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Adaptive and augmented active anomaly detection on dynamic network traffic streams

Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 446-460页

作者： Bin li yijie WANG li CHENG National Key Laboratory of Parallel and Distributed Computing College of ComputerNational University of Defense TechnologyChangsha 410073China College of System Engineering National University of Defense TechnologyChangsha 410073China

Active anomaly detection queries labels of sampled instances and uses them to incrementally update the detection model,and has been widely adopted in detecting network attacks.However,existing methods cannot achieve desirable performance on dynamic network traffic streams because(1)their query strategies cannot sample informative instances to make the detection model adapt to the evolving stream and(2)their model updating relies on limited query instances only and fails to leverage the enormous unlabeled instances on streams.To address these issues,we propose an active tree based model,adaptive and augmented active prior-knowledge forest(A3PF),for anomaly detection on network trafic streams.A prior-knowledge forest is constructed using prior knowledge of network attacks to find feature subspaces that better distinguish network anomalies from normal traffic.On one hand,to make the model adapt to the evolving stream,a novel adaptive query strategy is designed to sample informative instances from two aspects:the changes in dynamic data distribution and the uncertainty of anomalies.On the other hand,based on the similarity of instances in the neighborhood,we devise an augmented update method to generate pseudo labels for the unlabeled neighbors of query instances,which enables usage of the enormous unlabeled instances during model updating.Extensive experiments on two benchmarks,CIC-IDS2017 and UNSW-NB15,demonstrate that A3PF achieves significant improvements over previous active methods in terms of the area under the receiver operating characteristic curve(AUC-ROC)(20.9%and 21.5%)and the area under the precision-recall curve(AUC-PR)(44.6%and 64.1%).

关键词： Active anomaly detection Network traffic streams Pseudo labels Prior knowledge of network attacks

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Robust multi-sensor image matching based on normalized self-similarity region descriptor

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Chinese Journal of Aeronautics 2024年第1期37卷 271-286页

作者： Xuecong liU Xichao TENG Jing LUO Zhang li Qifeng YU yijie BIAN College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China High-Tech Institute Qingzhou 262500China

Multi-modal image matching is crucial in aerospace applications because it can fully exploit the complementary and valuable information contained in the amount and diversity of remote sensing images.However,it remains a challenging task due to significant non-linear radiometric,geometric differences,and noise across different sensors.To improve the performance of heterologous image matching,this paper proposes a normalized self-similarity region descriptor to extract consistent structural information.We first construct the pointwise self-similarity region descriptor based on the Euclidean distance between adjacent image blocks to reflect the structural properties of multi-modal images.Then,a linear normalization approach is used to form Modality Independent Region Descriptor(MIRD),which can effectively distinguish structural features such as points,lines,corners,and flat between multi-modal images.To further improve the matching accuracy,the included angle cosine similarity metric is adopted to exploit the directional vector information of multi-dimensional feature descriptors.The experimental results show that the proposed MIRD has better matching accuracy and robustness for various multi-modal image matching than the state-of-the-art methods.MIRD can effectively extract consistent geometric structure features and suppress the influence of SAR speckle noise using non-local neighboring image blocks operation,effectively applied to various multi-modal image matching.

关键词： Remote sensing Multi-modal image matching Template matching Feature descriptor Similarity metric Synthetic Aperture Radar(SAR)

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3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome

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Neural Regeneration Research 2024年第10期19卷 2270-2280页

作者： Yize Qi Yao Zhou Jiyang li Fangyuan Zhu Gengni Guo Can Wang Man Yu yijie Wang Tengfei Ma Shanwu Feng li Zhou Institute for Stem Cell and Neural Regeneration and Key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology The Second People’s Hospital of LianyungangLianyungangJiangsu ProvinceChina Department of Anesthesiology Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu ProvinceChina

Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic plasticity is associated with the activation of the NOD-like receptor family pyrin domain containing-3(NLRP3) inflammasome. 3′-Deoxyadenosin, an active component of the Chinese fungus Cordyceps militaris, has strong anti-inflammatory effects. However, whether 3′-deoxyadenosin attenuates methamphetamine-induced aberrant synaptic plasticity via an NLRP3-mediated inflammatory mechanism remains unclear. We first observed that 3′-deoxyadenosin attenuated conditioned place preference scores in methamphetamine-treated mice and decreased the expression of c-fos in hippocampal neurons. Furthermore, we found that 3′-deoxyadenosin reduced the aberrant potentiation of glutamatergic transmission and restored the methamphetamine-induced impairment of synaptic plasticity. We also found that 3′-deoxyadenosin decreased the expression of NLRP3 and neuronal injury. Importantly, a direct NLRP3 deficiency reduced methamphetamine-induced seeking behavior, attenuated the impaired synaptic plasticity, and prevented neuronal damage. Finally, NLRP3 activation reversed the effect of 3′-deoxyadenosin on behavior and synaptic plasticity, suggesting that the anti-neuroinflammatory mechanism of 3′-deoxyadenosin on aberrant synaptic plasticity reduces methamphetamine-induced seeking behavior. Taken together, 3′-deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.

关键词： 3′-deoxyadenosin hippocampus long-term potentiation methamphetamine NOD-like receptor family pyrin domain containing-3(NLRP3)inflammasome synaptic plasticity

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Improvement of Ga_(2)O_(3)vertical Schottky barrier diode by constructing NiO/Ga_(2)O_(3)heterojunction

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Journal of Semiconductors 2024年第4期45卷 63-68页

作者： Xueqiang Ji Jinjin Wang Song Qi yijie liang Shengrun Hu Haochen Zheng Sai Zhang Jianying Yue Xiaohui Qi Shan li Zeng liu Lei Shu Weihua Tang Peigang li School of Integrated Circuits&State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China College of Integrated Circuit Science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China Beijing Microelectronics Technology Institute Beijing 100076China

The high critical electric field strength of Ga_(2)O_(3)enables higher operating voltages and reduced switching losses in power electronic devices.Suitable Schottky metals and epitaxial films are essential for further enhancing device performance.In this work,the fabrication of vertical Ga_(2)O_(3)barrier diodes with three different barrier metals was carried out on an n--Ga_(2)O_(3)homogeneous epitaxial film deposited on an n+-β-Ga_(2)O_(3)substrate by metal-organic chemical vapor deposition,excluding the use of edge terminals.The ideal factor,barrier height,specific on-resistance,and breakdown voltage characteristics of all devices were investigated at room temperature.In addition,the vertical Ga_(2)O_(3)barrier diodes achieve a higher breakdown volt-age and exhibit a reverse leakage as low as 4.82×10^(-8)A/cm^(2)by constructing a NiO/Ga_(2)O_(3)heterojunction.Therefore,Ga_(2)O_(3)power detailed investigations into Schottky barrier metal and NiO/Ga_(2)O_(3)heterojunction of Ga_(2)O_(3)homogeneous epitaxial films are of great research potential in high-efficiency,high-power,and high-reliability applications.

关键词： Ga_(2)O_(3) Schottky barrier diode NiO/Ga_(2)O_(3)heterojunction

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New insights for infection mechanism and potential targets of COVID-19:Three Chinese patent medicines and three Chinese medicine formulas as promising therapeutic approaches

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Chinese Herbal Medicines 2023年第2期15卷 157-168页

作者： Kexin Jia yijie li Tiegang liu Xiaohong Gu Xiaojiaoyang li School of life Sciences Beijing University of Chinese MedicineBeijing 100029China Institute of Chinese Epidemic Disease Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide.Currently,there is no accepted specific drug for COVID-19 treatment.Therefore,it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with COVID-19.According to several reliable reports from China,traditional Chinese medicine(TCM),especially for three Chinese patent medicines and three Chinese medicine formulas,has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western medicines.In this review,we systematically summarized and analyzed the pathogenesis of COVID-19,the detailed clinical practice,active ingredients investigation,network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 combat.Additionally,we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism,which provides guidance for the development of new drugs against COVID-19.Collectively,by addressing critical challenges,for example,unclear targets and complicated active ingredients of these medicines and formulas,we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.

关键词： COVID-19 Huashi Baidu Formula Jinhua Qinggan Granules lianhua Qingwen Capsule Qingfei Paidu Decoction SARS-CoV-2 traditional Chinese medicine Xuanfei Baidu Formula Xuebijing Injection

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Interpreting Larix principis-rupprechti radial growth in northern China based on the Vaganov-Shashkin model

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Journal of Forestry Research 2024年第3期35卷 99-110页

作者： Jiachuan Wang Shuheng li Qiang li Yili Guo yijie Han Qi liu Yiqi Zhao College of Urban and Environmental Sciences Northwest UniversityXi'an 710127People's Republic of China Institute of Global Environmental Change Xi'an Jiaotong UniversityXi'an 710049People's Republic of China Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity Northwest UniversityXi'an 710127People's Republic of China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061People's Republic of China

