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Evolution of HIV Epidemic and Emerging Challenges—China,1989–2023

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China CDC weekly 2024年第48期6卷 1251-1256页

作者： Chang Cai Houlin Tang Dongmin Li Qianqian Qin Fangfang Chen yichen jin Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:This study aimed to provide a comprehensive analysis of the human immunodeficiency virus(HIV)epidemiological landscape in China through a historical review and current ***:Data were extracted from China’s HIV/AIDS Comprehensive Response Information Management System(CRIMS).Transmission patterns across different phases were visualized using stacked area *** correlations between transmission routes were analyzed using scatter plots and Pearson correlation *** extent and trends of HIV spread among the general population were evaluated using Venn diagrams and Cochran-Armitage ***:The HIV epidemic in China evolved through four distinct phases:injecting drug user(IDU)dominated(1989–1994),former plasma donor(FPD)outbreak(1995–2005),sexual transmission dominance(2006–2014),and general population spread(2015–present).A strong correlation was observed between provinces reporting high numbers of IDU cases and those with elevated heterosexual transmission(r=0.88,P<0.001).Between 2015 and 2023,393,926 cases were identified among the general population through non-marital and non-commercial heterosexual contact(NMNCHC).The proportion of general population cases among heterosexual transmissions increased significantly from 46.2%to 55.7%(Z=42.7,P<0.001).Conclusion:The significant spread of HIV into the general population necessitates the development of targeted prevention strategies for both high-risk and general populations to address emerging epidemiological challenges.

关键词： prevention elevated IDU

An overview of current development and barriers on liquid biopsy in patients with early-stage non-small-cell Lung cancer

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Holistic Integrative Oncology 2023年第1期2卷 447-459页

作者： yichen jin Fan Yang Kezhong Chen Thoracic Oncology Institute Peking University People’s HospitalBeijingChina Department of Thoracic Surgery Peking University People’s HospitalBeijingChina

Purpose Liquid biopsy is a promising technological method in patient management of early-stage non-small-cell lung cancer(NSCLC).The detection platforms exhibit high efficiency and related clinical applications also emerge with high-quality *** overview of the current status is in need for an integrated perception on this *** NSCLC takes up the largest proportion of lung cancer and there is a tendency for more early-stage patients in real ***,early-stage NSCLC participants occupy an important position in clinical *** biopsy,as a promising non-invasive detection method,had great potential in various aspects of the whole diagnosis-treatment *** went through the landmark articles according to liquid biopsy in the field of early-stage NSCLC management and concluded the status quo of *** In this review,we summarized the improvement of the detection technologies regarding the most widely studied biomarkers and elucidated the current clinical applications of liquid biopsy in early detection,prognostic performance assessment,and predictive value respectively,in early-stage NSCLC *** Liquid biopsy has achieved favorable outcomes in different aspects of early-stage *** there are still barriers yet to conquer,liquid biopsy is a hopeful detection means to be put into clinical use.

关键词： Liquid biopsy ctDNA CTCs Exosome Detection technology Clinical application

Survival of People Living with HIV/AIDS from Pre-ART Era to Treat-all Era—China,1985–2022

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China CDC weekly 2024年第48期6卷 1264-1270页

作者： Shi Wang Houlin Tang Decai Zhao Chang Cai yichen jin QianQian Qin Fangfang Chen Liping Fei Hehe Zhao Zhongnian Yang Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:A comprehensive analysis of nationwide survival trends for people living with human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS,PLWHA)from the initial reported case to present has not been *** study evaluated the survival outcomes of PLWHA reported in China from 1985 to ***:We analyzed data from PLWHA recorded in the National HIV/AIDS Comprehensive Response Information Management System from 1985 to *** rates were calculated using Kaplan-Meier curves,and factors associated with survival time were analyzed using Cox proportional hazard ***:Progressive relaxation of antiretroviral therapy initiation criteria led to significant improvements in survival rates across different diagnostic periods in *** 1-year and 5-year cumulative survival rates increased from 85.2%and 66.1%in the 1985–2003 cohort to 91.1%and 81.4%in the 2016–2022 *** proportional hazard analysis revealed elevated mortality risks among males,individuals aged≥65 years,those with injection drug use or other transmission routes,hospital-tested patients,and those with lower CD4 counts at diagnosis or without ***:Antiretroviral therapy has effectively reduced mortality risk among PLWHA in *** efforts should focus on expanding HIV testing to reduce the proportion of late diagnoses with lower CD4 counts and providing targeted,differentiated services for older populations to further decrease mortality risk among PLWHA.

