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跨境电信网络诈骗犯罪脚本分析及干预对策

辽宁警察学院学报 2024年第2期26卷 64-71页

作者：乔一丹毛哲玮郑滋椀浙江警察学院国际学院大数据与网络安全研究院浙江杭州310053

近年来,跨境电信网络诈骗犯罪形势十分严峻,该类犯罪具有犯罪组织严密、犯罪手段隐蔽性强、链条化运作和涉案者年轻化等特点。以2018年至2021年中国裁判文书网上61例冒充公检法式跨境电信网络诈骗犯罪信息公开案件为样本,归纳分析冒充... 详细信息

近年来,跨境电信网络诈骗犯罪形势十分严峻,该类犯罪具有犯罪组织严密、犯罪手段隐蔽性强、链条化运作和涉案者年轻化等特点。以2018年至2021年中国裁判文书网上61例冒充公检法式跨境电信网络诈骗犯罪信息公开案件为样本,归纳分析冒充公检法跨境电信网络诈骗的犯罪脚本。通过对犯罪脚本准备阶段、事前阶段、实施阶段和事后阶段等四个阶段的分析,发现当前跨境电信网络诈骗治理仍存在年轻人易轻信诱惑、出入境管控仍存在漏洞、“两卡”问题突出等多个薄弱环节,导致跨境电信网络诈骗犯罪的高发。通过脚本分析设计情境干预措施,引导年轻人树立正确就业观,加强出入境管控力度,加强“两卡”问题监管,实现对跨境电信网络诈骗的有效治理。

关键词：跨境犯罪电信网络诈骗犯罪脚本情境干预

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46,XX卵睾型性发育障碍1例及文献复习

河南医学研究 2024年第11期33卷 2109-2112页

作者：刘艳霞耿垚琦刘彦玲邵明玮乔一丹郑州大学第一附属医院内分泌与代谢病科河南郑州450000

46,XX性发育障碍病因复杂,临床表现多样,诊断较为困难,本文通过对1例男性表型的46,XX的临床特点进行分析,并对该病的发病机制、临床表现、诊断及治疗等进行文献复习,以期提高临床医生对该类疾病的诊疗水平。

关键词：性发育异常 46,XX 尿道下裂 SRY基因

Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins

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Cancer Communications 2023年第7期43卷 788-807页

作者： yidan qiao Jie Chen Xuemei Wang Shumei Yan Jizhou Tan Baijin Xia Yongjian Chen Keming Lin Fan Zou Bingfeng Liu Xin He Yiwen Zhang Xu Zhang Hui Zhang Xiangyuan Wu Lijuan Lu Department of Medical Oncology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Key Laboratory of Tropical Disease Control of Ministry Education Guangdong Engineering Research Center for Antimicrobial Agent and ImmunotechnologyInstitute of Human VirologySun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangzhou National Laboratory Bio-IslandGuangzhouGuangdongP.R.China

Background:Existing treatments for cholangiocarcinoma have poor ***,chimeric antigen receptor-T(CAR-T)cells are emerging as a potential therapeutic *** tumors possess multiple adverse factors in an immunosuppressive microenvironment that impair CAR-T cell infiltration and *** study aimed to improve the function of CAR-T cells through knock down immune checkpoints and immunosuppressive molecular ***:We evaluated the expression of epidermal growth factor receptor(EGFR)and B7 homolog 3 protein(B7H3)antigens in cholangiocarcinoma tissues using immunohistochemistry and screened specific immune checkpoints in the cholangiocarcinoma microenvironment via flow ***,we engineered CAR-T cells targeting EGFR and B7H3 *** simultaneously knocked down immune checkpoints and immunosuppressive molecular receptors in CAR-T cells by constructing two clusters of small hairpin RNAs and evaluated the engineered CAR-T cells for antitumor activity both in vitro,using tumor cell lines and cholangiocarcinoma organoid models,and in vivo,using humanized mouse ***:We observed high expression of EGFR and B7H3 antigens in cholangiocarcinoma ***-CAR-T and B7H3-CAR-T cells demonstrated specific anti-tumor *** found an abundance of programmed cell death protein 1(PD-1),T cell immunoglobulin and mucin domain-containing protein 3(Tim-3),and T cell immunoglobulin and ITIM domain(Tigit)on infiltrated CD8^(+)T cells in the cholangiocarcinoma *** then decreased the expression of these 3 proteins on the surface of CAR-T cells,named PTG-scFV-CAR-T ***,we knocked-down the expression of transforming growth factor beta receptor(TGFβR),interleukin-10 receptor(IL-10R),and interleukin-6 receptor(IL-6R)of PTG-scFV-CAR-T *** cells,named PTG-T16R-scFVCAR-T cells,potently killed tumor cells in vitro and promoted apoptosis of tumor cells in a cholangiocarcinoma ***

