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基于新型示踪技术检测乳腺癌内乳淋巴结转移并分析其危险因素

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中国普外基础与临床杂志 2023年第6期30卷 698-702页

作者：陈燕石一涵邢雷杨光伦重庆医科大学附属第一医院乳腺甲状腺外科重庆400016

目的探讨基于新型示踪技术检测乳腺癌内乳淋巴结(internal mammary lymph node,IMLN)转移并分析其危险因素,为明确肿瘤TNM分期及制定精准治疗方案提供参考。方法回顾性收集2019年2月至2020年1月期间重庆医科大学附属第一医院收治且基于... 详细信息

目的探讨基于新型示踪技术检测乳腺癌内乳淋巴结(internal mammary lymph node,IMLN)转移并分析其危险因素,为明确肿瘤TNM分期及制定精准治疗方案提供参考。方法回顾性收集2019年2月至2020年1月期间重庆医科大学附属第一医院收治且基于新型示踪技术行组织穿刺活检病理检查确诊为乳腺癌并行手术切除的女性患者,均行IMLN清扫,分析IMLN转移与乳腺癌患者的年龄、肿瘤大小(指长径)、肿瘤位置、肿瘤分级、雌激素和孕激素受体状态、人表皮生长因子受体-2状态、腋窝淋巴结(axillary lymph node,ALN)转移数目及病理分子分型的关系。结果本研究共纳入28例患者,采用新型示踪技术对ALN及IMLN的显影率分别为96.4%(27/28)和35.7%(10/28)。IMLN活检组织病理结果证实6例患者发生IMLN转移(此6例均为显影患者),IMLN转移率为21.4%。乳腺癌患者的IMLN转移与肿瘤位置及ALN转移数目有关(P0.05)。ALN转移数目评估IMLN转移的受试者操作特征曲线下面积为0.697。结论从本研究总结的病例结果看,新型示踪技术对IMLN显影率较高,当乳腺癌位于内侧象限及ALN转移数目≥4枚时,建议积极行IMLN活检以明确其病理诊断性质,以精准评估肿瘤分期及制定合适的个体化治疗方案。

关键词：乳腺癌内乳淋巴结腋窝淋巴结危险因素

超声造影在评估乳腺癌腋窝及内乳淋巴结转移中的价值

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中国普外基础与临床杂志 2023年第3期30卷 333-337页

作者：陈燕石一涵邢雷杨光伦重庆医科大学附属第一医院乳腺甲状腺外科重庆400016

目的探讨超声造影(contrast-enhanced ultrasonography,CEUS)在浸润性乳腺癌腋窝及内乳淋巴结转移中的诊断价值。方法选取2020年9月至2022年9月期间就诊于重庆医科大学附属第一医院乳腺甲状腺外科的100例浸润性乳腺癌患者,术前完善CEUS... 详细信息

目的探讨超声造影(contrast-enhanced ultrasonography,CEUS)在浸润性乳腺癌腋窝及内乳淋巴结转移中的诊断价值。方法选取2020年9月至2022年9月期间就诊于重庆医科大学附属第一医院乳腺甲状腺外科的100例浸润性乳腺癌患者,术前完善CEUS检查,动态观察淋巴结的灌注顺序、增强模式及增强顺序。比较转移性淋巴结与良性淋巴结的CEUS特征;以术后病理结果为金标准,分析CEUS评估淋巴结状态的诊断效能。结果100例患者中28例患者术后病理活检确诊为转移性腋窝淋巴结,CEUS评估腋窝淋巴结状态的敏感度、特异度、准确率、阳性预测率和阴性预测率分别为71.4%、87.5%、83.0%、69.0%和88.7%。9例患者CEUS检查提示内乳淋巴结转移,术后病理学检查证实5例患者内乳淋巴结为转移淋巴结,CEUS的阳性预测率为55.6%。结论CEUS能较好地评估腋窝及内乳淋巴结的转移状态。

关键词：超声造影腋窝淋巴结内乳淋巴结诊断价值

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高尿酸血症和心血管疾病相关性研究的趋势及热点分析

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中国现代医生 2024年第32期62卷 29-33页

作者：史易晗曾林苏巴提江·帕尔哈提张磊孙荣鑫新疆医科大学第六附属医院关节外科新疆乌鲁木齐830092

目的采用CiteSpace软件和VOSviewer软件分析近20年高尿酸血症和心血管疾病的研究热点及发展趋势。方法检索Web of Science数据库2005年1月至2024年7月关于高尿酸血症和心血管疾病相关研究的文献,使用CiteSpace软件和VOSviewer软件对文... 详细信息

