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安徽医科大学学报 2022年第8期57卷 1338-1344页

作者：杨书瀚裴筱涵祁义军安徽医科大学第一附属医院普外科合肥230022 中国科学技术大学附属第一医院临床病理中心合肥230002

目的研究LAMP5在结直肠癌组织中的表达水平及其与临床预后相关性,探讨其在结直肠癌发生发展中的作用。方法使用GEPIA和LinkedOmics数据库分析LAMP5在结直肠癌组织和配对癌旁组织中的表达水平、临床参数结直肠癌患者生存预后的关系并通... 详细信息

目的研究LAMP5在结直肠癌组织中的表达水平及其与临床预后相关性,探讨其在结直肠癌发生发展中的作用。方法使用GEPIA和LinkedOmics数据库分析LAMP5在结直肠癌组织和配对癌旁组织中的表达水平、临床参数结直肠癌患者生存预后的关系并通过临床样本验证。使用LinkedOmics数据库和DAVID网站进行基因富集分析,研究LAMP5在结直肠癌发生发展中涉及的分子功能和相关信号通路。结果免疫组化结果显示,LAMP5在结直肠癌组织中的表达水平高于配对癌旁组织(n=120,P<0.05);LAMP5表达水平与结直肠癌分化程度呈负相关,与N分期和M分期呈正相关(P<0.05),但与年龄、性别和T分期无相关性。GEPIA分析和临床样本Kaplan-Meier分析显示LAMP5高表达结直肠癌患者的总生存期和无病生存期均短于LAMP5低表达者(P<0.05),COX回归分析提示LAMP5高表达是结直肠癌患者独立预后因素。GO分析显示LAMP5与结直肠癌细胞外基质、细胞外基质黏附、细胞外基质定位和胶原定位等功能相关(P<0.05);KEGG分析显示LAMP5可能与TGF-β和PI3K-AKT通路相关(P<0.05)。结论LAMP5在结直肠癌组织中表达水平升高,并且与结直肠癌分化水平、淋巴结转移、远处转移和临床预后相关,因此LAMP5可能作为结直肠癌诊断、治疗和预后预测新的分子指标。

关键词：结直肠癌 LAMP5 预后

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Evaluation of 3D crustal seismic velocity models in southwest China:Model performance,limitation,and prospects

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Science China Earth Sciences 2024年第2期67卷 604-619页

作者： Xin WANG Ling CHEN qi-Fu CHEN Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China

Southwest China is a tectonically and seismically active region,witnessing strong deformation due to the collision between the Indian and Eurasian *** the subsurface velocity structure of this region is thus important in understanding the tectonics and geodynamic processes of continental collision and in mitigating seismic *** studies have provided various 3D seismic velocity models in southwest ***,discrepancies exist among these models,and less effort has been made to quantify the reliability and accuracy of these existing velocity *** this study,we use regional 3D waveform simulation to evaluate the performance of various regional crustal 3D velocity models in reproducing observed *** particularly focus on two recent earthquake sequence in the region,the 2021 Yunnan Yangbi MS_(6.4) earthquake sequence and the 2022 Sichuan Luding MS_(6.8) earthquake *** tested 3D velocity models include the Southwest China Community Velocity model V1.0,the Unified Seismic Tomography Models for Continental China Lithosphere V2.0,the adjoint full waveform tomography model of the crustal and upper mantle beneath Eastern Tibetan Plateau,and the shallow seismic structure model beneath continental *** results show that the tested 3D velocity models generally capture well long-period(<0.2 Hz)waveforms,indicating that the 3D models adequately resolve overall large-scale subsurface ***,the 3D synthetics show discrepancies in higher frequencies(0.05–0.3 Hz)and the performance of the 3D velocity models varies from region to region,suggesting that smaller scale heterogeneities are not well *** shallow velocity structures(<10 km)can improve the waveform fitting,emphasizing the importance of incorporating shallow structures in waveform *** full-waveform tomography model shows a slighter better performance than the other models,especially for the body-waves,highlighting the advantages

关键词： Southwest China Seismic tomography models Shallow Structures Waveform simulation Model evaluation

Deciphering and integrating invariants for neural operator learning with various physical mechanisms

