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Dynamic simulation and parametric influence analysis on thermal performance of a quartz tube solid particle receiver in solar tower power plants

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Particuology 2023年第8期79卷 161-171页

作者： Qiang Yu Xueyan Li Yihui Yang Zihao Li Fuliang Nie College of Information and Electrical Engineering China Agricultural UniversityBeijing100083China Institute of Electrical Engineering Chinese Academy of SciencesBeijing100190China

Due to a higher operating temperature(≥800 ℃),Solar Particle Receiver(SPR)which uses particles as the working medium is considered as one of best candidates to improve the thermoelectric conversion efficiency of concentrating solar power plants.In this paper,a quartz tube solid particle receiver model is fully developed by using the discretized lumped parameter method,in which the calculation process of particle temperature and thermal loss is clearly given.In order to improve the manipulation level of particle receiver during the operation,the dynamic characteristics of the quartz tube particle receiver are comprehensively studied by the disturbance test of selected input parameters.Besides,in order to grasp the influence rule of key parameters on the thermal performance of particle receiver,the key parameters'sensitivity analysis is also deeply studied.The results show that the particle outlet temperature can reach as high as 810 ℃ under a relatively small value of solar flux 600 kW/m^(2),but the receiver efficiency is only about 75%;Besides,the receiver efficiency shows a variation tendency that it rises first falls afterwards with the increase of incident solar flux.The validity of proposed model is verified by a heating experi-mental system with a single quartz tube,and the relative error is not more than 7.9%.The research results are beneficial for understanding the dynamic characteristics and designing the particle receiver.

关键词： Solar thermal power plant Solid particle receiver Quartz tube Discretized lumped method Sensitivity analysis

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Hybrid effect on mechanical properties and high-temperature performance of copper matrix composite reinforced with micro-nano dual-scale particles

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Journal of Materials Science & Technology 2024年第5期172卷 94-103页

作者： Xingde Zhang yihui Jiang Fei Cao Tian yang Fan Gao Shuhua Liang School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048China Engineering Research Center of Conducting Materials and Composite Technology Ministry of EducationXi’an University of TechnologyXi’an 710048China Shaanxi Province Key Laboratory of Electrical Materials and Infiltration Technology Xi’an University of TechnologyXi’an 710048China

A dual-scale hybrid HfB_(2)/Cu-Hf composite with HfB_(2) microparticles and Cu_(5) Hf nanoprecipitates was designed and prepared.The contribution of the hybrid effect to the mechanical properties and high-temperature performances was studied from macro and micro perspectives,respectively.The hybrid of dual-scale particles can make the strain distribution of the composite at the early deformation stage more uniform and delay the strain concentration caused by the HfB_(2) particle.The dislocation pinning of HfB_(2) particles and the coherent strengthening of Cu_(5) Hf nanoprecipitates simultaneously play a strengthening role,but the strength of the hybrid composite is not a simple superposition of two strengthening mod-els.In addition,both Cu_(5) Hf nanoprecipitates and HfB_(2) microparticles contribute to the high-temperature performance of the composite,the growth and phase transition of nanoprecipitates at high temperature will reduce their contribution to strength,while the stable HfB_(2) particles can inhibit the coarsening of matrix grains and maintain the high-density geometrically necessary dislocations(GNDs)in the matrix,which ensures more excellent high-temperature resistance of the hybrid composite.As a result,the hy-brid structure can simultaneously possess the advantages of multiple reinforcements and make up for the shortcomings of each other.Finally,a copper matrix composite with high strength,high conductivity,and excellent high-temperature performance is displayed.

关键词： Copper matrix composite HfB 2 particles Hybrid effect High strength and high conductivity High-temperature performance

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Tumorigenic bacteria in colorectal cancer:mechanisms and treatments

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Cancer Biology & Medicine 2022年第2期19卷 147-162页

作者： Sha Li Jinyi Liu Xiangjin Zheng Liwen Ren Yihui Yang Wan Li Weiqi Fu Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Colorectal cancer(CRC)is the third most common and the second most fatal cancer.In recent years,more attention has been directed toward the role of gut microbiota in the initiation and development of CRC.Some bacterial species,such as Fusobacterium nucleatum,Escherichia coli,Bacteroides fragilis,Enterococcus faecalis,and Salmonella sp.have been associated with CRC,based upon sequencing studies in CRC patients and functional studies in cell culture and animal models.These bacteria can cause host DNA damage by genotoxic substances,including colibactin secreted by pks+Escherichia coli,B.fragilis toxin(BFT)produced by Bacteroides fragilis,and typhoid toxin(TT)from Salmonella.These bacteria can also indirectly promote CRC by influencing host-signaling pathways,such as E-cadherin/β-catenin,TLR4/MYD88/NF-κB,and SMO/RAS/p38 MAPK.Moreover,some of these bacteria can contribute to CRC progression by helping tumor cells to evade the immune response by suppressing immune cell function,creating a proinflammatory environment,or influencing the autophagy process.Treatments with the classical antibacterial drugs,metronidazole or erythromycin,the antibacterial active ingredients,M13@Ag(electrostatically assembled from inorganic silver nanoparticles and the protein capsid of bacteriophage M13),berberine,and zerumbone,were found to inhibit tumorigenic bacteria to different degrees.In this review,we described progress in elucidating the tumorigenic mechanisms of several CRC-associated bacteria,as well as progress in developing effective antibacterial therapies.Specific bacteria have been shown to be active in the oncogenesis and progression of CRC,and some antibacterial compounds have shown therapeutic potential in bacteria-induced CRC.These bacteria may be useful as biomarkers or therapeutic targets for CRC.