目的采用CiteSpace软件和VOSviewer软件分析近20年高尿酸血症和心血管疾病的研究热点及发展趋势。方法检索Web of Science数据库2005年1月至2024年7月关于高尿酸血症和心血管疾病相关研究的文献,使用CiteSpace软件和VOSviewer软件对文献的关键词、发文作者、发文机构、发文国家等进行分析并绘制网络合作图谱。结果共分析75个国家和1713个机构的5844位作者撰写的2344篇文献。Nutrition Metabolism and Cardiovascular Diseases杂志在该领域发表文献最多,共36篇。学者Johnson在该研究领域共发表19篇文献,位居第一。共有2678个关键词被纳入,确定研究前沿并持续到2024年的关键词为“asymptomatic hyperuricemia”“xanthine oxidoreductase”“adults”。结论通过文献计量学和可视化分析全面概述2005年至2024年关于高尿酸血症和心血管疾病相关性研究领域发表的文献,梳理该领域近20年的发展趋势和研究热点,有望为该领域研究者后续的研究提供参考。

关键词：高尿酸血症心血管疾病文献计量学

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5G+北斗高精度定位服务质量测试方案与质差原因

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电信科学 2023年第12期39卷 144-151页

作者：严茂胜刘学刚刘玮马学军石一涵马骠李天任中国移动通信集团有限公司北京100032 中国移动通信集团设计院有限公司北京100080

随着我国北斗导航产业的发展与北斗卫星全球组网的成熟建设,5G+北斗高精度定位服务在如测量测绘、形变监测、驾考驾培、自动驾驶等行业的应用正处在规模推广阶段。行业客户对高精度定位产品服务质量评估的需求也逐渐显现,现有的评估方... 详细信息

随着我国北斗导航产业的发展与北斗卫星全球组网的成熟建设,5G+北斗高精度定位服务在如测量测绘、形变监测、驾考驾培、自动驾驶等行业的应用正处在规模推广阶段。行业客户对高精度定位产品服务质量评估的需求也逐渐显现,现有的评估方法侧重在基准站、接收机终端侧,无法为行业用户所有使用或选择高精度定位服务提供参考。因此,需要一套面向行业应用的高精度定位服务质量评价体系为行业应用提供参考。创新性地提出了一套评估指标体系,特别是结合3GPPRelease17定义及车企等行业客户需求,搭建了完整的类指标体系,并在全国范围的不同区域、不同场景进行了验证。最后,通过对大量数据结果进行处理分析,以及对动态遮挡场景的影响、高精度定位平台与终端适配等用户侧更为关注的方面进行了分析,给出了服务质量改善的优化建议。特殊地,对比分析了单北斗条件下的服务质量。

关键词： 5G 高精度定位测试方案质差原因

Comprehensive insight into the occurrence characteristics,influencing factors and risk assessments of antibiotics in the Chaohu Basin

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 57-71页

作者： Shuanggang Hu Hongzhi Zhang Yongjie Yang Kangping Cui Junjie Ao Xuneng Tong Mengchen shi Yi Wang Xing Chen Chenxuan Li yihan Chen School of Resources and Environmental Engineering Hefei University of TechnologyHefei230009China Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai200092China Department of Civil & Environmental Engineering National University of SingaporeSingapore117576Singapore College of Resources and Environment Anhui Agricultural UniversityHefei230036China

The pollution of antibiotics in aquatic environments has received extensive ***,research on antibiotic contamination in river-lake systems,a significant form of modern aquatic environments,still needs to be *** study focuses on the Chaohu Basin(China)investigating the occurrence characteristics,influencing factors,and risk assessments of antibiotics in the river-lake *** total antibiotic concentrations in the water phase and sediment phase were 3.14–1887.49 ng/L and 0.92–1553.75 ng/g,*** was the predominant antibiotic in the water phase,whereas tetracycline prevailed in the sediment *** differences in concentration and structural composition of antibiotics between the tributaries(river system)and Chaohu Lake were observed,indicating the involvement of various geochemical processes in the attenuation of antibiotics during transport to the receiving *** analysis suggested that the western river is the primary source of antibiotics in Chaohu *** nutrient influx in heavily polluted areas is crucial to addressing the escalating issue of antibiotic pollution in the river-lake *** widespread occurrence of clindamycin in the waters is likely due to wastewater treatment plant discharges,and high-intensity human activities continue to exacerbate antibiotic *** assessment indicated that sulfamethoxazole,tetracycline,lincomycin,and clindamycin ranked in the top four with the highest risks to the most sensitive aquatic ***,the antibiotics presented no risk to consumer *** study provides valuable insights for controlling antibiotic pollution in riverlake systems.

