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Reconfigurable logic and in-sensor encryption operations in an asymmetrically tunable van der Waals heterostructure

Nano Research 2024年第4期17卷 3113-3119页

作者： Fan Gong Wenjie Deng Yi wu Fengming Liu yihao Guo Zelin Che Jingjie Li Jingzhen Li Yang Chai Yongzhe Zhang Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Department of Applied Physics Hong Kong Polytechnic UniversityKowloonHong KongChina

Reconfigurable devices can be used to achieve multiple logic operation and intelligent optical sensing with low power consumption,which is promising candidates for new generation electronic and optoelectronic integrated circuits.However,the versatility is still limited and need to be extended by the device architectures design.Here,we report an asymmetrically gate two-dimensional(2D)van der Waals heterostructure with hybrid dielectric layer SiO_(2)/hexagonal boron nitride(h-BN),which enable rich function including reconfigurable logic operation and in-sensor information encryption enabled by both volatile and non-volatile optoelectrical modulation.When the partial gate is grounded,the non-volatile light assisted electrostatic doping endowed partially reconfigurable doping between n-type and p-type,which allow the switching of logic XOR and not implication(NIMP).When the global gate is grounded,additionally taking the optical signal as another input signal,logic AND and OR is realized by combined regulation of the light and localized gate voltage.Depending on the high on/off current ratio approaching 105 and reliable&switchable logic gate,in-sensor information encryption and decryption is demonstrated by manipulating the logic output.Hence,these results provide strong extension for current reconfigurable electronic and optoelectronic devices.

关键词： in-sensor encryption reconfigurable logic van der Waals heterostructure asymmetrical tunable architecture

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Manipulating Na occupation and constructing protective film of P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2) as long-term cycle stability cathode for sodium-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 603-611,I0013页

作者： Yiran Sun Pengfei Zhou Siyu Liu Zhongjun Zhao yihao Pan Xiangyan Shen Xiaozhong wu Jinping Zhao Junying Weng Jin Zhou School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 0255000ShandongChina School of Materials Science and Engineering Shandong University of TechnologyZibo 255049ShandongChina

P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2)(NNMO)is promising cathode material for sodium-ion batteries(SIBs)due to its high specific capacity and fast Na+diffusion rate.Nonetheless,the irreversible P2-O_(2)phase transformation,Na+/vacancy ordering,and transition metal(TM)dissolution seriously damage its cycling stability and restrict its commercialization process.Herein,Na occupation manipulation and interface stabilization are proposed to strengthen the phase structure of NNMO by synergistic Zn/Ti co-doping and introducing lithium difluorophosp(LiPO_(2)F_(2))film-forming electrolyte additive.The Zn/Ti co-doping regulates the occupancy ratio of Nae/Nafat Na sites and disorganizes the Na+/vacancy ordering,resulting in a faster Na+diffusion kinetics and reversible P2-Z phase transition for P2-Na_(0.67)Ni_(0.28)Zn_(0.05)Mn_(0.62)Ti_(0.05)O_(2)(NNZMTO).Meanwhile,the LiPO_(2)F_(2)additive can form homogeneous and ultrathin cathode-electrolyte interphase(CEI)on NNZMTO surface,which can stabilize the NNZMTO-electrolyte interface to prevent TM dissolution,surface structure transformation,and micro-crack generation.Combination studies of in situ and ex situ characterizations and theoretical calculations were used to elucidate the storage mechanism of NNZMTO with Li PO_(2)F_(2)additive.As a result,the NNZMTO displays outstanding capacity retention of 94.44%after 500 cycles at 1C with 0.3 wt%Li PO_(2)F_(2),excellent rate performance of 92.5 mA h g^(-1)at 8C with 0.1 wt%Li PO_(2)F_(2),and remarkable full cell capability.This work highlights the important role of manipulating Na occupation and constructing protective film in the design of layered materials,which provides a promising direction for developing high-performance cathodes for SIBs.

