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LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia

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Science Bulletin 2021年第20期66卷 2124-2134,M0004页

作者： Li-Na Shi yihua zhou Chao Wu Wenfeng Huang Feng Yuan Jianjun Chen Zhiwei Wu Wenwei Tu Hairong Chen Quanjiao Chen Mingzhao Zhu Hua Peng Yan Yang Hong Tang CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Department of Infectious Disease Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Center for Public Health Research and State Key Laboratory of Analytical Chemistry for Life Sciences Nanjing UniversityNanjing 210093China Department of Paediatrics and Adolescent Medicine The University of Hong KongHong Kong 999077China The Pateurien College Soochow UniversitySuzhou 215006China The Graduate School of University of Chinese Academy of Sciences Beijing 100049China

CD1d-restricted natural killer T(NKT)cells are innate-like T lymphocytes with protective or pathogenic roles in the development of influenza ***,we show that lung-infiltrated and activated NKT cells are the major cellular source of LIGHT/TNFSF14,which determines the severity of pulmonary pneumonia by highly deteriorative influenza A virus(IAV)*** to wild-type mice,LIGHT^(-/-)mice exhibit much lower morbidity and mortality to IAV,due to alleviated lung damage and reduced apoptosis of alveolar macrophages(AMs).LIGHT preferentially promotes cell death of lymphotoxin β receptors positive(LTβR^(+))AMs but not herpesvirus entry mediator positive(HVEM^(+))***,these results suggest that NKT-derived LIGHT augments cell death of the tissue protective AMs in exacerbating lung pathology and susceptibility to fatal influenza *** of LIGHT signaling might be a viable option in the treatment of influenza-associated acute respiratory distress syndrome.

关键词： Influenza A virus LIGHT/TNFSF14 Natural killer T cells Alveolar macrophages

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基于f-mOPE的数据库密文检索方案

电子与信息学报 2019年第8期41卷 1793-1799页

作者：周艺华吉文杨宇光北京工业大学信息学部

在云数据库环境下,为保证云存储数据的安全性,通常将数据加密存储。针对加密存储数据查询开销大,不支持密文排序,查询等缺点,该文提出一种f-mOPE数据库密文检索方案。该方案基于可变保序编码(mOPE),采用二叉排序树数据结构思想,生成明... 详细信息

在云数据库环境下,为保证云存储数据的安全性,通常将数据加密存储。针对加密存储数据查询开销大,不支持密文排序,查询等缺点,该文提出一种f-mOPE数据库密文检索方案。该方案基于可变保序编码(mOPE),采用二叉排序树数据结构思想,生成明文一一对应的保序编码;基于AES加密方案将数据明文转化为密文存储;采用改进的部分同态加密算法提升保序加密方案的安全性。通过安全性分析及实验结果表明,该方案在保证数据隐私的基础上,不但能抵御统计型攻击,而且能够有效地降低服务器计算开销,提高数据库处理效率。

关键词：密文数据库保序加密算法可变保序编码

Effects of virtual agents on interaction efficiency and environmental immersion in MR environments

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虚拟现实与智能硬件（中英文） 2024年第2期6卷 169-179页

作者： yihua BAO Jie GUO Dongdong WENG Yue LIU Zeyu TIAN Beijing Engineering Research Center of Mixed Reality and Advanced Display Beijing Institute of TechnologyBeijing 100081China Pengcheng Laboratory Shenzhen 518038China

Background Physical entity interactions in mixed reality(MR)environments aim to harness human capabilities in manipulating physical objects,thereby enhancing virtual environment(VEs)*** MR,a common strategy is to use virtual agents as substitutes for physical entities,balancing interaction efficiency with environmental ***,the impact of virtual agent size and form on interaction performance remains *** Two experiments were conducted to explore how virtual agent size and form affect interaction performance,immersion,and preference in MR *** first experiment assessed five virtual agent sizes(25%,50%,75%,100%,and 125%of physical size).The second experiment tested four types of frames(no frame,consistent frame,half frame,and surrounding frame)across all agent ***,utilizing a head mounted display,performed tasks involving moving cups,typing words,and using a *** completed questionnaires assessing aspects such as the virtual environment effects,interaction effects,collision concerns,and *** Results from the first experiment revealed that agents matching physical object size produced the best overall *** second experiment demonstrated that consistent framing notably enhances interaction accuracy and speed but reduces *** balance efficiency and immersion,frameless agents matching physical object sizes were deemed *** Virtual agents matching physical entity sizes enhance user experience and interaction ***,familiar frames from 2D interfaces detrimentally affect interaction and immersion in virtual *** study provides valuable insights for the future development of MR systems.

