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Unveiling the time-temperature dependence of metastability of supercooled liquid using nano-calorimetry

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 119-127页

作者： yijun Ding Lijian song Zheng Wang Ruiqi Yu Junqiang Wang Lina Hu Yuanzheng Yue Edgar D.Zanotto Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong University Jinan 250061China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Experimental Teratology Shandong University Jinan 250061 China Department of Chemistry and Bioscience Aalborg UniversityAalborg 9220Denmark Department of Materials Engineering Federal University of Sao CarlosSao Carlos SP 13.565-905Brazil

There is a lack of understanding of both the conversion of an unstable glass into a metastable supercooled liquid(MSL) upon heating and the metastability of MSLs. In this study, we investigated the time-and temperature-dependent metastability of an MSL using an advanced nano-calorimetric technique. The chosen Au-based metallic glass(Au MG) allowed adequate probing of its MSL in a temperature range between 10 and 70 K above the standard glass transition temperature. We found that the survival time of the MSL state is a quadratic function of temperature. Beyond this duration threshold, the sample undergoes fast crystallization even if it is below the crystallization temperature that is measured using differential scanning *** transmission electron microscopy, we observed the formation of clusters with a partially ordered lattice structure during relaxation in the Au MG sample fabricated using a nano-calorimeter. The atomic ordering within the clusters was enhanced by increasing time and temperature in the MSL region. Once the as-produced glass entered the MSL stage upon heating followed by a quenching stage at a given rate, the mechanical properties of the quenched glass remained the same regardless of its holding temperature and duration within the MSL region. This work provides insights into the glass-MSL-crystal transformation and offers guidance for designing standard metallic glasses for property characterizations.

关键词： metallic glass supercooled liquid relaxation nucleation nano calorimetric technology

Long-term Variation of the Solar Polar Magnetic Fields at Different Latitudes

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Research in Astronomy and Astrophysics 2024年第7期24卷 193-200页

作者： Shuhong Yang Jie Jiang Zifan Wang yijun Hou Chunlan Jin Qiao song Yukun Luo Ting Li Jun Zhang Yuzong Zhang Guiping Zhou Yuanyong Deng Jingxiu Wang National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Science University of Chinese Academy of Sciences State Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of Sciences School of Space and Environment Beihang University Key Laboratory of Space Weather National Satellite Meteorological Center (National Center for Space Weather) Innovation Center for FengYun Meteorological Satellite (FYSIC) School of Physics and Materials Science Anhui University

The polar magnetic fields of the Sun play an important role in governing solar activity and powering fast solar wind. However, because our view of the Sun is limited in the ecliptic plane, the polar regions remain largely uncharted. Using the high spatial resolution and polarimetric precision vector magnetograms observed by Hinode from 2012 to 2021, we investigate the long-term variation of the magnetic fields in polar caps at different *** Hinode magnetic measurements show that the polarity reversal processes in the north and south polar caps are non-simultaneous. The variation of the averaged radial magnetic flux density reveals that, in each polar cap, the polarity reversal is completed successively from the 70° latitude to the pole, reflecting a poleward magnetic flux migration therein. These results clarify the polar magnetic polarity reversal process at different latitudes.

关键词： dynamo Sun: magnetic fields Sun: photosphere

Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction

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Neuroscience Bulletin 2016年第4期32卷 341-348页

作者： Wei Wu Linyang Cui Ying Fu Qianqian Tian Lei Liu Xuan Zhang Ning Du Ying Chen Zhijun Qiu yijun song Fu-Dong Shi Rong Xue Department of Neurology Tianjin Medical University General Hospital Department of Neurology Barrow Neurological InstituteSt.Joseph’s Hospital and Medical Center

In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction （AMTI）, we enrolled 27 patients with AMTI and 12 mat- ched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography （PSG） were performed on days 14 and 90 post-stroke. Compared to heal- thy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3; more sleep-related breathing disorders occurred; and cog- nitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance, sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients.

关键词： Acute minor thalamic infarction Polysomnography Cognition

尿蛋白水平对于评估子痫前期严重程度及母儿结局的价值

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中华妇产科杂志 2022年第5期57卷 325-331页

作者：王晓旭刘俊涛高劲松宋亦军宋英娜中国医学科学院北京协和医学院北京协和医院妇产科国家妇产疾病临床研究中心北京100730

目的探讨尿蛋白水平在评估子痫前期(PE)严重程度及母儿结局中的价值。方法回顾性分析2011年1月至2021年6月于北京协和医院治疗的265例PE孕妇的临床资料。根据孕妇分娩前24小时尿蛋白(24-hUPro)定量最高检测值,将265例孕妇分为蛋白尿组(2... 详细信息