关键词： Antibiotics Occurrence characteristics Influencing factors Risk assessments River-lake system

Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling

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Cellular & Molecular Immunology 2018年第1期15卷 58-73页

作者： Xiaoyu Zhang Juliang Qin Junyan Zou Zhangsheng Lv Binghe Tan Jueping shi yihan Zhao Hua Ren Mingyao Liu Min Qian Bing Du Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiChina

As the most prominent clinical drug targets for the inhibition of platelet aggregation, P2Y12 and P2Y13 have been found to be highly expressed in both platelets and macrophages. However, the roles and function of P2Y12/13 in the regulation of macrophage-mediated innate immune responses remain unclear. Here, we demonstrate that adenosine 5′-diphosphate (ADP), the endogenous ligand of P2Y1, P2Y12 and P2Y13, was released both in E. coli-infected mice and from macrophages treated with either lipopolysaccharide (LPS) or Pam3CSK4. Furthermore, the expression of P2Y13 was clearly increased in both LPS-treated macrophages and tuberculosis patients. ADP protected mice from E. coli 0111-induced peritonitis by recruiting more macrophages to the infected sites. Consistent with this, ADP and ADP-treated cell culture medium attracted more macrophages in the transwell assay by enhancing the expression of MCP-1. Nevertheless, P2Y1 is dispensable for ADP-mediated protection against bacterial infection. However, either P2Y12/P2Y13 deficiency or blocking the downstream signaling of P2Y12/P2Y13 blocked the ADP-mediated immune response and allowed more bacteria to persist in the infected mice. Furthermore, extracellular signal-regulated kinase (ERK) phosphorylation was clearly increased by ADP, and this type of activation could be blocked by either forskolin or analogs of cyclic AMP (cAMP) (for example, 8-bromo-cAMP). Accordingly, ADP-induced MCP-1 production and protection against bacterial infection could also be reduced by U0126, forskolin and 8-bromo-cAMP. Overall, our study reveals a relationship between danger signals and innate immune responses, which suggests the potential therapeutic significance of ADP-mediated purinergic signaling in infectious diseases.

关键词： ADP cAMP danger signal MCP-1 purinergic receptors

基于Gp/CoZn-MOF/SA柔性电极电化学检测羟基自由基

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广东化工 2023年第17期50卷 17-19,52页

作者：赵乐张清霞王鑫史依涵史亿霏马阳阳李心悦位冰宇娄睿刘芮语蔡宜言董辉商丘师范学院生物与食品学院河南商丘476000 商丘师范学院化学化工学院河南省生物分子识别与传感重点实验室河南商丘476000

本文基于石墨纸(Gp)优异的导电性,通过一步水热法,在其表面原位生长钴锌双金属有机骨架(CoZn-MOF);之后,水杨酸(SA)通过分子间相互作用力修饰于Gp/CoZn-MOF电极表面,得到电极Gp/CoZn-MOF/SA。该电极与·OH浓度在2~180 nmol/L范围内具有... 详细信息

本文基于石墨纸(Gp)优异的导电性,通过一步水热法,在其表面原位生长钴锌双金属有机骨架(CoZn-MOF);之后,水杨酸(SA)通过分子间相互作用力修饰于Gp/CoZn-MOF电极表面,得到电极Gp/CoZn-MOF/SA。该电极与·OH浓度在2~180 nmol/L范围内具有良好的非线性拟合关系。血清样品的加回收率为96.1%~105.5%,表明该方法具有较高的准确度。该方法的建立为其他活性分子的检测提供了一种新的设计策略,可用于对与活性氧相关疾病的早期诊断。

关键词：石墨纸金属有机骨架水杨酸羟基自由基电化学

A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy

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Asian Journal of Pharmaceutical Sciences 2022年第2期17卷 206-218页

作者： yihan Wu Jingjing Li Xuemei Zhong Jinfeng shi Yanfen Cheng Chenglin He Jiaxin Li Liang Zou Chaomei Fu Meiwan Chen Jinming Zhang Huile Gao School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Department of Pharmacology and Pharmacy The University of Hong KongHong Kong SARChina School of Food and Biological Engineering Chengdu UniversityChengdu 610106China Institute of Chinese Medical Sciences University of MacaoMacaoChina West China School of Pharmacy Sichuan UniversityChengdu 610041China

The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their ***,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor ***,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–guest complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer *** Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization *** view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in ***,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free *** expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 *** importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/***,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment.

关键词： Triptolide Chemo-photodynamic pH-sensitive supramolecular Nanosystem Co-delivery

Primary Research on Protective Effect of Houttuynia cordata Flavonoid and Sophora japonica L. Polysaccharide as Anti-UV Sun-screening Supplement

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Agricultural Biotechnology 2019年第2期8卷 63-67页

作者： Yawen ZHANG Liyan LI Yujie GAO Kangru shi Peiyun LIU yihan LIU Medical School Huanghe Science & Technology College

Houttuynia cordata flavonoid and Sophora japonica L. polysaccharide were investigated to develop anti-UV sun-screening agent through UV wavelength scanning spectrum, antioxidant ability and cell viability after UVB irradiation. The results showed that the extracts had strong UVA and UVB absorption ability and hydroxyl free radical scavenging ability. The S. japonica L. polysaccharide showed strong anti-UVB irradiation ability according to the cell viability experiment. It suggests that the H. cordata flavonoid and S. japonica L. polysaccharide could be combined as a candidate of anti-UV sun-screening supplement and compensate for the shortcomings of chemical sunscreens against UVA ray.

关键词： Houttuynia cordata Flavonoid Sophora japonica L. Polysaccharide Anti-UV radiation