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Longitudinal proteomic investigation of cOVID-19 vaccination

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Protein & Cell 2023年第9期14卷 668-682页

作者： Yingrui Wang Qianru Zhu Rui Sun xiao Yi Lingling Huang yifan Hu Weigang Ge Huanhuan Gao Xinfu Ye Yu Song Li Shao Yantao Li Jie Li Tiannan Guo Junping Shi Marker Lab Westlake Laboratory of Life Sciences and BiomedicineKey Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake University18 Shilongshan RoadHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024China Research Centerfor Industries of theFuture WestlakeUniversity600D unyu RoadHangzhou 310030China Center for Infectious Disease Research Westlake University18 Shilongshan RoadHangzhou 310024China Westlake Omics(Hangzhou)Biotechnology Co. Ltd.Hangzhou 310024China Department of Translational Medicine Platform The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015China The Fourth School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Medical college of Hangzhou Normal University Hangzhou 311121China Department of Infectious Diseases Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Institute of Viruses and Infectious Diseases Nanjing UniversityNanjing 210093China Department of Infectious and Hepatology Diseases The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015China

Although the development of covID-19 vaccines has been a remarkable success,the heterogeneous individual antibody generation and decline over time are unknown and still hard to predict.In this study,blood samples were collected from 163 participants who next received two doses of an inactivated COvVID-19 vaccine(CoronaVac)at a 28-day interval.Using TMT-based proteomics,we identified 1,715 serum and 7,342 peripheral blood mononuclear cells(PBMCs)proteins.We proposed two sets of potential biomarkers(seven from serum,five from PBMCs)at baseline using machine learning,and predicted the individual seropositivity 57 days after vaccination(AUC=0.87).Based on the four PBMC's potential biomarkers,we predicted the antibody persistence until 180 days after vaccination(AUC=0.79).Our data highlighted characteristic hematological host responses,including altered lymphocyte migration regulation,neutrophil degranulation,and humoral immune response.This study proposed potential blood-derived protein biomarkers before vaccination for predicting heterogeneous antibody generation and decline after coVID-19 vaccination,shedding light on immunization mechanisms and individual booster shot planning.

关键词： COVID-19 vaccination proteomics neutralizing antibodies(NAbs) machine learning

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互感器检定装置整体检定技术综述

中国高新科技 2024年第5期 66-67页

作者：陈骁汪一帆周毅傅月江孔祥峰国网浙江省电力有限公司营销服务中心浙江杭州311100

文章提出了一种互感器检定装置整体检定技术,从二次回路状态评估、电源校验技术、环境电磁干扰试验3个方面展开说明。该技术克服了传统单独检验部件的局限性,实现了测量用互感器检定装置整体性能的有效评估,在国内企业的推广应用中显著... 详细信息

文章提出了一种互感器检定装置整体检定技术,从二次回路状态评估、电源校验技术、环境电磁干扰试验3个方面展开说明。该技术克服了传统单独检验部件的局限性,实现了测量用互感器检定装置整体性能的有效评估,在国内企业的推广应用中显著提高了产品质量,为电力系统的安全稳定经济运行提供了有力保障。

关键词：互感器检定装置整体检定方法二次回路状态评估电源校验技术环境电磁干扰试验

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四甲基二丙烯三胺的制备及其应用研究进展

化学世界 2024年第2期65卷 76-82页

作者：孙逸帆姚羽佳肖兴玥张媛媛黄旭娟闫鑫焱蔡照胜盐城工学院化学化工学院江苏盐城224051

四甲基二丙烯三胺(TMBPA)为一种具有仲胺和叔胺结构的线性多胺,在精细化学品的制备中有广泛的应用。介绍了TMBPA的典型制备方法及其在聚氨酯和环氧树脂材料、表面活性剂、基因转染材料、气体吸附与分离材料等领域的应用,分析了制备TMBP... 详细信息

四甲基二丙烯三胺(TMBPA)为一种具有仲胺和叔胺结构的线性多胺,在精细化学品的制备中有广泛的应用。介绍了TMBPA的典型制备方法及其在聚氨酯和环氧树脂材料、表面活性剂、基因转染材料、气体吸附与分离材料等领域的应用,分析了制备TMBPA的重点研究方向。

关键词：四甲基二丙烯三胺制备应用开发精细化学品

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针灸治疗压力性尿失禁研究文献可视化分析

中国中医药图书情报杂志 2024年第1期48卷 133-138页

作者：李佳蔚吴一凡施嘉旎李沛琦张宇宸肖彬上海中医药大学上海201203

目的利用CiteSpace可视化分析软件对2002-2022年针灸治疗压力性尿失禁的中文文献进行筛选和分析,了解我国针灸治疗压力性尿失禁的发展脉络、研究热点及未来研究发展趋势,为该领域的深入研究提供客观依据。方法在中国知识资源总库(CNKI... 详细信息

