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Gut microbiome evolution impacts the clinical outcomes of diseases

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 261-263页

作者： Lejia Sun Jiawei Li yifei feng Yueming Sun Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina The First School of Clinical Medicine Nanjing Medical UniversityNanjingChina Colorectal Institute of Nanjing Medical University NanjingChina

The human digestive tract is home to trillions of microbes,and owing to the advent of next-generation sequencing at the turn of the century and the development of bioinformatics technology,researchers have been able t... 详细信息

关键词： Gut microbiome evolution single nucleotide variant(SNV)

Self-assembled TiO_(2)hole-blocking layers for efficient perovskite solar cells

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1280-1285页

作者： Zhongbao Que Liang Chu Shuaibo Zhai yifei feng Chen Chen Wei Liu Ruiyuan Hu Jing Hu Xing’ao Li New Energy Technology Engineering Laboratory of Jiangsu Province&School of Science&School of Materials Science and Engineering&School of Electronic and Optic Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China

The self-assembly process for compatible functional layers of devices is a simple,feasible,and energy-saving *** mesoporous perovskite solar cells(PSCs),compact and scaffold TiO_(2) films generally function as the hole-blocking and electron-transporting layers,***,both of these layers are usually generated through a high-temperature annealing ***,we deposited TiO_(2) compact films through a room-temperature self-assembly process as effective hole-blocking layers for *** thickness of TiO_(2) compact films can be easily controlled by the deposition *** the optimization of TiO_(2) compact films(80 nm),the power conversion efficiency(PCE)of mesoporous PSCs without and with hole conductor layers increases up to 10.66%and 17.95%,***,an all-low-temperature planar PSC with the self-assembled TiO_(2) layer exhibits a PCE of 16.41%.

关键词： perovskite solar cells titanium dioxide self-assembly power conversion efficiency

Novel photoelectric material of perovskite-like(CH_(3))_(3)SPbI_(3) nanorod arrays with high stability

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Journal of Energy Chemistry 2021年第8期30卷 581-588,I0012页

作者： Ruiyuan Hu Chuangye Ge Liang Chu yifei feng Shanshan Xiao Yuhui Ma Wei Liu Xing'ao Li Mohammad Khaja Nazeeruddin Institute of Advanced Materials&New Energy Technology Engineering Laboratory of Jiangsu Province&School of Materials Science and Engineering&School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Hoffmann Institute of Advanced Materials Shenzhen PolytechnicShenzhen 518055China Group for Molecular Engineering of Functional Materials EPFL Valais WallisCH-1951 SionSwitzerland

Organometallic halide perovskite materials make great achievements in optoelectronic fields,especially in solar cells,in which the organic cations contain amine ***,the amine with NàH bonds is easily hydrolyzed with moisture in the air,weakening the perovskite materials *** is desirable to develop other non-amine stable perovskite *** this work,sulfur-based perovskite-like(CH_(3))_(3)SPbI_(3) nanorod arrays were fabricated by a solution-processed method,which can be indexed hexagonal crystal structure in the space group P63 *** binding force is exceptionally strong between the non-amine(CH_(3))_(3) S+and[PbI_(6)]_(4)-octahedral,leading to high stability of(CH_(3))_(3)SPbI_(3).The(CH_(3))_(3)SPbI_(3) nanorod arrays can keep the morphology and crystal structure in an ambient atmosphere over 60 *** addition,the(CH_(3))_(3)SPbI_(3) nanorod arrays can offer direct charge transfer channels,which show excellent optoelectronic ***(CH_(3))_(3)SPbI_(3) nanorod arrays-based solar cells with VOx hole transfer layers achieved a power conversion efficiency of 2.07%with negligible *** the(CH_(3))_(3)SPbI_(3) nanorod arrays were also effectively applied in photodetectors with interdigitated gold *** work demonstrates that sulfur-based perovskite-like(CH_(3))_(3)SPbI_(3) is a novel promising stable compound with great potential for practical optoelectronic applications.

