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Study on the effect and mechanism of Yanghe decoction Huacai(阳和汤化裁) on tissue repair of Yin syndrome after anal fistula surgery

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Journal of Traditional Chinese Medicine 2024年第4期44卷 813-821页

作者： WU yijuan sun Xinghong GUO Haixia ZHANG Xiangan Department of Anorectology the first Affiliated Hospital of Henan University of Chinese Medicine

OBJECTIVE: To observe the clinical efficacy and safety of Yanghe decoction Huacai(阳和汤化裁) for the repair of Yin syndrome wounds with slow-healing after anal fistula surgery. METHODS: A total of 120 patients with slow-healing negative wounds with after low-grade anal fistula surgery who met the inclusion criteria were divided into a treatment group and a control group based on a random number table method, with 60 patients in the treatment group and 60 patients in the control group. The treatment group was given Yanghe decoction Huacai in combination with routine treatment; the control group was only given routine treatment, in which the wound surface was disinfected with iodine, and then covered with sterile gauze. The course of treatment in both groups was 10 d. After treatment, the wound secretion score, wound granulation tissue score, the expression levels of basic fibroblast growth factor(bFGF), transforming growth factor β1(TGF-β1), and epidermal growth factor(EGF) in the wound, wound healing time and clinical efficacy were compared. RESULTS: There was no significant difference in age or gender between the two groups(P > 0.05). On the 10th and 15th days after the surgery, the wound secretion scores were higher in the treatment group than in the control group(P < 0.01). Comparing the two groups at the 10th and 15th day after surgery, the granulation tissue growth scores in the treatment group were better than the in control group(P < 0.01). On the 10th and 15th day after operation, the expression levels of bFGF, TGF-β1 and EGF factors in the treatment group were stronger than those in the control group. The healing time of the wounds in the treatment group was significantly shorter than in the control group(P < 0.01). The clinical efficacy of the two groups after treatment was compared, and the overall efficacy of the treatment group was significantly higher than that of the control group(P < 0.01). CONCLUSIONS: Yanghe decoction Huacai have significant efficacy i

关键词： general surgery intercellular signaling peptides and proteins mechanism negative wound rectal fistula Yanghe decoction huacai

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不同艾司氯胺酮给药方案在学龄前儿童泌尿外科日间手术中的应用

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麻醉安全与质控 2024年第2期6卷 61-65页

作者：杨亮邓恋漆冬梅陈祥楠黎昆伟孙艺娟广东省妇幼保健院麻醉科广东广州511400

目的研究不同艾司氯胺酮给药方案在学龄前儿童泌尿外科日间手术中的麻醉管理及术后疼痛的影响。方法选取广东省妇幼保健院2022-06/2023-01期间计划在气管插管全身麻醉下进行择期泌尿外科日间手术的患儿60例,年龄2~6岁,ASA分级Ⅰ或Ⅱ级,... 详细信息

目的研究不同艾司氯胺酮给药方案在学龄前儿童泌尿外科日间手术中的麻醉管理及术后疼痛的影响。方法选取广东省妇幼保健院2022-06/2023-01期间计划在气管插管全身麻醉下进行择期泌尿外科日间手术的患儿60例,年龄2~6岁,ASA分级Ⅰ或Ⅱ级,采用随机数字表法将患儿分为对照组(C组,n=20);艾司氯胺酮0.3 mg/kg组(MK组,n=20);艾司氯胺酮0.5 mg/kg组(HK组,n=20)。术中吸入1.3 MAC七氟醚维持麻醉,记录入室后(T_(0))、麻醉诱导后3 min(T_(1))、手术切皮时(T_(2))、手术开始后10 min(T_(3))、拔出喉罩时(T_(4))的心率(HR)、平均动脉压(MAP)。记录麻醉时间、手术时间及麻醉拔管时间、麻醉恢复室(PACU)停留时间。记录拔出喉罩后5 min(T_(5))、1 h(T_(6))、24 h(T 7)的疼痛评分和镇静评分情况,记录术后不良反应发生情况,记录术中及PACU舒芬太尼的追加剂量和追加次数。结果在T_(1)时间点,MK组和HK组的MAP较C组有统计学意义(P<0.05),在T_(5)和T_(6)时间点,MK组和HK组镇痛评分低于C组(P<0.05);HK组镇静评分高于C组和MK组(P<0.05);MK组和HK组舒芬太尼在术中及PACU追加剂量低于C组(P<0.05);与C组、MK组比较,HK组会明显延长拔管时间和在PACU的停留时间(P<0.05);HK组术后头晕的发生率高于C组和MK组(P<0.05);在舒芬太尼的追加次数上,C组明显高于MK和HK组(P<0.05)。结论艾司氯胺酮0.3 mg/kg静脉诱导可以降低学龄前患儿泌尿外科日间手术舒芬太尼的使用量,并能维持较稳定的血流动力学水平,减轻术中和术后的疼痛,获得更加满意的镇静效果,且不会增加拔管时间、复苏时长及术后不良反应等。