关键词： Layered cathode Zn/Ti co-doping Na occupation Electrolyte additive Sodium-ion batteries

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Coastal bathymetry inversion using SAR-based altimetric gravity data:A case study over the South Sandwich Island

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Geodesy and Geodynamics 2023年第3期14卷 212-222页

作者： yihao wu Junjie Wang Xiufeng He Yunlong wu Dongzhen Jia Yueqian Shen School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan 430079China

The global bathymetry models are usually of low accuracy over the coastline of polar areas due to the harsh climatic environment and the complex topography.Satellite altimetric gravity data can be a supplement and plays a key role in bathymetry modeling over these regions.The Synthetic Aperture Radar(SAR)altimeters in the missions like CryoSat-2 and Sentinel-3A/3B can relieve waveform contamination that existed in conventional altimeters and provide data with improved accuracy and spatial resolution.In this study,we investigate the potential application of SAR altimetric gravity data in enhancing coastal bathymetry,where the effects on local bathymetry modeling introduced from SAR altimetry data are quantified and evaluated.Furthermore,we study the effects on bathymetry modeling by using different scale factor calculation approaches,where a partition-wise scheme is implemented.The numerical experiment over the South Sandwich Islands near Antarctica suggests that using SARbased altimetric gravity data improves local coastal bathymetry modeling,compared with the model calculated without SAR altimetry data by a magnitude of 3:55 m within 10 km of offshore areas.Moreover,by using the partition-wise scheme for scale factor calculation,the quality of the coastal bathymetry model is improved by 7.34 m compared with the result derived from the traditional method.These results indicate the superiority of using SAR altimetry data in coastal bathymetry inversion.

关键词： Coastal bathymetry inversion Synthetic aperture radar altimeter Sentinel-3A/3B CryoSat-2 Altimetric gravity data Scale factor

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Assessment of the safety and efficacy of combination chemotherapy and PD-1/PD-L1 inhibitor treatment of breast cancer:A meta-analysis

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Chinese Medical Journal 2023年第14期136卷 1663-1670页

作者： Da Qian Yuhao Xu yihao wu Jie Qiu Weimin Hong Xuli Meng Department of Burn and Plastic Surgery-Hand Surgery The Changshu Hospital Affiliated to Soochow UniversityChangshuSoochowJiangsu 215500China Second Clinical College Zhejiang Chinese Medical UniversityHangzhouZhejiang 310000China College of Pharmaceutical Science Zhejiang University of TechnologyHangzhouZhejiang 310000China Faculty of Basic Medicine Hangzhou Medical CollegeHangzhouZhejiang 310000China Department of Breast Surgery Cancer CenterZhejiang Provincial People’s HospitalHangzhouZhejiang 310000China

Background:As the efficacy of programmed cell death-1/programmed death-ligand 1(PD-1/PD-L1)inhibitors combined with chemotherapy in curing breast cancer is still controversial,this meta-analysis compares the efficacy and safety of PD-1/PD-L1 inhibitors combined with chemotherapy and chemotherapy alone in the treatment of breast cancer,which provides guidance for the clinical treatment.Methods:Relevant studies published as of April 2022 in the various databases including EMBASE,PubMed,and Cochrane Library were selected.Randomized controlled trials(RCTs)in which control patients underwent chemotherapy alone and experimental group patients underwent combination chemotherapy and PD-1/PD-L1 inhibitor treatment were included in this investigation.Investigations without complete information,researches from which information could not be extracted,duplicate articles,animal studies,review articles,and systematic reviews were excluded.STATA 15.1 was employed for all statistical analyses.Results:In total,eight eligible studies were identified,revealing that combination chemotherapy and PD-1/PD-L1 inhibitor treatment was linked to significant increases in progression-free survival(PFS)relative to chemotherapy alone(hazard ratio[HR]=0.83,95%confidence interval[CI]:0.70–0.99,P=0.032)but not overall survival(HR=0.92,95%CI:0.80–1.06,P=0.273).Pooled adverse event rates were also increased within the group of combination treatment relative to the chemotherapy group(risk ratio[RR]=1.08,95%CI:1.03–1.14,P=0.002).Specifically,nausea rates were lesser within the group of combination treatment relative to the group of chemotherapy(RR=0.48,95%CI:0.25–0.92,P=0.026).Subgroup analyses indicated that the PFS of patients who underwent combination atezolizumab or pembrolizumab and chemotherapy treatment were substantially longer than those of patients who underwent chemotherapy alone(HR=0.79,95%CI:0.69–0.89,P≤0.001;HR=0.79,95%CI:0.67–0.92,P=0.002).Conclusions:The pooled results suggest that combination chemotherapy and PD-1/PD-L1 inhibitor tre

