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Plant Diseases and Pests 2024年第1期15卷 22-25页

作者： Shuizhan PAN Lianhu SUN Minyan LIU Zhenkun wang yicun wang Longnan Institute of Agricultural Sciences/Gansu Provincial Engineering Technology Center for the Development and Utilization of Traditional Chinese Medicine Resources Longnan 746000China

Based on different types of diseases,pests and weeds in the whole growth period of rhubarb(sowing period-harvesting period),the corresponding green prevention and control technology is proposed,aiming to further reduce the application amount of pesticides and fertilizers in the production of medicinal sources of Lixian rhubarb during the"14 th Five-Year Plan"period.The results will provide a theoretical basis for increasing the promotion and application of agricultural prevention and control(including disease-resistant varieties,ecological regulation),physical prevention and control,biological prevention and control measures,thus ensuring effective protection of the ecological environment,green,healthy and sustainable development of traditional Chinese medicine agriculture in Longnan,and source quality of authentic medicinal materials.

关键词： Lixian rhubarb Disease Pest Weed Green prevention and control

Fluid inclusion and H-O isotope study of the Jiguanshan porphyry Mo deposit,Xilamulun Metallogenic Belt:implications for characteristics and evolution of ore-forming fluids

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Acta Geochimica 2020年第4期39卷 497-511页

作者： Changhong wang Keyong wang Wenyan Cai Jian Li Hanlun Liu yicun wang College of Earth Sciences Jilin UniversityChangchun 130061China College of Geology and Mining Engineering Xinjiang UniversityUrumqi 830047China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Land and Resources of ChinaChangchun 130061China

We studied the fluid inclusions of the Jiguanshan Mo deposit in China,which is a large porphyry deposit located in the southern Xilamulun Metallogenic Belt.The irregular Mo ore body with various types of hydrothermal veinlets is hosted by Late Jurassic granite porphyry.Intense hydrothermal alterations in the deposit from the core to margin are silicification-potassium feldspar alteration,pyrite-quartz-sericite-fluorite alteration,and propylitic alteration.Based on the mineral assemblages and crosscutting relationships of ore veins,the ore-forming process were divided into three stages and two substages:quartz-pyrite veins(stage I)associated with potassic alteration;quartz-molybdenite-chalcopyrite-pyrite veins(substage Ⅱ-1)and quartz-molybdenite-fluorite veins(substage Ⅱ-2)associated with phyllic alteration;and fluorite-quartz-carbonate veins(stage Ⅲ)with carbonation.Five majorfluid inclusions(FIs)types were distinguished in the quartz associated with oxide and sulfide minerals,i.***.polyphase brine(Pb-type),opaque-bearing brine(Ob-type),solid halite(S-type),two-phase aqueous(A-type),and vapor(Vtype)inclusions.The FIs of stage I were composed of liquid-rich S-,A-,and V-type FIs with homogenization temperatures and salinities of 490 to 511℃ and 8.9 to 56.0 wt%NaCl equiv.,respectively.The FIs of substage Ⅱ-1 are composed of Pb-,Ob-,S-,A-,and V-type FIs with homogenization temperatures and salinities of 352 to 460℃ and 3.7 to 46.1 wt%NaCl equiv,respectively.The FIs of substage Ⅱ-2 are Ob-,S-,A-,and V-type FIs with homogenization temperatures and salinities of 234 to309°C and 3.7 to 39.2 wt%NaCl equiv,respectively.The FIs of stage Ⅲ are A-type FIs with homogenization temperatures and salinities of 136 to 172℃ and 1.1 to 8.9 wt%NaCl equiv,respectively.Fluid boiling,which resulted in the precipitation of sulfides,occurred in stages I andⅡ.The initial ore-forming fluids of the Jiguanshan deposit had high temperature,high salinity,and belonged to an F-rich NaCl±KCl-H2O system.The fluids gradually evolved to low temperature,

关键词： Fluid inclusions Fluid inclusion assemblages H-O isotope Xilamulun Metallogenic Belt Porphyry Mo deposit

Nontoxic virus nanofibers improve the detection sensitivity for the anti-p53 antibody, a biomarker in cancer patients

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Nano Research 2015年第11期8卷 3562-3570页

作者： Pengtao Pan yicun wang Ye Zhu Xiang Gao Zhigang Ju Penghe Qiu Li wang Chuanbin Mao Institute of Genetics and Cytology School of Life Sciences Northeast Normal University 5268 Renmin Street Changchun 130024 China Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center University of Oklahoma Norman Oklahoma 73019 USA

