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艾滋病患者体重指数与代谢综合征的关系

临床内科杂志 2021年第5期38卷 322-325页

作者：邓琼燕周仪铖李零燕孙家忠武汉大学中南医院内分泌科武汉430071

目的探讨艾滋病患者体重指数(BMI)与代谢综合征(MS)及其组分的关系。方法收集艾滋病住院患者482例,按BMI分为低体重组(BMI <18.5 kg/m^(2))、正常体重组(18.5 kg/m^(2)≤BMI≤23.9 kg/m^(2))、超重/肥胖组(BMI≥24.0 kg/m^(2)),比较3组... 详细信息

目的探讨艾滋病患者体重指数(BMI)与代谢综合征(MS)及其组分的关系。方法收集艾滋病住院患者482例,按BMI分为低体重组(BMI <18.5 kg/m^(2))、正常体重组(18.5 kg/m^(2)≤BMI≤23.9 kg/m^(2))、超重/肥胖组(BMI≥24.0 kg/m^(2)),比较3组患者的一般资料、实验室指标、MS患病率、MS各组分患病率及MS组分检出量情况。采用Spearman相关分析探讨BMI与MS患病率、MS组分检出率等的相关性。采用二元logistic回归分析探讨MS的危险因素。结果与低体重组和正常体重组比较,超重/肥胖组MS患病率及MS组分检出数均明显增加(P <0.05)。随着BMI增长,艾滋病患者合并高血压、高TG血症的比例明显增加(P <0.05)。Spearman相关分析结果显示,艾滋病患者BMI与MS和MS组分检出数量均呈正相关(P <0.001)。校正性别、年龄及MS中除BMI外其他组分的混杂因素后行logistic回归分析结果显示,高BMI是艾滋病患者发生MS的独立危险因素(P <0.05)。结论艾滋病患者BMI与MS关系密切。BMI越高,合并MS风险越大,MS组分检出数量越高。BMI为艾滋病患者合并MS及其组分的重要危险因素。

关键词：代谢综合征艾滋病体重指数危险因素

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无骨折脱位颈段脊髓损伤的MRI表现

放射学实践 1999年第3期14卷 164-166页

作者：杜中立周义成王承缘武汉同济医科大学附属同济医院放射科 430030

目的：探讨无骨折脱位颈段脊髓损伤的机制及MRI表现。方法：收集15例经X线、CT或MRI检查未见骨折脱位的颈段脊髓损伤的病例。所有病例均行矢状位、轴位扫描，均行SE序列TlWI及FSE序列T2WI。结果:7例有颈椎间盘突出，其中40岁以上的有6... 详细信息

目的：探讨无骨折脱位颈段脊髓损伤的机制及MRI表现。方法：收集15例经X线、CT或MRI检查未见骨折脱位的颈段脊髓损伤的病例。所有病例均行矢状位、轴位扫描，均行SE序列TlWI及FSE序列T2WI。结果:7例有颈椎间盘突出，其中40岁以上的有6例。前纵韧带撕裂5例，4例为40岁以上。脊髓受压7例，为突出间盘及肥厚黄韧带压迫所致。所有病例在T2WI均呈现出明显的异常信号。脊髓挫伤、水肿11例，出血2例，囊变2例。结论：无骨折脱位的预段脊髓损伤机制主要有2种：①脊髓的一过性损伤：主要由伤时椎间瞬间移位造成，原先存在的间盘退变因素也参与了损伤。②脊髓的持续性压迫：主要内外伤性椎间盘突出造成。本组资料表明，儿童无骨折脱位的预段脊髓损伤范围较大，多无脊髓的持续性压迫。年长者损伤范围较小，多伴有脊髓的持续性压迫。MRI是无骨折脱位脊髓损伤的最佳检查方法。

关键词：脊髓损伤磁共振成像

A Braille Reading System Based on Electrotactile Display With Flexible Electrode Array

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IEEE/CAA Journal of Automatica Sinica 2022年第4期9卷 735-737页

作者： Ziliang zhou yicheng Yang Honghai Liu IEEE the State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University the State Key Laboratory of Robotics and Systems Harbin Institute of Technology Shenzhen

Dear editor,Due to visual impairment and lack of social attention,the reading problem of the blind has not been well *** existing Braille reading devices still have many problems and are not accepted by the *** paper developed a portable Braille reading system based on electrotactile display *** proposed system is composed of a six-channel electrotactile stimulator,a flexible electrode array for Braille display and a graphical user interface(GUI)for monitoring and *** on the flexibility of the system,two Braille reading strategies have been designed:spatial mode and sequential *** system was preliminary tested by six sighted *** results showed that subjects were able to recognize Braille characters with more than 80%accuracy within less than 10 seconds for the initial *** to existing Braille reading systems,this system is portable,wearable and flexible in control.

