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Stability and Stabilization of Sampled-Data Based LFC for Power Systems:A Data-Driven Method

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： Yu-Long fan Chuan-Ke Zhang Yong He the School of Automation China University of Geosciences the Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems the Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stability analysis and stabilization design for sampled-data based load frequency control(LFC) systems via a data-driven method. By describing the dynamic behavior of LFC systems based on a data-based representation, a stability criterion is derived to obtain the admissible maximum sampling interval(MSI) for a given controller and a design condition of the PI-type controller is further developed to meet the required MSI. Finally, the effectiveness of the proposed methods is verified by a case study.

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

Relationship Between Developmental Intensity of Landslide and Malan Loess Cohesion at a Regional Horizontal Space Scale

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Journal of Earth Science 2025年

作者： Yongheng Zhou Yaming Tang Bo Hong fan Feng Longhui Wang Institute of Geological Survey， China University of Geosciences (Wuhan) Institute of Earth Environment， Chinese Academy of Sciences Xi'an Geological Survey Center China Geological Survey Chinese Academy of Geological Sciences

Malan loess is highly water-sensitive， with its shear strength， particularly cohesive strength， significantly decreasing under the influence of water. The Western Shanxi Loess Plateau （WSLP） is especially prone to loess landslides， which are closely linked to rainfall infiltration. Understanding the regional variation of Malan loess cohesion (cm) and its distribution in relation to the developmental intensity of landslides in this area can provide essential scientific evidence for effective landslide prevention. Loess landslides and Malan loess were selected as the objects of study for the current research. The regional variation and distribution pattern of the cmwere revealed through undisturbed loess direct shear tests and Inverse Distance Weighting （IDW） interpolation. The relationship between the developmental intensity of landslide and the regional variation of the cmwas explored using the Cumulative Sum Variable Dimension Fractal （CSVDF）， Frequency Ratio （FR） model， and Certainty Factor （CF） model. The following conclusions were drawn: Results from the direct shear tests and IDW method indicate that the cmtends to decrease from south to north and exhibits a positively skewed spatial distribution pattern. The CSVDF results indicates a similarity between the regional variation of the cmand the development intensity of loess landslides. The FR and CF results reveal that loess landslides are more likely to occur when the cmis between 0 and 16.14 kPa.

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Long-read sequencing reveals novel genetic polymorphisms in the major histocompatibility complex region and their impacts on the Han Chinese population

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Science China Life Sciences 2025年

作者： Cong Zhou Tingting Gong Shuhang Li Li Jin Shaohua fan State Key Laboratory of Genetic Engineering Lab for Evolutionary Synthesis School of Life Sciences Human Phenome Institute Fudan University Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Human leukocyte antigen(HLA) genes in the major histocompatibility complex(MHC) region are crucial for immunity and are associated with numerous diseases and phenotypes. The MHC region's complexity and high genetic diversity make it challenging to analyze using short-read sequencing(SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using both long-read sequencing(LRS) and SRS platforms at approximately 30X coverage to study genetic alterations and their potential functional impacts. LRS provides significantly greater coverage of the MHC region and eight classical HLA genes, particularly at the HLA-DRB1 locus, compared with SRS. We detect 78,249 single nucleotide polymorphisms(SNPs) using LRS, with 26.0% undetectable by SRS. Based on SNP and inferred HLA allele types, we construct an LRS-based MHC reference panel for the Han Chinese, containing approximately 2.6 times more genetic variants than the SRS-based Han-MHC reference panel. A phenome-wide association study assessing 26,024 phenotypes across 15 categories identifies significant associations for 7,879 independent variants(including 809 LRS-specific SNPs) with 409 phenotypes in nine categories. This analysis reveals 24 unreported HLA allele associations in the bioelectric and cellular categories. The conditional analysis identifies 530independent signals across the 409 phenotypes, including 28 previously unreported signals of eight classical HLA genes associated with 33phenotypes. Of the top-associated SNPs, 191 are detected by LRS only. Fine-mapping identifies 126 independent candidate causal SNPs for three immune-related cellular phenotypes, with 17 detected exclusively by LRS. Our study reveals previously unreported variants and their functional impacts in the MHC region, enhancing our understanding of genetic diversity and its potential biological implications in the Han Chinese population.