关键词： CAR-T cholangiocarcinoma immunosuppression liver cancer T cell receptor tumor microenvironment

Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques

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Cellular & Molecular Immunology 2021年第4期18卷 1058-1060页

作者： Rong Li Xiancai Ma Jieyi Deng Qier Chen Weiwei Liu Zhilin Peng yidan qiao Yingtong Lin Xin He Hui Zhang institute of Hum an Virology Zh ongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Tropical Disease Control of Ministry of Education Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Engineering Research Center of Gene Vaccine of Ministry of Education Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China

New strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with several dominant mutations in the spike protein have been identified recently,and crucial issues associated with the possible reinfection ... 详细信息

关键词： patients acute respiratory

Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction:A randomized non-inferiority trial

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Chinese Medical Journal 2024年第3期137卷 312-319页

作者： Xingshan Zhao yidan Zhu Zheng Zhang Guizhou Tao Haiyan Xu Guanchang Cheng Wen Gao Liping Ma Liping Qi Xiaoyan Yan Haibo Wang Qingde Xia Yuwang Yang Wanke Li Juwen Rong Limei Wang Yutian Ding Qiang Guo Wanjun Dang Chen Yao Qin Yang Runlin Gao Yangfeng Wu Shubin qiao Department of Cardiology Beijing Jishuitan HospitalCapital Medical UniversityThe Fourth Clinical Medical College of Peking UniversityBeijing 100035China Peking University Clinical Research Institute Peking University First HospitalBeijing 100191China Department of Cardiology The First Hospital of Lanzhou UniversityLanzhouGansu 730013China Department of Cardiology The First Affiliated Hospital of Liaoning Medical UniversityJinzhouLiaoning 110002China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Huaihe Hospital of Henan UniversityKaifengHenan 450001China Department of Cardiology Bayannur HospitalBayannurInner Mongolia 015208China Department of Cardiology Puyang People’s HospitalPuyangHenan 457099China Department of Cardiology Xingtai Third HospitalXingtaiHebei 054099China Department of Cardiology Lintao County People’s HospitalDingxiGansu 730599China Department of Cardiology Dancheng County People’s HospitalZhoukouHenan 477150China Department of Cardiology The First People’s Hospital of LingbaoSanmenxiaHenan 472500China Department of Cardiology Shanyin County People’s HospitalShuozhouShanxi 036999China Department of Cardiology Uxin Banner People’s HospitalOrdosInner Mongolia 017399China Department of Cardiology Lingqiu County People’s HospitalDatongShanxi 034499China Department of Cardiology Huaibin County People’s HospitalXinyangHenan 464411China Department of Cardiology Tianzhu County People’s HospitalWuweiGansu 733200China Guangzhou Recomgen Biotech Co. LtdGuangzhouGuangdong 510530China