目的探讨尿蛋白水平在评估子痫前期(PE)严重程度及母儿结局中的价值。方法回顾性分析2011年1月至2021年6月于北京协和医院治疗的265例PE孕妇的临床资料。根据孕妇分娩前24小时尿蛋白(24-hUPro)定量最高检测值,将265例孕妇分为蛋白尿组(24-hUPro≥0.3 g,255例)和无蛋白尿组(24-hUPro0.05),但新生儿出生体重、新生儿多项并发症的发生率均有统计学差异(P均<0.05)。与蛋白尿组比较,无蛋白尿组PE孕妇的诊断孕周(中位数分别为34.7、37.6周)及分娩孕周(中位数分别为36.0、38.4周)均较晚、眼部血管病变比例低[分别为56.7%(135/238)和2/9]、新生儿出生体重高[中位数分别为2325和2750 g]、新生儿重症监护病房入住率低[分别为54.3%(127/234)和1/10],两组分别比较,差异均有统计学意义(P均<0.05)。结论尿蛋白水平在评估PE病情的严重程度、母儿结局中具有重要意义,但其并非必要性指标,无蛋白尿的PE孕妇仍然可能出现严重的母儿不良结局。

关键词：蛋白尿先兆子痫疾病严重程度指数妊娠并发症妊娠结局

住院患者CRPA菌耐药特点及院内感染危险因素分析

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中国药物滥用防治杂志 2022年第8期28卷 1039-1042页

作者：袁敏宋义军乌鲁木齐市友谊医院药剂科新疆乌鲁木齐830049

目的:探讨耐碳青霉烯类铜绿假单胞菌(Carbapene-resistant Pseudomonas Aeruginosa,CRPA)在住院患者中的耐药特点,并分析院内感染相关危险因素。方法:选择2019年1月—2021年12月乌鲁木齐市友谊医院收治的因PA感染住院患者90例作为研究... 详细信息

目的:探讨耐碳青霉烯类铜绿假单胞菌(Carbapene-resistant Pseudomonas Aeruginosa,CRPA)在住院患者中的耐药特点,并分析院内感染相关危险因素。方法:选择2019年1月—2021年12月乌鲁木齐市友谊医院收治的因PA感染住院患者90例作为研究对象。按照药敏结果将未发生CRPA院内感染患者设为对照组(n=71),发生CRPA院内感染患者设为研究组(n=19)。比较两组病原菌耐药特点,并采用单因素及多因素Logistic回归分析CRPA院内感染的影响因素。结果:研究组亚胺培南、美罗培南耐药性高于对照组(P0.05);两组有入侵性操作、PA分离出前ICU住院>3 d、合并其他病原菌感染、联用2种及以上抗菌药比较,差异有统计学意义(P3 d、合并其他病原菌感染、联用2种及以上抗菌药等因素是CRPA院内感染的影响因素(P3 d等,因此,临床应在患者住院期间重点监测病区环境,以免PA耐药株的大面积流行。

关键词：耐碳青霉烯类铜绿假单胞菌住院患者院内感染耐药特点危险因素

GC-IMS法比较不同酒龄猕猴桃酒特征香气物质差异

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食品与生物技术学报 2023年第2期42卷 58-65页

作者：宋艺君庞来祥袁筱庞柏均郭涛陕西中医药大学药学院陕西咸阳712046 陕西百贤酒业有限公司陕西宝鸡722305 空军第九八六医院陕西西安710054

比较不同酒龄猕猴桃酒挥发性特征香气物质的差异,为建立不同酒龄猕猴桃酒的鉴别方法和进一步建立不同酒龄猕猴桃酒整体品质评价的新方法提供思路。对不同酒龄猕猴桃酒的挥发性物质,采用气相色谱-离子迁移谱(Gas Chromatography-Ion Mobi... 详细信息

比较不同酒龄猕猴桃酒挥发性特征香气物质的差异,为建立不同酒龄猕猴桃酒的鉴别方法和进一步建立不同酒龄猕猴桃酒整体品质评价的新方法提供思路。对不同酒龄猕猴桃酒的挥发性物质,采用气相色谱-离子迁移谱(Gas Chromatography-Ion Mobility Spectrometry,GC-IMS)进行检测并比较成分变化,结合主成分分析(PCA)和“最近邻”指纹分析分析其挥发性物质的差异。GC-IMS指纹图谱显示,不同酒龄猕猴桃酒的挥发性物质存在差异,明确定性的挥发性物质有单体及部分物质的二聚体共29种;糠醛、3-甲基丁醛、2-甲基丁酸乙酯、异戊酸乙酯等可作为5年酒龄猕猴桃酒的特征挥发性物质;苯甲醛可作为4年酒龄猕猴桃酒的特征挥发性物质;乙酸丁酯、乙酸异丁酯、乙酸等可作为3年酒龄猕猴桃酒的特征挥发性物质。PCA和“最近邻”指纹分析结果显示,各组样品分离度良好。GC-IMS技术结合聚类分析方法证明不同酒龄猕猴桃酒所含挥发性物质存在差异,研究结果可为不同酒龄猕猴桃酒的辨识提供一定的思路。

关键词：猕猴桃酒香气物质主成分分析 “最近邻”指纹分析气相色谱-离子迁移谱

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妊娠合并系统性红斑狼疮与子痫前期的临床特点及处理

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中华围产医学杂志 2019年第3期22卷 207-210页