在浆液的 anti-p53 抗体的存在是为癌症的 biomarker。然而，它的高敏感察觉仍然是在癌症诊断的一个问题。处理这挑战，我们使用了 fd 噬菌体，对人安全的细菌特定的病毒 nanofiber 那能被以一种无差错的方式感染主人细菌大量生产，并... 详细信息

在浆液的 anti-p53 抗体的存在是为癌症的 biomarker。然而，它的高敏感察觉仍然是在癌症诊断的一个问题。处理这挑战，我们使用了 fd 噬菌体，对人安全的细菌特定的病毒 nanofiber 那能被以一种无差错的方式感染主人细菌大量生产，并且遗传上设计了它显示能够在它的方面墙上认出并且捕获 anti-p53 抗体的肽。我们作为一根俘获探针采用了结果的噬菌体 nanofibers 开发连接酶的 immunosorbent 试金(ELISA ) 的一个修改版本方法，称为的 phage-ELISA。我们为 anti-p53 抗体的察觉把它比作传统的 ELISA 方法， p53-ELISA，哪个使用 recombinant 捕获 anti-p53 的野类型的 p53 蛋白质抗体。我们使用了 phage-ELISA 与恶意的肿瘤的各种各样的类型在 316 个病人的一个试验性的组检测 anti-p53 抗体。我们发现 17.7% 的察觉率(56 个积极盒子) 被 phage-ELISA 完成，它为 p53-ELISA (65 个积极盒子) 比得上 20.6% 的察觉率。然而，当噬菌体和 p53 被联合为 phage/p53-ELISA 形成捕获抗体的探针时， 30.4% 的察觉率(96 个积极盒子) 被完成。我们的工作证明由于由噬菌体 nanofibers 和 p53 的 anti-p53 抗体的联合俘获， phage/p53-ELISA 与癌症的各种各样的类型在病人为 anti-p53 抗体完成了最高诊断的精确性和察觉效率。我们的工作建议那 nanofibers 和抗原的联合，哪个俘获抗体，能导致增加的察觉敏感，它为在生命科学，临床的药，和环境科学的应用是有用的。

关键词： p53基因抗体检测纳米纤维生物标志物癌症患者高灵敏度酶联免疫吸附法 ELISA方法

Directed Evolution of Insoluble Arabidopsis thaliana Zeta Class Glutathione S-Transferase Mutants for Higher Solubility in Escherichia coli

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Journal of Genetics and Genomics 2013年第6期40卷 319-322页

作者： yicun wang Feng Zhang Haiwei Chen Xiwen Chen Defu Chen Laboratory of Molecular Genetics College of Life SciencesNankai University College of Life Sciences Chifeng CollegeChifeng 024000China

Expression of recombinant protein in Escherichia coli （E.coli） is generally considered as one of the ideal systems to produce proteins for industrial production.However,the majority of proteins usually fail to fold into their native state and accumulate as insoluble inclusion bodies with no biological activity in E.coli（Yang et al.,2003）.

关键词： Directed Evolution of Insoluble Arabidopsis thaliana Zeta Class Glutathione S-Transferase Mutants for Higher Solubility in Escherichia coli coli

Age,Genesis,and Tectonic Setting of the Mo-W Mineralized Dongshanwan Granite Porphyry from the Xilamulun Metallogenic Belt,NE China

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Journal of Earth Science 2017年第3期28卷 433-446页

作者： Xuebing Zhang Keyong wang Chengyang wang Wen Li Qi YU yicun wang Jianfeng Li Duo Wan Guanghuan Huang College of Earth Sciences Jilin UniversityChangchun 130061China Department of Earthquake Seienee Institute of Disaster Prevention Science and TechnologyBeijing 101601China Inner Mongolia Shandong Gold Minerals Survey Co.Ltd. Chifeng 024005China Heilongjiang Institute of Regional Geology Survey Harbin 150080China College of Urban and Environmental Sciences Liaoning Normal UniversityDalian 116029China