关键词： Mixed reality Virtual agents Interaction performance Environmental immersion Virtual environments

Click chemistry and natural products

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Chinese Journal of Natural Medicines 2024年第2期22卷 97-99页

作者： ZHANG Chen WU Jianbing ZHANG yihua HUANG Zhangjian State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Key Laboratory of Natural Medicines Active Components and Drug Release TechnologySchool of PharmacyXinjiang Medical UniversityUrumqi 830054China

The 2022 Nobel Prize in Chemistry was awarded to American scientists Carolyn Bertozzi,*** Sharpless,and Danish scientist Morten *** for their contributions to the development of click chemistry and bioorthogonal chemi... 详细信息

关键词： Click chemistry Natural product Target identification Drug discovery

Cross-resistance and genetics of field-evolved resistance to chlorfenapyr in Plutella xylostella

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Insect Science 2024年第2期31卷 533-541页

作者： Cheng Qian Jialin Li Shuwen Wu yihua Yang Yidong Wu Xingliang Wang Sanya Institute of Nanjing Agricultural Universty SanyaHainanChinaand College of Plant Protection Nanjing Agricultural UniversNanjingChina

Chlorfenapyr is a broad-spectrum halogenated pyrrole insecticide with a unique mode of *** to the misuse and overuse of this chemical,resistance has been reported in several arthropods,including Plutella xylostella,which is one of the most destructive insect pests afflicting crucifers worldwide.A better understanding of the cross-resistance and genetics of field-evolved chlorfenapyr resistance could effectively guide resistance management ***,the chlorfenapyr resistance of a fieldderived population of P xylostella was introgressed into the susceptible IPP-S strain using a selection-assisted multigenerational backcrossing *** constructed nearisogenic strain,TH-BCsF2,shared 98.4%genetic background with the recurrent parent IPP-S *** TH-BCsF2 strain showed 275-fold resistance to chlorfenapyr,but no significant cross-resistance to spinosad,abamectin,chlorpyrifos,β-cypermethrin,indoxacarb,chlorantraniliprole,or broflanilide(no more than 4.2-fold).Genetic analysis revealed that resistance was autosomal,incompletely dominant,and conferred by 1 major gene or a few tightly linked *** synergism of metabolic inhibitors(PBO,DEM,and DEF)to chlorfenapyr was very weak(<1.7-fold),and the metabolic enzyme activities in the TH-BCsF2 strain were not significantly elevated compared with the IPP-S *** results enhances our understanding of the genetic traits of chlorfenapyr resistance,and provides essential information for improving resistance management strategies.

关键词： chlorfenapyr cross-resistance mode of inheritance near-isogenic line Plutellaxylostella

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基于喷墨打印石墨烯透明导电薄膜研究进展

影像科学与光化学 2016年第5期34卷 482-490页

作者：罗妍周奕华钱俊武汉大学印刷与包装系湖北武汉430079

随着柔性电子产品的应用日渐广泛,采用喷墨打印技术制备大面积柔性电子产品的技术引起了人们的关注。石墨烯由于具有优异的光学和机械性能,成为制备透明导电薄膜的理想材料。石墨烯可以通过物理或化学方法制备得到。而喷墨打印技术因具... 详细信息

随着柔性电子产品的应用日渐广泛,采用喷墨打印技术制备大面积柔性电子产品的技术引起了人们的关注。石墨烯由于具有优异的光学和机械性能,成为制备透明导电薄膜的理想材料。石墨烯可以通过物理或化学方法制备得到。而喷墨打印技术因具有成本低廉、操作简单等优点成为制备大面积柔性电子产品的方法之一。本文首先对石墨烯的性质和制备方法进行了简述,然后分别阐述了喷墨打印墨水条件和喷墨打印图案化控制,最后总结了透明导电薄膜的应用进展以及发展趋势。

关键词：石墨烯喷墨打印图案化透明导电薄膜

Audio-Text Multimodal Speech Recognition via Dual-Tower Architecture for Mandarin Air Traffic Control Communications

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Computers, Materials & Continua 2024年第3期78卷 3215-3245页

