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保留近端尿道及无热前列腺切除策略在机器人辅助根治性前列腺切除术中的应用(附手术视频)

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机器人外科学杂志（中英文） 2024年第4期5卷 505-510页

作者：成功承逸飞梁玲辉尚今伟史杰嵘董来华立新宋宁宏南京医科大学第一附属医院泌尿外科江苏南京210029

目的:探讨机器人辅助下根治性前列腺切除术(RARP)中行保留近端尿道及无热切除策略对术后尿控恢复的临床价值。方法:回顾性分析2022年6月—2022年12月于南京医科大学第一附属医院行RARP的97例患者的临床资料,按是否进行保留近端尿道及无... 详细信息

目的:探讨机器人辅助下根治性前列腺切除术(RARP)中行保留近端尿道及无热切除策略对术后尿控恢复的临床价值。方法:回顾性分析2022年6月—2022年12月于南京医科大学第一附属医院行RARP的97例患者的临床资料,按是否进行保留近端尿道及无热前列腺切除将其分为试验组(n=39)和对照组(n=58)。试验组行保留近端尿道及无热前列腺切除,对照组未保留近端尿道并行电剪刀切除。所有患者随访6个月。比较两组患者尿控恢复情况,观察结局包括术后尿控时间、术后是否短期尿控及每日使用尿垫数量。结果:与对照组相比,试验组尿控恢复更快(P<0.001);试验组术后近期(1个月)尿控比例显著高于对照组(P<0.001)。试验组平均每日使用尿垫数显著少于对照组(P=0.001)。结论:在机器人辅助根治性前列腺切除术中采用保留近端尿道及无热切除技术,有助于患者术后尿路控制恢复和生活质量改善,值得临床推广。有必要进行更大样本量和更长随访期的进一步研究,以验证这些发现并确定该策略的长期效果。

关键词：机器人辅助手术前列腺癌尿失禁近端尿道

Metal-organic layers induce in situ nano-structuring of Cu surface in electrocatalytic CO_(2)reduction

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Nano Research 2023年第4期16卷 4554-4561页

作者： Xinru He Jiawei Chen yifei Xu Yan Shen Yifan Zeng Jieyu Zhu Bingjun Xu cheng Wang iChem State Key Laboratory of Physical Chemistry of Solid SurfacesCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China

Cu-based catalysts have attracted widespread attention for its capability in electrocatalytically reducing CO_(2)to a variety of *** modification of Cu has become an interesting method for tuning the catalytic ***,we use Zrbased metal-organic layers(MOLs)as the additive of the Cu surface,which enhanced the Faradaic efficiency of CH4 by two times as compared to the untreated polycrystalline Cu ***,the MOLs were found to induce in situ nano-structuring of the Cu foil surface within seconds in the electrolysis,as revealed by a combination of scanning electron microscopy(SEM),grazing incidence X-ray diffractometry(GIXRD),and linear sweep voltammetry(LSV)*** surface changes are responsible for the shift of product *** experiments suggest that negatively chargedμ3-O−on the Zr-cluster in the MOL might interact with CO-covered Cu surface and induce roughing and *** work reveals a potential role of additive on Cu to induce surface nano-structuring that tunes catalytic activity and selectivity.

关键词： CO_(2)reduction CO_(2)methanation metal-organic layers Cu foil surface nano-structuring

One step hot-pressing method for hybrid Li metal anode of solid-state lithium metal batteries

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Journal of Materials Science & Technology 2023年第22期153卷 32-40页

作者： Kaiming Wang yifei Chen Liang Zhang Qihang Zhang Zhi cheng Yining Su Fei Shen Xiaogang Han State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Future Technology Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Smart Grid of Shaanxi Province Xi’anXi’an 710049China National Innovation Platform(Center)for Industry-Education Integration of Energy Storage Technology Xi’an 710049China

Safety issues induced by infinite anode volume change and uncontrolled lithium(Li)dendrite growth have become the biggest obstacle to the practical application of Li metal *** addition,the tra-ditional rolling method makes it difficult to manufacture thin Li foil with high mechanical strength and low Li ***,a three-dimensional(3D)lithophilic carbon paper/copper(Cu)current collector hybrid anode with ultra-low Li metal content is prepared by a hot-pressing *** highly re-versible and stable lithiophilic layer LiC_(x) formed in situ by heating/pressing treatment provides abun-dant nucleation sites and reduces the Li nucleation overpotential,thereby effectively suppressing Li den-drite ***,the volume change and pulverization problems of Li metal anode during depo-sition/stripping also can be accommodated by the 3D *** optimization effect has been directly confirmed by in-situ optical and ex-situ scanning electron microscope ***,highly sta-ble performance(158.4 mA h g^(-1) at 2 C after 200 cycles with a capacity retention of 95.24%)in Li@LCP-Cu||NCM811 coin cell can be ***,the solid-state battery assembled with the hybrid anode,poly(vinylidene fluoride)(PVDF)-based polymer electrolyte and polyethylene oxide(PEO)interface functional layer also exhibits the best electrochemical and safety performance,which also proves that the Li@LCP-Cu anode has great potential for application in solid-state batteries.

