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Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-κB/IL-6/STAT3 and JNK/PTX3 pathways

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4390-4406页

作者： Wan Li Hongqing Cai Liwen Ren yihui Yang Hong Yang Jinyi Liu Sha Li Yizhi Zhang Xiangjin Zheng Wei tan Guanhua Du Jinhua Wang The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Department of Neurosurgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Center for Cancer Precision MedicineNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Pharmacy Xinjiang Medical UniversityUrumqi 830011China Xinjiang Institute of Materia Medica Urumqi 830004China

Glioblastoma(GBM)is the most challenging malignant tumor of the central nervous system because of its high morbidity,mortality,and recurrence rate.Currently,mechanisms of GBM are still unclear and there is no effective drug for GBM in the clinic.Therefore,it is urgent to identify new drug targets and corresponding drugs for GBM.In this study,in silico analyses and experimental data show that sphingosine kinase 1(SPHK1)is up-regulated in GBM patients,and is strongly correlated with poor prognosis and reduced overall survival.Overexpression of SPHK1 promoted the proliferation,invasion,metastasis,and clonogenicity of GBM cells,while silencing SPHK1 had the opposite effect.SPHK1 promoted inflammation through the NF-κB/IL-6/STAT3 signaling pathway and led to the phosphorylation of JNK,activating the JNK-JUN and JNK-ATF3 pathways and promoting inflammation and proliferation of GBM cells by transcriptional activation of PTX3.SPHK1 interacted with PTX3 and formed a positive feedback loop to reciprocally increase expression,promote inflammation and GBM growth.Inhibition of SPHK1 by the inhibitor,PF543,also decreased tumorigenesis in the U87-MG and U251-MG SPHK1 orthotopic mouse models.In summary,we have characterized the role and molecular mechanisms by which SPHK1 promotes GBM,which may provide opportunities for SPHK1-targeted therapy.

关键词： Glioblastoma Drug target SPHK1 Inflammation NF-κB/IL-6/STAT3 signal pathway ATF3 PXT3

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Flexible planar micro supercapacitor diode

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Journal of Energy Chemistry 2024年第6期93卷 429-435页

作者： yihui Ma Pei tang Zhenyuan Miao Wuyang tan Qijun Wang Yuecong Chen Guosheng Li Qingyun Dou Xingbin Yan Lingling Shui Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and Engineering & South China Academy of Advanced Optoelectronics Department of Materials Science and Engineering Sun Yat-Sen University College of Materials Science and Engineering Guilin University of Technology

Supercapacitor diode is a novel ion device that performs both supercapacitor energy storage and ion diode rectification functions.However,previously reported devices are limited by their large size and complex processes.In this work,we demonstrate a screen-printed micro supercapacitor diode(MCAPode) that based on the insertion of a finger mode with spinel ZnCo2O4as cathode and activated carbon as anode for the first time,and featuring an excellent area specific capacitance(1.21 mF cm-2at 10 mV s-1) and high rectification characteristics(rectification ratio Ⅰ of 11.99 at 40 mV s-1).Taking advantage of the ionic gel electrolyte,which provides excellent stability during repeated flexing and at high temperatures.In addition,MCAPode exhibits excellent electrochemical performance and rectification capability in "AND" and "OR" logic gates.These findings provide practical solutions for future expansion of micro supercapacitor diode applications.

关键词： Logic gates Micro devices Rectification Screen-printing Supercapacitor diodes

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Directional terahertz holography with thermally active Janus metasurface

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Light(Science & Applications) 2023年第6期12卷 1162-1171页

作者： Benwen Chen Shengxin Yang Jian Chen Jingbo Wu Ke Chen Weili Li Yihui Tan Zhaosong Wang Hongsong Qiu Kebin Fan Caihong Zhang Huabing Wang Yijun Feng Yunbin He Biaobing Jin Xinglong Wu Jian Chen Peiheng Wu Research Institute of Superconductor Electronics(RISE) School of Electronic Science and EngineeringNanjing UniversityNanjing 210023China Purple Mountain Laboratories Nanjing 211111China Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan 430062China School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China National Laboratory of Solid State Microstructures and School of Physics Nanjing UniversityNanjing 210093China

