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语言科学 2010年第1期9卷 46-54页

作者：杨一飞复旦大学中国语言文学系上海200234

文章在分类的基础上,选取各小类中的典型成员,从历时的角度探索实义副词的形成诱因,追溯各个下属小类的不同演化轨迹和虚化机制,并结合词语本身的语义积淀,对实义副词的来源、成因、语义等特点作出力所能及的解释。

关键词：实义副词语法化机制动因

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垂直轴风力发电机技术综述及研究进展

中国机械工程 2013年第5期24卷 703-709页

作者：杨益飞潘伟朱熀秋江苏大学镇江212013

系统阐述了垂直轴风力发电机几种主要类型的结构、原理及应用情况,简要介绍了在提高风能利用率方面所作的性能改进以及垂直轴风力发电机几个关键的组成部分取得的最新研究进展,指出垂直轴风力发电机是今后风力发电发展的主要方向。最后... 详细信息

系统阐述了垂直轴风力发电机几种主要类型的结构、原理及应用情况,简要介绍了在提高风能利用率方面所作的性能改进以及垂直轴风力发电机几个关键的组成部分取得的最新研究进展,指出垂直轴风力发电机是今后风力发电发展的主要方向。最后,针对目前垂直轴风力发电机研究现状的不足之处,提出了需要进一步研究的问题。

关键词：垂直轴风力发电机性能结构关键技术

<i>In Vitro</i>Study of the Nephrotoxicity of Tripterygium Tablet Extract and Triptolide in Monolayer HK-2 Cells Cultured in a Transwell Chamber

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Chinese Medicine 2018年第1期9卷 34-54页

作者： Ran Hao Lianqiang Hui Chun Li Chunyu Cao yifei yang Jiyuan Zhang Ting Liu Yi Zhang Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China

We established a monolayer polarized cell model using human kidney 2 (HK-2) cells cultured in a transwell chamber to examine the changes in the morphology and physiological functions of human-derived renal proximal tubular epithelial cells caused by tripterygium tablet extract (TTE) and triptolide. HK-2 cells were cultured on PCF membranes to form a complete monolayer of cells. A MTT assay was used to select 10, 40, 160, 640 μg·ml-1 TTE or 4, 16, 64, 256 ng·ml-1 triptolide to treat HK-2 monolayer cells. After 24 hours, a FITC permeability assay was performed;GGT, LDH and NAG secretion on the apical (AP) and basolateral (BL) sides of the cells by HK-2 cells were examined. The morphology and the monolayer structure of HK-2 cells was observed via optical microscope and scanning electron microscope, respectively. The effect on the cytoskeleton of HK-2 cells was observed under a fluorescence microscope. The IC50 of TTE was 277.122 μg·ml-1, and the IC50 of triptolide was 148.035 ng·ml-1. Compared with the DMSO group, the FITC leakage rate with TTE 160, 640 μg·ml-1 treated group and 4 - 256 ng·ml-1 triptolide dose group exhibited statistically significant increase. TTE significantly increased secretion of GGT and LDH at 160, 640 μg·ml-1, meanwhile, dramatically increased the AP/BL ratio of LDH at 160 μg·ml-1;triptolide significantly increased secretion and AP/BL ratio of GGT and LDH at 256 ng·ml-1. The morphological observations via optical and electron microscope indicated various degrees of damage to HK-2 cells by TTE and triptolide, and the degree of damage correlated positively with the dosage of the tested articles. Compared with DMSO group, the cellular damage degrees at TTE dosages of 40 - 640 μg·ml-1 and triptolide dose group at 16, 256 ng·ml-1 exhibited statistically significant differences via observation under optical microscope. Both TTE and triptolide caused various degrees of shortening and thickening of intracellular F-actin bundles of HK-2 cells;aggravation

关键词： Nephrotoxicity Tripterygium Tablet Extract Triptolide HK-2 Cell Transwell Chamber

P2Y1 receptor in Alzheimer’s disease

维普期刊数据库评论

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： Shan Luo yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

