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Perovskite-Enhanced Silicon-Nanocrystal Optoelectronic Synaptic Devices for the Simulation of Biased and Correlated Random-Walk Learning

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Research 2020年第1期2020卷 1321-1329页

作者： Yiyue Zhu Wen Huang yifei He Lei yin Yiqiang Zhang Deren Yang Xiaodong Pi State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhouZhejiang 310027China School of Materials Science and Engineering Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhouHenan 450001China Institute of Advanced Semiconductors Hangzhou Innovation CenterZhejiang UniversityHangzhouZhejiang 311215China

Silicon-(Si-)based optoelectronic synaptic devices mimicking biological synaptic functionalities may be critical to the development of large-scale integrated optoelectronic artificial neural *** a type of important Si materials,Si nanocrystals(NCs)have been successfully employed to fabricate optoelectronic synaptic *** this work,organometal halide perovskite with excellent optical asborption is employed to improve the performance of optically stimulated Si-NC-based optoelectronic synaptic *** improvement is evidenced by the increased optical sensitivity and decreased electrical energy consumption of the *** is found that the current simulation of biological synaptic plasticity is essentially enabled by photogating,which is based on the heterojuction between Si NCs and organometal halide *** using the synaptic plasticity,we have simulated the well-known biased and correlated random-walk(BCRW)learning.

关键词： perovskite plasticity Silicon

Theoretical model of pediatric orbital trapdoor fractures and provisional personalized 3D printing-assisted surgical solution

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Bioactive Materials 2021年第2期6卷 559-567页

作者： Guangrui Chai Deming Zhang Weijian Hua Jun yin yifei Jin Ming Chen Department of Ophthalmology Shengjing Hospital of China Medical UniversityShenyangLiaoning 110004China Department of Mechanical and Aerospace Engineering University of FloridaGainesvilleFL 32611USA Department of Mechanical Engineering University of Nevada RenoRenoNV89557USA The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhouZhejiang 310027China

Pediatric orbital trapdoor fractures are common in children and adolescents and usually require emergency surgical ***,a personalized 3D printing-assisted approach to surgical treatment is proposed,serving to accurately and effectively repair pediatric orbital trapdoor *** first investigated stress distribution in external force-induced orbital blowout fractures via numerical simulation,determining that maximum stresses on inferior and medial walls exceed those on superior and lateral walls and thus confer higher probability of *** also examined 36 pediatric patients treated for orbital trapdoor fractures between 2014 and 2019 to verify our theoretical *** 3D printing technique,we then created orbital models based on computed tomography(CT)studies of these *** implants were tailor-made,replicating those of 3D-printed models during surgical repairs of fractured orbital *** follow-up,we compared CT images and clinical parameters(extraocular movements,diplopia,enophthalmos)before and 12 months after operative *** were only two patients with diplopia and six with enophthalmos>2 mm at 12 months,attesting to the efficacy of our novel 3D printing-assisted strategy.

关键词： Pediatric orbital fracture Stress analysis Trapdoor 3D printing Personalized surgery

Ce-Ti catalysts modified with copper and vanadium to effectively remove slip NH_(3) and NO_x from coal-fired plants

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Journal of Rare Earths 2023年第7期41卷 1022-1030,I0002页

作者： Wenjie Liu yifei Long Shinian Liu Yongyan Zhou Xin Tong Yajie yin Xiaoyi Li Kang Hu Jiangjun Hu School of Resource and Environmental Sciences Wuhan UniversityWuhan 430079China China Southern Power Grid Technology Co. Ltd.Guangzhou 510080China Electric Power Research Institute of Guangdong Power Grid Co.Ltd. Guangzhou 510080China

In this work,V/Ce-Ti catalysts were modified with different kinds of transition metals(Cu,Fe,Co,Mn) by sol-gel and impregnation *** NH_(3) oxidation performance of them was tested to select the most active catalyst in NH_(3)-selective catalytic oxidation(NH_(3)-SCO).The effect of NO,SO_(2) and H_(2)O was also *** experimental results indicate that 1% Cu-V/Ce-Ti catalyst exhibits the most significant ability to remove slip ammonia discharged from coal-fired plants and its NH_(3) conversion efficiency reaches90% at 300℃.In additio n,97% NO_x can be removed when NO is introduced in the ***-V/Ce-Ti catalyst also obtains good resistance to H_(2)O and SO_(2).Based on the characterization experiment,the introduced Cu and V are highly dispersed on Ce-Ti catalyst and they can increase the redox properties and the number of acidic ***,the redox cycles among Cu,V and Ce species on Cu-V/Ce-Ti catalyst surface are conducive to generating more active oxygen and promoting the oxidation capacity of the catalyst.

