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Lateral quantum confinement regulates charge carrier transfer and biexciton interaction in CdSe/CdSeS core/crown nanoplatelets

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Nano Research 2023年第7期16卷 10420-10428页

作者： yige Yao Xiaotian bao Yunke Zhu Xinyu Sui An Hu Peng Bai Shufeng Wang Hong Yang Xinfeng Liu Yunan Gao State Key Laboratory for Artificial Microstructure and Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Frontiers Science Center for Nano-optoelectronics Beijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Dalian National Laboratory for Clean Energy Dalian 116023China

Charge carrier dynamics essentially determines the performance of various optoelectronic applications of colloidal semiconductor nanocrystals.Among them,two-dimensional nanoplatelets provide new adjustment freedom for their unique core/crown heterostructures.Herein,we demonstrate that by fine-tuning the core size and the lateral quantum confinement,the charge carrier transfer rate from the crown to the core can be varied by one order of magnitude in CdSe/CdSeS core/alloy-crown nanoplatelets.In addition,the transfer can be affected by a carrier blocking mechanism,i.e.,the filled carriers hinder further possible transfer.Furthermore,we found that the biexciton interaction is oppositely affected by quantum confinement and electron delocalization,resulting in a non-monotonic variation of the biexciton binding energy with the emission wavelength.This work provides new observations and insights into the charge carrier transfer dynamics and exciton interactions in colloidal nanoplatelets and will promote their further applications in lasing,display,sensing,etc.

关键词： nanoplatelets core/crown charge carrier transfer ultrafast spectroscopy biexciton

2023 ASCO-GU尿路上皮癌精粹解读

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中华泌尿外科杂志 2023年第4期44卷 251-254页

作者：鲍一歌韩苏军黄海四川大学华西医院泌尿外科成都610041 中国医学科学院肿瘤医院泌尿外科北京100021 中山大学孙逸仙纪念医院泌尿外科广州510289

2023年美国临床肿瘤学会泌尿男生殖系肿瘤研讨会(ASCO-GU)报告多项尿路上皮癌进展。新方案应用于非肌层浸润性膀胱癌(NMIBC)治疗, 为卡介苗抵抗/失败NMIBC提供更多选择。肌层浸润性膀胱癌(MIBC)围手术期治疗中, CheckMate274研究3年随... 详细信息

2023年美国临床肿瘤学会泌尿男生殖系肿瘤研讨会(ASCO-GU)报告多项尿路上皮癌进展。新方案应用于非肌层浸润性膀胱癌(NMIBC)治疗, 为卡介苗抵抗/失败NMIBC提供更多选择。肌层浸润性膀胱癌(MIBC)围手术期治疗中, CheckMate274研究3年随访数据显示纳武利尤单抗辅助治疗组无疾病生存率优势。转移性尿路上皮癌(mUC)方面, IMvigor130研究总生存率(OS)报告发布, 引发mUC一线治疗思考。会议还关注上尿路尿路上皮癌(UTUC)研究。

关键词：尿路上皮癌非肌层浸润性膀胱癌肌层浸润性膀胱癌肿瘤免疫治疗 ASCO-GU会议

Comparative assessment of efficacy and safety of different treatment for de novo overactive bladder children: A systematic review and network meta-analysis

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Asian Journal of Urology 2019年第4期6卷 330-338页

作者： Shi Qiu Siwei Bi Tianhai Lin Zhuheng Wu Qi’an Jiang Jiwen Geng Liangren Liu Yige Bao Xiang Tu Mingjing He Lu Yang Qiang Wei Department of Urology Institute of UrologyWest China Hospital of Sichuan UniversityChengduChina

Objective:To compare these managements focusing on the efficacy and safety to treat overactive bladder(OAB)in children through network meta-analysis(NMA).Methods:We searched PubMed,Embase,the Cochrane Library Central Register of Controlled Trials(CENTRAL)and the reference lists up to May 1st,2017.Data from eligible randomized controlled trails(RCT)studies including three different treatment options were extracted.The primary outcome was maximal voiding volume(MVV).We performed pairwise metaanalyses by random effects model and NMA by Bayesian model.We used the Grading of Recommendations,Assessment,Development and Evaluations(GRADE)framework to assess the quality of evidence contributing to each network estimate.Results:Six RCTs(462 patients)comparing three different interventions fulfilled the inclusion criteria.A low risk of bias was shown for the majority of the study items.The results of NMA showed that compared with antimuscarinic drugs,Parasacral transcutaneous electrical nerve stimulation was associated with significant improvement in the MVV(mean difference[MD]=58.50,95% confidential interval[CI]:45.95-69.52),followed by urotherapy group(MD=21.03,95%CI:11.85-29.97).When it comes to the constipation,antimuscarinic drugs exerted significant benefit than PTENS(odds ratio[OR]:0.22,95%CI:0.01-0.46).No significant difference was found between other treatments.Conclusion:Compared with antimuscarinic drugs,PTENS was associated with significant better efficacy considering MVV,but more constipation events in de novo OAB children.Antimuscarinic drugs showed remarkably better efficacy considering MVV and comparable safety profile compared with urotherapy.Clinicians should take all known safety and compliance of patients into account when choosing an optimal strategy.