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National Science Review 2024年第4期11卷 111-122页

作者： Rui Zhang qi Meng Zhi-Ming Ma Academy of Mathematics and Systems Science Chinese Academy of Sciences(CAS) Microsoft Research

Neural operators have been explored as surrogate models for simulating physical systems to overcome the limitations of traditional partial differential equation(PDE) solvers. However, most existing operator learning methods assume that the data originate from a single physical mechanism, limiting their applicability and performance in more realistic scenarios. To this end, we propose the physical invariant attention neural operator(PIANO) to decipher and integrate the physical invariants for operator learning from the PDE series with various physical mechanisms. PIANO employs self-supervised learning to extract physical knowledge and attention mechanisms to integrate them into dynamic convolutional *** to existing techniques, PIANO can reduce the relative error by 13.6%–82.2% on PDE forecasting tasks across varying coefficients, forces or boundary conditions. Additionally, varied downstream tasks reveal that the PI embeddings deciphered by PIANO align well with the underlying invariants in the PDE systems, verifying the physical significance of PIANO.

关键词： neural operator PDE solver contrastive learning physical invariants

A new centrality measure based on neighbor loop structure for network dismantling

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Digital Communications and Networks 2024年第2期10卷 472-480页

作者： qingxia Liu Bang Wang Jiming qi Xianjun Deng School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan430074China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Nearly all real-world networks are complex networks and usually are in danger of ***,it is crucial to exploit and understand the mechanisms of network attacks and provide better protection for network *** dismantling aims to find the smallest set of nodes such that after their removal the network is broken into connected components of sub-extensive *** overcome the limitations and drawbacks of existing network dismantling methods,this paper focuses on network dismantling problem and proposes a neighbor-loop structure based centrality metric,NL,which achieves a balance between computational efficiency and evaluation *** addition,we design a novel method combining NL-based nodes-removing,greedy tree-breaking and ***,we compare five baseline methods with our algorithm on ten widely used real-world networks and three types of model networks including Erd€os-Renyi random networks,Watts-Strogatz smallworld networks and Barabasi-Albert scale-free networks with different network generation *** results demonstrate that our proposed method outperforms most peer methods by obtaining a minimal set of targeted attack ***,the insights gained from this study may be of assistance to future practical research into real-world networks.

关键词： Complex networks Network dismantling Centrality measure

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域名与商标的冲突及解决机制

科技与法律 2005年第2期 78-81页

作者：祁轶军国家知识产权局审查二部

域名又称网址,是一个主体通过计算机在因特网上登录的地址.域名设定的最初目的是为了识别主机,使人们在浩如烟海的网络世界中惟一地确认并访问所需的任何一台计算机.

关键词：域名解决机制信息资源库冲突标的计算机网络世界网络技术电子商务互联网贸易

Experimental study on the activation of coal gasification fly ash from industrial CFB gasifiers

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Chinese Journal of Chemical Engineering 2024年第1期65卷 8-18页

作者： qiyao Yang Xiaobin qi qinggang Lyu Zhiping Zhu North China Electric Power University Beijing 102206China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Shanxi Key Laboratory of Coal Flexible Combustion and Thermal Conversion Datong 037000China University of Chinese Academy of Sciences Beijing 100049China Shanxi Engineering Research Center of Coal Clean Efficient Combustion and GasificationDatong 037000China