关键词：艾司氯胺酮日间手术学龄前儿童泌尿外科

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多囊卵巢综合征患者卵泡液的拉曼光谱分析及其对小鼠卵母细胞体外成熟的影响

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中华生殖与避孕杂志 2023年第5期43卷 490-500页

作者：伏静杨天颖武田宇谷瑞环孙贻娟隋宜伦李路孙晓溪上海集爱遗传与不育诊疗中心上海200011 复旦大学附属妇产科医院妇科上海200011 复旦大学生物医学研究院上海200032

目的探究多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者与非PCOS患者卵泡液中的差异性代谢物及其对小鼠卵母细胞体外成熟(in vitro maturation,IVM)和体外受精(in vitro fertilization,IVF)胚胎发育的影响。方法本研究的临床资... 详细信息

目的探究多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者与非PCOS患者卵泡液中的差异性代谢物及其对小鼠卵母细胞体外成熟(in vitro maturation,IVM)和体外受精(in vitro fertilization,IVF)胚胎发育的影响。方法本研究的临床资料采取回顾性队列研究的研究方法获取;动物实验采取随机对照试验。收集2019年6月至2020年6月期间在上海集爱遗传与不育诊疗中心第一次接受IVF或卵胞质内单精子注射(intracytoplasmic sperm injection,ICSI)周期的女性患者的卵泡液。根据是否为PCOS患者,分为PCOS组(n=71)和非PCOS组(n=70),回顾性分析两组患者的临床资料,并利用深度学习的拉曼光谱分析技术检测两组患者卵泡液的代谢谱差异。后续进行实验性研究,在PCOS患者和非PCOS患者卵泡液中进行小鼠GV期卵母细胞IVM培养,收集两组成熟的鼠卵母细胞进行IVF,进一步探讨卵泡液中差异性代谢物对鼠卵成熟及胚胎发育的影响。结果PCOS组患者卵母细胞成熟率[82.19%(886/1078)]和受精第3天的有效胚胎率[51.30%(553/1078)]显著低于非PCOS组[85.85%(625/728),P=0.038;53.30%(388/728),P=0.042],两组患者的累积临床妊娠率和累积活产率差异均无统计学意义(均P>0.05)。PCOS患者和非PCOS患者卵泡液之间存在差异性拉曼代谢光谱。两组间特征性拉曼位移主要集中在600~1000 cm^(-1)、1168 cm^(-1)、1344 cm^(-1)、1440 cm^(-1)、1504 cm^(-1)、1632 cm^(-1)、1664 cm^(-1)。拉曼特征位移数据库显示,两组卵泡液样本的差异代谢物主要集中蛋白质、脂质、游离核酸、葡萄糖、胆固醇、类胡萝卜素和氨基酸等物质。利用两组卵泡液行鼠卵IVM,PCOS卵泡液组的鼠卵MⅡ率[49.04%(77/157)]较非PCOS组更低[65.07%(95/146),P=0.005],利用小鼠MⅡ卵进行IVF,PCOS卵泡液组卵裂率[46.75%(36/77)]显著低于非PCOS组[63.16%(60/95),P=0.031],而两组囊胚率差异无统计学意义(P>0.05)。结论PCOS患者卵泡液存在差异性拉曼代谢光谱,其差异性代谢物可能导致卵母细胞成熟障碍,并进一步影响IVF胚胎的发育,拉曼光谱为PCOS诊断和代谢组学的差异物分析提供了简便有效的方法。

