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Amplifying colorectal cancer progression: impact of a PDIA4/SP1 positive feedback loop by circPDIA4 sponging miR-9-5p

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Cancer Biology & Medicine 2024年第10期21卷 916-933页

作者： Yan Zhuang yiding ai Peng Li Xin Yue Yue Li Luling Shan Tongtong Wang Peng Zhao Xun Jin Department of Colorectal Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin 300060China Department of Biochemistry and Molecular Biology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin 300060China Department of Neurosurgery and Neuro-Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin 300060China Department of Gastro Colorectal Oncology Tianjin Cancer Hospital Airport HospitalTianjin 300308China

Objective:Colorectal cancer(CRC)is a prevalent malignant tumor with a high fatality ***4 has been shown to have a vital role in cancer development by acting as a ***,the impact of the circPDIA4/miR-9-5p/SP1 axis on development of CRC has not been ***:Western blot,immunohistochemistry,and reverse transcription-quantitative polymerase chain reaction assays were used to analyze gene *** CCK-8 assay was used to assess cell *** Transwell assay was used to detect invasion and migration of *** luciferase reporter and RNA immunoprecipitation tests were used to determine if miR-9-5p and circPDIA4(or SP1)bind to one *** in vivo assay was used to measure tumor ***:It was shown that circPDIA4 expression was greater in CRC cell lines and tissues than healthy cell lines and ***4 knockdown prevented the invasion,migration,and proliferation of cells in ***,the combination of circPDIA4 and miR-9-5p was confirmed,as well as miR-9-5p binding to *** experiments also showed that the circPDIA4/miR-9-5p/SP1 axis accelerated the development of *** addition,SP1 combined with the promoter region of circPDIA4 and induced circPDIA4 ***4 was shown to facilitate tumor growth in an in vivo ***:The circPDIA4/miR-9-5p/SP1 feedback loop was shown to aggravate CRC *** finding suggests that the ceRNA axis may be a promising biomarker for CRC patient treatment.

关键词： CircRNA positive feedback loop colorectal cancer PDIA4 SP1

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胶质母细胞瘤恶性亚型形成与临床相关性探讨

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中国肿瘤临床 2022年第21期49卷 1103-1107页

作者：艾依丁吕超解杨杨永畅徐星金勋天津医科大学肿瘤医院生化及分子生物学研究室国家恶性肿瘤临床医学研究中心天津市"肿瘤防治"重点实验室天津市恶性肿瘤临床医学研究中心天津市300060

胶质母细胞瘤(glioblastoma,GBM)是一种最常见恶性的原发性脑肿瘤,即使行标准化治疗后,患者中位总生存期仅12~16个月。GBM的治疗瓶颈主要来自于肿瘤的异质性。近年来,单细胞组学和细胞生物学研究的进展揭示了GBM中转录组亚型的混合和交... 详细信息

胶质母细胞瘤(glioblastoma,GBM)是一种最常见恶性的原发性脑肿瘤,即使行标准化治疗后,患者中位总生存期仅12~16个月。GBM的治疗瓶颈主要来自于肿瘤的异质性。近年来,单细胞组学和细胞生物学研究的进展揭示了GBM中转录组亚型的混合和交互转化与其治疗效果密切相关。本文从GBM亚型分布特点,重点对恶性亚型(间充质亚型)形成及转化过程中的分子机制及环境因素进行综述,并讨论表型重塑相关机制,研究其在逆转胶质母细胞临床治疗抗性中的应用前景。

关键词：胶质母细胞瘤亚型转化分子机制肿瘤微环境临床治疗

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Experimental and numerical study of ?ow structures of the second-mode instability

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Applied Mathematics and Mechanics(English Edition) 2019年第2期40卷 273-282页

作者： yiding ZHU State Key Laboratory for Turbulence and Complex Systems Peking University Department of Aeronautics and Astronautics College of EngineeringPeking University

Flow structures of a Mach 6 transitional boundary layer over a 260 mm long flared cone are investigated by the particle image velocimetry(PIV). Particle images near the curved wall are initially transformed into surface-fitted orthogonal coordinates and spliced with their 180?-symmetric images to satisfy a no-slip condition at the *** results are then reversely transformed to the physical domain. Direct numerical simulation(DNS) is also performed to validate the experimental results. The experimental and numerical results are in agreement, indicating a strong dilatation process within the second-mode instability.