关键词： Overactive bladder Meta-analysis Anticholinergics Parasacral transcutaneous electrical nerve stimulation

2020版EAU前列腺癌指南更新解读之三——根治性前列腺切除术及围手术期处理新进展

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中华泌尿外科杂志 2020年第6期41卷 408-409页

作者：鲍一歌曾浩四川大学华西医院泌尿外科泌尿外科研究所成都610041

2020年欧洲泌尿外科学会(EAU)前列腺癌指南在手术这一章节进行了大幅更新,新增了大量内容。推荐意见上"开放、腹腔镜和机器人手术整体效果没有明显差异"和"当怀疑肿瘤存在包膜外侵犯时不应行同侧保留性神经手术"两点推荐等级调整为"弱"... 详细信息

2020年欧洲泌尿外科学会(EAU)前列腺癌指南在手术这一章节进行了大幅更新,新增了大量内容。推荐意见上"开放、腹腔镜和机器人手术整体效果没有明显差异"和"当怀疑肿瘤存在包膜外侵犯时不应行同侧保留性神经手术"两点推荐等级调整为"弱"。同时介绍了大量手术技术的改进,外科医生可根据自己的习惯选用以达到最佳手术效果。

关键词：前列腺肿瘤前列腺癌根治性前列腺切除术尿失禁手术切缘指南更新

Cell softness reveals tumorigenic potential via ITGB8/AKT/glycolysis signaling in a mice model of orthotopic bladder cancer

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Chinese Medical Journal 2024年第2期137卷 209-221页

作者： Shi Qiu Yaqi Qiu Linghui Deng Ling Nie Liming Ge Xiaonan Zheng Di Jin Kun Jin Xianghong Zhou Xingyang Su Boyu Cai Jiakun Li Xiang Tu Lina Gong Liangren Liu Zhenhua Liu Yige Bao Jianzhong Ai Tianhai Lin Lu Yang Qiang Wei Department of Urology Institute of UrologyNational Clinical Research Center for Geriatrics and Center of Biomedical Big DataWest China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Molecular Oncology Institute of Oncology Research(IOR)Oncology Institute of Southern Switzerland(IOSI)Bellinzona 6500Switzerland Department of Science and Drug Technology University of TurinTurinItaly National Clinical Research Center of Geriatrics The Center of Gerontology and GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610000China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pharmaceutics and Bioengineering School of Chemical EngineeringSichuan UniversityChengduSichuan 610000China

Background:Bladder cancer,characterized by a high potential of tumor recurrence,has high lifelong monitoring and treatment costs.To date,tumor cells with intrinsic softness have been identified to function as cancer stem cells in several cancer types.Nonetheless,the existence of soft tumor cells in bladder tumors remains elusive.Thus,our study aimed to develop a microbarrier microfluidic chip to efficiently isolate deformable tumor cells from distinct types of bladder cancer cells.Methods:The stiffness of bladder cancer cells was determined by atomic force microscopy(AFM).The modified microfluidic chip was utilized to separate soft cells,and the 3D Matrigel culture system was to maintain the softness of tumor cells.Expression patterns of integrinβ8(ITGB8),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)were determined by Western blotting.Double immunostaining was conducted to examine the interaction between F-actin and tripartite motif containing 59(TRIM59).The stem-cell-like characteristics of soft cells were explored by colony formation assay and in vivo studies upon xenografted tumor models.Results:Using our newly designed microfluidic approach,we identified a small fraction of soft tumor cells in bladder cancer cells.More importantly,the existence of soft tumor cells was confirmed in clinical human bladder cancer specimens,in which the number of soft tumor cells was associated with tumor relapse.Furthermore,we demonstrated that the biomechanical stimuli arising from 3D Matrigel activated the F-actin/ITGB8/TRIM59/AKT/mTOR/glycolysis pathways to enhance the softness and tumorigenic capacity of tumor cells.Simultaneously,we detected a remarkable up-regulation in ITGB8,TRIM59,and phospho-AKT in clinical bladder recurrent tumors compared with their non-recurrent counterparts.Conclusions:The ITGB8/TRIM59/AKT/mTOR/glycolysis axis plays a crucial role in modulating tumor softness and stemness.Meanwhile,the soft tumor cells become more sensitive to chemotherapy after stiffening,that offers new insights fo

关键词： Soft tumor cells 3D Matrigel Stemness Non-muscle invasive bladder neoplasms Microfluidic analytical techniques

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机器人辅助根治性前列腺切除术技术进展

中华外科杂志 2024年第2期62卷 116-121页

作者：赵浩辰廖鑫扬鲍一歌魏强四川大学华西医院泌尿外科、泌尿外科研究所成都610041

机器人辅助根治性前列腺切除术自问世以来,其手术理念、技术和设备历经20余年的创新与发展,手术效果也大幅提升。时至今日,仍有大量研究对比前入路、后入路、侧入路、经膀胱入路和经会阴入路等不同术式在控制肿瘤、恢复功能、减少并发... 详细信息