Coal gasification fly ash(CGFA)is an industrial solid waste from the coal circulating fluidized bed(CFB)gasification process,and it needs to be effectively disposed to achieve sustainable development of the *** realize the application of CGFA as a precursor of porous carbon materials,the physicochemical properties of three kinds of CGFA from industrial CFB gasifiers are ***,the activation potential of CGFA is acquired via steam activation experiments in a tube furnace ***,the fluidization activation technology of CGFA is practiced in a bench-scale CFB test rig,and its advantages are *** results show that CGFA is characterized by a high carbon content in the range of 54.06%–74.09%,an ultrafine particle size(d50:16.3–26.1 μm),and a relatively developed pore structure(specific surface area SSA:139.29–551.97 m^(2)·g^(-1)).The proportion of micropores in CGFA increases gradually with the coal *** activation experiments show that the pore development of CGFA mainly includes three stages:initial pore development,dynamic equilibrium between micropores and mesopores and pore *** SSA of lignite fly ash(LFA),subbituminous fly ash(SBFA)and anthracite fly ash(AFA)is maximally increased by 105%,13%and 72%after steam activation;the order of the largest carbon reaction rate and decomposition ratio of steam among the three kinds of CGFA is SBFA>LFA>*** the ratio of oxygen to carbon during the fluidization activation of LFA is from 0.09 to 0.19,the carbon conversion ratio increases from 14.4%to 26.8%and the cold gas efficiency increases from 6.8%to 10.2%.The SSA of LFA increases by up to 53.9%during the fluidization activation process,which is mainly due to the mesoporous *** to steam activation in a tube furnace reactor,fluidization activation takes an extremely short time(seconds)to achieve the same activation *** is expected to further improve the activation effect of LFA by regulating the carbo

关键词： Circulating fluidized bed Coal gasification fly ash Steam activation Pore structure evolution Fluidization activation

Simulation study on the security of consensus algorithms in DAG-based distributed ledger

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Frontiers of Computer Science 2024年第3期18卷 171-182页

作者： Shuzhe LI Hongwei XU qiong LI qi HAN Faculty of Computing Harbin Institute of TechnologyHarbin 150001China

Due to the advantages of high volume of transactions and low resource consumption,Directed Acyclic Graph(DAG)-based Distributed Ledger Technology(DLT)has been considered a possible next-generation alternative to ***,the security of the DAG-based system has yet to be comprehensively *** at verifying and evaluating the security of DAG-based DLT,we develop a Multi-Agent based IOTA Simulation platform called *** MAIOTASim,we model honest and malicious nodes and simulate the configurable network environment,including network topology and *** double-spending attack is a particular security issue related to *** perform the security verification of the consensus algorithms under multiple double-spending attack *** simulations show that the consensus algorithms can resist the parasite chain attack and partially resist the splitting attack,but they are ineffective under the large weight *** take the cumulative weight difference of transactions as the evaluation criterion and analyze the effect of different consensus algorithms with parameters under each attack ***,MAIOTASim enables users to perform largescale simulations with multiple nodes and tens of thousands of transactions more efficiently than state-of-the-art ones.

关键词： distributed ledger IOTA Multi-Agent system simulation

A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-qi Yu Tao Yu Jian-Hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

Recursive Filtering for Stochastic Systems With Filter-and-Forward Successive Relays

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1202-1212页

作者： Hailong Tan Bo Shen qi Li Hongjian Liu School of Mathematics-Physics and Finance Anhui Polytechnic UniversityWuhu 241000China Anhui Future Technology Research Institute Anhui Polytechnic UniversityWuhu 241000China College of Information Science and Technology Donghua UniversityShanghai 201620China Engineering Research Center of Digitalized Textile and Fashion Technology Ministry of EducationShanghai 201620China School of Information Science and Engineering Hangzhou Normal UniversityHangzhou 311121China

In this paper,the recursive filtering problem is considered for stochastic systems over filter-and-forward successive relay(FFSR)*** FFSR is located between the sensor and the remote filter to forward the *** the successive relay,two cooperative relay nodes are adopted to forward the signals alternatively,thereby existing switching characteristics and inter-relay interferences(IRI).Since the filter-and-forward scheme is employed,the signal received by the relay is retransmitted after it passes through a linear *** objective of the paper is to concurrently design optimal recursive filters for FFSR and stochastic systems against switching characteristics and IRI of ***,a uniform measurement model is proposed by analyzing the transmission mechanism of ***,novel filter structures with switching parameters are constructed for both FFSR and stochastic *** the help of the inductive method,filtering error covariances are presented in the form of coupled difference ***,the desired filter gain matrices are further obtained by minimizing the trace of filtering error ***,the stability performance of the filtering algorithm is analyzed where the uniform bound is guaranteed on the filtering error ***,the effectiveness of the proposed filtering method over FFSR is verified by a three-order resistance-inductance-capacitance circuit system.

关键词： filtering successive stochastic