目的利用CiteSpace可视化分析软件对2002-2022年针灸治疗压力性尿失禁的中文文献进行筛选和分析,了解我国针灸治疗压力性尿失禁的发展脉络、研究热点及未来研究发展趋势,为该领域的深入研究提供客观依据。方法在中国知识资源总库(CNKI)检索2002年1月1日-2022年8月31日针灸治疗压力性尿失禁的中文期刊文献,导出至CiteSpace6.1.R2,对作者、机构、关键词和突现词进行知识图谱构建和可视化分析。结果共检索到文献403篇,筛选后纳入313篇。发文量最高的作者是汪司右,为14篇;发文量最高的机构是上海中医药大学和上海针灸经络研究所;关键词聚类共11个;中介中心性最高的关键词为尿失禁(0.48),其次为电针(0.42);主要研究热点包括女性患者(研究对象)、电针、艾灸、温针灸(干预方式)及中髎、八髎、会阳(常用腧穴)。结论电针治疗压力性尿失禁将持续是一个热门研究方向,目前针对男性压力性尿失禁患者的针灸治疗研究较少;针灸治疗压力性尿失禁的规范化操作和相关标准有待深入研究。

关键词：针灸压力性尿失禁 CiteSpace 知识图谱可视化分析

Iceberg calving from the Antarctic Nansen Ice Shelf in April 2016 and its local impact

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Science Bulletin 2016年第15期61卷 1157-1159页

作者： Tian Li yifan Ding Tiancheng Zhao xiao Cheng State Key Laboratory of Remote Sensing Science College of Global Change and Earth System ScienceBeijing Normal UniversityBeijing 100875China Joint Center for Global Change Studies Beijing 100875China

Owing to global warming,frequent ice shelf disintegration and rapid acceleration of inland ice flow have occurred in recent decades,which impacts the Antarctic mass balance and the global sea level[1].These events are closely linked to atmospheric and oceanic processes.The prolonged melt season and larger extent of melt ponds on the ice shelf surface[2],as well as enhanced basal melting caused by warmer sea water[3],will induce crevasses that

关键词：冰架南极冰山海洋环境全球变暖质量平衡浮游植物科学探险

视觉发育关键期单眼剥夺对小鼠大脑不同区域星形胶质细胞的影响

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眼科新进展 2024年第7期44卷 517-521页

作者：孙一帆王宵杨诗巧王凯磊王雪纯陈亚敏张孝然吕盼盼郝瑞天津医科大学眼科临床学院天津市300020 天津市眼科医院天津市300020 南开大学附属眼科医院天津市300020

目的研究视觉发育关键期单眼剥夺(MD)对小鼠上丘、海马、视皮层星形胶质细胞表达的影响。方法选取C57BL/6J小鼠18只,随机分为正常对照组(CON组)和MD组,每组各9只,在12 h/12 h昼夜循环环境中饲养。CON组不做处理,MD组小鼠在生后27 d右眼... 详细信息

目的研究视觉发育关键期单眼剥夺(MD)对小鼠上丘、海马、视皮层星形胶质细胞表达的影响。方法选取C57BL/6J小鼠18只,随机分为正常对照组(CON组)和MD组,每组各9只,在12 h/12 h昼夜循环环境中饲养。CON组不做处理,MD组小鼠在生后27 d右眼行MD,7 d后取材。逆转录实时荧光定量聚合酶链式反应(RT-qPCR)检测两组小鼠上丘、海马、视皮层胶质纤维酸性蛋白(GFAP)mRNA表达情况。Western blot检测两组小鼠上丘、海马、视皮层GFAP蛋白表达的变化。免疫荧光染色检测两组小鼠上丘、海马、视皮层GFAP和中枢神经特异性蛋白(S100β)共定位标记的星形胶质细胞数量。结果RT\|qPCR和Western blot检测结果显示,与CON组相比,MD组小鼠上丘、海马(锥体细胞1区、锥体细胞3区、齿状回区)、视皮层GFAP mRNA和蛋白表达均减少,差异均有统计学意义(均为P<0.05)。免疫荧光染色结果显示,与CON组相比,MD组小鼠上丘、海马(锥体细胞1区、锥体细胞3区、齿状回区)、视皮层GFAP和S100β共定位标记的星形胶质细胞数量均减少,差异均有统计学意义(均为P<0.05)。结论视觉发育关键期对小鼠进行MD导致其上丘、海马、视皮层星形胶质细胞数量减少。

关键词：单眼剥夺视皮层上丘海马星形胶质细胞

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Changes of the colonic physiologic functions after colonic anastomosis with a degradable stent in a porcine model

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Chinese Medical Journal 2014年第18期127卷 3249-3253页

作者： Feng Xu Liang xiao Wang yifan He Shilin Cai Xiujun College of Medicine Zhejiang University Hangzhou Zhejiang310016 China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University Institute of Minimally Invasive Surgery ofZhejiang University Key Laboratory of Laparoscopic Technique ofZhejiang Province Hangzhou Zhejiang 310016 China