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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复杂光机部件仿真平台结构设计与研究

机械工程师 2019年第3期 26-29页

作者：范依航徐亚辉郝兆朋林洁琼长春工业大学机电工程学院长春130012

复杂光机部件图像采集地面仿真平台姿态扰动发生装置,是一种航空相机地面空中环境模拟装置。文中主要通过分析现有振动器,并结合其优点,设计出一种新型的仿真平台,用以实现在地面实验室中对航空相机进行空中飞行环境的模拟,从而进行探... 详细信息

复杂光机部件图像采集地面仿真平台姿态扰动发生装置,是一种航空相机地面空中环境模拟装置。文中主要通过分析现有振动器,并结合其优点,设计出一种新型的仿真平台,用以实现在地面实验室中对航空相机进行空中飞行环境的模拟,从而进行探究影响航空相机拍照质量的影响因子,进而可以研制出解决该影响因子的云台,并可以测试云台的合理性。以及基于ADAMS虚拟样机并联机构运动学和动力学特性分析,为仿真平台整体结构的优化设计提供理论依据和主要参数。

关键词：振动台结构设计有限元法 ADAMS

六堡茶改善痰湿质功效评价及基于肠道菌群调节的祛湿机制研究

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食品工业科技 2021年第21期42卷 361-369页

作者：侯粲肖杰王黎明陈洁瑜赵晓山范怡航李颂郝彬秀应剑张均伟中粮营养健康研究院有限公司北京102209 营养健康与食品安全北京市重点实验室北京102209 南方医科大学中医药学院广东广州510515 中茶科技(北京)有限公司北京102209 梧州中茶茶业有限公司广西梧州543001

为研究六堡茶调理亚健康状态痰湿体质的有效性,并探究其作用机制,本研究以六堡茶新茶和五年陈化茶(10 g,200 mL沸水浸泡2 min口服,每日2次)作为干预手段,纳入亚健康状态痰湿质人群进行随机、对照的临床试验,进行90 d的标准化干预,记录... 详细信息

为研究六堡茶调理亚健康状态痰湿体质的有效性,并探究其作用机制,本研究以六堡茶新茶和五年陈化茶(10 g,200 mL沸水浸泡2 min口服,每日2次)作为干预手段,纳入亚健康状态痰湿质人群进行随机、对照的临床试验,进行90 d的标准化干预,记录干预前后与痰湿质有关的中医诊断指标、血液生化指标,并重点分析肠道菌群的变化。结果显示,六堡茶新茶干预组和陈茶干预组在干预后痰湿质转化分均有下降趋势,其中六堡茶新茶干预组在干预后的25、45和90 d三个时间点痰湿质转化分差异有显著性(P<0.05)。六堡茶新茶及五年陈茶干预均有助于痰湿质体质改善,其中新茶起效较快。生化结果显示,六堡茶陈茶和新茶均具有降低胆红素的作用,陈茶作用较为明显,差异具有统计学意义(P<0.05)。肠道菌群分析显示,六堡茶干预后,六堡茶新茶干预组拟杆菌门(Bacterioidetes)水平下降为0.49±0.17、厚壁菌门(Firmicutes)水平上升至0.42±0.23,六堡茶陈茶干预组拟杆菌门(Bacterioidetes)水平下降为0.48±0.35、厚壁菌门(Firmicutes)水平上升至0.45±0.08;嗜胆菌(Bilophila)的相对丰度提高至六堡茶新茶干预组的0.0024±0.0013和六堡茶陈茶干预组的0.0022±0.0034,改变了肠道菌群中的厚壁菌门和拟杆菌门的相对比例,促进嗜胆菌增殖。与代谢疾病、能量代谢有关的萨特氏菌属(Sutterella)、Izimaplasmatales菌和瘤胃球菌属(Ruminococcus)的相对丰度水平发生改变,因此六堡茶可能通过调节肠道微生态,改善痰湿质等亚健康人群的代谢状态。

关键词：六堡茶痰湿质痰湿质转化分胆红素肠道菌群

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玄武湖公园乔灌木植物物种组成分析

安徽农学通报 2023年第7期29卷 100-102,106页

作者：杨偲越张马宇剑樊一航李湘玉南京林业大学生物与环境学院江苏南京210037

通过对玄武湖公园内乔、灌木植物的多次野外调查,分析研究区域内乔、灌植物的种类组成、数量特点和分布格局。结果表明,(1)玄武湖公园中植物种类众多,调查共记录到乔灌木植物56科99属147种,其中裸子植物6科10属13种,被子植物50科89属13... 详细信息

通过对玄武湖公园内乔、灌木植物的多次野外调查,分析研究区域内乔、灌植物的种类组成、数量特点和分布格局。结果表明,(1)玄武湖公园中植物种类众多,调查共记录到乔灌木植物56科99属147种,其中裸子植物6科10属13种,被子植物50科89属134种。植物物种丰富度较高,物种多样性丰富,乔木层植物物种数明显多于灌木层物种数。(2)蔷薇科在2个层次中均具有较明显的优势性,但总体来看种数在科、属内分布不均匀,大部分科内属、种贫乏,单种及单属科所占比例大。该研究结果可为玄武湖公园植物多样性保护、园区规划设计及城市绿地建设提供科学依据。

关键词：城市公园种类组成物种多样性

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