关键词： Hot-pressing Hybrid anode Lithiophilic layer licx Li dendrite Solid-state batteries

利妥昔单抗为基础治疗儿童再生障碍性贫血单倍体移植后EB病毒相关淋巴细胞增殖性疾病的前瞻性单中心临床研究

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中华血液学杂志 2024年第7期45卷 678-682页

作者：张枫胡冠华锁盼徐郑丽柏露王慧芳黄山雅美许兰平常英军张晓辉黄晓军程翼飞北京大学人民医院北京大学血液病研究所国家血液系统疾病临床医学研究中心造血干细胞移植北京市重点实验室北京100044

EB病毒(EBV)相关移植后淋巴细胞增殖性疾病(PTLD)是造血干细胞移植后最严重并发症之一。本研究纳入31例再生障碍性贫血(AA)行单倍体移植后发生PTLD的病例,归纳其临床特点,并按照利妥昔单抗治疗1次后是否能下降1个log分为利妥昔单抗单药... 详细信息

EB病毒(EBV)相关移植后淋巴细胞增殖性疾病(PTLD)是造血干细胞移植后最严重并发症之一。本研究纳入31例再生障碍性贫血(AA)行单倍体移植后发生PTLD的病例,归纳其临床特点,并按照利妥昔单抗治疗1次后是否能下降1个log分为利妥昔单抗单药治疗组或联合治疗组。AA患儿移植后PTLD发生率为10.16%,年龄>10岁者PTLD发生率明显升高(χ^(2)=11.336,P=0.010)。31例患者中临床诊断27例,病理确诊4例。利妥昔单抗单药治疗组15例,联合治疗组15例。最终27例患儿治愈。3例患儿死亡,2年总生存率为(89.7±5.6)%。标准预处理方案、EBV复阳是影响PTLD预后的危险因素。两种治疗方案对预后影响差异无统计学意义。

关键词：利妥昔单抗预处理方案单药治疗预后影响单倍体移植复阳总生存率治疗组

Computational and experimental analysis of Mach 2 air flow over a blunt body with plasma aerodynamic actuation

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Science China(Technological Sciences) 2013年第4期56卷 795-802页

作者： SUN Quan cheng BangQin LI YingHong KONG WeiSong LI Jun ZHU yifei JIN Di Science and Technology on Plasma Dynamics Laboratory School of Aeronautics and Astronautics EngineeringAir Force Engineering University

According to the mechanism of the arc plasma heating effect,and from a phenomenological perspective of view,the plasma actuation was simplified as heating energy injected into the supersonic flow field for the numerical research on controlling detached shock of the blunt body in non-center symmetrical ***,experimental research on the form and strength of detached shock wave control by plasma aerodynamic actuation in non-center symmetrical positions was conducted in a high-speed shock tunnel(M=2).The results showed that the detached distance of shock wave increased and the strength of normal shock wave ahead of the detached shock wave reduced when plasma actuation was *** control effect was greatly improved after the magnetic field was applied and the effect of upwind-direction flow was the best *** the upwind-direction flow was applied with 1000 V voltage actuation,the distance of detached shock wave would increase from 3.4 to 7.6 mm and the time average strength of normal shock wave was weaken by 5.5%.At last,the mechanism of plasma actuation on controlling the detached shock wave was briefly analyzed.

关键词： blunt body detached shock wave supersonic plasma shock tunnel

Dual active sites over Cu-ZnO-ZrO_(2) catalysts for carbon dioxide hydrogenation to methanol

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Journal of Environmental Sciences 2023年第9期131卷 162-172页

作者： Xiucheng Sun yifei Jin Zaizhe cheng Guojun Lan Xiaolong Wang Yiyang Qiu Yanjiang Wang Huazhang Liu Ying Li Institute of Industrial Catalysis Zhejiang University of TechnologyHangzhou 310014China

CO_(2) hydrogenation to methanol is a significant approach to tackle the problem of global warming and simultaneously meet the demand for the portable ***-ZnO catalysts with various kinds of promoters have received wide ***,the role of promoter and the form of active sites in CO_(2) hydrogenation are still in ***,various molar ratios of ZrO_(2) were added into the Cu-ZnO catalysts to tune the distributions of Cu^(0) and Cu+species.A volcano-like trend between the ratio of Cu+/(Cu++Cu^(0))and the amount of ZrO_(2) is presented,among which the CuZn10Zr(the molar ratio of ZrO_(2) is 10%)catalyst reaches the highest ***,the maximum value of space-time yield to methanol with 0.65 gMeOH/(gcat·hr)is obtained on CuZn10Zr at reaction conditions of 220°C and 3 *** characterizations demonstrate that dual active sites are proposed during CO_(2) hydrogenation over CuZn10Zr *** exposed Cu^(0) takes participate in the activation of H_(2),while on the Cu^(+) species,the intermediate of formate from the co-adsorption of CO_(2) and H_(2) prefers to be further hydrogenated to CH_(3)OH than decomposing into the by-product of CO,yielding a high selectivity of methanol.