关键词： Ce-Ti catalyst Transition metals Slip ammonia NO reduction Rare earths

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涂装工业挥发性有机化合物治理技术研究进展

电镀与涂饰 2024年第9期43卷 143-153页

作者：何曦叶明强周益辉周杰谭绪凤朱鹏程李先华丁沛文尹艺霏沈言锦航天凯天环保科技股份有限公司湖南长沙410100 长沙工研院环保有限公司湖南长沙410100 湖南汽车工程职业大学湖南株洲412001

[目的]涂装工业因使用有机溶剂而产生大量挥发性有机化合物(VOCs),它们不仅危害人类健康,还会引发雾霾、光化学烟雾,导致温室效应。但VOCs种类繁多,性质差异大,治理技术多样,如何选择合适的技术成为工程应用的关键。[方法]对涂装工业VOC... 详细信息

[目的]涂装工业因使用有机溶剂而产生大量挥发性有机化合物(VOCs),它们不仅危害人类健康,还会引发雾霾、光化学烟雾,导致温室效应。但VOCs种类繁多,性质差异大,治理技术多样,如何选择合适的技术成为工程应用的关键。[方法]对涂装工业VOCs治理技术的进展进行总结,分析各种治理技术的研究重点及应用条件,为VOCs治理技术的工程应用提供参考。[结果]对于水溶性好、生物毒性弱的VOCs,宜选择生物法;对于风量大、浓度低的VOCs,宜浓缩后再处理;对于无回用价值的VOCs,宜选择热力氧化法;对于低浓度、易分解的VOCs,宜选择等离子体法。[结论]工程应用时应根据VOCs的种类和浓度,综合考虑具体的治理技术。

关键词：涂装挥发性有机化合物治理工程应用综述

催醒宁缩瞳与催醒安降低眼压临床应用的初步探讨

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解放军医学杂志 1984年第5期 340-343页

作者：徐玉华黄一飞尹素云韩素义解放军总医院

催醒宁、催醒安系军事医学科学院药理毒理研究所自行设计合成的新药,通过动物试验和志愿正常人的检测,证明两药不仅有缩瞳作用而且有降眼压作用。本文分别对催醒宁的缩瞳作用,催醒安的降压作用进行了临床观察。(1)选不同强度的敌瞳剂散... 详细信息

催醒宁、催醒安系军事医学科学院药理毒理研究所自行设计合成的新药,通过动物试验和志愿正常人的检测,证明两药不仅有缩瞳作用而且有降眼压作用。本文分别对催醒宁的缩瞳作用,催醒安的降压作用进行了临床观察。(1)选不同强度的敌瞳剂散瞳后的患者,应用不同浓度的催醒宁缩瞳,并与匹罗卡品、依色林作对照。缩瞳作用与依色林相似,强于匹罗卡品,无毒性反应。(2)选用确诊的开角青光眼患者,一组为1滴药组与匹罗卡品对照,另一组为多次点药组,观察时间最短1周,最长28周。结果表明催醒安与匹罗卡品降压作用相似,而且不引起调节痉挛,易被患者接受。

关键词：匹罗卡品滴药依色林眼压缩瞳临床应用

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

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Frontiers of Medicine 2021年第3期15卷 460-471,F0004页

作者： Lingli Cai Jun yin Xiaojing Ma yifei Mo Cheng Li Wei Lu Yuqian Bao Jian Zhou Weiping Jia Department of Endocrinology and Metabolism Shanghai Clinical Center for DiabetesShanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Lifestyle interventions,including dietary adjustments and exercise,are important for obesity *** study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet(LCD)or exercise is more effective in metabolism ***-five eligible subjects were randomly divided into an LCD group(n=22)and an exercise group(EX,n=23).The subjects either adopted LCD(carbohydrate intake<50 g/day)or performed moderate-to-vigorous exercise(≥30 min/day)for 3 *** the interventions,LCD led to a larger weight loss than EX(−3.56±0.37 kg vs.−1.24±0.39 kg,P<0.001),as well as a larger reduction in fat mass(−2.10±0.18 kg vs.−1.25±0.24 kg,P=0.007)and waist circumference(−5.25±0.52 cm vs.−3.45±0.38 cm,P=0.008).Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin *** decreased in both two groups,whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX *** glycemic parameters,including serum glycated albumin,mean sensor glucose,coefficient of variability(CV),and largest amplitude of glycemic excursions,substantially declined in the LCD *** CV slightly decreased after *** pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin *** with exercise,LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

关键词： low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose

Zinc finger-inspired peptide-metal-phenolic nanointerface enhances bone-implant integration under bacterial infection microenvironment through immune modulation and osteogenesis promotion