关键词： PD-1/PD-L1 inhibitors Breast cancer Chemotherapeutics Meta-analysis

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Hsa-miR-105-5p acts as an oncogene in triple-negative breast cancer

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Chinese Medical Journal 2023年第24期136卷 3022-3024页

作者： Da Qian Tao Zhou Hanchu Xiong Yuhao Xu Jie Qiu yihao wu Weimin Hong Xuli Meng Department of Burn and Plastic Surgery-Hand Surgery The Changshu Hospital Affiliated to Soochow UniversityChangshuJiangsu 215000China Faculty of Basic Medicine Hangzhou Medical CollegeHangzhouZhejiang 310014China Cancer Center Department of Radiation OncologyZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhouZhejiang 314408China Second Clinical College Zhejiang Chinese Medical UniversityHangzhouZhejiang 310014China College of Pharmaceutical Science Zhejiang University of TechnologyHangzhouZhejiang 310014China Cancer Center Department of Breast SurgeryZhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhouZhejiang 314408China

To the Editor:Breast cancer(BC)is the most common malignancy in women.Statistics show that 1.2 million women worldwide have BC each year,and 500,000 women die from BC.It is the leading cause of death in women.[1]According to the different expressions of estrogen receptor(ER),progesterone receptor(PR),and epidermal growth factor receptor 2(HER2),three receptor markers,BC is divided into four subtypes in clinical diagnosis.[2]MicroRNAs(miRNAs)have a wide range of regulatory effects and can regulate a variety of normal or pathogenic cell processes.

关键词： cancer Breast breast

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MicroRNA-29b suppresses TGF-β-induced epithelial-mesenchymal transition in renal interstitium of spontaneously hypertensive rats

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Chinese Medical Journal 2022年第7期135卷 857-859页

作者： yihao wu Zhi Zhang Zhe Chen Chen Fu Lu Huang Jiabing Wang Jian Li Andrew Barszczyk Deye Yang Department of Cardiology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China Department of Cardiology The First People’s Hospital of Yuhang DistrictHangzhouZhejiang 311100China Department of Cardiology the Affiliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang 310000China Department of Applied Psychology and Human Development University of TorontoTorontoCanada

To the Editor:Hypertension is a well-known cardiovascular disease in which the kidney is an important target due to its role in the regulation of fluid,electrolyte balance,and blood pressure.^([1])Glomerulosclerosis,renal tubule interstitial fibrosis,and proteinuria are the main pathological characteristics of hypertensive kidney injury.^([2])

关键词： hypertensive kidney cardiovascular

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高密度城市人口动静集聚与街坊形态关联解析——基于曼哈顿的实证

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城市规划 2024年第6期48卷 36-46页

作者：吴屹豪庄宇上海建筑设计研究院有限公司规划与城市设计院同济大学建筑与城市规划学院

高密度城市中人口具有高度流动性,其动静态人口的集聚现象和城市空间形态之间存在着一定程度的关联性。本文以曼哈顿为例,回溯其城市建设与形态演进轨迹,基于当前市域范围内静态和动态人口数据,运用空间聚类分析和曼哈顿人口探索器,识... 详细信息

高密度城市中人口具有高度流动性,其动静态人口的集聚现象和城市空间形态之间存在着一定程度的关联性。本文以曼哈顿为例,回溯其城市建设与形态演进轨迹,基于当前市域范围内静态和动态人口数据,运用空间聚类分析和曼哈顿人口探索器,识别出人口密度的空间分布特征。然后分别选取两个动、静态人口密度集中的1 km×1 km城市地段切片,通过空间矩阵分析其中典型街坊形态的量值特征,结果发现4个地段的形体密度存在梯度分异格局,并且与人口动静态分布的差异化现象相关。在此基础上,辨识并抽象出高密度街坊的组构类型,并揭示构成影响城市形态的隐性秩序和关联因素,最后提出曼哈顿城市形态对我国高密度城市建设的三点启示。

关键词：动静态人口高密度城市形态曼哈顿

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Investigation of the Tikhonov Regularization Method in Regional Gravity Field Modeling by Poisson Wavelets Radial Basis Functions

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Journal of Earth Science 2018年第6期29卷 1349-1358页

作者： yihao wu Bo Zhong Zhicai Luo MOE Key Laboratory of Fundamental Physical Quantities Measurement School of PhysicsHuazhong University of Science and Technology School of Geodesy and Geomatics Wuhan University Key Laboratory of Geospace Environment and Geodesy Ministry of EducationWuhan University