The Xilamulun molybdenum polymetallic metallogenic belt in eastern Inner Mongolia forms one of the most important Mo metallogenic belts in northeastern China. The Dongshanwan porphyry Mo-W polymetallic deposit, in the northeastern part of the Xilamulun metallogenic belt, occurs along the periphery of a granite porphyry and consists of Mo-W-Ag sulfide and oxide disseminations and veinlets in hydrothermal assemblages. LA-ICP-MS zircon U-Pb dating of the Dongshanwan granite porphyry yields a crystallization age of 142.15± 0.91 Ma, whereas molybdenite Re-Os isotopic dating model ages are of 139.9–141.5 Ma and an isochron age is of 140.5± 3.2 Ma（MSWD=1.2）. The age consistency indicates that the Dongshanwan deposit was a product of Early Cretaceous magmatism. The Dongshanwan granite porphyry is a high-alkali high-potassium intrusion and has high SiO_2（75.39 wt.%–76.15 wt.%）, low Al_2O_3（12 wt.%–13 wt.%）, Ba, Ti, P, and Sr contents, with negative Eu anomalies. The Y/Nb ratios are comparable to those of average continental crust and island arc basalts, corresponding to type-A2 granites. Our geochemical data indicate that the granite porphyry emplaced in an Early Cretaceous post-orogenic extensional environment following Mongol-Okhotsk oceanic subduction and subsequent continental collision.

关键词： Dongshanwan porphyry Mo-W deposit zircon U-Pb dating Re-Os dating geochemistry Xilamulun metallogenic belt

Nontoxic engineered virus nanofibers as an efficient agent for the prevention and detection of fungal infection

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Nano Research 2018年第4期11卷 2248-2255页

作者： yicun wang Hongxi Shi Shuai Dong Yan Li Meng wang Yanyan Huai Xintong Zhang Xi Chen Chuanbin Mao Xiang Gao Li wang Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics & Cytology Northeast Normal University Changchun 130024 China Jilin Provincial Key Laboratory on Molecular and Chemical Genetic The Second Hospital of Jilin University Changchun 130024 China Department of Respiratory Medicine Harbin Medical University Cancer Hospital Harbin 150081 China School of Materials Science and Engineering Zhejiang University Hangzhou 310027 China Department of Chemistry & Biochemistry Stephenson Life Science Research Center University of Oklahoma Norman 73019-5300 USA

Candida albicans （C. albicans） infection has a high mortality rate in immunocompromised patients. Owing to the inefficiency of the current diagnostic system and the absence of licensed vaccines against candidiasis, the prevention of C. albicans infection remains a challenge. C. albicans infection can be evaluated and prevented by the anti-secreted aspartyl proteinase 2 antibody （anti-Sap2 IgG） and Hsp90 antibody （anti-Hsp90 IgG）. In this study, to explore a new agent for the improvement of the diagnosis and the prevention of C. albicans infection, an engineered fd bacteriophage, which is considered a human-safe virus nanofiber, was designed and prepared with two epitopes that could induce and capture anti-Sap2 IgG and anti-Hsp90 IgG. The dual-display phage was employed as a novel capture probe to develop a new enzyme-linked immunosorbent assay （ELISA） method, which significantly improved the detection rate compared with those of the ELISA in which recombinant protein Sap2 was used as coating antigen to capture the spedfic antibodies （rSap2-ELISA） and the ELISA in which recombinant protein Hsp90 was used as coating antigen to capture the specific antibodies （rHsp90-ELISA）. In addition, the nanofibers acted as a potential vaccine to immunize mice, as well as recombinant proteins, more efficiently mediated humoral and cellular immune responses, decreased levels of C. albicans colonization, and increased the survival rates in C. albicans-infected mice. Therefore, the phage dual-display nanofiber has been shown to be a powerful bifunctional agent for protection against and sensitive detection of clinical infections, which has the potential to be widely used in the life sciences, clinical medicine, and environmental sciences.

关键词： phage,nanofiber,Candida albicans,diagnosis,vaccine

Variance Estimation for High-Dimensional Varying Index Coefficient Models

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Open Journal of Statistics 2019年第5期9卷 555-570页

作者： Miao wang Hao Lv yicun wang Department of Statistics School of Economics Jinan University Guangzhou China

This paper studies the re-adjusted cross-validation method and a semiparametric regression model called the varying index coefficient model. We use the profile spline modal estimator method to estimate the coefficients of the parameter part of the Varying Index Coefficient Model (VICM), while the unknown function part uses the B-spline to expand. Moreover, we combine the above two estimation methods under the assumption of high-dimensional data. The results of data simulation and empirical analysis show that for the varying index coefficient model, the re-adjusted cross-validation method is better in terms of accuracy and stability than traditional methods based on ordinary least squares.