关键词：多囊卵巢综合征拉曼光谱卵泡液代谢组学

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基于免疫反应-肠道微生物轴探究大肠癌湿热蕴结病机的生物学内涵

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中国实验方剂学杂志 2024年第6期30卷 228-237页

作者：吴毅娟孙兴红郭海霞张相安河南中医药大学郑州450046 河南中医药大学第一附属医院郑州450000

大肠癌(CRC)是以排便习惯改变,便血、及疼痛为主要临床表现的肠道恶性肿瘤。近年来随着生活方式及饮食结构的改变,发病率逐年上升。CRC的发病机制与异常免疫反应及慢性炎症、肠道微生物失调及致癌代谢产物产生等密切相关。肠道微生物群... 详细信息

大肠癌(CRC)是以排便习惯改变,便血、及疼痛为主要临床表现的肠道恶性肿瘤。近年来随着生活方式及饮食结构的改变,发病率逐年上升。CRC的发病机制与异常免疫反应及慢性炎症、肠道微生物失调及致癌代谢产物产生等密切相关。肠道微生物群和机体免疫之间是一种双向沟通,不仅在维持机体健康方面起着关键作用,而且还与疾病的发生发展有密切关系。越来越多的研究表明,异常的免疫反应通过产生炎症因子、引起机体慢性炎症,破坏肠黏膜屏障及增加黏膜通透性,造成肠道微生物生态失调,大量致病性微生物及其代谢产物加速疾病进程;另一方面,肠道微生物失调,通过抑制正常的免疫反应,导致体内多种代谢途径紊乱,影响肠道内外应激反应,诱导炎症发生,从而产生疾病。故免疫反应-肠道微生物轴之间复杂的串扰机制与大肠癌的发生关系密切。基于中医理论及临床研究发现,饮食因素是CRC发病的重要诱因,正气不足是其致病之本,湿热蕴结是关键病机。通过现代医学与生物学研究,认为异常的免疫反应是湿热内蕴的微观表现,而肠道微生物失调是毒注大肠生物学基础,并且在CRC的发病中,免疫反应-肠道微生物轴失衡与中医湿热蕴结相契合。从免疫反应-肠道微生物轴探讨CRC湿热蕴结的生物学内涵,力争用客观数据诠释CRC湿热蕴结的病机内涵,对于CRC湿热蕴结证的发病机制及诊疗策略提供新的思路及理论依据。

关键词：免疫反应-肠道微生物轴大肠癌免疫反应肠道微生物串扰机制湿热蕴结生物学内涵

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Advanced wasting in peritoneal dialysis patients

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World Journal of Nephrology 2017年第3期6卷 143-149页

作者： Zhi Xu Glen H Murata Robert H Glew yijuan sun Darlene Vigil Karen S Servilla Antonios H Tzamaloukas Nephrology Division Department of MedicineUniversity of New Mexico School of Medicine Research Service Raymond G.Murphy Veterans Affairs Medical Center Department of Surgery University of New Mexico School of Medicine Renal Section Medicine ServiceRaymond G.Murphy VA Medical Center Department of Medicine University of New Mexico School of Medicine Research Service and Renal Section Raymond G.Murphy VA Medical Center