作者： Shuting Ge Jin Ren yihua Shi Yujun Zhang Shunzhi Yang Jinfeng Yang School of Computer Science and Software Engineering University of Science and Technology LiaoningAnshan114051China Institute of Applied Artificial Intelligence of the Guangdong-Hong Kong-Macao Greater Bay Area Shenzhen Polytechnic UniversityShenzhen518055China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen518055China Industrial Training Centre Shenzhen Polytechnic UniversityShenzhen518055China

In air traffic control communications (ATCC), misunderstandings between pilots and controllers could result in fatal aviation accidents. Fortunately, advanced automatic speech recognition technology has emerged as a promising means of preventing miscommunications and enhancing aviation safety. However, most existing speech recognition methods merely incorporate external language models on the decoder side, leading to insufficient semantic alignment between speech and text modalities during the encoding phase. Furthermore, it is challenging to model acoustic context dependencies over long distances due to the longer speech sequences than text, especially for the extended ATCC data. To address these issues, we propose a speech-text multimodal dual-tower architecture for speech recognition. It employs cross-modal interactions to achieve close semantic alignment during the encoding stage and strengthen its capabilities in modeling auditory long-distance context dependencies. In addition, a two-stage training strategy is elaborately devised to derive semantics-aware acoustic representations effectively. The first stage focuses on pre-training the speech-text multimodal encoding module to enhance inter-modal semantic alignment and aural long-distance context dependencies. The second stage fine-tunes the entire network to bridge the input modality variation gap between the training and inference phases and boost generalization performance. Extensive experiments demonstrate the effectiveness of the proposed speech-text multimodal speech recognition method on the ATCC and AISHELL-1 datasets. It reduces the character error rate to 6.54% and 8.73%, respectively, and exhibits substantial performance gains of 28.76% and 23.82% compared with the best baseline model. The case studies indicate that the obtained semantics-aware acoustic representations aid in accurately recognizing terms with similar pronunciations but distinctive semantics. The research provides a novel modeling pa

关键词： Speech-text multimodal automatic speech recognition semantic alignment air traffic control communications dual-tower architecture

对《中国乙型肝炎病毒母婴传播防治指南(2019年版)》的商榷

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临床肝胆病杂志 2020年第1期36卷 59-61页

作者：周乙华李彤庄辉南京大学医学院附属鼓楼医院感染科南京210008 北京大学基础医学院病原生物学系和感染病研究中心北京100191

中华医学会感染病学分会和GRADE中国中心最近发布了《中国乙型肝炎病毒母婴传播防治指南(2019年版)》。该指南存在参考文献引用不当;对预防乙型肝炎病毒母婴传播的部分关键策略缺乏推荐意见;部分推荐意见证据不足或缺乏证据等问题。本... 详细信息

中华医学会感染病学分会和GRADE中国中心最近发布了《中国乙型肝炎病毒母婴传播防治指南(2019年版)》。该指南存在参考文献引用不当;对预防乙型肝炎病毒母婴传播的部分关键策略缺乏推荐意见;部分推荐意见证据不足或缺乏证据等问题。本着学术争鸣原则,本文对该指南提出一些管见,愿与作者和读者商榷。

关键词：乙型肝炎病毒母婴传播阻断乙型肝炎疫苗乙型肝炎免疫球蛋白抗病毒药

我国预防乙型肝炎母婴传播的进展和亟待研究的问题

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中华围产医学杂志 2018年第8期21卷 505-509页

作者：周乙华胡娅莉南京大学医学院附属鼓楼医院肝炎研究室 210008 南京大学医学院附属鼓楼医院妇产科 210008

预防乙型肝炎病毒（hepatitis B virus，HBV）母婴传播是控制慢性HBV感染的关键。我国为之付出了极大努力，也取得了巨大成就。本文介绍了我国预防HBV母婴传播的主要免疫措施和研究进展，总结了对高病毒载量孕妇妊娠晚期口服抗病毒药物... 详细信息

预防乙型肝炎病毒（hepatitis B virus，HBV）母婴传播是控制慢性HBV感染的关键。我国为之付出了极大努力，也取得了巨大成就。本文介绍了我国预防HBV母婴传播的主要免疫措施和研究进展，总结了对高病毒载量孕妇妊娠晚期口服抗病毒药物预防HBV母婴传播的效果和安全性，并提出了亟待进一步研究的相关问题。

关键词：乙型肝炎传染性疾病传播垂直传染病控制