关键词： High-Dimensional Data Refitted Cross-Validation Varying Index Coefficient Models Variance Estimation

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两种栽培模式对岷归1号产量形成特征的影响

南方农业 2024年第7期18卷 9-11,24页

作者：张小玉王义存李国业陇南市农业科学研究所甘肃武都746000

为了探明不同栽培模式对岷归1号产量形成特征的影响,设置覆膜移栽和露地移栽2种栽培模式,比较研究岷归1号产量构成特征。结果表明,覆膜移栽能显著提高岷归1号根茎产量。2019、2020年覆膜移栽岷归1号的根茎产量较露地移栽分别提高了17.83... 详细信息

为了探明不同栽培模式对岷归1号产量形成特征的影响,设置覆膜移栽和露地移栽2种栽培模式,比较研究岷归1号产量构成特征。结果表明,覆膜移栽能显著提高岷归1号根茎产量。2019、2020年覆膜移栽岷归1号的根茎产量较露地移栽分别提高了17.83%、20.12%。相关分析表明,较高的地上部分干物质积累量是覆膜移栽当归根茎产量形成的关键。覆膜移栽岷归1号的株高、单株叶片数、叶片直径均高于露地移栽。覆膜移栽能够提高岷归1号特级当归和一级当归的产出率。两种栽培模式的岷归1号的早抽薹率、麻口病发病率和病情指数差异不显著。岷归1号大田生产推广覆膜栽培技术。

关键词：栽培模式岷归1号产量

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高级别肉瘤患者肺部不确定性质结节胸部CT影像学特征与转归:一项单中心回顾性研究

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肿瘤防治研究 2024年第2期51卷 99-103页

作者：王远荣张黎明索朗达吉朱岩樊根涛王一村施鑫吴苏稼周光新中国人民解放军东部战区总医院(南京大学医学院附属金陵医院)骨科南京210018

目的分析肺部高级别软组织肉瘤患者肺部不确定性质结节(IPN)的影像学特征与转归。方法回顾性分析82例伴IPN的高级别肉瘤患者的临床资料,IPN的CT影像学特征以及转归。结果IPN平均大小6.453±0.864 mm。IPN直径、形状、密度及结节发现间... 详细信息

目的分析肺部高级别软组织肉瘤患者肺部不确定性质结节(IPN)的影像学特征与转归。方法回顾性分析82例伴IPN的高级别肉瘤患者的临床资料,IPN的CT影像学特征以及转归。结果IPN平均大小6.453±0.864 mm。IPN直径、形状、密度及结节发现间期可能是恶性转归相关的CT影像特征。年龄(HR=1.047,95%CI:1.007~1.088)与结节发现间期(HR=3.194,95%CI:1.052~9.694)是影响恶性IPN患者生存期的独立因素。结论胸部CT的影像学特征可能为良恶性结节性质和生存预后的判断提供重要指导意义。

关键词：高级别软组织肉瘤肺结节计算机体层摄影预后

Seismic and geological evidence of hidden faults in the Yinpan Reservoir area based on a dense seismic array

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Science China Earth Sciences 2024年第7期67卷 2401-2407页

作者： Guangyao YIN Huai ZHANG Liwen GONG Q ipeng BAI yicun GUO Bing ZHANG Yaolin SHI Key Laboratoryof Earth System Numerical Modeling and Application(Chinese Academyof Sciences) College of Earth and Planetary SciencesUniversity of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Computational Geodynamics Chinese Academy of SeiencesBeijing 100049China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China Beijing Yanshan Critical Zone National Field Scientific Observation and Research Station Beijing 101408China Chongging Earthquake Agency Chongqing 401147 China Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China Hangzhou Applied Acoustics Research Institute Hangzhou 311100China Siaie Key Laboratory of Geodesy and Earths Dynamics Innovation Academy for Precision Measurement Science and TechnologyCASWuhan 430077China

1.Introduction.On November 23,2017,an M_(S)5.0 earthquake occurred in Wulong,Chongqing,China,resulting in tens of casualties and considerable economic loss.Geologically,the epicenter of this earthquake was located in the transition zone from the Central Chongqing Fold Belt to the southeast,characterized by a low tectonic loading rate.

关键词： earthquake southeast seismic