Background A new procedure of colonic anastomosis with a degradable stent has already been proven to be simple, feasible, and safe in our porcine model. In this study, we evaluated its impact on the colonic physiologic functions. Methods A total of 20 pigs were assigned randomly to either a stent anastomosis group （SA, n=10） or a conventional anastomosis group （CA, n=10）. Colonic anastomosis with a degradable stent was performed in the SA group, and conventional hand-sewn anastomosis was performed in the CA group. Body weight, fecal weight, total colonic transit time, immunohistochemistry staining of interstitial cells of Cajal （ICC）, plasma diamine oxidases （DAO） levels, and Western blotting analysis of occludin were evaluated before and after anastomosis. Results No obvious diarrhea or constipation was observed in all pigs. No significant difference in body weight between the groups was detected at any time. Yet, the fecal weight was less in the CA group compared with the SA group on postoperative day （POD） 7. No observable colonic paralysis or retention occurred. For total colonic transit time, there was no significant difference between the two groups at any time or among different time points in the same group. The integrated optical density of ICC showed no significant difference on either POD 14 or 30. The plasma DAO levels were remarkably elevated after surgery, and began to decrease since POD 3. However, there was no significant difference between both two groups in plasma DAO levels at any time either. For both groups, the expression of occludin was not significantly different from their pre-surgery level on either POD 14 or 30. Conclusions According to these results, this procedure with a degradable stent was supposed to be the same as the conventional hand-sewn procedure in their impact on the colonic physiologic functions.

关键词： colonic anastomosis degradable stent physiologic function intestinal anastomosis

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黄花菜主要虫害的发生与防治

山西大同大学学报（自然科学版） 2024年第3期40卷 8-11页

作者：张红利韩志平张睿张永芳武娟曲怡帆肖菲山西大同大学农学与生命科学学院山西大同037009 山西大同大学特色作物有机旱作大同市重点实验室山西大同037009

通过查询文献资料,结合2021—2023年大同市云州区黄花菜主产区害虫发生动态和防治策略调研结果,分析总结了黄花菜主要害虫蓟马、蚜虫和叶螨的发生规律、为害特点和防控策略,着重推荐了黄花菜生产中针对这3种害虫采用的物理防控措施、生... 详细信息

通过查询文献资料,结合2021—2023年大同市云州区黄花菜主产区害虫发生动态和防治策略调研结果,分析总结了黄花菜主要害虫蓟马、蚜虫和叶螨的发生规律、为害特点和防控策略,着重推荐了黄花菜生产中针对这3种害虫采用的物理防控措施、生物防治策略及化学防治农药,以期为黄花菜的科学防控提供参考。

关键词：黄花菜蓟马蚜虫叶螨

Injectable bone cement with magnesium-containing microspheres enhances osteogenesis via anti-inflammatory immunoregulation

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Bioactive Materials 2021年第10期6卷 3411-3423页

作者： Shenglong Tan yifan Wang Yingying Du Yin xiao Shengmin Zhang Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and TechnologyWuhan430074China Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan430074China Institute of Regulatory Science for Medical Devices Huazhong University of Science and TechnologyWuhan430074China Institute of Health and Biomedical Innovation Queensland University of TechnologyBrisbane60 Musk AveKelvin GroveBrisbaneQueensland4059Australia Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of Technology60 Musk AveKelvin GroveBrisbaneQueensland4059Australia

Injectable bone cement is especially useful in minimally invasive surgeries to repair small and irregular bone defects.Amongst different kinds of injectable bone cements,bioactive calcium phosphate bone cement(CPC)has been widely studied due to its biological activity.However,its dense structure and poor biodegradability prevent the ingrowth of living tissue,which leads to undesirable bone regeneration and clinical translation.To address this issue,we prepared bone cement based on Magnesium-containing microspheres(MMSs)that can not only be cured into a 3D porous scaffold but also have controllable biodegradability that continuously provides space for desired tissue ingrowth.Interestingly,magnesium ions released from MMSs cement(MMSC)trigger positive immunomodulation via upregulation of the anti-inflammatory genes IL-10 and M2 macrophage polarization with increased expression of CD206,which is beneficial to osteogenesis.Moreover,the physicochemical properties of MMSC,including heat release,rheology and setting time,can be tuned to meet the requirements of injectable bone cement for clinical application.Using a rat model,we have demonstrated that MMSC promoted osteogenesis via mediation of tissue ingrowth and anti-inflammatory immunomodulation.The study provides a paradigm for the design and preparation of injectable bone cements with 3D porous structures,biodegradability and anti-inflammatory immunoregulation to efficiently promote osteogenesis.

关键词： Injectable bone cement microsphere Mg Immunomodulation Anti-inflammation Osteogenesis