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Highly Fluorescent Semiconducting Two-Dimensional Conjugated Polymer Films Achieved by Side-Chain Engineering Showing Large Exciton Diffusion Length

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CCS Chemistry 2023年第10期5卷 2366-2377页

作者： Yongshuai Wang Qing Zhang Xiao-Ze Li Zhibin Shu yihan Zhang Can Gao Yang Li Hao Liu Chenguang Li Hong-Hua Fang Hong-Bo sun Xiaotao Zhang Wenping Hu Huanli Dong Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100190 Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207 Department of Chemistry National University of SingaporeSingapore 117543 State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084 Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072

Semiconducting two-dimensional conjugated polymers(2DCPs)with strong fluorescence emission have great potential for various optoelectronic ***,it is enormously challenging to achieve this goal due to the significant compact interlayerπ-πstacking-induced quenching effect in these *** this work,we found that highly fluorescent semiconducting 2DCPs can be prepared through an effective side-chain engineering approach in which interlayer spacers are introduced to reduce the fluorescence quenching *** obtained two truxene-based 2DCP films that,along with-C6H13 and-C_(12)H_(25)alkyl side chains as interlayer spacers both demonstrate superior fluorescence properties with a high photoluminescence quantum yield of 5.6%and 14.6%,*** are among the highest values currently reported for 2DCP ***,an ultralong isotropic quasi-twodimensional exciton diffusion length constrained in the plane with its highest value approaching 110 nm was revealed by the transient photoluminescence microscopy technique,suggesting that theπ-conjugated structure in these truxene-based 2DCP films has effectively been *** work can enable a broad exploration of highly fluorescent semiconducting 2DCP films for more deeply fundamental properties and optoelectronic device applications.

关键词： two-dimensional conjugated polymer side-chain engineering enlarged interlayer distance strong fluorescence emission large exciton diffusion length

Cocrystal engineering: Tuning the charge transfer excitons for highly sensitive luminescent switching materials under multiple stimuli

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Science China Materials 2022年第5期65卷 1320-1328页

作者： yihan Zhang Hongnan Wu Yajing sun Shuyu Li Si Liu Lei Zheng Lingjie sun Fangxu Yang Xiaotao Zhang Wenping Hu Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China School of Chemistry and Chemical Engineering Qinghai Minzu UniversityQinghai 810007China

This paper presents a multi-stimuli responsive cocrystal system with luminescent properties that can be dynamically controlled and demonstrates the responsive mechanism of cocrystals under multiple stimuli(acid/alkali vapor, force, and heat). Detailed spectroscopic, computational, and structural studies exhibit that obvious charge transfer interactions occur in loosely mixed-stacking cocrystals. Such interactions can be weakened by acid vapor fuming due to the strong electron-withdrawing effect of acid cations and strengthened under mechanical grinding. Furthermore,the response time of the cocrystal is in the order of seconds,which is much superior to those of most previously reported stimuli-responsive cocrystals. Accordingly, a high-sensitive fluorescence switching is demonstrated under multiple stimuli, providing an effective strategy to develop smart materials.

关键词： organic cocrystal charge transfer stimuli-responsive behavior smart materials

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基于事理图谱的红色档案资源开发利用研究

档案学研究 2023年第5期 73-80页

作者：孙大东张怡涵郑州大学信息管理学院郑州450001 郑州市区域档案工作发展战略研究中心郑州450001

红色档案资源是红色精神的载体与符号象征,事理图谱对事件类红色档案资源的开发利用具有良好的助力作用。本文阐述了全方位红色档案资源采集整合、网络化红色档案事理图谱构建流程;基于红色档案资源事理图谱提出其多维活态开发利用路径... 详细信息

红色档案资源是红色精神的载体与符号象征,事理图谱对事件类红色档案资源的开发利用具有良好的助力作用。本文阐述了全方位红色档案资源采集整合、网络化红色档案事理图谱构建流程;基于红色档案资源事理图谱提出其多维活态开发利用路径,包括多源化红色档案事理图谱编研、知识化红色档案事理图谱查询,可视化红色档案事理图谱展陈、多维度红色档案文旅场景应用。

关键词：红色档案资源事理图谱开发利用

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铝合金析出强化颗粒的微合金化调控

中国材料进展 2019年第3期38卷 231-241+250页

作者：高一涵刘刚孙军西安交通大学金属材料强度国家重点实验室

微合金化是目前改善铝合金结构材料综合力学性能最为高效的方法之一。而如何有针对性地选择利用微合金化手段,实现更为有效的微合金化效果,并在更深层次理解微合金化作用机制,是研发高性能铝合金结构材料长期以来所面对的瓶颈与挑战。... 详细信息