AIM To identify patients with end-stage renal disease treated by peritoneal dialysis(PD) who had zero body fat(BF) as determined by analysis of body composition using anthropometric formulas estimating body water(V) and to compare nutritional parameters between these patients and PD patients whose BF was above *** Body weight(W) consists of fat-free mass(FFM) *** formulas for calculating V allow the calculation of FFM as V/0.73,where 0.73 is the water fraction of FFM at normal *** from loss of BF has adverse survival outcomes in *** wasting was defined as zero BF when V/0.73 is equal to or exceeds *** study,which analyzed 439 PD patients at their first clearance study,used the Watson formulas estimating V to identify patients with V_(Watson)/0.73 ≥ W and compared their nutritional indices with those of PD patients with V_(Watson)/0.73 < *** The study identified at the first clearance study two male patients with V_(Watson)/0.73 ≥ W among 439 patients on *** to 260 other male patients on PD,the two subjects with advanced wasting had exceptionally low body mass index and serum albumin *** first of the two subjects also had very low values for serum creatinine concentration and total(in urine and spent peritoneal dialysate) creatinine excretion rate while the second subject had an elevated serum creatinine concentration and high creatinine excretion rate due,most probably,to non-compliance with the PD *** Advanced wasting(zero BF) in PD patients,identified by the anthropometric formulas that estimate V,while rare,is associated with indices of poor somatic and visceral nutrition.

关键词：肾病体重指数治疗方法临床分析

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Reproducibility of serial creatinine excretion measurements in peritoneal dialysis

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World Journal of Nephrology 2017年第4期6卷 201-208页

作者： ZhiXu Glen H Murata yijuan sun Robert H Glew Clifford Qualls Darlene Vigil Karen SServilla Thomas A Golper Antonios H Tzamaloukas Nephrology Division Department of MedicineUni-versity of New Mexico School of MedicineAlbuquerqueNM 87131United States Research Service Raymond G Murphy Veterans Affairs Medical CenterAlbuquerqueNM 87108United States Renal Section Medicine ServiceRaymond G Murphy VA Medical Center and Department of MedicineUniversity of New Mexico School of MedicineAlbuquerqueNM 87108United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87131United States Division of Nephrology and Hypertension Vanderbilt UniversityNashvilleTN 37212United States Renal Section and Research Service Raymond G Murphy VA Medical Center and Department of MedicineUniversity of New Mexico School of MedicineAlbu-querqueNM 87108United States

AIM To test whether muscle mass evaluated by creatinine excretion(EXCr) is maintained in patients with end-stage kidney disease(ESKD) treated by peritoneal dialysis(PD),we evaluated repeated measurements of EXCr in a PD *** One hundred and sixty-six PD patients(94 male,72 female) receiving the same PD dose for the duration of the study(up to approximately 2.5 years) had repeated determinations of total(in urine plus spent dialysate) 24-h EXCr(EXCr T) to assess the adequacy of PD by creatinine *** 166 patients had two EXCr T determinations,84 of the 166 patients had three EXCr T determinations and 44 of the 166 patients had four EXCr T *** T values were compared using the paired t test in the patients who had two studies and by repeated measures ANOVA in those who were studied three or four *** In patients who were studied twice,with the first and second EXCr T measurements performed at 9.2 ± 15.2 mo and 17.4 ± 15.8 mo after onset of PD,respectively,EXCr T did not differ between the first and second *** patients studied three times and whose final assessment occurred 24.7 ± 16.3 mo after initiating PD,EXCr T did not differ between the first and second study,but was significantly lower in the third study compared to the first *** patients who were studied four times and whose fourth measurement was taken 31.9 ± 16.8 mo after onset of PD,EXCr T did not differ between any of the *** average EXCr T value did not change significantly,with the exception of the third study in the patients studied ***,repeated determinations of EXCr T in individuals showed substantial variability,with approximately 50% of the repeated determinations being higher or lower than the first determination by 15% or *** The average value of EXCr T remains relatively constant for up to 2.5 years of follow-up in PD patients who adhere to the same PD ***,repeated individual EXCr T values vary conside

关键词：肾病患者肌肉临床分析

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卵巢组织冷冻技术在女性生育力保存中的应用

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中华生殖与避孕杂志 2018年第10期38卷 812-816页