作者：丁文艳宋亦军中国医学科学院北京协和医学院北京协和医院妇产科 100730

系统性红斑狼疮(systemic lupus erythematosus, SLE)是一种风湿免疫病,但常常会影响育龄女性的妊娠结局。子痫前期是常见妊娠期并发症。SLE在孕期复发或新发与子痫前期有很多相同的临床表现,如高血压、蛋白尿、血小板计数减少等,因此... 详细信息

系统性红斑狼疮(systemic lupus erythematosus, SLE)是一种风湿免疫病,但常常会影响育龄女性的妊娠结局。子痫前期是常见妊娠期并发症。SLE在孕期复发或新发与子痫前期有很多相同的临床表现,如高血压、蛋白尿、血小板计数减少等,因此不易鉴别。当SLE为孕期或产后新发时,患者常常首先表现为子痫前期症状,SLE相关的皮肤及关节症状往往较轻或不典型。SLE也是子痫前期的高危因素。二者相互联系,共同影响着母婴结局。研究表明,多种血清学指标可用于预测SLE患者是否会发生子痫前期。阿司匹林可作为SLE患者预防子痫前期的药物。当SLE活动与子痫前期难以鉴别时,按SLE处理可以使母胎风险降低。

关键词：先兆子痫妊娠并发症红斑狼疮,系统性诊断,鉴别

A comprehensive profile and inter-individual variations analysis of the human normal amniotic fluid proteome

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A comprehensive profile and inter-individual variations anal...

《2022中国系统性红斑狼疮患者生殖与妊娠管理指南》解读

第三届全国质谱分析学术报告会

作者： Xiang Liu yijun song Zhengguang Guo Wei Sun Juntao Liu Core Facility of Instrument Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College

Amniotic fluid(AF)contains large amounts of proteins produced by amnion epithelial cells,fetal tissues,fetal excretions and placental tissues;thus,it is an important potential source of biomarkers for identifying fetal *** this study,a pooled AF sample from 7 healthy volunteers was used to provide a comprehensive profile of normal human AF proteome using immunoaffinity depletion of 14 high-abundance *** individual AF sample was used to analyze inter-individual variations with i TRAQ method(Fig.1).As a result,a total of 2881 non-redundant proteins were identified,and 1624 proteins were quantified based on the peak intensity-based semi-quantification method(i BAQ)(Fig.2).The normal AF proteome was expanded to 3170,which is the largest database for the AF proteome(Fig.3).Gene Ontology(GO)analysis showed that the AF proteome was enriched in extracellular region and extracellular *** function annotation showed that the top canonical pathway was axonal guidance *** inter-individual variation analysis of 7individual AF samples showed that the median inter-individual CV was 0.22,and 90%of proteins had an individual CV lower than 0.46(Fig.4).iBAQ quantification analysis revealed that the inter-individual variations were not correlated with protein *** analysis indicated that intracellular proteins tended to have higher CVs,and extracellular proteins tended to have lower *** data will contribute to a better understanding of amniotic fluid proteomic analysis and biomarker discovery.

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协和医学杂志 2023年第3期14卷 504-513页

作者：田新平赵久良李梦涛宋亦军刘俊涛曾小峰中国医学科学院北京协和医院风湿免疫科国家皮肤与免疫疾病临床医学研究中心疑难重症及罕见病国家重点实验室风湿免疫病学教育部重点实验室中国医学科学院北京协和医院产科中心国家妇产疾病临床医学研究中心北京100730

系统性红斑狼疮(systemic lupus erythematosus,SLE)多发于育龄期女性,其生育管理已成为SLE患者疾病管理的重要内容。在国家皮肤与免疫疾病临床医学研究中心、国家妇产疾病临床医学研究中心、中国系统性红斑狼疮研究协作组、中国风湿免... 详细信息

系统性红斑狼疮(systemic lupus erythematosus,SLE)多发于育龄期女性,其生育管理已成为SLE患者疾病管理的重要内容。在国家皮肤与免疫疾病临床医学研究中心、国家妇产疾病临床医学研究中心、中国系统性红斑狼疮研究协作组、中国风湿免疫病相关生殖及妊娠研究委员会的联合组织与指导下,制定了我国首部系统性红斑狼疮患者生殖与妊娠管理指南。该指南针对13个亟待解决的临床问题作出基于循证证据的推荐,涵盖了孕前准备(孕前咨询、妊娠风险评估、妊娠时机选择、辅助生育措施选择)、妊娠期疾病监测与治疗、胎儿监测与并发症诊治、产后随访与哺乳注意事项及新生儿监护的母婴全程管理,指南还就SLE患者妊娠的适应证、禁忌证、妊娠过程中一些重要脏器损害的识别与治疗、妊娠与哺乳期药物的使用、妊娠终止的适应证与围妊娠终止期药物的调整、合并抗磷脂抗体综合征患者的诊治等临床关心的重大问题作出了详细推荐,旨在提高SLE患者的妊娠成功率,降低母婴病死率。

关键词：系统性红斑狼疮生殖妊娠指南解读