Background:A phase II trial on recombinant human tenecteplase tissue-type plasminogen activator(rhTNK-tPA)has previously shown its preliminary efficacy in ST elevation myocardial infarction(STEMI)*** study was designed as a pivotal postmarketing trial to compare its efficacy and safety with rrecombinant human tissue-type plasminogen activator alteplase(rt-PA)in Chinese patients with ***:In this multicenter,randomized,open-label,non-inferiority trial,patients with acute STEMI were randomly assigned(1:1)to receive an intravenous bolus of 16 mg rhTNK-tPA or an intravenous bolus of 8 mg rt-PA followed by an infusion of 42 mg in 90 *** primary endpoint was recanalization defined by thrombolysis in myocardial infarction(TIMI)flow grade 2 or *** secondary endpoint was clinically justified *** endpoints included 30-day major adverse cardiovascular and cerebrovascular events(MACCEs)and safety ***:From July 2016 to September 2019,767 eligible patients were randomly assigned to receive rhTNK-tPA(n=384)or rt-PA(n=383).Among them,369 patients had coronary angiography data on TIMI flow,and 711 patients had data on clinically justified *** used a–15%difference as the non-inferiority efficacy *** comparison to rt-PA,both the proportion of patients with TIMI grade 2 or 3 flow(78.3%[148/189]vs.81.7%[147/180];differences:–3.4%;95%confidence interval[CI]:–11.5%,4.8%)and clinically justified recanalization(85.4%[305/357]vs.85.9%[304/354];difference:–0.5%;95%CI:–5.6%,4.7%)in the rhTNK-tPA group were *** occurrence of 30-day MACCEs(10.2%[39/384]vs.11.0%[42/383];hazard ratio:0.96;95%CI:0.61,1.50)did not differ significantly between *** safety outcomes significantly differed between ***:rhTNK-tPA was non-inferior to rt-PA in the effect of improving recanalization of the infarct-related artery,a validated surrogate of clinical outcomes,among Chinese patients with acute ***

关键词： Thrombolytic therapy rhTNK-tPA Randomized controlled trial ST elevation myocardial infarction

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儿童神经母细胞瘤合并儿茶酚胺心肌病1例

临床心血管病杂志 2022年第12期38卷 1006-1010页

作者：姚晓利于霞王芳洁陶菁乔一丹郑州大学附属儿童医院、河南省儿童医院、郑州儿童医院心血管内科郑州450000 国家儿童医学中心首都医科大学附属北京儿童医院心血管内科

报道1例儿童神经母细胞瘤合并儿茶酚胺心肌病并进行文献复习。3岁10个月患儿,起病隐匿,以慢性心功能不全为主要表现,合并高血压,完善心脏彩超、血及尿儿茶酚胺、腹部影像学及术后病理组织检查,确诊左肾上腺节细胞神经母细胞瘤(结节型)... 详细信息

报道1例儿童神经母细胞瘤合并儿茶酚胺心肌病并进行文献复习。3岁10个月患儿,起病隐匿,以慢性心功能不全为主要表现,合并高血压,完善心脏彩超、血及尿儿茶酚胺、腹部影像学及术后病理组织检查,确诊左肾上腺节细胞神经母细胞瘤(结节型)。神经母细胞瘤长期分泌过多儿茶酚胺,导致儿茶酚胺心肌病及高血压。儿童儿茶酚胺心肌病较为罕见。对于以心功能不全起病,尤其合并高血压患儿,应警惕肿瘤源性儿茶酚胺心肌病,应早期进行相关检查,改善心功能,并尽早手术,以改善预后。

关键词：儿茶酚胺心肌病高血压神经母细胞瘤儿童

Study on Proteomics of Duddingtonia flagrans

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Study on Proteomics of Duddingtonia flagrans

The Studies on Aoz1 Gene and its Promoter

第十一届全国寄生虫学青年工作者学术研讨会

作者： Xiangji YIN Meng LIANG Fugui NIE Kexin DUAN yidan qiao Zehao LI Rui WANG College of Veterinary.Inner Mongolia Agricultural University

In order to study the molecular background and nematode-trapping mechanism of the *** was selected and extraction method for mycelia proteins of the fungus was optimized;Then proteomes of different predation periods were analyzed to determine the changes of the mycelium at the levels of protein by using i TRAQ technology,and verified by q *** main research results were as follows:i TRAQ technology was carried out for qualitative and quantitative *** results showed that 4244 proteins were *** the control group,compared with group of 12 h,the number of differential proteins in group of 72 h was the highest,with a total of 572;In the experimental group,there were 474 differential proteins identified between group of 12 h and 0 *** the same time point,compared with the control group,there were 296 differential proteins identified in group of 48 h,and 104 proteins were identified in 72 *** GO function of the differential proteins in each treatment group was *** results showed that the differential proteins in the fungus related catalytic activity,molecular binding function,transport activity,metabolic process,biological regulation,stress response,biolocation,carbon utilization,and substance synthesis showed significant *** KEGG enrichment analysis,it was found that the differential protein mainly involved in ubiquitin-mediated proteolysis,endoplasmic reticulum protein processing,sphingolipid metabolism,adhesion process,MAPK signaling pathway,AMPK signaling pathway,energy metabolism and carbon metabolism,peroxidase,oxidative phosphorylation and other eight *** pathways were related to the process of the fungus-feeding *** the above analysis,it was predicted that such as neutral ceramidase,sphingomyelin phosphodiesterase,tyrosinase,might play key role in the predation *** findings would supply the foundations for revealing the biological processes of the fungus,fungal acti