关键词： portable editor Bra

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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创伤性脑损伤颅内压波动对患者预后的影响

中华创伤杂志 2018年第3期34卷 196-200页

作者：周义成李雪珮张秋铭关俊文严洪立余杭李永红四川大学华西医院神经外科成都61004l 四川大学卫生部时间生物学重点实验室成都信息工程大学电子工程学院

目的探讨创伤肚脑损伤（TBI）患者颅内压波动趋势对TBI预后的影响。方法采用回顾性病例系列研究分析2012年6月-2014年6月收治的30例TBI患者的临床资料，其中男2l例，女9例；年龄（43．0±19．8）岁。在完成颅内压探头置人术后，分别对TB... 详细信息

目的探讨创伤肚脑损伤（TBI）患者颅内压波动趋势对TBI预后的影响。方法采用回顾性病例系列研究分析2012年6月-2014年6月收治的30例TBI患者的临床资料，其中男2l例，女9例；年龄（43．0±19．8）岁。在完成颅内压探头置人术后，分别对TBI患者的颅内压进行连续监测并每分钟记录一次数据。使用单一余弦法对记录的颅内压数据进行近日节律分析。选择近日节律参数振幅（A）与中值（M）的比值（A／M）来评估患者的生物节律。采用线性回归分析近日节律参数A／M与格拉斯哥昏迷评分（GCS）以及A／M与扩展格拉斯哥预后评分（GOS-E）的相关性。结果所有患者无论受伤的严重程度如何，监测到术后颅内压的波动均存在近日节律（P〈0．01）。颅内压的近日节律参数A／M与患者出院时GCS呈正相关（R^2=0．346，F：14．797，P〈0．01）；颅内压的近日节律参数A／M与GOS-E呈正相关（R^2=0．356，F=15．502，P〈0．01）。结论TBI患者的颅内压存在近日节律；颅内压近日节律的波动趋势可能与TBI患者的预后有一定相关性。

关键词：脑损伤颅内压预后生物节律

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng zhou Wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu Wei-Zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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稻虾综合种养水稻品种筛选研究进展

中国稻米 2021年第5期27卷 38-40页

作者：郭哈伦李阳阳陈林荣周翌城窦志徐强高辉扬州大学江苏省作物遗传生理国家重点实验室培育点/粮食作物现代产业技术协同创新中心江苏扬州225009

稻虾(克氏原螯虾)综合种养是推进水稻绿色生产的重要方式,促进了水稻产业的提质增效,有利于水稻产业转型升级。近年来,稻虾综合种养在全国多地迅速推广,但当前稻虾还存在种养产量和效益不稳、稻虾种养技术亟待优化、尤其是优质高产抗倒... 详细信息

稻虾(克氏原螯虾)综合种养是推进水稻绿色生产的重要方式,促进了水稻产业的提质增效,有利于水稻产业转型升级。近年来,稻虾综合种养在全国多地迅速推广,但当前稻虾还存在种养产量和效益不稳、稻虾种养技术亟待优化、尤其是优质高产抗倒水稻品种较为缺乏的问题。已有研究者针对稻虾连作或共生种养条件下的水稻品种选用开展了各有侧重的研究。本文阐述了目前稻虾种养下水稻品种筛选的研究进展,探讨了不同稻虾种养模式对水稻品种特性的要求,提出了今后稻虾种养品种选育和筛选应用的发展方向,可为提高稻虾综合种养质量和效益提供参考。

关键词：水稻克氏原螯虾综合种养品种筛选

Crack evolution of soft–hard composite layered rock-like specimens with two fissures under uniaxial compression

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Frontiers of Structural and Civil Engineering 2021年第6期15卷 1372-1389页

作者： Dong zhou yicheng YE Nanyan HU Weiqi WANG Xianhua WANG School of Resources and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China Hubei Key Laboratory for Efficient Utilization and Agglomeration of Metallurgic Mineral Resources Wuhan 430081China Sinosteel Wuhan Safety and Environmental Protection Research Institute Co. Ltd.Wuhan 430081China

Acoustic emission and digital image correlation were used to study the spatiotemporal evolution characteristics of crack extension of soft and hard composite laminated rock masses(SHCLRM)containing double fissures under uniaxial *** effects of different rock combination methods and prefabricated fissures with different orientations on mechanical properties and crack coalescence patterns were *** characteristics of the acoustic emission source location distribution,and frequency changes of the crack evolution process were also *** test results show that the damage mode of SHCLRM is related to the combination mode of rock layers and the orientation of *** layers predominantly produce tensile cracks;soft layers produce shear *** first crack always sprouts at the tip or middle of prefabricated fractures in hard *** acoustic emission signal of SHCLRM with double fractures has clear stage characteristics,and the state of crack development can be inferred from this signal to provide early warning for rock fracture *** study can provide a reference for the assessment of the fracture development status between adjacent roadways in SHCLRM in underground mines,as well as in roadway layout and support.

关键词： soft−hard composite layered rock mass double cracks crack evolution acoustic emission digital image correlation

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浙江省城乡公交数智应用平台建设实践

交通与运输 2024年第1期40卷 53-58页

作者：崔优凯马佳杰周义程杜璇张国栋浙江数智交院科技股份有限公司杭州310030

为促进城乡公交一体化发展,助力浙江高质量发展建设共同富裕示范区,构建基于城乡公交数据的智慧化应用平台。首先,介绍平台建设背景以及浙江省城乡公交一体化发展现状;其次,平台设计思路从上至下依次为一个省市县联动驾驶舱、两大主功... 详细信息

为促进城乡公交一体化发展,助力浙江高质量发展建设共同富裕示范区,构建基于城乡公交数据的智慧化应用平台。首先,介绍平台建设背景以及浙江省城乡公交一体化发展现状;其次,平台设计思路从上至下依次为一个省市县联动驾驶舱、两大主功能、三个端集成以及多个应用场景。通过“一村一表、一县一档”技术措施,在线展示全省每个建制村的公交班次、票价、支付方式等基本情况,并归集形成每个区县的城乡公交一体化档案;最后,经过态势分析可以得到区县的一体化率提升方案。通过平台,既可以实时掌握全省城乡公交运行情况和一体化进度,又可以找出区县在城乡公交发展中的不足之处,为财政补贴政策、公交运营策略的制定提供依据。

关键词：城乡公交一体化数字化运营监测