关键词： Survival HIV/AIDS mortality

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HIV感染者的高危行为接触者追踪研究进展

中华流行病学杂志 2024年第5期45卷 755-760页

作者：刘欢金怡晨汤后林中国疾病预防控制中心性病艾滋病预防控制中心流行病学室/传染病溯源预警与智能决策全国重点实验室北京102206

对HIV感染者开展高危行为接触者追踪,能够促进HIV感染者的诊断发现,及时采取诊疗和干预措施,有助于减少二代传播,对控制艾滋病流行具有重要意义。随着HIV基因序列检测和分析技术的发展,将HIV分子传播网络应用于传统流行病学调查的高危... 详细信息

对HIV感染者开展高危行为接触者追踪,能够促进HIV感染者的诊断发现,及时采取诊疗和干预措施,有助于减少二代传播,对控制艾滋病流行具有重要意义。随着HIV基因序列检测和分析技术的发展,将HIV分子传播网络应用于传统流行病学调查的高危行为接触者追踪,有助于准确揭示HIV传播模式、阐明HIV传播特征和识别高传播风险人群,为精准防控提供科学依据。本文对HIV感染者的高危行为接触者追踪研究进行综述,为开展相关工作提供科学参考。

关键词：艾滋病病毒高危行为追踪流行病学调查分子传播网络

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我国老年人群艾滋病防控现状与挑战

中华流行病学杂志 2023年第11期44卷 1669-1672页

作者：汤后林金怡晨吕繁中国疾病预防控制中心性病艾滋病预防控制中心北京102206

近年来我国老年人群艾滋病疫情呈现快速上升趋势,老年人群艾滋病防治面临新的挑战。老年人群对HIV感染风险认知较低,发生无保护的临时性行为或商业性行为比例较高,HIV感染风险较高。老年HIV感染者和感染风险较高的老年人群文化程度和社... 详细信息

近年来我国老年人群艾滋病疫情呈现快速上升趋势,老年人群艾滋病防治面临新的挑战。老年人群对HIV感染风险认知较低,发生无保护的临时性行为或商业性行为比例较高,HIV感染风险较高。老年HIV感染者和感染风险较高的老年人群文化程度和社会经济水平普遍偏低,获取艾滋病相关知识和检测服务机会较为有限,老年HIV感染者由于检测发现晚、合并慢性疾病等因素,死亡风险显著上升。需从行为特征、社会经济、文化、心理等方面多维度深入开展老年人艾滋病防治研究,探索和采取适合老年人群特点的防治艾滋病健康服务的策略措施,强化对老年感染者全流程综合管理模式的研究。

关键词：艾滋病病毒/艾滋病老年人群流行防治

基于EMD优化NAR动态神经网络的地铁客流量短时预测模型

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应用科学学报 2020年第6期38卷 936-943页

作者：马飞虎金依辰孙翠羽华东交通大学土木建筑学院江西南昌330013

为了能够更加准确地实现地铁客流预测,提出了一种基于经验模态分解算法(empirical mode decomposition,EMD)优化非线性自回归(nonlinear auto regressive,NAR)动态神经网络的地铁客流量短时预测模型.分析地铁客流量数据后发现日客流量... 详细信息

为了能够更加准确地实现地铁客流预测,提出了一种基于经验模态分解算法(empirical mode decomposition,EMD)优化非线性自回归(nonlinear auto regressive,NAR)动态神经网络的地铁客流量短时预测模型.分析地铁客流量数据后发现日客流量具有一定的变化规律,为此使用了基于时间序列的NAR动态神经网络,该网络具有优秀的非线性动态拟合能力和反馈记忆的功能.结合EMD经验模态分解算法优化NAR动态神经网络预测模型,以此来减少预测误差,提高预测精度.结果显示,EMD-NAR神经网络组合预测模型适用于地铁客流的短时预测,预测精度可达93%,具有较好的应用价值.