The application of Tikhonov regularization method dealing with the ill-conditioned problems in the regional gravity field modeling by Poisson wavelets is studied. In particular, the choices of the regularization matrices as well as the approaches for estimating the regularization parameters are investigated in details. The numerical results show that the regularized solutions derived from the first-order regularization are better than the ones obtained from zero-order regularization. For cross validation, the optimal regularization parameters are estimated from L-curve, variance component estimation（VCE） and minimum standard deviation（MSTD） approach, respectively, and the results show that the derived regularization parameters from different methods are consistent with each other. Together with the firstorder Tikhonov regularization and VCE method, the optimal network of Poisson wavelets is derived, based on which the local gravimetric geoid is computed. The accuracy of the corresponding gravimetric geoid reaches 1.1 cm in Netherlands, which validates the reliability of using Tikhonov regularization method in tackling the ill-conditioned problem for regional gravity field modeling.

关键词： regional gravity field modeling Poisson wavelets radial basis functions Tikhonov regularization method L-curve variance component estimation（VCE）

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Cobalt doping amount determines dominant reactive species in peroxymonosulfate activation via porous carbon catalysts co-doped by cobalt and nitrogen

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Journal of Environmental Sciences 2024年第4期138卷 212-226页

作者： Xiang Li Limeng wu Aiqin Zhang Shaohua wu Yan Lin Chunping Yang Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Academy of Environmental and Resource Sciences School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaoming 525000China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China

Switching the reaction routes in peroxymonosulfate(PMS)-based advanced oxidation processes have attracted much attention but remain challenging.Herein,a series of Co-N/C catalysts with different compositions and structures were prepared by using bimetallic zeolitic imidazolate frameworks based on ZIF-8 and ZIF-67(x Zn/Co-ZIFs).Results show that Co doping amount could mediate the transformation of the activation pathway of PMS over CoN/C.When Co doping amount was less than 10%,the constructed x Co-N/C/PMS system(x≤10%)was singlet oxygen-dominated reaction;however further increasing Co doping amount would lead to the generation and coexistence of sulfate radicals and high-valent cobalt,besides singlet oxygen.Furthermore,the nitrogen-coordinated Co(Co-NX)sites could serve as main catalytically active sites to generate singlet oxygen.While excess Co doping amount caused the formation of Co nanoparticles from which leached Co ions were responsible for the generation of sulfate radicals and high-valent cobalt.Compared to undoped N/C,Co doping could significantly enhance the catalytic performance.The 0.5%Co-N/C could achieve the optimum degradation(0.488 min^(-1))and mineralization abilities(78.4%)of sulfamethoxazole among the investigated Co-N/C catalysts,which was superior to most of previously reported catalysts.In addition,the application prospects of the two systems in different environmental scenarios(pH,inorganic anions and natural organic matter)were assessed and showed different degradation behaviors.This study provides a strategy to regulate the reactive species in PMS-based advanced oxidation process.

关键词： Peroxymonosulfate Sulfate radical Singlet oxygen Cobalt Zeolitic imidazolate framework Advanced oxidation process

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The physiological role of the unfolded protein response in the nervous system

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Neural Regeneration Research 2024年第11期19卷 2411-2420页

作者： Shuangchan wu Wensheng Lin Department of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Translational Neuroscience University of MinnesotaMinneapolisMNUSA

The unfolded protein response(UPR)is a cellular stress response pathway activated when the endoplasmic reticulum,a crucial organelle for protein folding and modification,encounters an accumulation of unfolded or misfolded proteins.The UPR aims to restore endoplasmic reticulum homeostasis by enhancing protein folding capacity,reducing protein biosynthesis,and promoting protein degradation.It also plays a pivotal role in coordinating signaling cascades to determine cell fate and function in response to endoplasmic reticulum stress.Recent research has highlighted the significance of the UPR not only in maintaining endoplasmic reticulum homeostasis but also in influencing various physiological processes in the nervous system.Here,we provide an overview of recent findings that underscore the UPR’s involvement in preserving the function and viability of neuronal and myelinating cells under physiological conditions,and highlight the critical role of the UPR in brain development,memory storage,retinal cone development,myelination,and maintenance of myelin thickness.

关键词： myelin neuron oligodendrocyte Schwann cell unfolded protein response

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