关键词： Colorectal cancer microbiota tumorigenic mechanism genotoxicity cancer pathways tumor immunity

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Equidistant combination wavelength screening and step-by-step phase-out method for the near-infrared spectroscopic analysis of serum urea nitrogen

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Journal of Innovative Optical Health Sciences 2019年第6期12卷 85-96页

作者： Yihui Yang Fenfen Lei Jing Zhang Lijun Yao Jiemei Chen Tao Pan Department of Optoelectronic Engineering Jinan University Huangpu Road West 601 Tianhe DistrictGuangzhou 510632P.R.China Department of Biological Engineering Jinan University Huangpu Road West 601 Tianhe DistrictGuangzhou 510632P.R.China

We applied near-infrared(NIR)spectroscopy with chemometrics for the rapid and reagent-fee analysis of serum urea nitrogen(SUN).The modeling is based on the average effect of multiple sample partitions to achieve parameter selection with stability.A multiparameter optimization platform with Norris derivative filter-partial least squares(Norris-PLS)was developed to select the most suitable mode(d=2,s=33,g=15).Using equidistant combination PLS(EC-PLS)with four parameters(initial wavelength I,number of wavelengths N,number of wavelength gaps G and latent variables LV),we performed wavelength screening after eliminating high-absorption wavebands.The optimal EC-PLS parameters were I=1228 nm,N=26,G=16 and LV=12.The root-mean square error(SEP),correlation coefficient(R_(p))for prediction and ratio of performance-to-deviation(RPD)for validation were 1.03 mmol L^(-1),0.992 and 7.6,respectively.We proposed the wavelength step-by-step phase-out PLS(WSP-PLS)to remove redun-dant wavelengths in the top 100 EC-PLS models with improved prediction performance.The combination of 19 wavelengths was identifed as the optimal model for SUN.The SEP,Rp and RPD in validation were 1.01 mmol L^(-1),0.992 and 7.7,respectively.The prediction effect and wavelength complexity were better than those of EC-PIS.Our results showed that NIR spectroscopy combined with the EC-PLS and WSP-PLS methods enabled the high-precision analysis ofSUN.WSP-PLS is a secondary optimization method that can further optimize any wavelength moc odel obtained through other continuous or discrete strategies to establish a simple and better model.

关键词： Serum urea nitrogen near infrared spectroscopic analysis Norris derivative filter equidistant combination wavelength screening wavelength step-by-step phase-out

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Three-Dimensional Urban Thermal Effect across a Large City Cluster during an Extreme Heat Wave:Observational Analysis

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Journal of Meteorological Research 2022年第3期36卷 387-400页

作者： Yue MA Ping LIANG Sue GRIMMOND Xuchao yang Jun LYU yihui DING Key Laboratory of Cities’Mitigation and Adaptation to Climate Change in Shanghai Shanghai Regional Climate CenterChina Meteorological AdministrationShanghai 200030China Shanghai Jiading District Meteorological Bureau Shanghai 201800China Department of Meteorology University of ReadingReading RG66ETUnited Kingdom Ocean College Zhejiang UniversityZhoushan 316021China Jiangsu Meteorological Information Center Jiangsu Meteorological BureauNanjing 210008China National Climate Center China Meteorological AdministrationBeijing 100081China

Given extensive and rapid urbanization globally,assessing regional urban thermal effects(UTE)in both canopy and boundary layers under extreme weather/climate conditions is of significant interest.Rapid population and economic growth in the yangtze River Delta(YRD)have made it one of the largest city clusters in China.Here,we explore the three-dimensional(3D)UTE in the YRD using multi-source observations from high-resolution automatic weather stations,radiosondes,and eddy covariance sensors during the record-setting heat wave(HW)of July-August 2013.It is found that the regional canopy layer UTE is up to 0.6-1.2℃,and the nocturnal UTE(0.7-1.6℃)is larger than daytime UTE(0.2-0.5℃)during the HW.The regional canopy layer UTE is enhanced and expanded northwards,with some rural sites contaminated by the urban influences,especially at night.In the boundary layer,the strengthened regional UTE extends vertically to at least 925 hPa(~750 m)during this HW.The strengthened 3D UTE in the YRD is associated with an enlarged Bowen ratio difference between urban and non-urban areas.These findings about the 3D UTE are beneficial for better understanding of the thermal environment of large city clusters under HW and for more appropriate adaption and mitigation strategies.