吗替麦考酚酯诱导治疗狼疮性肾炎的Meta分析

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武汉大学学报（医学版） 2015年第5期36卷 831-838页

作者：张任杨一菲湖北医药学院附属东风总医院湖北十堰442008 武汉大学人民医院肾内科湖北武汉430060

目的:用Meta分析方法评价吗替麦考酚酯与环磷酰胺治疗狼疮性肾炎(LN)的疗效和安全性。方法:运用万方数据库、Cochrane图书馆、PubMed和中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)检索吗替麦考酚酯治疗狼疮性肾炎的随机对... 详细信息

目的:用Meta分析方法评价吗替麦考酚酯与环磷酰胺治疗狼疮性肾炎(LN)的疗效和安全性。方法:运用万方数据库、Cochrane图书馆、PubMed和中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)检索吗替麦考酚酯治疗狼疮性肾炎的随机对照临床试验(RCTs),2014年3月25日检索文献截止,对符合标准的文献进行质量评价,用RevMan 5.1软件对符合质量标准的RCT进行Meta分析。结果:初步检索168篇相关文献中有7篇文献入选,共纳入699例患者,结果显示,实验组吗替麦考酚酯,治疗LN的总缓解率(OR=1.56,95%CI[1.13-2.14])、完全缓解率(OR=2.09,95%CI[1.08-4.05])均高于对照组环磷酰胺,且差异有统计学意义,两者部分缓解率无明显差异(OR=1.10,95%CI[0.80-1.51])。药物相关不良反应分析显示,吗替麦考酚酯组白细胞减少、月经紊乱、脱发发生率均明显低于环磷酰胺组,差异具有统计学意义。而其它不良反应如感染、胃肠道反应、带状疱疹发生率两者无明显差异。结论:吗替麦考酚酯治疗狼疮性肾炎疗效优于环磷酰胺,且药物不良反应白细胞减少、闭经、秃头发生率下降,较环磷酰胺具有更好的疗效及安全性。

关键词：吗替麦考酚酯环磷酰胺狼疮性肾炎 Meta分析

公元11至17世纪北京地区多层砖石塔建筑形制分期研究

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故宫博物院院刊 2024年第8期 20-35,155页

作者：杨怡菲徐怡涛北京大学考古文博学院

本文运用建筑考古形制类型学研究方法,对北京地区辽代至明代多层砖石塔进行了建筑形制分期研究,并在此基础上,对北京地区砖石塔建造过程中的“模仿”、重修问题以及年代存疑的个案进行深入探讨。

关键词：砖石塔仿木构北京建筑考古

探讨中药致胆汁淤积型肝损伤的特点及调控机制

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中国实验方剂学杂志 2024年第23期30卷 64-71页

作者：杨云张国壮刘婷杨依霏中国中医科学院中药研究所北京100700

目的:基于数据挖掘、网络药理学及分子对接技术探讨中药导致胆汁淤积型肝损伤(CLI)的特点及其相关的调控路径。方法:利用中国知网、PubMed等数据库检索建库至2024年关于中药导致的相关文献,规范信息后汇总并进行聚类分析;运用中药系统... 详细信息