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Bioactive Materials 2024年第11期41卷 564-576页

作者： Lin Xu Jie Fang Jiezhou Pan Hexu Qi Yun yin Yunxiang He Xueqi Gan yifei Li Yu Li Junling Guo State Key Laboratory of Oral Diseases National Center for StomatologyNational Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of Pediatric DentistryWest China Second University HospitalSichuan UniversityChengdu610041China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu610065China State Key Laboratory of Oral Diseases National Center for StomatologyNational Clinical Research Center for Oral DiseasesDepartment of ProsthodonticsWest China Hospital of StomatologySichuan UniversityChengdu610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of PediatricsWest China Second University HospitalSichuan UniversityChengdu610041China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China Bioproducts Institute Department of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBCV6T 1Z4Canada

Orthopedic and dental implantations under bacterial infection microenvironment face significant challenges in achieving high-quality bone-implant integration. Designing implant coatings that incorporate both immune defense and anti-inflammation is difficult in conventional single-functional coatings. We introduce a multifunctional nanointerface using a zinc finger-inspired peptide-metal-phenolic nanocoating, designed to enhance implant osseointegration under such conditions. Abaloparatide (ABL), a second-generation anabolic drug for treating osteoporosis, can be integrated into the design of a zinc-phenolic network constructed on the implant surface (ABL@ZnTA). Importantly, the phenolic-coordinated Zn2+ ions in ABL@ZnTA can act as zinc finger motif to co-stabilize the configuration of ABL through multiple molecular interactions, enabling high bioactivity, high loading capacity (1.36 times), and long-term release (>7 days) of ABL. Our results showed that ABL@ZnTA can modulate macrophage polarization from the pro-inflammatory M1 towards the anti-inflammatory M2 phenotype, promoting immune osteogenesis with increased OCN, ALP, and SOD 1 expression. Furthermore, the ABL@ZnTA significantly reduces inflammatory fibrous tissue encapsulation and enhances the long-term stability of the implants, indicated by enhanced binding strength (6 times) and functional connectivity (1.5−3 times) in the rat bone defect model infected by S. aureus. Overall, our research offers a nano-enabled synergistic strategy that balances infection defense and osteogenesis promotion in orthopedic and dental implantations.

关键词： Metal-phenolic network Implant Osseointegration Inflammation Abaloparatide

Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders-a Mendelian randomization study

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Food Science and Human Wellness 2024年第4期13卷 1877-1885页

作者： Yuanyuan Wang Lirong Dong Meng Zhao Shiyu yin Pan Da Dengfeng Xu yifei Lu Jiayue Xia Niannian Wang Shaokang Wang Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Integrated Service and Management Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009China

Mental disorders seriously affect people’s health and social *** Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D(25(OH)D)levels and mental *** data used for the MR analysis were derived from the summary genome-wide association studies(GWAS)database for VC and 25(OH)D and from the Finn Gen consortium for fourteen mental *** on the inverse variance weighted(IVW)method,we found a potential causal association between circulating VC and anxiety disorders(IVW:OR=1.139,95%CI:1.023-1.269,P=0.018).However,no causal association was found between VC or 25(OH)D and other mental disorders(P>0.05).In the reverse MR analysis,individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC(P=0.012),while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D(P=0.012).However,the current evidence does not support a causal relationship between VC or 25(OH)D and other mental *** addition,there was no causal association between circulating VC and 25(OH)D(P>0.05).Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.

关键词： Circulating vitamin C 25-Hydroxyvitamin D Mental disorder Mendelian randomization

Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration

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Nano Research 2024年第8期17卷 7449-7460页

作者： yin Yuan Lijun Chen Jing Yang Sining Zhou Yangxin Fang Qi Zhang Ning Zhang yifei Li Li Yuan Fan Jia Shuo Ni Charlie Xiang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Biology The David H.Koch Institute for Integrative Cancer Research at MITMassachusetts Institute of TechnologyCambridgeMA 02139USA Research Units of Infectious disease and Microecology Chinese Academy of Medical SciencesHangzhou 310003China Innovative Precision Medicine(IPM)Group Hangzhou 311215China MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Cancer Immunology and Virology Dana-Farber Cancer InstituteBostonMA 02215USADepartment of ImmunologyHarvard Medical SchoolBoston MA 02115USA Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China

Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis ***,limited sources and poor tissue-homing efficiency limit their clinical *** this study,we isolated a kind of MSCs from women’s menstrual blood(MenSCs)noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet *** were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for *** this delivery system,MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse ***,scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting *** recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone *** study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis.

关键词： mesenchymal stem cells microfluidics bone marrow homing stem cell niche postmenopausal osteoporosis