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Effect of Wave Nonlinearity on the Instantaneous Seabed Liquefaction

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china Ocean Engineering 2024年第1期38卷 93-103页

作者： WANG Zhao-jun SUI Ti-ti ZHANG chi PAN Jun-ning Key Laboratory of Port Waterway and Sedimentation Engineering of the Ministry of TransportNanjing Hydraulic Research InstituteNanjing 210024China Key Laboratory of Coastal Disaster and Protection(Hohai University) Ministry of EducationNanjing 210098China The National Key Laboratory of Water Disaster Prevention Nanjing 210098China

The nonlinear variation of wave is commonly seen in nearshore area,and the resulting seabed response and liquefaction are of high concern to coastal *** this study,an analytical formula considering the nonlinear wave skewness and asymmetry is adopted to provide wave pressure on the seabed *** liquefaction depth attenuation coefficient and width growth coefficient are defined to quantitatively characterize the nonlinear effect of wave on seabed *** on the 2D full dynamic model of wave-induced seabed response,a detailed parametric study is carried out in order to evaluate the influence of the nonlinear variation of wave loadings on seabed ***,new empirical prediction formulas are proposed to fast predict the maximum liquefaction under nonlinear *** indicate that(1)Due to the influence of wave nonlinearity,the vertical transmission of negative pore water pressure in the seabed is hindered,and therefore,the amplitude decreases significantly.(2)In general,with the increase of wave nonlinearity,the liquefaction depth of seabed decreases *** under asymmetric and skewed wave loading,the attenuation of maximum seabed liquefaction depth is the most significant among all the nonlinear wave ***,highly skewed wave can cause the liquefaction depth of seabed greater than that under linear wave.(3)The asymmetry of wave pressure leads to the increase of liquefaction width,whereas the influence of skewedness is not significant.(4)Compared with the nonlinear waveform,seabed liquefaction is more sensitive to the variation of nonlinear degree of wave loading.

关键词： nonlinear wave seabed response seabed liquefaction numerical simulation liquefaction prediction

肿瘤生长速率在神经内分泌肿瘤早期疗效评估中的价值

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中华医学杂志 2022年第14期102卷 1000-1006页

作者：周玉陶夏艳飞李颖朱永健依荷芭丽·迟蒋力明国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院影像诊断科北京100021 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院内科北京100021

目的探讨肿瘤生长速率(TGR)评估神经内分泌肿瘤(NEN)早期药物治疗疗效的临床应用价值。方法回顾性分析2010年1月至2018年12月于中国医学科学院北京协和医学院肿瘤医院就诊的NEN患者共30例,其中男16例,女14例,年龄26~73(53±11)岁。测量... 详细信息

目的探讨肿瘤生长速率(TGR)评估神经内分泌肿瘤(NEN)早期药物治疗疗效的临床应用价值。方法回顾性分析2010年1月至2018年12月于中国医学科学院北京协和医学院肿瘤医院就诊的NEN患者共30例,其中男16例,女14例,年龄26~73(53±11)岁。测量患者基线治疗前及治疗后3个月的靶病灶最大直径总和及检查间隔天数,利用公式计算治疗后3个月的TGR。采用组内相关系数(ICC)评估TGR测量观察者间一致性。采用受试者工作特征(ROC)曲线确定TGR预测无进展生存期(PFS)的最佳截断值。在治疗后3个月采用实体瘤疗效评价标准评估疗效,将评定为疾病稳定(SD)的患者及总体患者分别通过TGR最佳截断值分组;采用Kaplan-Meier法分析组间生存差异。采用多因素Cox比例风险回归模型分析TGR对于预后的影响。结果TGR最佳截断值是-5.8(%/月),ROC曲线下面积为0.921(95%CI:0.824~0.999,P<0.001),观察者间ICC为0.955(95%CI:0.907~0.978,P<0.001)。根据TGR分组,两组患者无进展生存差异有统计学意义(P<0.001)。多因素Cox分析显示相较于TGR<-5.8组,TGR≥-5.8组不论在总体患者(HR:10.906,95%CI:1.953~60.898,P=0.006)或是SD患者(HR:14.354,95%CI:1.602~128.627,P=0.017)中都观察到更高的进展风险,TGR≥-5.8是影响预后的独立危险因素。结论TGR能够反映NEN早期抗肿瘤药物治疗疗效并且与预后相关。

关键词：神经内分泌瘤肿瘤生长速率实体瘤疗效评价标准疗效评估无进展生存期诊断试验

Anthracene-bridged“Texas-sized”box for the simultaneous detection and uptake of tryptophan

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chinese Chemical Letters 2024年第9期35卷 175-178页