微合金化是目前改善铝合金结构材料综合力学性能最为高效的方法之一。而如何有针对性地选择利用微合金化手段,实现更为有效的微合金化效果,并在更深层次理解微合金化作用机制,是研发高性能铝合金结构材料长期以来所面对的瓶颈与挑战。藉由原子探针技术等多种先进实验测试技术及第一性原理等计算模拟手段,铝合金中的微合金化研究在近期取得了诸多引人注目的成果,对微合金化机理的理解也向更精细的纳米层级乃至原子层级迈进。结合当前国内外有关微合金化铝合金中析出相优化改性的一系列最新进展,分别阐述了3类典型的微合金化机制,包括:作为异质点促进原有析出相形核;提供界面偏聚以提升析出相热稳定性;析出额外的强化相以进一步提升合金强度,并对其进一步的复合微合金化机制做了探讨。文末对铝合金微合金化研究的发展趋势进行了展望。

关键词：铝合金微合金化析出相微观组织强韧化机制

GPU-CA model for large-scale land-use change simulation

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Chinese Science Bulletin 2012年第19期57卷 2442-2452页

作者： LI Dan LI Xia LIU XiaoPing CHEN YiMin LI ShaoYing LIU Kai QIAO JiGang ZHENG YiZhong ZHANG yihan LAO ChunHua Guangdong Key Laboratory for Urbanization and Geo-simulation School of Geography and PlanningSun Yat-sen UniversityGuangzhou 510275China Guangzhou lnstitue of Geogrophy Guangzhou 510070China Resource and Environment School Guangdong University of Business StudiesGuangzhou 501320China

Land-use change simulation for large-scale regions(*** regions or countries) is very useful for many global *** simulation,however,is affected by computational capability of general *** paper proposes a method to implement cellular automata(CA) for land use change simulation based on graphics processing units(GPUs).This method can be applied to large-scale land-use change simulations by combining the latest GPU high-performance computing technology and *** carried out the experiments by simulating land-use change processes at a provincial *** involves a lot of sophisticated techniques,such as model mapping,and computational procedure of GPU-CA *** proposed model has been validated by land-use change simulation in Guangdong Province,*** comparison indicates that the GPU-CA model is faster than traditional CA by 30 *** improvement is crucial for land-use change simulations in provincial regions and *** outputs of the simulation can be further used to provide information to other global change models.

关键词：土地利用变化模拟实验 CA模型高性能计算技术图形处理单元元胞自动机 GPU 计算能力

KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling

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Cellular & Molecular Immunology 2020年第8期17卷 834-842页

作者： Qingqing Zhou Yunkai Zhang Bo Wang Wenhui Zhou Yong Bi Wanwan Huai Xi Chen yihan Chen Zhongmin Liu Xingguang Liu Zhenzhen Zhan Institute of Heart Failure Shanghai East HospitalTongji University School of Medicine200120ShanghaiChina National Key Laboratory of Medical Immunology&Institute of Immunology Second Military Medical University200433ShanghaiChina Shanghai Fourth People’s Hospital Tongji University School of Medicine200081ShanghaiChina Institute of Immunology Zhejiang University School of Medicine310058HangzhouChina Key Laboratory of Arrhythmias of the Ministry of Education of China Shanghai East HospitalTongji University School of Medicine200120ShanghaiChina

IL-6 plays important and pleiotropic roles in infection and inflammatory diseases,and its production needs to be tightly ***,the epigenetic mechanism underlying Il6 gene transcription remains to be fully ***,we report that lysine-specific demethylase 2b(KDM2B),which demethylates H3K4me3 and H3K36me2,is required in macrophages and dendritic cells for the induction of IL-6 but not TNF-α,IL-1,and IFN-β.Compared to wild-type mice,KDM2B-deficient mice were more resistant to endotoxin shock and colitis,with a less severe inflammatory pathogenesis phenotype and decreased IL-6 production in ***2B selectively bound the Il6 promoter but did not alter histone demethylation;instead,KDM2B interacted with Brahma-related gene 1(Brg1),the core ATPase subunit of SWI/SNF chromatin remodeling complexes,to facilitate chromatin accessibility of the Il6 ***,KDM2B directly recruited RNA Polymerase II to further initiate and promote Il6 ***,our finding identifies a novel nonclassical function of KDM2B in gene-specific transcription initiation and enhancement of Il6 independent of its demethylase activity and adds new insight into the specific epigenetic modification mechanism of inflammatory immune responses.

关键词： KDM2B IL-6 Brg1 Chromatin remodeling Inflammation

Toxoplasma gondii glutathione S-Transferase 2(GST2) plays an important role in partial secretory protein transport

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Toxoplasma gondii glutathione S-Transferase 2(GST2) plays an...