关键词： hypersonic transition particle image velocimetry(PIV) direct numerical simulation(DNS)

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Community Characteristics of Early Recovery Vegetation on Abandoned Lands of Shifting Cultivation in Bawangling of Hainan Island, South China

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Journal of Integrative Plant Biology 2005年第5期47卷 530-538页

作者： yiding Run-GuoZANG KeyLaboratoryofForestEcologyandEnvironment theStateForestryAdministrationInstituteofForestEcologyEnvironmentandProtectiontheChineseAcademyofForestryBeijing100091China

: Shifting cultivation is a major form of agricultural practice in most parts of tropical regions worldwide. In places where the bush fallow period is excessively shortened or the period of cultivation is extended for too long, the rate of vegetation recovery and biodiversity on abandoned lands of shifting cultivation would decline. The recovery of the secondary plant communities could even be inhibited for a prolonged period because of grass occupancy. Because of the vital significance of the early recovery communities to secondary succession, we studied the community characteristics of early recovery vegetation on abandoned lands of shifting cultivation in Bawangling of Hainan Island. Measurements were made of the community composition and structure of early recovery vegetation. The sprouting abilities of different functional groups and different species in the same functional group, and the effect of the grass functional group on the composition and quantitative characteristics of tree and shrub functional groups were analyzed. Results indicated that only a few families, genera, or species apparently dominated in the early recovery vegetation on the abandoned lands of shifting cultivation and that deciduous species occurred with a rather high percentage in this early recovery community compared with the natural secondary or old growth forests. Small-sized individuals dominated the woody community. The abundance and basal area of sprouting stems for species in the tree functional group were greater than those of seeder stems, whereas the abundance and basal area of resprouters and seeders for species in the shrub functional group did not differ. The total abundance of stems for the community, stem abundances for species in tree or shrub functional groups, and for seeder or resprouter stems were all negatively correlated with coverage of the grass functional group. The mean sprouting ability in the tree functional group was greater than in the shrub functional grou

关键词： early recovery vegetation functional groups regeneration mode shifting cultivation sprouting ability tropical forest

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Does the transformation of energy structure promote green technological innovation?A quasi-natural experiment based on new energy demonstration city construction

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Geoscience Frontiers 2024年第3期15卷 373-388页

作者： Chuanming Liu Chang Tang yiding Liu School of Economics Shandong University of Finance and EconomicsJinan 250014China School of Economics&Management Changsha University of Science and TechnologyChangsha 410076China School of Economic and Management Southeast UniversityNanjing 211189China

New energy development is essential to achieving carbon peaks and neutrality and promoting green technological *** the causal relationship between new energy demonstration city construction and green technological innovation is crucial for the expansion and promotion of new energy demonstration *** this study,we take the construction of new energy demonstration cities as a quasi-natural experiment,study their impact on green technological innovation using difference-indifference(DID),and conduct a robustness test using DID after propensity score matching(PSM-DID).The research results indicate the following:First,energy structure optimization can significantly improve the level of urban green technological innovation(this result was shown to be valid using PSM-DID and other tests involving the effects of placebo and instrumental variables).Second,new energy demonstration city construction mainly improves the level of urban green technological innovation through technology research and development,the improvement of the industrial innovation environment,and the promotion of environmental ***,the impact of energy structure optimization on green technological innovation has regional,financial,and economic development ***,new energy demonstration city policy affects the flow of capital,labor,technology,and other production factors to pilot areas according to new energy demonstration city policy,forming a“siphon effect”.The carbon reduction effect of new energy demonstration city construction is greater than its pollution reduction *** the results of the study,policy recommendations to promote the expansion of new energy demonstration cities are proposed.

关键词： New energy demonstration city Green technological innovation Theoretical mechanism Difference-in-difference

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Safety modeling and protection for lithium-ion batteries based on artificial neural networks method under mechanical abuse

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Science China(Technological Sciences) 2021年第11期64卷 2373-2388页

作者： LI yiding WANG WenWei LIN Cheng ZUO FengHao National Engineering Laboratory for Electric Vehicles Beijing Institute of TechnologyBeijing 100081China Shenzhen Automotive Research Institute Beijing Institute of TechnologyShenzhen 518118China

The safety of lithium-ion batteries under mechanical abuse has become one of the major obstacles affecting the development of electric vehicles. In this paper, the lithium-ion battery safety model under mechanical abuse conditions is proposed by the Back Propagation Artificial Neural Network(BP-ANN) optimized by the Genetic Algorithm(GA). By experimental and simulation results, the proposed method can effectively predict battery mechanical properties. The corresponding correlation coefficient is greater than 0.99, the failure warning model has more safety margin, and the average security margin is greater than 29%. The multi-source warning weight shows that the mechanical soft short-circuit has the greatest warning margin, followed by that of the soft short-circuit of the electrical signal. The thermal soft short-circuit has the lowest warning margin because of the low thermal conductivity. The qualitative simulation results of the battery module reveal that, when electric vehicles are subjected to mechanical abuse conditions, the rapid reduction in the state-of-charge(SOC) of the rear batteries can effectively increase the reliability of the battery module. The proposed safety model is important to protect the safety and stability of lithium-ion batteries, which is conducive to promoting new energy vehicles and protecting the environment.