Dynamic manipulation of electromagnetic(EM)waves with multiple degrees of freedom plays an essential role in enhancing information processing.Currently,an enormous challenge is to realize directional terahertz(THz)holography.Recently,it was demonstrated that Janus metasurfaces could produce distinct responses to EM waves from two opposite incident directions,making multiplexed dynamic manipulation of THz waves possible.Herein,we show that thermally activated THz Janus metasurfaces integrating with phase change materials on the meta-atoms can produce asymmetric transmission with the designed phase delays.Such reconfigurable Janus metasurfaces can achieve asymmetric focusing of THz wave and directional THz holography with free-space image projections,and particularly the information can be manipulated via temperature and incident THz wave direction.This work not only offers a common strategy for realizing the reconfigurability of Janus metasurfaces,but also shows possible applications in THz optical information encryption,data storage,and smart windows.

关键词： directional Directional asymmetric

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Research into tritium and helium-3 contents distributions in steel wall of spherical pressure vessel

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Science China(Technological Sciences) 2011年第6期54卷 1521-1524页

作者： LIU YuanDong YIN yihui tan Yun SUN Yin MEI Jun Institute of Structural Mechanics China Academy of Engineering Physics P. O. Box 919-401 Mianyang 621900 China Committee of Science and Technology China Academy of Engineering Physics Mianyang 621900 China

The tritium quantity stored in a steel pressure vessel decreases with time because of helium-3 decay and permeation of tritium into the steel wall of the pressure vessel.Meanwhile,the tritium quantity permeating into the steel wall also decreases with time due to helium-3 decay and diffusion in and out of the wall of tritium.Tritium and helium-3 in the steel wall will cause hydrogen and helium embrittlement of the wall material,respectively,and thereby change the carrying capacity of the vessel.Taking contemporarily both decay and permeation of tritium within the vessel and decay and diffusion of tritium having permeated into the wall into consideration,the governing equations of tritium and helium-3 contents in the wall were established and solved,and relevant formulas were deduced.Through analytical calculations,curves of tritium and helium-3 contents versus radius and time were theoretically plotted,the contents spatio-temporal distributions laws were obtained,and a law about helium-3 contents distribution in steel wall of a spherical pressure vessel was discovered which was called the law of double helium-3 content.

关键词：压力容器用钢氚渗透氦-3 容器壁球形时空分布规律渗透扩散材料脆化

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国内“高校学生组织”研究的文献计量分析

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中国青年研究 2010年第6期 90-95页

作者：谭翀张亦慧南京大学政府管理学院深圳职业技术学院

通过对国内"高校学生组织"研究进行文献计量分析,发现该研究领域的文献累积率开始变得比较高而稳定;发文期刊表现出了一定的集中趋势;从事此项研究的作者队伍很不稳定,核心作者群和区域性的研究中心没有形成;作者合作率和合作度较高,反... 详细信息

通过对国内"高校学生组织"研究进行文献计量分析,发现该研究领域的文献累积率开始变得比较高而稳定;发文期刊表现出了一定的集中趋势;从事此项研究的作者队伍很不稳定,核心作者群和区域性的研究中心没有形成;作者合作率和合作度较高,反映了该领域的作者比较重视合作和交叉研究;通过对文献关键词的统计,反映了研究热点的变化情况。

关键词：高校学生组织学生社团文献计量分析

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Electroacupuncture at Tianshu (ST 25) for diarrhea-predominant irritable bowel syndrome using positron emission tomography Changes in visceral sensation center

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Neural Regeneration Research 2010年第16期5卷 1220-1225页

作者： Huirong Liu Li Qi Xiaolong Wang yihui Guan Chuantao Zuo Linying tan Lingsong Yuan Xiaopeng Ma Xiaomei Wang Enhua Zhou Huangan Wu Key Laboratory of Acupuncture-Moxibustion and Immunological Effects Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese Medicine Shanghai 200030 China PET Center Huashan Hospital Fudan University Shanghai 200235 China

Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome （IBS）. We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions： resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range： bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu （ST 25） manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain.