机器人辅助根治性前列腺切除术自问世以来,其手术理念、技术和设备历经20余年的创新与发展,手术效果也大幅提升。时至今日,仍有大量研究对比前入路、后入路、侧入路、经膀胱入路和经会阴入路等不同术式在控制肿瘤、恢复功能、减少并发症等方面的优劣并对不同术式加以改进,以期最大程度实现无术后并发症、手术切缘阴性、长期肿瘤控制、保留尿控和保留勃起功能的目标。随着5G远程手术和人工智能等新技术的出现,应在确保患者安全的前提下,科学探索并积极尝试将新技术融入机器人辅助根治性前列腺切除术的临床实践中,使广大前列腺癌患者获益。

关键词：前列腺肿瘤前列腺切除术机器人辅助根治性前列腺切除术手术入路并发症

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2023 ESMO尿路上皮癌精粹解读

中华泌尿外科杂志 2023年第12期44卷 889-892页

作者：鲍一歌陈俊儒曾浩魏强四川大学华西医院泌尿外科、四川大学华西医院泌尿外科研究所成都610041

本文对2023年欧洲肿瘤内科学会(ESMO)年会中尿路上皮癌领域的重要研究进行荟萃解读。本次会议报道了53项尿路上皮癌相关研究,包括6项新进展、7项口头报道和40项壁报交流。在非肌层浸润性膀胱癌(NMIBC)领域,多种新方案被报道,为卡介苗抵... 详细信息

本文对2023年欧洲肿瘤内科学会(ESMO)年会中尿路上皮癌领域的重要研究进行荟萃解读。本次会议报道了53项尿路上皮癌相关研究,包括6项新进展、7项口头报道和40项壁报交流。在非肌层浸润性膀胱癌(NMIBC)领域,多种新方案被报道,为卡介苗抵抗/失败的NMIBC保留膀胱治疗提供了更多选择。在肌层浸润性膀胱癌(MIBC)的围手术期治疗方面,研究进一步探讨了新辅助治疗方案的优化问题。对于转移性尿路上皮癌(mUC),CheckMate-901研究和EV-302研究为一线治疗方案提供了思考。这些研究为尿路上皮癌领域的临床实践提供了重要的指导意义。

关键词：尿路上皮癌非肌层浸润性膀胱癌肌层浸润性膀胱癌肿瘤系统治疗欧洲肿瘤内科学会

2024 ASCO-GU尿路上皮癌热点精读

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中华泌尿外科杂志 2024年第4期45卷 254-257页

作者：鲍一歌虞巍何志嵩魏强四川大学华西医院泌尿外科四川大学华西医院泌尿外科研究所成都610041 北京大学第一医院泌尿外科北京100034

回顾了2024年ASCO-GU会议上关于尿路上皮癌的最新研究,主要讨论了淋巴结阳性肌层浸润性膀胱癌(N_(+)MIBC)的治疗策略和MIBC术后的辅助治疗。N_(+)MIBC患者面临较高的复发风险,需要综合治疗策略。新辅助化疗和免疫治疗的联合方案显示出... 详细信息

回顾了2024年ASCO-GU会议上关于尿路上皮癌的最新研究,主要讨论了淋巴结阳性肌层浸润性膀胱癌(N_(+)MIBC)的治疗策略和MIBC术后的辅助治疗。N_(+)MIBC患者面临较高的复发风险,需要综合治疗策略。新辅助化疗和免疫治疗的联合方案显示出显著的疗效,此外,保留膀胱治疗和免疫维持治疗在延长无病生存期方面展现出潜力。AMBASSADOR和CheckMate-274研究的结果显示,高危MIBC术后免疫辅助治疗有利于延缓疾病复发。这些进展为高危MIBC患者的治疗提供了新的希望,并可能改善患者的预后。

关键词：尿路上皮癌肌层浸润性膀胱癌肿瘤免疫治疗 ASCO-GU会议

Exploration and design of knitted composites for architectural application: The MeiTing project

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Frontiers of Architectural Research 2022年第4期11卷 594-608页

作者： yige Liu Hao Hua Biao Li Institute of Architectural Algorithms&Applications School of ArchitectureSoutheast UniversityNanjing 210096China

Knitted composites are textile composite materials that consist of knitted textile reinforcement and polymer matrix. Knitted composites exhibit great design flexibility by allowing the customization of shapes, textures, and material properties. These features facilitate the optimization of buildings’ material systems and the creation of buildings with light weight and high material efficiency.To achieve such a lightweight, material-efficient building structure with knitted composites, this research investigates the material properties of knitted composites and proposes a design process for building-scale knitted composite systems. In the material study, this research examines certain mechanical properties of the material and the effects of additional design elements. In the design exploration, this research explores the design workflow of the structural form, element arrangement, and knit distribution of the material system at the macro-, meso-, and microscales. The project of MeiTing serves as proof of the concept and the design workflow.

关键词： Knitted composites Architectural application CNC knitting Material study Design workflow