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Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern

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Life Metabolism 2024年第1期3卷 21-36页

作者： Shuo Wang lingling Zhang Jingyu Zhao Meijuan Bai yijun lin Qianqian Chu Jue Gong Ju Qiu Yan Chen CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

The monocarboxylate transporter 1(MCT1),encoded by gene Slc16a1,is a proton-coupled transporter for lactate and other monocar***1-mediated lactate transport was recently found to regulate various biological ***,how MCT1 and lactate in the intestine modulate the physiology and pathophysiology of the body is *** this study,we generated a mouse model with specific deletion of Slc16a1 in the intestinal epithelium(Slc16a1IKO mice)and investigated the functions of MCT1 in the *** fed a high-fat diet,Slc16a1IKO male mice had improvement in glucose tolerance and insulin sensitivity,while Slc16a1IKO female mice only had increased *** of intestinal MCT1 in male mice was associated with downregulation of pro-inflammatory pathways,together with decreased circulating levels of inflammatory cytokines including tumor necrosis factor alpha(TNFα)and C-C motif chemokine ligand 2(CCL2).Lactate had a stimulatory effect on pro-inflammatory macrophages in *** number of intestinal macrophages was reduced in Slc16a1IKO male mice in *** deletion of Slc16a1 in male mice reduced interstitial lactate level in the *** addition,treatment of male mice with estrogen lowered interstitial lactate level in the intestine and abolished the difference in glucose homeostasis between Slc16a1IKO and wild-type *** of intestinal MCT1 also blocked the transport of lactate and short-chain fatty acids from the intestine to the portal *** effect of Slc16a1 deletion on glucose homeostasis in male mice was partly mediated by alterations in gut *** conclusion,our work reveals that intestinal MCT1 regulates glucose homeostasis in a sex-dependent manner.

关键词： MCT1 intestine lactate short-chain fatty acids insulin resistance obesity

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海洋生物产业发展创新平台建设的对策--以厦门为例

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海洋开发与管理 2024年第4期41卷 73-83页

作者：林逸君自然资源部第三海洋研究所厦门361005

海洋药物和生物制品产业是国家重点培育的海洋战略性新兴产业之一,产业的发展离不开一流的产业发展创新平台的科技支撑,目前我国海洋药物和生物制品产业尚缺乏一支以成果转化与产业化为目标的强有力的国家科技力量支撑。文章通过调研全... 详细信息

海洋药物和生物制品产业是国家重点培育的海洋战略性新兴产业之一,产业的发展离不开一流的产业发展创新平台的科技支撑,目前我国海洋药物和生物制品产业尚缺乏一支以成果转化与产业化为目标的强有力的国家科技力量支撑。文章通过调研全国海洋生物领域产业发展创新平台建设的发展经验、存在问题,梳理在厦门建设海洋生物产业发展创新平台政策、科技、产业等资源现状,为在厦门布局海洋生物国家级产业发展创新平台提出优化体制机制、明确定位和“造血”能力、畅通人才交流和上升通道的建议,以提高创新转换效率,推动海洋药物和生物制品产业发展。

关键词：海洋药物海洋生物制品科技创新产业发展创新平台科技成果转化

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Single-cell RNA-Seq reveals transcriptional regulatory networks directing the development of mouse maxillary prominence

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Journal of Genetics and Genomics 2023年第9期50卷 676-687页

作者： Jian Sun yijun lin Nayoung Ha Jianfei Zhang Weiqi Wang Xudong Wang Qian Bian Department of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai 200011China Shanghai Institute of Precision Medicine Shanghai 200125China Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China

During vertebrate embryonic development,neural crest-derived ectomesenchyme within the maxillary prominences undergoes precisely coordinated proliferation and differentiation to give rise to diverse craniofacial structures,such as tooth and ***,the transcriptional regulatory networks underpinning such an intricate process have not been fully ***,we perform single-cell RNA-Seq to comprehensively characterize the transcriptional dynamics during mouse maxillary development from embryonic day(E)*** single-cell transcriptome atlas of~28,000 cells uncovers mesenchymal cell populations representing distinct differentiating states and reveals their developmental trajectory,suggesting that the segregation of dental from the palatal mesenchyme occurs at ***,we identify a series of key transcription factors(TFs)associated with mesenchymal fate transitions and deduce the gene regulatory networks directed by these ***,our study provides important resources and insights for achieving a systems-level understanding of craniofacial morphogenesis and abnormality.