Changes in annual radial growth is an important indication of climate change.Dendroclimatology studies in northern China have focused on linear statistical analysis,but lacking studies based on the process of ring formation to clarify the radial growth of trees.Tree-ring width standard chronology(STD)was established using samples of Larix principis-rupprechti collected at 2303 m altitude on Luya Mountain.Using the Vaganov-Shashkin(VS)model to sim-ulate growth and development,the internal physiological mechanism of radial growth is identified.It was concluded that:(1)the growing season of L.principis-rupprechti was May to September;(2)soil moisture was a significant factor in the early and late growing seasons,and temperature was the dominant factor in its main growth period;and(3)formation of narrow ring widths was closely related to drought stress,the development of wide ring widths will be restricted by increasing future temperatures.The VS model is applicable for radial growth simulation of subalpine coniferous forests and for guiding the cultivation of local tree species inthe future.

关键词： Vaganov-Shashkin model Larix principis-rupprechti Tree-ring width Annual growth

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Interpreting Larix principis-rupprechtii radial growth in northern China based on the Vaganov-Shashkin model

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Journal of Forestry Research 2024年第3期 100-111页

作者： Jiachuan Wang Shuheng li Qiang li Yili Guo yijie Han Qi liu Yiqi Zhao College of Urban and Environmental Sciences Northwest University Institute of Global Environmental Change Xi'an Jiaotong University Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity Northwest University State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences

Changes in annual radial growth is an important indication of climate change. Dendroclimatology studies in northern China have focused on linear statistical analysis,but lacking studies based on the process of ring formation to clarify the radial growth of trees. Tree-ring width standard chronology(STD) was established using samples of Larix principis-rupprechtii collected at 2303 m altitude on Luya Mountain. Using the Vaganov-Shashkin(VS) model to simulate growth and development, the internal physiological mechanism of radial growth is identified. It was concluded that:(1) the growing season of L. principis-rupprechtii was May to September;(2) soil moisture was a significant factor in the early and late growing seasons, and temperature was the dominant factor in its main growth period; and(3) formation of narrow ring widths was closely related to drought stress, the development of wide ring widths will be restricted by increasing future temperatures. The VS model is applicable for radial growth simulation of subalpine coniferous forests and for guiding the cultivation of local tree species in the future.

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A novel pulmonary fibrosis murine model with immune-related liver injury

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Animal Models and Experimental Medicine 2023年第3期6卷 274-282页

作者： Kexin Jia Jianzhi Wu yijie li Jia liu Runping liu Yajie Cai Yinhao Zhang Xiaojiaoyang li School of life Sciences Beijing University of Chinese MedicineBeijingChina School of Chinese Materia Medica Beijing University of Chinese MedicineBeijingChina

Idiopathic pulmonary fibrosis(IPF),characterized by aggravated alveolar destruc-tion and fibrotic matrix deposition,tendentiously experiences the stage called acute exacerbation IPF(AE-IPF)and progresses to multiple organ damage,especially liver injury.Recent studies have found a variety of immune microenvironment disorders associated with elevated IPF risk and secondary organ injury,whereas current animal models induced with bleomycin(BLM)could not completely reflect the pathologi-cal manifestations of AE-IPF patients in clinic,and the exact underlying mechanisms are not yet fully explored.In the current study,we established an AE-IPF model by tracheal administration of a single dose of BLM and then repeated administrations of lipopolysaccharide in mice.This mouse model successfully recapitulated the clinical features of AE-IPF,including excessive intrapulmonary inflammation and fibrosis and extrapulmonary manifestations,as indicated by significant upregulation of Il6,Tnfa,Il1b,Tgfb,fibronectin,and Col1a1 in both lungs and liver and elevated serum aspartate transaminase and alanine transaminase levels.These effects might be attributed to the regulation of Th17 cells.By sharing this novel murine model,we expect to pro-vide an appropriate experimental platform to investigate the pathogenesis of AE-IPF coupled with liver injury and contribute to the discovery and development of targeted interventions.