关键词： Cu-ZnO-ZrO_(2) CO_(2)hydrogenation Methanol Dual active sites Formate

A Photocaged Azidosugar for Light-Controlled Metabolic Labeling of Cell-Surface Sialoglycans

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Chinese Journal of Chemistry 2022年第7期40卷 806-812页

作者： Bo cheng Yi Wan Qi Tang yifei Du Feiyang Xu Zhimin Huang Wei Qin Xing Chen College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences Peking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Synthetic and Functional Biomolecules Center Peking University Beijing 100871China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Peking UniversityBeijing 100871China

The photocaging strategy has been widely used for activating biomolecules and hence regulating the underlying biological processes with high temporal and spatial ***,we integrate this strategy into metabolic glycan labeling,which enables optical-ly-controlled metabolic labeling of cell-surface sialoglycans with azides.N-Azidoacetylmannosamine(ManNAz)is caged with a 4,5-dimethoxy-2-nitrobenzyl(DMNB)group at the anomeric hydroxyl group to block its cellular *** feeding to the cells,irradiation with 365 nm UV light or 405 nm visible light cleaves the photocage and generates ManNAz within the *** is metabolically converted to azido sialic acid,which is then incorporated into cell-surface *** demonstrated spatial and temporal control of this strategy by specifically labeling sialoglycans on a single cell and tracking the metabolism of ManNAz based on light-triggered pulse-chase labeling,*** light-controlled metabolic glycan labeling strategy should facilitate probing of glycosylation in complex biological systems with high spatiotemporal precision.

关键词： Sialic acids Caged compounds Click chemistry Pulse-chase Single cell

Ambipolar tribotronic transistor of MoTe_(2)

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Nano Research 2023年第9期16卷 11907-11913页

作者： Yonghai Li Jinran Yu Yichen Wei yifei Wang Liuqi cheng Zhenyu Feng Ya Yang Zhong Lin Wang Qijun Sun Center on Nanoenergy Research School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Georgia Institute of Technology AtlantaGA 30332-0245USA

Two-dimensional(2D)tribotronic devices have been successfully involved in electromechanical modulation for channel conductance and applied in intelligent sensing system,touch screen,and logic *** transistors and corresponding complementary inverters based on one type of semiconductors are highly promising due to the facile fabrication process and readily tunable ***,we demonstrate an ambipolar tribotronic transistor of molybdenum ditelluride(MoTe_(2)),which shows typical ambipolar transport properties modulated by triboelectric *** is comprised of a MoTe_(2)transistor and a lateral sliding triboelectric nanogenerator(TENG).The induced triboelectric potential by Maxwell’s displacement current(a driving force for TENG)can readily modulate the transport properties of both electrons and holes in MoTe_(2)channel and effectively drive the *** performance tribotronic properties have been achieved,including low cutoff current below 1 pA·μm^(−1)and high current on/off ratio of~103 for holes and electrons dominated *** working mechanism on how to achieve tribotronic ambipolarity is discussed in detail.A complementary tribotronic inverter based on single flake of MoTe_(2)is also demonstrated with low power consumption and high *** work presents an active approach to efficiently modulate semiconductor devices and logic circuits based on 2D materials through external mechanical signal,which has great potential in human–machine interaction,intelligent sensor,and other wearable devices.

关键词： ambipolar tribotronic transistor triboelectric potential mechanical displacement logic gate

羟基氧化铁纳米棒复合材料制备及其光热抗肿瘤特性研究

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徐州医科大学学报 2021年第7期41卷 469-474页

作者：李宝龙顾青浩韩筱茜程薏霏刘周杰黄庆利徐洲徐州医科大学第一临床医学院江苏徐州221004 徐州医科大学公共实验研究中心

目的制备氧化石墨烯量子点(GQD)和聚多巴胺(PDA)修饰的羟基氧化铁(FeOOH)纳米棒复合材料并考察其体外光热抗肿瘤性能。方法制备了GQD修饰和PDA包覆的FeOOH复合纳米材料,并对其粒径分布、微观形貌、成分组成以及光热转换效率等理化性质... 详细信息

目的制备氧化石墨烯量子点(GQD)和聚多巴胺(PDA)修饰的羟基氧化铁(FeOOH)纳米棒复合材料并考察其体外光热抗肿瘤性能。方法制备了GQD修饰和PDA包覆的FeOOH复合纳米材料,并对其粒径分布、微观形貌、成分组成以及光热转换效率等理化性质进行考察评价。以SKOV3卵巢癌细胞为研究对象,观察该纳米材料在近红外激光辐照下的抗肿瘤特性。结果光热实验表明制备的纳米复合材料和修饰前的FeOOH相比,光热性能大幅提高,具备较好的光热性能。体外细胞实验表明该复合材料对卵巢癌细胞具用较好的抑制效果,可以应用于肿瘤的光热治疗。结论采用本实验方法制备的复合纳米材料具有极好的生物相容性和优异的光热转换性能,有望成为一种新型肿瘤光热治疗材料。

关键词：石墨烯量子点聚多巴胺羟基氧化铁光热治疗肿瘤