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Adjustment of flood discharge capacity with varying boundary conditions in a braided reach of the Lower Yellow River

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Journal of Geographical Sciences 2021年第11期31卷 1615-1632页

作者： cheng yifei XIA Junqiang ZHOU Meirong DENG Shanshan LI Zhiwei State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China

It is of necessity to investigate the adjustment of flood discharge capacity in the Lower Yellow River(LYR)because of its profound importance in sediment transport and flood control decision-making,and additionally its magnitude is influenced by the channel and upstream boundary conditions,which have significantly varied with the ongoing implementation of soil and water conservation measures in the Loess Plateau and the operation of the Xiaolangdi *** braided reach between two hydrometric stations of Huayuankou and Gaocun in the LYR was selected as the study *** parameters in the study reach during the period 1986-2015 were calculated,covering bankfull discharge(the indicator of flood discharge capacity),the pre-flood geomorphic coefficient(the indicator of channel boundary condition),and the previous five-year average fluvial erosion intensity during flood seasons(the indicator of incoming flow and sediment regime).Functional linkages at scales of section and reach were then developed respectively to quantitatively demonstrate the integrated effects of channel and upstream boundary conditions on the flood discharge *** show that:(1)the reach-scale bankfull discharge in the pre-dam stage(1986-1999)decreased rapidly by 50%,accompanied with severe channel aggradation and main-channel *** recovered gradually as the geometry of main channel became narrower and deeper in the post-dam stage,with the geomorphic coefficient continuously reducing to less than 15 m-12.(2)The response of bankfull discharge to the channel and upstream boundary conditions varied at scales of section and reach,and consequently the determination coefficients differed for the comprehensive equations,with a smallest value at the Jiahetan station and a highest value(0.91)at reach ***,the verified results calculated using the comprehensive equations agreed well with the corresponding measured values in 2014-2015.(3)The effect of channel boundary c

关键词： flood discharge capacity channel boundary flow-sediment regime braided reach Lower Yellow River

Genetic variation of circHIBADH enhances prostate cancer risk through regulating HNRNPA1-related RNA splicing

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Journal of Biomedical Research 2024年第4期38卷 358-368页

作者： yifei cheng Rongjie Shi Shuai Ben Silu Chen Shuwei Li Junyi Xin Meilin Wang Gong cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Cancer Hospital Jiangsu Institute of Cancer Researchthe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China

The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the *** first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc *** then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls,and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio=1.20,95%confidence interval:1.08-1.34,P=7.06×10^(-4))in a dominant genetic model,which altered the secondary structure of the corresponding RNA *** the in silico analysis,we found that circHIBADH sponged and silenced 21 RNA-binding proteins(RBPs)enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house(four tissue samples)and publicly available single-cell ***,we demonstrated that HNRNPA1 influenced hallmarks including MYC target,DNA repair,and E2F target signaling pathways,thereby promoting *** conclusion,genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1,playing an oncogenic role in PCa.

关键词： genetic variants prostate cancer circRNA RNA-binding protein RNA splicing sing-cell RNA sequencing

Sino-German vocational education cooperationkicksoff

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Voice of Friendship 2018年第3期 32-34页

作者： cheng yifei 不详

Thirteen women radiant with youthful vigor gathered in a newly festooned meeting room in the compound of the Chinese People’s Association for Friendship with Foreign Countries in Beijing on Jan3,*** were the protagonists at a seeing-off ceremony hosted by the association’s Friendship Center for a Sino-German Nursing Exchange Program.

关键词： Sino-German vocational education cooperation

Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated FAM227A expression

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Journal of Biomedical Research 2024年第2期38卷 149-162,I0001-I0010页

作者： Lulu Fan Hao Wang Shuai Ben yifei cheng Silu Chen Zhutao Ding Lingyan Zhao Shuwei Li Meilin Wang Gong cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving *** studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor ***,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular *** the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics *** then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target ***,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate *** current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors.

关键词： super-enhancer prostate cancer genetic variants AhR BaP FAM227A

Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation

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Engineering 2019年第1期5卷 150-155页

作者： yifei cheng Yuhong Chen Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu Xiaohui Zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People’s Hospital Beijing 100044 China Collaborative Innovation Center of Hematology Peking University Beijing 100084 China Shenzhen Geno-Immune Medical Institute Shenzhen 518057 China Innovative Cellular Therapeutics Co. Ltd. Shanghai 201499 China

Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI.