目的:基于数据挖掘、网络药理学及分子对接技术探讨中药导致胆汁淤积型肝损伤(CLI)的特点及其相关的调控路径。方法:利用中国知网、PubMed等数据库检索建库至2024年关于中药导致的相关文献,规范信息后汇总并进行聚类分析;运用中药系统药理数据分析平台(TCMSP)、中医药整合药理学研究平台(TCMIP),GeneCards、在线人类孟德尔遗传数据库(OMIM)、DisGeNET数据库检索核心药物靶点及相关靶点;利用韦恩图绘制核心药物与CLI的交集靶点;利用Cytoscape3.10.2构建交集靶点的蛋白相互作用(PPI)网络图;通过DAVID数据库对核心靶点进行基因本体(GO)和京都基因与基因组百科全书(KEGG)富集分析;最后用AutoDock Vina进行分子对接。结果:该研究共筛选出符合条件的文献849篇,统计出39味可导致胆汁淤积的中药及其单体成分64个。按2020年版《中华人民共和国药典》进行归类,其中报道频次由高到低依次为清热药、解表药、活血化瘀药、泻下药、化痰止咳平喘药、补益药、祛风湿药、温里药、利水渗湿药、理气药、止血药、攻毒杀虫止痒药、收涩药、化湿药、安神药。聚类分析发现清热药致CLI的研究报道数量最多,占比39.69%。其中,清热药中报道较多的是栀子(92篇,占比10.84%)、黄芩(76篇,占比8.95%)、苦参(69篇,占比6.95%)。网络毒理学研究可知被报道导致CLI的中药引起胆汁淤积的核心靶点主要包括肿瘤坏死因子(TNF)、过氧化物酶体增殖物激活受体α(PPARA)、法尼醇X受体(FXR)、谷丙转氨酶2抗体(GPT2)、超氧化歧化酶1(SOD1)、干扰素γ(IFN-γ)、白细胞介素-6(IL-6)、CD36、载脂蛋白A1(APOA1)、血管紧张素转化酶(ACE)、细胞色素P4503A4酶(CYP3A4)、蛋白激酶B1(Akt1)、APOB、白蛋白(ALB)、ATP结合盒转运蛋白B4(ABCB4)、SLC10A1、雌激素受体α(ESR1)、信号转导与转录激活因子1(STAT1)、肌动蛋白(ACTB)、内皮素1(EDN1)、ABCG2、过氧化物酶体增殖物激活受体γ(PPARG)等,涉及的信号通路有胆汁分泌、ABC转运体、类固醇激素的生物合成、DNA加合物、药物代谢、细胞色素P450、过氧化物酶体、初级胆汁酸的生物合成、视黄醇代谢、Toll样受体等。分子对接结果表明,被高频报道可导致胆汁淤积肝损伤的清热药的有效成分(如黄芩苷和黄连素等)与ABCG2、IFN-γ、EDN1、IL-6、SOD1等靶点结合良好,结合能在-13~-9 kcal·mol^(-1),调控途径与转运体、微血管功能调节、炎症和氧化应激等高度相关,这与聚类分析的结果一致。结论:根据文献报道及数据库分析,致CLI的中药主要集中在清热药,且核心作用靶点为ABCG2、IFN-γ、EDN1、IL-6、SOD1等,调控途径主要与转运体、微血管功能调节、炎症、氧化应激等有关。

关键词：中药胆汁淤积分子对接网络毒理学调控机制

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan yang Lingxi Qing yifei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis

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Chinese Herbal Medicines 2023年第2期15卷 181-200页

作者： yifei yang Yi Wang Long Zhao Fang Wang Mingxing Li Qin Wang Haoming Luo Qianyun Zhao Jiuping Zeng Yueshui Zhao Fukuan Du Yu Chen Jing Shen Shulin Wei Zhangang Xiao Xu Wu Laboratory of Molecular Pharmacology Department of PharmacologySchool of PharmacySouthwest Medical UniversityLuzhou 646000China Luzhou Key Laboratory of Cell Therapy&Cell Drugs Luzhou 646000China Sichuan Fifth People’s Hospital Chengdu 610015China Department of Spleen and Stomach Diseases The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 646000China South Sichuan Institute of Translational Medicine Luzhou 646000China State Key Laboratory of Quality Research in Chinese Medicine University of MacaoMacao 999078China

Ulcerative colitis(UC)is one of types of inflammatory bowel disease with high *** studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a series of inflammatory responses in the *** the gut microbiota-intestinal immunity loop has been suggested as one of key strategies for relieving *** Chinese herbal medicines including some of single herb,herbal formulas and the derived constituents have been reported with protective effect against UC through modulating gut microbiome and intestinal *** clinical trials have shown promising *** review thus focused on the current knowledge on using Chinese herbal medicines for treating UC from the mechanism aspects of regulating intestinal homeostasis involving microbiota and gut *** existing clinical trials are also summarized.

关键词： Chinese herbal medicines gut microbiota inflammation inflammatory bowel disease intestinal immunity ulcerative colitis