关键词： lithium-ion battery GA-BP model failure warning warning weight failure protection

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Optical tuning by the self-assembly and disassembly of chain-like plasmonic superstructures

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National Science Review 2018年第2期5卷 128-130页

作者： Qinqin Liu yiding Liu Yadong Yin School of Materials Science and Engineering Jiangsu University Department of Chemistry University of California Department of Radiology Xinqiao Hospital Third Military Medical University

Plasmonic nanostructures possess novel optical properties due to the collective oscillation of conduction electrons in the nanoparticles upon interaction with light,which is known widely as localized surface plasmon r... 详细信息

关键词： OPTICAL tuning NANOSTRUCTURED materials

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Mass‑Spring‑Damping Theory Based Equivalent Mechanical Model for Cylindrical Lithium‑ion Batteries under Mechanical Abuse

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Chinese Journal of Mechanical Engineering 2020年第2期33卷 161-174页

作者： Wenwei Wang yiding Li Cheng Lin Sheng Yang National Engineering Laboratory for Electric Vehicles Beijing Institute of TechnologyBeijing 100081China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing Institute of TechnologyBeijing 100081China

An equivalent mechanical model with the equivalent physical meaning of mass-spring-damping is proposed for cylindrical lithium-ion batteries through experiments and *** equivalent mechanical model of a cylindrical lithium-ion battery consists of a spring-damping parallel ***,a spring-damping parallel unit connecting a damping unit in series is selected to construct the constitutive characteristics of the battery under mechanical *** results show that the equivalent mechanical model can more effectively describe the mechanical properties of the batteries than most cubic fitting models,of which the average relative error of the equivalent mechanical model under different states-of-charge is less than 6.75%.Combined with the proposed equivalent mechanical model,the failure process of the batteries was simulated and analyzed using LS-Dyna and *** rigid rod tests,failure occurred at the core and bottom of the batteries;under hemispherical punch tests,failure occurred at the core and top,consistent with the experimental *** average prediction error for the failure displacement under different abuse conditions is less than 4%in the *** equivalent mechanical model requires only a few parameters and can be recognized *** the future,the model can be used in safety warning devices based on mechanical penetration.

关键词： Cylindrical lithium-ion battery Mass-spring-damping theory Equivalent mechanical model Mechanical abuse condition Failure analysis

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Generation of acoustic waves in the hypersonic boundary layer over a wavy wall

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 62-70页

作者： WenKai Zhu DingWei Gu yiding Zhu CunBiao Lee State KeyLaboratory of Turbulence and Complex Systems Collaborative Innovation Center of Advanced Aero-EnginePeking UniversityBeijing 100871China

The effects of a wavy wall on a hypersonic boundary layer of a flared cone are investigated using experimental measurements and direct numerical simulations(DNSs). Non-contact optical measurements using a focused laser differential interferometer(FLDI) show that a wavy wall can significantly suppress the second mode, and multiple perturbations of new frequencies are generated over the wavy surface, which agrees well with numerical results. Using Lagrangian tracking of marked particles, it is demonstrated that the wavy wall geometry can induce mean flow oscillations while exciting acoustic waves. The frequencies of the excited disturbances over a wavy wall agree with the classical Rossiter model. The superposition of a disturbance propagating downstream and an acoustic wave propagating upstream at the same frequency but with different amplitudes and propagation velocities results in a spatial distribution with a streamwise-oscillatory pattern over the wavy surface. A simple two-wave superposition model that takes into account the phase velocities and wavenumbers of the convective disturbance and acoustic wave can well describe the modal behavior of excited disturbances over a wavy wall.

关键词： instability of boundary layers compressible flows hypersonic flows

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Spatially distributed damage in sandstone under stress-freeze-thaw coupling conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第6期14卷 1910-1922页

作者： Lifeng Fan yiding Fan Yan Xi Jingwei Gao College of Architecture and Civil Engineering Beijing University of TechnologyBeijing100124China

In the present study,we tried to understand the spatially distributed damage in sandstone samples under the coupled stress-freeze-thaw(SFT)***,uniaxial compressive stresses(i.e.0 MPa,10 MPa,20 MPa,and 25 MPa)were applied to the samples,and then freeze-thaw(FT)cycles(0,8,16,and 24)were performed on the uniaxially stressed samples to realize the SFT ***,real-time CT scanning was conducted to observe the induced *** total porosity was introduced to quantitatively evaluate the damage *** local porosity variation,with the distance from the center of the sandstone sample,was analyzed to understand the spatial distribution of ***,the coupling effects of SFT on the damage gradient were *** results indicate that the porosity rises with FT cycles,and the applied stresses can accelerate the increase in *** damage increases exponentially with the distance from the center of the *** damage presents a spatial gradient distribution,not the commonly used uniform distribution in various *** damage gradient increases with FT cycles,and the increasing rate in damage gradient decreases at uniaxial stress of 0 MPa and 10 MPa first,but the increasing rate in damage gradient increases with FT cycles then at stress increasing to 20 MPa.

关键词： Rock damage Freeze-thaw(FT)cycles Uniaxial stress oupling effects

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