关键词： urban thermal effect three-dimensional yangtze River Delta heat wave

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A new tetracyclic triterpenoid from endophytic fungus Fusarium sporotrichioides

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Chinese Herbal Medicines 2024年第2期16卷 231-234页

作者： Yajing Wang Chunyue Liu Yihui Yang Chang Li Yuehu Pei Department of Medicinal Chemistry and Natural Medicine Chemistry Harbin Medical University College of Pharmacy

Objective: To isolate bioactive compounds from the endophytic fungus Fusarium sporotrichioides isolated from Rauwolfia yunnanensis, and investigate their pharmacological activities.Methods: The chemical constituents were isolated and purified by combining with ODS column chromatography, silica gel column chromatography and by performing semipreparative HPLC. Their structures were established on the basis of 1D NMR(1H-NMR and13C-NMR) and 2D NMR(1H–1H COSY,HSQC, HMBC and NOESY), as well as HRESIMS and comparison with literature data. In addition, the absolute configuration of compound 1 was determined by calculated ECD data.Results: One previously undescribed tetracyclic triterpenoid derivative, named as integracide L(1), 12aacetoxy-4,4-dimethyl-24-methylene-5a-cholesta-8,14-diene-2a,3β,11β-triol(2), 12a-acetoxy-4,4-dime thyl-24-methylene-5a-cholesta-8-momoene-2a,3β,11β-triol(3), 12a-acetoxy-4,4-dimethyl-24-methy lene-5a-cholesta-8,14-diene-3β,11β-triol(4), and 12a-acetoxy-4,4-dimethyl-24-methylene-5acholesta-8-momoene-3β,11β-triol(5) were isolated from F. sporotrichioide. Moreover, compound 1 was rare tetracyclic triterpenoid with single methyl replacement at C-4 position.Conclusion: Compound 1 was a new tetracyclic triterpenoid isolated from the endophytic fungus F.sporotrichioides. In addition, compound 2 could inhibit the growth of three different human cancer cells significantly. Compounds 3 and 5 were found to possess better cytotoxic activities on Hep G-2 cells than the other compounds, with IC50values of(2.8 ± 0.1) and(6.3 ± 0.3) μmol/L respectively.

关键词： antitumor Fusarium sporotrichioides integracide L tetracyclic triterpenoid 12 α -acetoxy-4,4-dimethyl-24-methylene-5 α -cholesta-8 14-diene-2 α, 3 β ,11 β -triol 12 α -acetoxy-4,4-dimethyl-24-methylene-5 α -cholesta-8-momoene-2 α, 3 β, 11 β -triol 12 α -acetoxy-4,4-dimethyl-24-methylene-5 α -cholesta-8-momoene-3 β, 11 β -triol

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NF-κB and STAT3 signaling pathways collaboratively link infl ammation to cancer

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Protein & Cell 2013年第3期4卷 176-185页

作者： yihui Fan Renfang Mao Jianhua yang Texas Children's Cancer Center Department of PediatricsDan L.Duncan Cancer CenterBaylor College of MedicineHoustonTX 77030USA The Methodist Hospital Research Institute and the Departments of Radiology the Methodist HospitalHoustonTX 77030USA

Although links between cancer and inflammation were fi rstly proposed in the nineteenth century,the molecular mechanism has not yet been clearly understood.Epidemiological studies have identified chronic infections and infl ammation as major risk factors for various types of cancer.NF-κB transcription factors and the signaling pathways are central coordinators in innate and adaptive immune responses.STAT3 regulates the expression of a variety of genes in response to cellular stimuli,and thus plays a key role in cell growth and apoptosis.Recently,roles of NF-κB and STAT3 in colon,gastric and liver cancers have been extensively investigated.The activation and interaction between STAT3 and NF-κB play vital roles in control of the communication between cancer cells and infl ammatory cells.NF-κB and STAT3 are two major factors controlling the ability of pre-neoplastic and malignant cells to resist apoptosis-based tumor-surveillance and regulating tumor angiogenesis and invasiveness.Understanding the molecular mechanisms of NF-κB and STAT3 cooperation in cancer will offer opportunities for the design of new chemo-preventive and chemotherapeutic approaches.