关键词： Perovskite solar cells High stability (CH_(3))_(3)SPbI_(3) nanorod arrays Photodetectors

KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2959-2976页

作者： Chaofan Peng Peng Yang Dongsheng Zhang Chi Jin Wen Peng Tuo Wang Qingyang Sun Zhihao Chen yifei feng Yueming Sun Department of General Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Colorectal Institute of Nanjing Medical University Nanjing 210029China The First School of Clinical Medicine Nanjing Medical UniversityNanjing 210029China Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine Nanjing 210029China

Excessive fructose diet is closely associated with colorectal cancer(CRC)***,fructose’s specific function and precise mechanism in colorectal cancer liver metastasis(CRLM)is rarely ***,this study reported that the fructose absorbed by primary colorectal cancer could accelerate CRLM,and the expression of KHK-A,not KHK-C,in liver metastasis was higher than in paired primary ***,KHK-A facilitated fructose-dependent CRLM in vitro and in vivo by phosphorylating PKM2 at ***2 phosphorylated by KHK-A inhibited its tetramer formation and pyruvic acid kinase activity but promoted the nuclear accumulation of *** and aerobic glycolysis activated by nuclear PKM2 enhance CRC cells’migration ability and anoikis resistance during CRLM ***-46 treatment,targeting the phosphorylation of PKM2,inhibited the pro-metastatic effect of ***,c-myc activated by nuclear PKM2 promotes alternative splicing of KHK-A,forming a positive feedback loop.

关键词： CRC CRLM Fructose KHK-A PKM2

航空发动机燃滑油附件后盖裂纹原因分析与预防对策

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国防科技大学学报 2013年第6期35卷 60-64页

作者：徐小军罗成冯逸飞国防科技大学机电工程与自动化学院 96623部队

针对某型航空发动机燃-滑油附件后盖同部位成批次出现裂纹的问题,提出了裂纹故障引导转移的避障策略。通过研究裂纹产生的主要原因,分析后盖不同部位所产生的裂纹可能对航空发动机造成的危害程度,调整改变原支撑结构,在后盖非关键部位... 详细信息

针对某型航空发动机燃-滑油附件后盖同部位成批次出现裂纹的问题,提出了裂纹故障引导转移的避障策略。通过研究裂纹产生的主要原因,分析后盖不同部位所产生的裂纹可能对航空发动机造成的危害程度,调整改变原支撑结构,在后盖非关键部位形成新的应力集中点,降低关键部位应力集中区的应力幅值,迫使故障从不可修复的关键部位转移到可修复的非关键部位。经计算机仿真,确定了裂纹引导缺口的最佳参数;同时,仿真结果表明,裂纹故障引导转移策略合理可行。

关键词：航空发动机燃-滑油附件后盖裂纹引导裂纹预防

多技术整合在中低位直肠癌全直肠系膜切除手术中的应用

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中华胃肠外科杂志 2024年第6期27卷 579-582页

作者：孙跃明封益飞南京医科大学第一附属医院普通外科南京210006

全直肠系膜切除术(TME)是治疗中低位直肠癌的标准术式。吻合口漏一直是中低位直肠癌患者手术的严重并发症之一。吻合口血供、张力及肠管质量等是影响吻合口质量的重要因素。如何优化手术技术、减少吻合口漏的发生,是外科医生追求的目标... 详细信息

全直肠系膜切除术(TME)是治疗中低位直肠癌的标准术式。吻合口漏一直是中低位直肠癌患者手术的严重并发症之一。吻合口血供、张力及肠管质量等是影响吻合口质量的重要因素。如何优化手术技术、减少吻合口漏的发生,是外科医生追求的目标。笔者在传统TME基础上,整合多项手术技术,包括保留左结肠动脉、高位离断肠系膜下静脉、模式化游离结肠脾曲和左侧横结肠、多平面结肠系膜裁剪以及选择性吻合口加强,提出了“多技术整合TME”的理念。并结合临床实践,探讨多技术整合TME在中低位直肠癌手术中的应用及意义。