关键词： Donor-derived CD19-targeted T cell infusion Hematopoietic stem cell transplantation B cell acute lymphoblastic leukemia Minimal residual disease

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造血干细胞移植后的截瘫

中华血液学杂志 2017年第4期38卷 357-360页

作者：程翼飞黄晓军北京大学人民医院、北京大学血液病研究所 100044

造血干细胞移植（HSCT）是治疗许多造血系统良、恶性疾病的有效手段。HSCT后6．6％～24．0％的患者出现神经系统并发症，包括可逆性后部脑病、瘫痪、惊厥、脑病、多发性神经炎、中枢神经系统感染等。

关键词：造血干细胞移植移植后中枢神经系统感染神经系统并发症截瘫多发性神经炎造血系统恶性疾病

造血干细胞移植后供者来源嵌合抗原受体T细胞相关移植物抗宿主病

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中华内科杂志 2019年第7期58卷 541-544页

作者：王莎莎程翼飞北京大学人民医院血液病研究所 100044

异基因造血干细胞移植是治疗B细胞来源恶性肿瘤的有效手段,但移植后复发仍然是治疗失败的主要原因。嵌合抗原受体(CAR)T细胞疗法是一种有效治疗难治、复发血液/淋巴系统肿瘤的细胞疗法。从来源上分,CAR-T细胞有自体来源及供者来源之分... 详细信息

异基因造血干细胞移植是治疗B细胞来源恶性肿瘤的有效手段,但移植后复发仍然是治疗失败的主要原因。嵌合抗原受体(CAR)T细胞疗法是一种有效治疗难治、复发血液/淋巴系统肿瘤的细胞疗法。从来源上分,CAR-T细胞有自体来源及供者来源之分。供者来源的CAR-T输注可能会导致移植物抗宿主病(GVHD)。单倍体移植及非单倍体移植后均可能发生GVHD。目前有一些措施可以减少供者来源CAR-T输注后的GVHD,使供者来源的CAR-T治疗更有效,副作用更小。

关键词：造血干细胞移植嵌合抗原受体T细胞供者来源移植物抗宿主病

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热处理对97NiBe合金组织和性能的影响

金属热处理 2015年第5期40卷 86-89页

作者：胡春文成亦飞北京航空材料研究院北京100095

研究了1020~1100℃固溶和480~520℃时效对冷轧97Ni Be合金带材的组织和力学性能的影响。结果表明,随固溶温度升高,合金组织内晶粒尺寸增大,未溶解β相减少,经时效后,抗拉强度和伸长率随固溶温度的升高而明显下降,屈服强度在1060℃固溶... 详细信息

研究了1020~1100℃固溶和480~520℃时效对冷轧97Ni Be合金带材的组织和力学性能的影响。结果表明,随固溶温度升高,合金组织内晶粒尺寸增大,未溶解β相减少,经时效后,抗拉强度和伸长率随固溶温度的升高而明显下降,屈服强度在1060℃固溶时达到最大值;在480~520℃时效,组织中产生富铍的G.P.区,G.P.区随温度升高或时间延长而增厚,当固溶温度为1020℃时,合金在480~500℃时效4~6 h,可获得良好的综合力学性能。

关键词： 97NiBe合金固溶时效组织力学性能

Bridging chimeric antigen receptor T-cell before transplantation improves prognosis of relapsed/refractory B-cell acute lymphoblastic leukemia

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Chinese Medical Journal 2023年第16期136卷 2011-2013页

作者： Xiangyu Zhao Haotian Wu yifei cheng Zhengli Xu Yuhong Chen Yingjun Chang Yu Wang Xiaohui Zhang Lanping Xu Xiaojun Huang Peking University People’s Hospital Peking University Institute of HematologyDepartment of HematologyBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationNational Clinical Research Center for Hematologic DiseaseXicheng DistrictBeijing 100044China Peking University Health Science Center Beijing 100191China Peking-Tsinghua Center for Life Sciences Beijing 100871China

To the Editor:For recipients with relapsed/refractory(R/R)B-cell acute lymphoblastic leukemia(B-ALL),allogeneic hematopoietic stem cell transplantation(allo-HSCT)often fails to provide them with a satisfactory *** chimeric antigen receptor T(CAR-T)cells are proven to be safe and effective for these patients.[1]But there are few published studies assessing the advantages of CAR-T compared to traditional chemotherapy as a bridging treatment followed by ***,we conducted this study to confirm whether children and young adult R/R B-ALL patients with CAR-T therapy could expect a better post-HSCT prognosis,compared to R/R patients only receiving traditional chemotherapy before transplantation.

关键词： chemotherapy lymphoblastic prognosis