作者： Dan Luo Jinya Tian Jianqiao Zhou Xiaodong chi State Key Laboratory of Materials Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518057China

Tryptophan(Trp)is an essential amino acid that plays a critical role in human *** increasing demand for Trp has created a highly promising market,underscoring the urgent necessity for the development of efficient strategies for the simultaneous detection and uptake of ***,we report an expanded“Texas-sized”molecular box(An-TxSB),which incorporates luminescent anthracene bridging subunits and molecular recognition *** luminescent molecular box demonstrates exceptional sensitivity to Trp in water,permitting its precise quantification with a notably low limit of detection(LOD)of 0.42μmol/***,An-TxSB facilitates the proficient uptake of Trp from simulated water samples,thereby revealing an impressive Trp adsorption capacity of up to 226.0μmol/g.

关键词： Macrocycles Host-guest chemistry Biomolecular sensors Molecular recognition Adsorption

Efficient Preparation and Electrochemical Properties of BiOCl/Graphite by One-step Solvothermal Method

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 651-657页

作者：门丽娟 FEI chi LIU An 陈春钰 ZHOU Jiankang JU Dianchun School of Metallurgy Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China

We used the surface-pretreated graphite paper(Gp)as a carrier and loaded BiOCl with high selectivity to Cl^(-)on its surface by solvothermal method to form BiOCl@Gp *** morphology,structure,and composition of the materials were characterized by scanning electron microscopy and nitrogen adsorption/desorption,and the results showed that the spherical BiOCl particles were uniformly dispersed on the surface of the Gp,forming a mesoporous BiOCl@Gp composite with a specific surface area of 22.82 m^(2)/g and a pore volume of 0.043 cm3/***,cyclic voltammetry and electrochemical impedance spectroscopy were used to test the electrochemical properties of the composites,and the stability of BiOCl and the high conductivity of Gp were synergistic,the BiOCl@Gp exhibited a specific capacitance of 30.2 F·g^(-1) at a current density of 0.5 A·g^(-1),and the selectivity of the BiOCl@Gp materials for Cl^(-)was significantly higher than that of SO_(4)^(2-),NO_(2)^(-),and HCO_(3)^(-).Therefore,BiOCl@Gp composite electrode materials can be used for the selective adsorption of Cl^(-)in wastewater,in order to achieve efficient wastewater recycling.

关键词： solvothermal method bismuth oxychloride electrochemistry electrode materials

chiral boryl radical catalyzed asymmetric radical cycloisomerization

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Science china Chemistry 2024年第7期67卷 2121-2123页

作者： Jiamiao Jin Shi-Chao Ren Yonggui Robin chi National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore

Asymmetric catalytic organic synthesis is of profound importance in modern research and industries,providing optically enriched molecules with diverse structures and functions[1].Enzymes,transition metal complexes,and simple organic molecules have all been found as powerful catalysts that enable the bond breaking and forming events with excellent control over stereo-selectivity *** the realm of designed small molecule organic catalysts.

关键词： radical catalyzed asymmetric

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结直肠癌中表皮生长因子受体靶向治疗的意义

癌症进展 2006年第6期4卷 517-522页

作者：依荷芭丽.迟李玉升中国医学科学院中国协和医科大学肿瘤医院北京100021

表皮生长因子受体抑制剂在结直肠癌治疗中的应用效果显著,近年来一系列的基础、临床研究表明,抗表皮长因子受体的单克隆抗体(C-225)联合化学治疗其疗效和生存均优于单纯化学治疗。表皮生长因子酪氨酸激酶受体抑制剂的临床研究结果到目... 详细信息

表皮生长因子受体抑制剂在结直肠癌治疗中的应用效果显著,近年来一系列的基础、临床研究表明,抗表皮长因子受体的单克隆抗体(C-225)联合化学治疗其疗效和生存均优于单纯化学治疗。表皮生长因子酪氨酸激酶受体抑制剂的临床研究结果到目前为止还不理想,但就目前的研究结果对其疗效进行评价还为时过早。目前有一些正在进行Ⅰ期临床研究的新型表皮生长因子受体的单克隆抗体和酪氨酸激酶受体抑制剂,有可能给结直肠癌的治疗带来新的希望。

关键词：结肠癌表皮生长因子受体的单克隆抗体表皮生长因子酪氨酸激酶受体抑制剂

Review of the Configuration and Transient Stability of Large-scale Renewable Energy Generation through Hybrid DC Transmission

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 115-126页

作者： Xinshou Tian Yongning chi Longxue Li Hongzhi Liu Institute of Energy Power Innovation North China Electric Power UniversityBeijing 102206China china Electric Power Research Institute No.15Xiaoying East RoadQingheHaidian DistrictBeijing 100192China.