关键词：地铁客流量短时预测非线性自回归动态神经网络经验模态分解组合模型

2018-2022年我国报告60岁及以上农民HIV感染者流行特征分析

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中华流行病学杂志 2023年第11期44卷 1686-1691页

作者：秦倩倩金怡晨蔡畅陈方方汤后林中国疾病预防控制中心性病艾滋病预防控制中心流行病学室北京102206

目的分析我国≥60岁农民HIV感染者的流行特征,为老年农民艾滋病防控政策制定提供依据。方法数据来源于中国疾病预防控制信息系统,选取2018-2022年报告年龄≥60岁、职业为农民的HIV感染者,应用SPSS 24.0软件进行描述性分析,采用χ2检验... 详细信息

目的分析我国≥60岁农民HIV感染者的流行特征,为老年农民艾滋病防控政策制定提供依据。方法数据来源于中国疾病预防控制信息系统,选取2018-2022年报告年龄≥60岁、职业为农民的HIV感染者,应用SPSS 24.0软件进行描述性分析,采用χ2检验进行农民和非农民两组间的比较,并选取6个有代表性的指标,通过样品系统聚类方法将31个省份分为A、B和C 3个亚流行区。结果2018-2022年共报告≥60岁农民感染者113311例,占全国该年龄段HIV感染者报告数的71.8%(113311/157792)。其中,男性86517例(76.4%),检测来源主要来自医疗机构80176例(70.8%)、分布在西部地区80667例(71.2%)。≥60岁农民HIV感染者中,小学及以下文化程度占81.4%(92191/113311),高于非农民HIV感染者中的比例(49.8%,22165/44481)。≥60岁农民HIV感染者96.7%(109562/113311)经异性性传播感染,其中,商业异性性行为占50.4%(55184/109562)、固定性伴性行为占9.1%(9958/109562)、其他异性性行为占40.5%(44420/109562)。聚类分析结果显示,A区为西部6省份(广西壮族自治区、重庆市、贵州省、四川省、云南省和新疆维吾尔自治区),现存活HIV感染者占比(30.2/万)、≥60岁农民HIV感染者占农村人口比例(22.8/万)、报告≥60岁农民HIV感染者县(区)数比例(93.4%)、HIV检测量占人口比例(44.2%),均高于B和C区。农民人均纯收入(1万元/年)低于B和C区,男性商业异性性行为比例(41.0%),略低于B区(46.1%),高于C区(15.2%)。结论2018-2022年我国报告≥60岁农民HIV感染者主要通过商业异性性行为等传播感染,该人群文化程度低,艾滋病自身防护意识不强,应重视老年农民艾滋病健康教育等干预措施,同时加强对农村卖淫妇女及HIV阳性配偶的预防干预工作。

关键词：艾滋病病毒/艾滋病老年流行特征

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文氏桥振荡电路行为仿真及实验分析

实验技术与管理 2018年第6期35卷 122-125页

作者：刘恒张易晨孙晋刘建成南京信息工程大学电子与信息工程学院江苏南京210044

在建立文氏桥振荡电路理论分析模型的基础上,推导了该电路振动幅度的表达式并进行了仿真和实验。实验表明:在满足起振条件后,幅度反馈电阻比值增大,振荡频率呈非线性减小;输出将由正弦波逐渐变为方波;运算放大器的两个输入端的电势差从... 详细信息

在建立文氏桥振荡电路理论分析模型的基础上,推导了该电路振动幅度的表达式并进行了仿真和实验。实验表明:在满足起振条件后,幅度反馈电阻比值增大,振荡频率呈非线性减小;输出将由正弦波逐渐变为方波;运算放大器的两个输入端的电势差从0逐步非线性增大;运算放大器也由线性模式过渡到非线性模式。文氏桥振荡电路输出不一定是正弦波,需结合具体电路参数确定波形。

关键词：文氏桥振荡器闭环仿真实验

Crystallization characteristics of lead iron phosphate

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Crystallization characteristics of lead iron phosphate