关键词： Craniofacial development Single-cell RNA-Seq Maxillary prominences Gene regulatory network Transcription factor

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Rethink Left-Behind Experience: New Categories and Its Relationship with Aggression

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International Journal of Mental Health Promotion 2021年第4期23卷 443-454页

作者： Chunyang Zhang yijun lin Yuyang Zhou Wei Xu Beijing Key Laboratory of Applied Experimental Psychology National Demonstration Center for Experimental Psychology Education(Beijing Normal University)Faculty of PsychologyBeijing Normal UniversityBeijing100875China College of Business Florida International UniversityMiami33199USA School of Psychology Nanjing Normal UniversityNanjing210097China

Left-behind experience refers to the experience of children staying behind in their hometown under the care of only one parent or their relatives while one or both of their parents leave to work in other *** students with left-behind experience showed higher aggression *** further explore the relationship between left-behind experience and aggression,the current study categorized left-behind experience using latent class analysis and explored its relationship with *** thousand twenty-eight Chinese college students with left-behind experience were recruited,and their aggression levels were *** results showed that there were four categories of left-behind experience:“starting from preschool,frequent contact”(35.5%),“less than 10 years in duration,limited contact”(27.0%),“starting from preschool,over 10 years in duration,limited contact”(10.9%),and“starting from school age,frequent contact”(26.6%).Overall,college students who reported frequent contact with their parents during the left-behind period showed lower levels of aggression than others *** were less aggressive than males in the“starting from preschool,frequent contact”left-behind situation,while males were less aggressive than females in the“starting from school age,frequent contact”*** indicate that frequent contact with leaving parents contributes to decreasing aggression of college students with left-behind ***,gender is an important factor in this relationship.

关键词： Aggression left-behind experience college students gender differences latent class analysis

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Risk Assessment Index System of Natural Gas Industrial Chain in China

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Petroleum Science 2006年第4期3卷 57-62页

作者： Liu yijun lin Shanshan Li Zhiwei China University of Petroleum Beijing 102249 China

This paper establishes a risk assessment index system for the natural gas industrial chain. China＇s natural gas industrial chain is entering a stage of rapid growth. In order to guarantee healthy development of the natural gas industrial chain, it is urgent to establish a risk alert system, which is based on a risk assessment index system. First of all, the risks of the natural gas industrial chain are defined in the paper; then the risk factors are analyzed according to the present status of the natural gas industrial chain, and five categories of risk factors are summarized： resource risk, transport risk, marketing risk, risk of unbalanced chain links, and environment risk. The paper presents the principles of the risk assessment index system. The natural gas industrial chain risk assessment index system is established with four levels and forty-six risk indices.

关键词： Natural gas natural gas industrial chain risk analysis index system

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White-light-emitting diodes using GaN-excited CdSe/CdS/ZnS quantum dots

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Particuology 2014年第4期12卷 90-93页

作者： yijun lin Yu Zhang Jia Zhao Pengfei Gu Ke Bi Qiuran Zhang Hairong Chu Tieqiang Zhang Tian Cui Yiding Wang Jun Zhao William W.Yu State Key Laboratory on Integrated Optoelectronics and College of Electronic Science and EngineeringJilin University State Key Laboratory of Superhard Materials and College of PhysicsJilin University Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of Sciences Department of Chemistry and Physics Louisiana State University.ShreveportLA 71115USA College of Material Science and Engineering.Qingdao University of Science and Technology

Fluorescence-based white-light-emitting diodes （WLEDs） were fabricated using blue GaN chips and green- and red-emitting CdSe/CdS/ZnS quantum dots （QDs）. The coordinate and color temperature of the WLEDs could be varied because of the size-tunable emission of CdSe QDs from 510 to 620 nm. Warm and cold white emissions were confirmed with the color temperature ranging from 4000 to 9000 K. Color coordinates were analyzed at different bias. The fast enhancement of blue emission resulted in the shift of color coordinates to the cold side. The stability of white emission during operation was analyzed; stable spectra were achieved within 90 min.

关键词： GaN Quantum dots White-light-emitting diode Stability

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Optimizing theπ-Bridge of Non-fullerene Acceptors to Suppress Dark Current in NIR Organic Photodetectors

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Chemical Research in Chinese Universities 2024年第4期40卷 712-721页

作者： SHAO lin HUANG yijun HONG ling XU Zishuo YANG Xiye LIU Chunchen HUANG Fei CAO Yong State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510640P.R.China Lumidar Technology Co. Ltd.Guangzhou510530P.R.China

