-118页

作者： lingyu Zhu Suizhi Gao Xinqian Wu Bo li Xiaohan Shi Xiaoyi Yin Huan Wang Meilong Shi Penghao li yikai li Chaoliang Zhong Chuanqi Teng Jiawei Han Yiwei Ren Jian Wang Zhendong Fua Xinyu liu Kailian Zheng Shiwei Guo Gang Jin Department of Pancreatic Hepatobiliary Surgery Changhai HospitalNaval Medical UniversityYangpu DistrictShanghaiChina

Objective:To evaluate the survival outcomes of patients who underwent conversion surgery for metastatic pancreatic ductal adenocarcinoma(mPDAC)after neoadjuvant therapy(NAT)and to identify potential candidates that may benefit from this treat-ment strategy.Background:The role and eligibility population of conversion surgery for mPDAC remains controversial in the era of NAT.Methods:A consecutive cohort of patients diagnosed with mPDAC and treated with NAT followed by conversion surgery be-tween 2019 and 2021 were confirmed from a prospective database maintained by the Department of Pancreatic Hepatobiliary Surgery of Changhai Hospital.In accordance with residual metastases and technical resectability after NAT,patients were classi-fied as the complete pathological response of metastases(ypM0)resection group,residual metastases(ypM1)resection group,and exploration group.Median overall survival(mOS)was calculated using the Kaplan-Meier method,uni-and multivariable cox regression was performed to identify clinicopathological predictors of OS.Results:A total of 244 patients with mPDAC were identified from the prospective database,with 19(7.8%)patients who un-derwent ypM0 resection,22(9.0%)underwent ypM1 resection,and 23(9.4%)underwent explorative laparotomy.The mOS was 32.6 months for ypM0 resected patients,15.1 months for ypM1 resected patients,and 13.4 months for those who underwent explorative laparotomy(Pligometastases and continued adjuvant therapy were associated with improved prognosis in the ypM1 resection group.Conclusion:In patients with mPDAC who underwent NAT followed by conversion surgery,the complete pathological response of metastases,normalization of preoperative CA19-9 levels,and continued adjuvant therapy were independent risk

关键词： Conversion surgery Metastatic pancreatic ductal adenocarcinoma Neoadjuvant therapy Survival

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hyperpolarization-activated cyclic nucleotide-gated 2 contributes to electroacupuncture analgesia on lumbar disc herniation-induced radicular pain through activation of microglia in spinal dorsal horn

引用

Journal of Traditional Chinese Medicine 2022年第3期42卷 372-378页

作者： QIN Qingguang CHEN Zujiang FAN Weimin li Junhua liAO liqing li yikai School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China

OBJECTIVE:To explore the mechanisms of dorsal root ganglia and spinal microglia cascade cross in electroacupuncture(EA)analgesia in the treatment of lumbar disc herniation.METHODS:A rat model of lumbar disc herniation(LDH)was established,EA was administered at Huantiao(GB30)acupoint 30 min once a day,for 3 d.Before and after modeling,and after EA,mechanical allodynia thresholds were detected.Hyperpolarization-activated cyclic nucleotide-gated 2(HCN2)in dorsal root ganglia was detected by quantitative polymerase chain reaction(qPCR)and Western blot.C-X3-C motif chemokine ligand 1(CX3CL1)and activity of microglia in spinal cord was observed separately via qPCR and immunofluorescence staining.RESULTS:The mechanical allodynia threshold of the right planta of model rats was significantly reduced(Plia.ZD7288(a blocker of HCN channel)reduced the analgesic effect of EA from 1.83±0.84 to 0.74±0.20(Plion,thereby decreasing the noxious stimulation entered to microglia in spinal dorsal horn.Our work supports EA is an effective treatment for radicular pain of LDH.

关键词： intervertebral disc displacement radicular pain electroacupuncture ganglia,spinal hyperpolarization-activated cyclic nucleotide-gated channels microglia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism of the Large Surface Deformation Caused by Rayleigh-Taylor Instability at Large Atwood Number

引用

Journal of Applied Mathematics and Physics 2014年第10期2卷 971-979页

作者： yikai li Akira Umemura Department of Aerospace Engineering Nagoya University Nagoya Japan

Studying the dynamical behaviors of the liquid spike formed by Rayleigh-Taylor instability is important to understand the mechanisms of liquid atomization process. In this paper, based on the information on the velocity and pressure fields obtained by the coupled-level-set and volume-of- fluid (CLSVOF) method, we describe how a freed spike can be formed from a liquid layer under falling at a large Atwood number. At the initial stage when the surface deformation is small, the amplitude of the surface deformation increases exponentially. Nonlinear effect becomes dominant when the amplitude of the surface deformation is comparable with the surface wavelength (~0.1λ). The maximum pressure point, which results from the impinging flow at the spike base, is essential to generate a liquid spike. The spike region above the maximum pressure point is dynamically free from the bulk liquid layer below that point. As the descending of the maximum pressure point, the liquid elements enter the freed region and elongate the liquid spike to a finger-like shape.

关键词： Fluid Mechanics Multi-Phase Flow Rayleigh-Taylor Instability Spike Formation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

燃油喷雾撞壁与油膜蒸发特性研究

引用

内燃机学报 2024年第4期42卷 299-307页

作者：黎一锴蔡畅王东方杨子明史中杰北京理工大学机械与车辆学院北京100081 联合汽车电子有限公司上海201206 昆明理工大学云南省内燃机重点实验室云南昆明650500

构建了一维非稳态燃油喷雾撞壁模型,综合考虑了液滴蒸发、油膜铺展和油膜温度等影响因素.针对燃油喷雾撞壁过程进行分阶段建模:在自由贯穿阶段,基于射流喷雾液相贯穿距离预测模型和液滴蒸发模型描述自由贯穿阶段,并确定喷雾撞壁时刻.在... 详细信息

构建了一维非稳态燃油喷雾撞壁模型,综合考虑了液滴蒸发、油膜铺展和油膜温度等影响因素.针对燃油喷雾撞壁过程进行分阶段建模:在自由贯穿阶段,基于射流喷雾液相贯穿距离预测模型和液滴蒸发模型描述自由贯穿阶段,并确定喷雾撞壁时刻.在撞壁阶段,燃油喷雾被离散为液滴微元撞击壁面的过程.耦合自由液滴蒸发模型、油膜表面温度模型和油膜蒸发模型,以油膜铺展半径为特征参数构建了附壁油膜在撞壁阶段、附壁油膜铺展阶段和油膜蒸发阶段的一维非稳态归一化模型.讨论了环境温度、压力、喷油压力和初始油膜厚度对喷雾内液滴直径、液滴蒸发质量和油膜蒸发速率的影响.结果表明:阶段化、离散化的一维非稳态撞壁喷雾模型能够准确地预测在宽范围环境温度工况下的喷雾贯穿、近壁面铺展、燃油附壁以及蒸发过程.提高环境温度、降低环境压力能够提高附壁油膜表面最高温度,增大油膜的蒸发速率.

关键词：喷雾撞壁油膜蒸发预测模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：