关键词：直肠肿瘤,中低位多技术整合全直肠系膜切除术吻合口漏

进展期低位直肠癌新辅助放化疗后侧方淋巴结清扫的选择和意义

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中华消化外科杂志 2021年第3期20卷 266-271页

作者：孙跃明封益飞张冬生南京医科大学第一附属医院结直肠外科 210029

侧方淋巴引流是低位直肠癌3个重要的淋巴引流方向之一。沿引流途径清扫淋巴结是直肠癌根治术基本要求,也决定淋巴结清扫范围。但侧方淋巴结是区域淋巴结还是远处淋巴结,一直存在争议。这带来新辅助放化疗和侧方淋巴结清扫、以及新辅助... 详细信息

侧方淋巴引流是低位直肠癌3个重要的淋巴引流方向之一。沿引流途径清扫淋巴结是直肠癌根治术基本要求,也决定淋巴结清扫范围。但侧方淋巴结是区域淋巴结还是远处淋巴结,一直存在争议。这带来新辅助放化疗和侧方淋巴结清扫、以及新辅助放化疗对侧方淋巴结转移疗效的争议。笔者综合分析国内外研究进展,对直肠癌侧方淋巴结转移规律、影响侧方淋巴结转移复发危险因素以及放化疗前后MRI检查对侧方淋巴结评估等进行深入阐述,并结合临床实践,探讨进展期低位直肠癌新辅助放化疗后侧方淋巴结清扫的选择和意义。

关键词：直肠肿瘤新辅助放化疗侧方淋巴结转移淋巴结清扫选择意义

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卵巢癌皮肤转移1例

中国皮肤性病学杂志 2019年第8期33卷 934-937页

作者：冯健清施辛程惠敏冯奕菲江苏省太仓市中医医院江苏太仓215400 苏州大学附属第二医院江苏苏州215000 南京医科大学江苏南京211100

患者女,64岁,腰腹部皮损伴轻度痒痛1个月余。体检:腰腹部、臀部、左腹股沟、左下肢多发浸润结节,色鲜红至暗红,未见破溃。皮损组织病理学检查:(左侧下腹部)转移性腺癌,结合HE形态及免疫标记,符合卵巢高级别浆液性腺癌转移。诊断:皮肤转... 详细信息

患者女,64岁,腰腹部皮损伴轻度痒痛1个月余。体检:腰腹部、臀部、左腹股沟、左下肢多发浸润结节,色鲜红至暗红,未见破溃。皮损组织病理学检查:(左侧下腹部)转移性腺癌,结合HE形态及免疫标记,符合卵巢高级别浆液性腺癌转移。诊断:皮肤转移癌。

关键词：卵巢癌皮肤转移

保妇康栓治疗宫颈炎合并HPV感染的效果探讨

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中国现代医生 2016年第22期54卷 46-48,52页

作者：冯翼飞沈阳市妇婴医院产科二病房辽宁沈阳110000

目的探讨保妇康栓治疗宫颈炎合并HPV感染的临床效果及价值。方法选择我院于2015年1月~2016年1月间收治的80例宫颈炎合并HPV（人乳头瘤病毒）患者为研究对象,按照时间顺序将其分为两组,采用干扰素栓剂治疗为对照组（40例）和采用保妇... 详细信息

目的探讨保妇康栓治疗宫颈炎合并HPV感染的临床效果及价值。方法选择我院于2015年1月~2016年1月间收治的80例宫颈炎合并HPV（人乳头瘤病毒）患者为研究对象,按照时间顺序将其分为两组,采用干扰素栓剂治疗为对照组（40例）和采用保妇康栓治疗为观察组（40例）,对比并分析两种治疗方法的治疗总有效率及不良反应发生率。结果观察组治疗总有效率（95.0%vs 77.5%）及不良反应发生率（2.5%vs 17.5%）均明显优于对照组,差异有统计学意义（P〈0.05）。结论对宫颈炎合并HPV感染患者实施保妇康栓治疗,效果显著,安全性高,值得推广和应用。

关键词：干扰素栓剂保妇康栓宫颈炎 HPV感染