作者：谷瑞环孙贻娟孙晓溪复旦大学附属妇产科医院上海集爱遗传与不育诊疗中心 200011 上海市女性生殖内分泌相关疾病重点实验室 200011

卵巢是雌性动物的重要生殖器官,富含许多不同发育阶段的卵泡,是一种天然的卵泡池。原始卵泡对冷冻保护剂的耐受性要高于生长卵泡,而卵巢皮质是原始卵泡的聚集地,因此卵巢皮质组织冷冻保存是一种更安全、有效、极具开发潜能的女性生育力... 详细信息

卵巢是雌性动物的重要生殖器官,富含许多不同发育阶段的卵泡,是一种天然的卵泡池。原始卵泡对冷冻保护剂的耐受性要高于生长卵泡,而卵巢皮质是原始卵泡的聚集地,因此卵巢皮质组织冷冻保存是一种更安全、有效、极具开发潜能的女性生育力保存方式。卵巢组织冷冻可以一次性保存大量的配子。然而,目前卵巢组织冷冻技术还是一个试验性的技术,临床应用面临很多困难和阻碍。本文将从卵巢组织冷冻技术、移植、临床应用及发展方向作一综述。

关键词：卵巢组织冷冻生育力保存

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BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

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World Journal of Transplantation 2016年第3期6卷 472-504页

作者： Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim yijuan sun Kavitha Ganta Antonios H Tzamaloukas Nephrology Section Medicine Service Raymond G. Murphy VA Medical Center and Department of Medicine University of New Mexico School of Medicine Department of Medicine University of Minnesota School of Medicine Department of Pathology University of New Mexico School of Medicine Division of Nephrology Department of Medicine University of New Mexico School of Medicine Division of Nephrology University of North Carolina School of Medicine

Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research.

关键词： BK viral infection BK nephropathy Cardiac transplant Bone marrow transplant Liver transplant Pancreatic transplant Lung transplant

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蛋黄油的古今应用及研究进展

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世界中医药 2024年第10期19卷 1532-1536页

作者：吴毅娟孙兴红郭海霞张相安河南中医药大学第一附属医院郑州450000

蛋黄油的应用伴随着中医药的发展而发展。中医在应用蛋黄油治疗一些疾病,尤其是皮肤病、烧烫伤、及其创面难愈方面的疾病,药效更显著,作用更为突出。现代药理学研究表明,蛋黄油具有抗炎、镇痛、促进创面愈合等作用。由于蛋黄油在临床使... 详细信息

蛋黄油的应用伴随着中医药的发展而发展。中医在应用蛋黄油治疗一些疾病,尤其是皮肤病、烧烫伤、及其创面难愈方面的疾病,药效更显著,作用更为突出。现代药理学研究表明,蛋黄油具有抗炎、镇痛、促进创面愈合等作用。由于蛋黄油在临床使用过程中对多种疾病的显著疗效,进一步推动了蛋黄油在临床更大范围的使用。

关键词：蛋黄油古籍考证临床应用作用机制

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大学生网络意见表达的引导路径

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办公自动化 2021年第14期26卷 18-20页

作者：孙艺娟河北民族师范学院马克思主义学院承德067000

互联网高速发展,深刻影响着人们的生活方式和思维方式,大学生通过网络进行意见表达已日渐成为一种趋势和潮流。但由于网络世界的虚拟性、匿名性,以及大学生生理心理等方面的局限,大学生网络意见表达存在主观性与片面性、情绪化、狭隘个... 详细信息

互联网高速发展,深刻影响着人们的生活方式和思维方式,大学生通过网络进行意见表达已日渐成为一种趋势和潮流。但由于网络世界的虚拟性、匿名性,以及大学生生理心理等方面的局限,大学生网络意见表达存在主观性与片面性、情绪化、狭隘个人主义倾向以及低俗化的问题,基于此,从正确意见表达观念的树立、社会热点焦点问题的分析引导、社会主义核心价值观的引导以及思想道德素质的提升等方面着手,引导大学生正确合理地进行网络意见表达,以增强高校思想政治教育的实效性。

关键词：互联网大学生网络意见表达

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