关键词： bleomycin idiopathic pulmonary fibrosis lipopolysaccharide liver injury murine model

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Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway

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Chinese Herbal Medicines 2023年第3期15卷 421-429页

作者： Mingning Ding Fei Zhou yijie li Chuanyang liu Yiqing Gu Jianzhi Wu Guifang Fan Yajing li Xiaojiaoyang li School of life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Objective:Cassiae Semen(CS,Juemingzi in Chinese)has been used for thousands of years in ancient Chinese history for relieving constipation,improving liver function as well as preventing myopia.Here we aimed to elucidate the anti-steatosis effect and underlying mechanism of CS against non-alcoholic fatty liver disease(NAFLD).Methods:High-performance liquid chromatography(HPLC)was used to identify the major components of CS water extract.Mice were fed with a high-fat and sugar-water(HFSW)diet to induce hepatic steatosis and then treated with CS.The anti-NAFLD effect was determined by measuring serum biomarkers and histopathology staining.Additionally,the effects of CS on cell viability and lipid metabolism in oleic acid and palmitic acid(OAPA)-treated HepG2 cells were measured.The expression of essential genes and proteins involved in lipid metabolism and autophagy signalings were measured to uncover the underlying mechanism.Results:Five compounds,including aurantio-obtusin,rubrofusarin gentiobioside,cassiaside C,emodin and rhein were simultaneously identified in CS extract.CS not only improved the diet-induced hepatic steatosis in vivo,as indicated by decreased number and size of lipid droplets,hepatic and serum triglycerides(TG)levels,but also markedly attenuated the OAPA-induced lipid accumulation in hepatocytes.These lipid-lowering effects induced by CS were largely dependent on the inhibition of fatty acid synthase(FASN)and the activation of autophagy-related signaling,including AMP-activated protein kinase(AMPK),light chain 3-II(LC3-II)/LC3-1 and autophagy-related gene5(ATG5).Conclusion:Our study suggested that CS effectively protected liver steatosis via decreasing FASN-related fatty acid synthesis and activating AMPK-mediated autophagy,which might become a promising therapeutic strategy for relieving NAFLD.

关键词： autophagy AMPK Cassia obtusifolia L. Cassia tora L. Cassiae Semenfatty acid synthesis non-alcoholic fatty acid disease

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Haplotype-based phylogenetic analysis and population genomics uncover the origin and domestication of sweetpotato

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Molecular Plant 2024年第2期17卷 277-296页

作者： Mengxiao Yan Ming li Yunze Wang Xinyi Wang M-Hossein Moeinzadeh Dora G.Quispe-Huamanquispe Weijuan Fan yijie Fang Yuqin Wang Haozhen Nie Zhangying Wang Aiko Tanaka Bettina Heider Jan F.Kreuze Godelieve Gheysen Hongxia Wang Martin Vingron Ralph Bock Jun Yang Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of life Sciences Chongqing Normal UniversityChongqing 401331China Biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural SciencesChengdu 610061China College of life Sciences Shanghai Normal UniversityShanghai 200234China Department of Computational Molecular Biology Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Department of Biotechnology Ghent University9000 GhentBelgium Guangdong Provincial Key Laboratory of Crops Genetics and Improvement Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Graduate School of Bioagricultural Sciences Nagoya UniversityChikusaNagoya 464-8601Japan international Potato Center(CIP) LimaPeru CAS Center for Excellence of Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexaploid sweetpotato(lpomoea batatas)is one of the most important root crops worldwide.However,its genetic origin remains controversial,and its domestication history remains unknown.In this study,we used a range of genetic evidence and a newly developed haplotype-based phylogenetic analysis to identify two probable progenitors of sweetpotato.The diploid progenitor was likely closely related to lpomoea ae-quatoriensis and contributed the B,subgenome,IbT-DNA2,and the lineage 1 type of chloroplast genome to sweetpotato.The tetraploid progenitor of sweetpotato was most likely l.batatas 4x,which donated the B2 subgenome,IbT-DNA1,and the lineage 2 type of chloroplast genome.Sweetpotato most likely originated from reciprocal crosses between the diploid and tetraploid progenitors,followed by a subsequent whole-genome duplication.In addition,we detected biased gene exchanges between the subgenomes;the rate of B,to B2 subgenome conversions was nearly three times higher than that of B2 to B subgenome conver-sions.Our analyses revealed that genes involved in storage root formation,maintenance of genome stabil-ity,biotic resistance,sugar transport,and potassium uptake were selected during the speciation and domestication of sweetpotato.This study sheds light on the evolution of sweetpotato and paves the way forimprovementofthiscrop.

关键词： sweetpotato origin gene conversion domestication IbT-DNA HPA

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