Recently,the rapid development of non-fullerene acceptors(NFAs)has laid the foundation for performance improvements in near-infrared(NIR)organic photodetectors(OPDs).However,reducing the bandgap of NFAs to achieve strong absorption in the shorter-wave region usually leads to increased dark current density(J_(d))and decreased responsivity(R),severely limiting the detectivity(D*)of *** date,it remains challenging to manipulate the J_(d) of NIR-OPDs through rational structure engineering of ***,three NIR-NFAs,namely bis(2-decyltetradecyl)4,4′-(2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(6-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thieno[3,4-b]thiophene-2-carboxylate)(TSIC-4F),bis(2-decyltetradecyl)6,6′-(2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(4-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thieno[3,4-b]thiophene-2-carboxylate)(STIC-4F),and 2,2′-((2Z,2′Z)-(((2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(2,3-bis(5-(2-butyloctyl)thiophen-2-yl)thieno[3,4-b]pyrazine-7,5-diyl))bis(metha-neylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile(TPIC-4F),were designed using the thieno[3,4-b]thiophene(TT)and thieno[3,4-b]pyrazine(TPy)derivatives as theπ-*** to the intramolecular S-S and S-N interactions,STIC-4F and TPIC-4F exhibited smaller backbone distortions than TSIC-4F.A significantly red-shifted absorption with a peak at 1015 nm was observed in TPIC-4F film,larger than that(ca.960 nm)for TSIC-4F and STIC-4F ***,OPDs operating in a photovoltaic mode were successfully fabricated,and TPIC-4F-based OPDs achieved the lowest J_(d) of 3.18×10^(-8) A/cm^(2) at-0.1 ***,although TPIC-4F-based OPDs exhibited the lowest R,higher shot-noise-limited specific detectivity(D_(sh)*)in 1000-1200 nm co

关键词： π-Bridge Near-infrared Non-fullerene acceptor Dark current Organic photodetector

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Self-polarized RGB device realized by semipolar micro-LEDs and perovskite-in-polymer films for backlight applications

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Opto-Electronic Advances 2024年第3期7卷 35-49页

作者： Tingwei Lu Yue lin Tianqi Zhang Yue Huang Xiaotong Fan Shouqiang Lai yijun Lu Hao-Chung Kuo Zhong Chen Tingzhu Wu Rong Zhang School of Electronic Science and Engineering Fujian Engineering Research Center for Solid-State LightingXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Department of Photonics and Graduate Institute of Electro-Optical Engineering College of Electrical and Computer EngineeringYang Ming Chiao Tung UniversityHsinchu 30010China Semiconductor Research Center Hon Hai Research InstituteTaipei 11492China.

In backlighting systems for liquid crystal displays,conventional red,green,and blue(RGB)light sources that lack polarization properties can result in a significant optical loss of up to 50%when passing through a *** address this inefficiency and optimize energy utilization,this study presents a high-performance device designed for RGB polarized *** device employs an array of semipolar blueμLEDs with inherent polarization capabilities,coupled with mechanically stretched films of green-emitting CsPbBr3 nanorods and red-emitting CsPbI3-Cs4PbI6 hybrid *** CsPbBr3 nanorods in the polymer film offer intrinsic polarization emission,while the aligned-wire structures formed by the stable CsPbI3-Cs4PbI6 hybrid nanocrystals contribute to substantial anisotropic emissions,due to their high dielectric *** resulting device achieved RGB polarization degrees of 0.26,0.48,and 0.38,respectively,and exhibited a broad color gamut,reaching 137.2%of the NTSC standard and 102.5%of the Rec.2020 *** compared to a device utilizing c-plane LEDs for excitation,the current approach increased the intensity of light transmitted through the polarizer by 73.6%.This novel fabrication approach for polarized devices containing RGB components holds considerable promise for advancing next-generation display technologies.

关键词： halide perovskite light-emitting-diodes polarized emission nanocrystals stability

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海洋药物和生物制品产业发展经验与对策

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科技管理研究 2023年第15期43卷 152-158页

作者：林逸君自然资源部第三海洋研究所福建厦门361005

为促进不同地区间相互借鉴学习,通过分析评价不同地区海洋药物和生物制品产业的科技创新环境、成果转化效率和政策发展经验,基于科技创新、专利产出与成果转化、产业发展三者关系,提出我国海洋药物和生物制品产业发展出路的对策建议:建... 详细信息

为促进不同地区间相互借鉴学习,通过分析评价不同地区海洋药物和生物制品产业的科技创新环境、成果转化效率和政策发展经验,基于科技创新、专利产出与成果转化、产业发展三者关系,提出我国海洋药物和生物制品产业发展出路的对策建议:建立深海遗传资源研究与开发方向的国家重点实验室,积极开发海洋药物;实施海洋生物科技创新提升计划,加大专利产出;以市场为导向建立联合实验室,促进成果转化;整合建设面向全产业链的产业技术开发平台,促进创新链和产业链融合。

关键词：海洋药物海洋生物制品科技创新产学研合作科技成果转化

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Harnessing cytokine-induced killer cells to accelerate diabetic wound healing:an approach to regulating post-traumatic inflammation

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Regenerative Biomaterials 2024年第2期3卷 88-99页

作者： Yixi Yang Cheng Zhang Yuan Jiang yijun He iawei Cai lin Liang Zhaohuan Chen Sicheng Pan Chu Hua Keke Wu Le Wang Zhiyong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China Department of Osteoarthropathy and Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface *** clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive ***,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical *** the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to *** demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory *** *** accelerateskin healing in diabetic *** results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic *** novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关键词： macrophage diabetic wound post-traumatic inflammation cytokine-induced killer cells vascularization

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