关键词： Proteomics Nematode-trapping fungi Duddingtonia flagrans iTRAQ RT PCR

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The Studies on Aoz1 Gene and its Promoter

第十一届全国寄生虫学青年工作者学术研讨会

作者： Fugui NIE Xinfang WANG Xiangji YIN Kexin DUAN yidan qiao Zehao LI Rui WANG College of Veterinary.Inner Mongolia Agricultural University

The natural enemies of nematodes,the nematode-trapping fungi,have been finally discovered through unremitting efforts of relevant scholars and shown good application prospects for the prevention and control of domestic animal *** years of research by scholars,it has been found that nematode-trapping fungi secrete a variety of extracellular proteases,including serine proteases working during the invasion and digestion of *** order to ascertain more information of the Aoz1 gene and its promoter,to further explain the role of in predation of nematode-destroying fungi against parasitic nematodes,the study on the Aoz1 gene of Arthrobotrys oligospora and searching for the gene promoter were carried *** research process and results are as follows:(1) Based on the published genome sequence and serine protease gene(Aoz1) of Arthrobotrys oligospora,BLAST was used to compare the two sequences to find the Aoz1 gene upstream sequence and design primers for amplification and cloning this *** the sequence was analyzed by the promoter online software Promoter Scan,NNPP,Promoter 2.0,and the Cp G island was also predicted with online software EMBOSS and Meth *** results showed that the length of the obtained sequence was 2009 bp,and the homology with the original sequence was 96%;There were TATA box,transcription start site TSS,transcription factor binding site and Cp G island in the sequence of 2009 bp upstream of the start codon of the extracellular serine protease Aoz1 of Arthrobotrys oligospora.(2) Recombinant of firefly luciferase reporter gene vector of p GL3-Basic-P1 and 5’-end deletion recombinant vectors,p GL3-Basic-P2 and p GL3-Basic-P3,were constructed and transfected into HEK-293 T cells and He La cells,*** the activity of the luciferase were *** results showed that the 2009 bp upstream of the start codon of the Aoz1 gene can significantly increase the expression activity of the firefly luciferase reporte

关键词： Aoz1 Gene Arthrobotrys oligospora Serine Protease Promoter

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婴幼儿原发性心脏肿瘤超声心动图诊断分析

中华心脏与心律电子杂志 2018年第3期6卷 140-142页

作者：乔一丹康瑾郑州儿童医院病理科郑州450000 郑州儿童医院功能科郑州450000

目的探讨超声心动图在婴幼儿原发性心脏肿瘤诊断中的应用价值。方法选取26例疑似原发性心脏肿瘤婴幼儿,均行超声心动图检查,完善相关检查后,经手术或穿刺活检明确诊断,分析超声心动图对原发性心脏肿瘤的诊断价值。结果 26例疑似心脏肿... 详细信息

目的探讨超声心动图在婴幼儿原发性心脏肿瘤诊断中的应用价值。方法选取26例疑似原发性心脏肿瘤婴幼儿,均行超声心动图检查,完善相关检查后,经手术或穿刺活检明确诊断,分析超声心动图对原发性心脏肿瘤的诊断价值。结果 26例疑似心脏肿瘤患儿中,1例确诊为原发性心脏肿瘤,属心脏黏液瘤(良性); 25例确诊为心内膜炎,其中19例伴瓣膜赘生物。超声心动图诊断2例原发性心脏肿瘤,其中1例为心内膜炎赘生物误诊为心脏肿瘤,诊断敏感度为100. 0%,特异度为96. 0%,与病理诊断符合率为96. 15%。结论超声心动图诊断婴幼儿原发性心脏肿瘤具有较高敏感度,可为临床正确诊断提供客观依据,有利于治疗方案的制定与实施。

关键词：原发性心脏肿瘤超声心动图诊断