Inflammatory macrophages exacerbate neutrophil-driven joint damage through ADP/P2Y_(1)signaling in rheumatoid arthritis

2021中国畜牧兽医学会兽医寄生虫学分会第16次学术研讨会

作者： Shuang Li Jing Liu Heng zhang Zhepeng sun Zhu Ying yihan Wu Jianhai Xu Qun Liu Key Laboratory of Animal Epidemiology of Ministry of Agriculture National Animal Protozoa LaboratoryCollege of Veterinary MedicineChina Agricultural University

Toxoplasma gondii is an apicomplexan parasite,which have three unique secretory organelles:micronemes,rhoptries,and dense *** all the secreted proteins are transported through the endoplasmic reticulum(ER) and Golgi system to function in their respective destination by accurate targeting and *** S-transferase(GST) is a supergene family enzyme that has multiple functions,which include regulation of cell proliferation and death signaling pathways,and participation in transportation and metabolism in mammal ***,the role of GST in Toxoplasma gondii has not been *** this study,we identified three GST proteins in ***,of which GST2 acts as a membrane protein that localizes to the Golgiendosomal system and colocalizes with proteins involved in vesicle transport as well,including synaptobrevin,putative sortilin(VPS 10),Rab5 and Rab6,which function as vesicle transport ***,the loss of TgGST2 leads to Rab5 and Rab6 distribution of discrete puncta,and incorrect localization and decreased expression of several secretory proteins,and to significantly reduced invasion capacity and virulence to *** with its relation to vesicle transport proteins,the distribution of TgGST2 relies on post-Golgi ***,our findings demonstrated that TgGST2 contributes to vesicle trafficking and plays a critical role in parasite lytic cycle.

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Science China(Life Sciences) 2022年第5期65卷 953-968页

作者： Xiaoyu Zhang Wenxiang Zhao yihan Zhao Zeda Zhao Zhangsheng Lv Zhen Zhang Hua Ren Qin Wang Mingyao Liu Min Qian Bing Du Juliang Qin Changning Maternity and Infant Health Hospital and School of Life Sciences Shanghai Key Laboratory of Regulatory BiologyEast China Normal UniversityShanghai 200241China Department of Orthopedics The Eighth Affiliated HospitalSun Yat-sen UniversityShenzhen 510275China Joint Center for Translational Medicine Fengxian District Central HospitalShanghai 201499China

Rheumatoid arthritis(RA)is a chronic autoimmune disease that primarily affects the joints and is associated with excessive immune cell ***,the complex interactions between the immune cell populations in the RA synovium remain ***,we demonstrate that inflammatory macrophages in the synovium exacerbate neutrophil-driven joint damage in RA through ADP/P2Y_(1)*** show that extracellular ADP(e ADP)and its receptors are obviously increased in synovial tissues of RA patients as well as collagen-induced arthritis(CIA)mice,and e ADP enhances neutrophil infiltration into joints through macrophages producing the chemokine CXCL2,aggravating disease ***,the arthritis mouse model had more neutrophils in inflamed joints following ADP injection,whereas P2Y_(1)deficiency and pharmacologic inhibition restored arthritis severity to basal levels,suggesting a dominant role of ADP/P2Y_(1)signaling in RA ***,cellular activity of ADP/P2Y_(1)-mediated CXCL2 production was dependent on the G_(αq)/Ca^(2+)-NF-κB/NFAT pathway in ***,this study reveals a non-redundant role of e ADP as a trigger in the pathogenesis of RA through neutrophil recruitment and disrupted tissue homeostasis and function.

关键词： extracellular ADP P2Y_(1) macrophage joint inflammation rheumatoid arthritis

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基于椭球拟合的磁力计误差校正方法研究

传感技术学报 2018年第9期31卷 1373-1376页

作者：孙伟杨一涵王野辽宁工程技术大学测绘与地理科学学院辽宁阜新123000

针对工作环境下的MEMS磁力计易受磁场干扰,且传统误差补偿速度慢、需要外部信息辅助而影响地磁信息获取时效性和精度的问题,提出一种基于椭球拟合的磁力计误差修正算法。建立基于刻度因子误差、非正交误差、零偏误差和软硬磁特性的磁力... 详细信息

针对工作环境下的MEMS磁力计易受磁场干扰,且传统误差补偿速度慢、需要外部信息辅助而影响地磁信息获取时效性和精度的问题,提出一种基于椭球拟合的磁力计误差修正算法。建立基于刻度因子误差、非正交误差、零偏误差和软硬磁特性的磁力计误差模型,采用最小二乘平差法估计椭球拟合算法中的椭球方程系数,得到校准后的磁场强度值。实验结果表明,经过论文提出的椭球拟合算法校正后的磁场强度波动幅度明显小于磁力计测量的原始磁场强度,能够有效降低磁力计测量误差。

关键词：磁力计误差模型椭球拟合校正