Based on the complementary advantages of Line Commutated Converter(LCC)and Modular Multilevel Converter(MMC)in power grid applications,there are two types of hybrid DC system topologies:one is the parallel connection of LCC converter stations and MMC converter stations,and the other is the series connection of LCC and MMC converter stations within a single *** hybrid DC transmission system faces broad application prospects and development potential in large-scale clean energy integration across regions and the construction of a new power system dominated by new energy sources in *** paper first analyzes the system forms and topological characteristics of hybrid DC transmission,introducing the forms and topological characteristics of converter-level hybrid DC transmission systems and system-level hybrid DC transmission ***,it analyzes the operating characteristics of LCC and MMC inverter-level hybrid DC transmission systems,provides insights into the transient stability of hybrid DC transmission systems,and typical fault ride-through control ***,it summarizes the networking characteristics of the LCC-MMC series within the converter station hybrid DC transmission system,studies the transient characteristics and fault ridethrough control strategies under different fault types for the LCC-MMC series in the receiving-end converter station,and investigates the transient characteristics and fault ride-through control strategies under different fault types for the LCC-MMC series in the sending-end converter station.

关键词： Hybrid DC transmission Transient stability Configuration Control system

Regulating the crystal phase of bismuth-based semiconductors for promoted photocatalytic performance

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Science china Chemistry 2024年第6期67卷 1839-1864页

作者： Zhaohui Wu Mei-chi Chong Shiying Zhang Junshan Li Yongfa Zhu Hunan Key Laboratory of Applied Environmental Photocatalysis Changsha UniversityChangsha410022China Department of Chemistry Tsinghua UniversityBeijing100084China Institute for Advanced Study Chengdu UniversityChengdu610106China

Numerous bismuth-based semiconductors(BBSs)with sophisticated and desirable structures used as photocatalysts for efficient photocatalytic degradation of water organic contaminants have attracted considerable ***,regulating the crystal phases and phase transition of BBSs for promoted photocatalytic performance is ***,the unique crystal structure and band structure features of each typical BBSs,and the vital roles on phase controlling of each phase were systematically presented based on the classification of ***,the critical factors for the phase transition of BBSs and intrinsic driving forces endowed by phases of BBSs for enhanced photocatalytic performance of organic contaminants removal were also *** review will provide systematical guidelines and horizons for regulating the crystal phase and phase transition of BBSs,promoting photocatalytic degradation and mineralization of organic contaminants.

关键词： bismuth-based semiconductors phase regulation photocatalytic performances organic contaminants

Coordinated Robust PID-based Damping Control of Permanent Magnet Synchronous Generators for Low-frequency Oscillations Considering Power System Operational Uncertainties

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1042-1051页

作者： Rehan Sadiq Zhen Wang chi Yung Chung Deqiang Gan Cunzhi Tong College of Electrical Engineering Zhejiang UniversityHangzhou 310058China The Hong Kong Polytechnic University Hong KongChina State Grid Zhejiang Electric Power Company Hangzhou 310007China

In recent years, with the growth of wind energy resources,the capability of wind farms to damp low-frequency oscillations(LFOs) has provided a notable advantage for the stabilityenhancement of the modern power grid. Meanwhile, owingto variations in the power system operating point (OP), thedamping characteristics of LFOs may be affected adversely. Inthis respect, this paper presents a coordinated robust proportional-integral-derivative (PID) based damping control approachfor permanent magnet synchronous generators (PMSGs)to effectively stabilize LFOs, while considering power system operationaluncertainties in the form of a polytopic model constructedby linearizing the power system under a given set ofOPs. The proposed approach works by modulating the DC-linkvoltage control loop of the grid-side converter (GSC) via a supplementaryPID controller, which is synthesized by transformingthe design problem into H-infinity static output feedback(SOF) control methodology. The solution of H-infinity SOF controlproblem involves satisfying linear matrix inequality (LMI)constraints based on the parameter-dependent Lyapunov functionto ensure asymptotic stability such that the minimal H-infinityperformance objective is simultaneously accomplished forthe entire polytope. The coordinated damping controllers forthe multiple wind farms are then designed sequentially by usingthe proposed approach. Eigenvalue analysis confirms the improveddamping characteristics of the closed-loop system forseveral representative OPs. Afterward, the simulation results, includingthe performance comparison with existing approaches,validate the higher robustness of the proposed approach for awide range of operating scenarios.

关键词： Permanent magnet synchronous generator(PMSG) low-frequency oscillation(LFO) proportional-integralderivative(PID) robust control H-infinity static output feed-back control linear matrix inequality(LMI)