关键词： irritable bowel syndrome functional brain mapping positron emission tomography anterior cingulate cortex electroacupuncture neural regeneration

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基于微搜索的高分辨率图像前景遮罩提取算法

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模式识别与人工智能 2023年第6期36卷 530-543页

作者：冯夫健杨圆谭棉苟洪山梁椅辉王林贵州民族大学数据科学与信息工程学院贵阳550025 贵州民族大学贵州省模式识别与智能系统重点实验室贵阳550025 电子科技大学中山学院计算机学院中山528400

高分辨率图像抠图问题本质是前景背景像素对的大规模组合优化问题,目前相关研究成果较少.文中针对前景背景极相似时容易出现前景遮罩抠反的问题,设计决策集分解策略,实现高分辨率图像抠图问题的有效分解.此外,设计优化信息传递策略,获... 详细信息

高分辨率图像抠图问题本质是前景背景像素对的大规模组合优化问题,目前相关研究成果较少.文中针对前景背景极相似时容易出现前景遮罩抠反的问题,设计决策集分解策略,实现高分辨率图像抠图问题的有效分解.此外,设计优化信息传递策略,获取子问题间的权重关系,建立图像抠图问题的优化序列.在优化信息传递策略的基础上,提出基于微搜索的前景遮罩提取算法.算法通过对有效决策子集的搜索代替对决策集的搜索,解决高分辨率图像抠图问题中的前景遮罩抠反问题,为大规模组合优化问题分析提供借鉴.选用alphamatting基准数据集作为测试数据,与典型的抠图优化算法对比分析,验证文中算法可以解决前景背景信息极为相似时的前景遮罩抠反问题,并且在高分辨率图像抠图问题维度显著降低的情况下,提高前景遮罩提取精度.

关键词：高分辨率图像抠图前景遮罩微搜索有效决策子集等同关系

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表面活化附着纳米银的聚醚砜抗菌膜的制备以及其在罗非鱼保鲜中的应用

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食品与发酵工业 2024年第10期50卷 88-95页

作者：谭树良赵奕辉黄惠华董浩何其吴炜亮南方医科大学公共卫生学院广东广州510515 仲恺农业工程学院轻工食品学院广东广州510225

水产品在贮藏过程中,细菌侵染导致的腐烂变质是一个备受关注的问题。为此,该研究致力于开发一种新型抗菌包装来提高罗非鱼的保鲜效果。通过用浓硫酸将聚醚砜(polyethersulfone,PES)材料磺化并将其作为膜基质。傅里叶红外光谱仪(Fourier ... 详细信息

水产品在贮藏过程中,细菌侵染导致的腐烂变质是一个备受关注的问题。为此,该研究致力于开发一种新型抗菌包装来提高罗非鱼的保鲜效果。通过用浓硫酸将聚醚砜(polyethersulfone,PES)材料磺化并将其作为膜基质。傅里叶红外光谱仪(Fourier transform infrared spectrometer,FTIR)、热重法(thermal analysis,TG)和接触角(contact angle,CA)分析结果表明,磺化改性后提高了材料的亲水性和表面活性。在此基础上,将银纳米颗粒(silver nanoparticles,AgNPs)嵌合到膜材料中合成磺化聚醚砜-银纳米颗粒(sulfonated polyethersulfone-silver nanoparticles,SPES-AgNPs)抗菌膜。用扫描电子显微镜、原子力电子显微镜及X射线等方法分析该抑菌膜的表征,通过Ag^(+)释放实验测定其安全范围,并采用抗菌环实验测定该膜的抗菌性能。结果表明,磺化改性后的SPES材料与AgNPs结合良好,AgNPs在膜上平均尺寸约为10~100 nm。Ag^(+)释放实验显示,SPES-AgNPs膜的Ag^(+)释放量始终保持在安全范围内。SPES-AgNPs膜可以有效抑制铜绿假单胞菌、金黄色葡萄球菌、小肠结肠炎耶尔森菌、李斯特菌及大肠杆菌,其平均抑制率达到85%以上。将SPES-AgNPs膜用于罗非鱼的保鲜,所有样品在(1±0.1)℃的冷冻箱贮存18 d,通过定期对菌落总数、厌氧菌落总数、嗜冷菌落总数、总挥发性盐基氮值以及k值进行测定,并以感官评分为基础对罗非鱼样品新鲜度进行分析。结果表明,该膜能够延缓鱼肉样品保存时在化学、微生物和感官等方面的变化,可以提高罗非鱼的贮存品质并延长其保质期,是具有广阔应用前景的水产品包装材料。

关键词：聚醚砜 AgNPs 抗菌膜罗非鱼

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