关键词： infl ammation tumorigenesis NF-κB STAT3

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Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-κB/IL-6/STAT3 and JNK/PTX3 pathways

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4390-4406页

作者： Wan Li Hongqing Cai Liwen Ren Yihui Yang Hong yang Jinyi Liu Sha Li Yizhi Zhang Xiangjin Zheng Wei Tan Guanhua Du Jinhua Wang The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Department of Neurosurgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Center for Cancer Precision MedicineNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Pharmacy Xinjiang Medical UniversityUrumqi 830011China Xinjiang Institute of Materia Medica Urumqi 830004China

Glioblastoma(GBM)is the most challenging malignant tumor of the central nervous system because of its high morbidity,mortality,and recurrence rate.Currently,mechanisms of GBM are still unclear and there is no effective drug for GBM in the clinic.Therefore,it is urgent to identify new drug targets and corresponding drugs for GBM.In this study,in silico analyses and experimental data show that sphingosine kinase 1(SPHK1)is up-regulated in GBM patients,and is strongly correlated with poor prognosis and reduced overall survival.Overexpression of SPHK1 promoted the proliferation,invasion,metastasis,and clonogenicity of GBM cells,while silencing SPHK1 had the opposite effect.SPHK1 promoted inflammation through the NF-κB/IL-6/STAT3 signaling pathway and led to the phosphorylation of JNK,activating the JNK-JUN and JNK-ATF3 pathways and promoting inflammation and proliferation of GBM cells by transcriptional activation of PTX3.SPHK1 interacted with PTX3 and formed a positive feedback loop to reciprocally increase expression,promote inflammation and GBM growth.Inhibition of SPHK1 by the inhibitor,PF543,also decreased tumorigenesis in the U87-MG and U251-MG SPHK1 orthotopic mouse models.In summary,we have characterized the role and molecular mechanisms by which SPHK1 promotes GBM,which may provide opportunities for SPHK1-targeted therapy.

关键词： Glioblastoma Drug target SPHK1 Inflammation NF-κB/IL-6/STAT3 signal pathway ATF3 PXT3

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Global Optimization of Norris Derivative Filtering with Application for Near-Infrared Analysis of Serum Urea Nitrogen

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American Journal of Analytical Chemistry 2019年第5期10卷 143-152页

作者： Yihui Yang Tao Pan Jing Zhang Department of Optoelectronic Engineering Jinan University Guangzhou China

Near-infrared (NIR) spectroscopy combined with chemometrics methods was applied to the rapid and reagent-free analysis of serum urea nitrogen (SUN). The mul-partitions modeling was performed to achieve parameter stability. A large-scale parameter cyclic and global optimization platform for Norris derivative filter (NDF) of three parameters (the derivative order: d, the number of smoothing points: s and the number of differential gaps: g) was developed with PLS regression. Meantime, the parameters’ adaptive analysis of NDF algorithm was also given, and achieved a significantly better modeling effect than one without spectral pre-processing. After eliminating the interference wavebands of saturated absorption, the modeling performance was further improved. In validation, the root mean square error (SEP), correlation coefficient (RP) for prediction and the ratio of performance to deviation (RPD) were 1.66 mmol?L-1, 0.966 and 4.7, respectively. The results showed that the high-precision analysis of SUN was feasibility based on NIR spectroscopy and Norris-PLS. The global optimization method of NDF is also expected to be applied to other analysis objects.

关键词： Near-Infrared Spectral Analysis Serum Urea Nitrogen Norris Derivative Filter Norris-Partial Least Squares Global Optimization

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Nanocrystals of halide perovskite:Synthesis,properties,and applications

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Journal of Energy Chemistry 2018年第3期27卷 622-636页

作者： Chi yang yihui Wu Qingshan Ma Wen-Hua Zhang Sichuan Research Center of New Materials Institute of Chemical MaterialsChina Academy of Engineering PhysicsChengdu 610200Sichaan.China National Energy Novel Materials Center 596 Yinhe Road.Shuangliu.Chengdu 610200Sichuan.China

Recently, halide perovskite materials have become an exciting topic of research mainly due to their outstanding photovoltaic performance with the highest efficiency up to 22.1% at present. The nanocrystals（NCs） of these perovskites show quantum size effect, tunable bandgap, and excellent photoluminescence quantum yield（PLQY） in specific cases. Perovskite NCs have hence displayed great potentials in a broad range of applications, such as solar cells, light-emitting devices（LEDs）, photodetectors, and lasers. In this review, we summarized the recent progress on the synthesis, optoelectronic properties and applications of the nanostructures of these halide perovskite materials, including hybrid organic–inorganic perovskites,pure inorganic perovskite, and perovskite-derived NCs. We have also provided a critical outlook into the challenges ahead.

关键词： Perovskite Nanocrystals Photoluminescence Optoelectronic devices

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