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数据采集与处理 2020年第4期35卷 781-790页

作者：熊毅超李晓欧周志勇上海健康医学院医疗器械学院上海201318 上海理工大学医疗器械与食品学院上海200093 上海电机学院设计与艺术学院上海200240

为了保证盲人和视障患者安全方便出行和减少误报警,设计一种基于步态检测算法的辅助行走系统。信号处理算法上利用小波包对信号进行降噪,提取三轴加速度的均值、标准差、方差与小波能量谱,并结合足底压力信息组成多维参数作为步态特征,... 详细信息

为了保证盲人和视障患者安全方便出行和减少误报警,设计一种基于步态检测算法的辅助行走系统。信号处理算法上利用小波包对信号进行降噪,提取三轴加速度的均值、标准差、方差与小波能量谱,并结合足底压力信息组成多维参数作为步态特征,选取基于遗传算法优化支持向量机进行步态识别。硬件部分主要包括三轴加速度信号和足底压力信号采集硬件设计。软件部分主要包括对足底压力信号和三轴加速度信号的采集和处理以及一款能够自动拨号安卓手机APP。实验结果表明,该系统基于多传感器融合的步态检测技术,步态检测识别率平均达90.48%。该系统便携性好、功耗低、测障效果好,在辅助行走领域具有一定的研究意义和实用价值。

关键词：超声波传感器足底压力特征融合步态检测支持向量机

Hedgehog信号通路在Barrett食管发病机制中的研究进展

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胃肠病学 2017年第1期22卷 43-46页

作者：侯一超胡强熊华上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所 200001

Hedgehog(Hh)信号通路在脊椎动物体内具有高度进化保守性,其过度活化可引起细胞分化异常、过度增殖、抗凋亡以及促进肿瘤细胞侵袭和转移。Hh通路参与维持正常早期胚胎食管柱状上皮的形成,而在成体食管鳞状上皮中不表达或微弱表达。有研... 详细信息

Hedgehog(Hh)信号通路在脊椎动物体内具有高度进化保守性,其过度活化可引起细胞分化异常、过度增殖、抗凋亡以及促进肿瘤细胞侵袭和转移。Hh通路参与维持正常早期胚胎食管柱状上皮的形成,而在成体食管鳞状上皮中不表达或微弱表达。有研究证实胃酸和胆汁酸盐可激活食管上皮Hh通路。异常激活的Hh通路可引起正常食管鳞状上皮逐步转化为柱状上皮和肠上皮,并最终诱导Barrett食管(BE)形成。因此,靶向作用于Hh通路的抑制剂有望成为治疗BE的新策略。本文就Hh信号通路在BE发病机制中的研究进展作一综述。

关键词： Hedgehog信号通路 Barrett食管信号转导化生治疗

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基于测距技术的避障方法综述

生物医学工程学进展 2018年第4期39卷 204-208页

作者：熊毅超李晓欧上海理工大学医疗器械与食品学院上海200093 上海健康医学院医疗器械学院上海201318

各种障碍物对盲人和视障患者出行带来极大的不便,安全避障成为重要研究课题之一。避障方法主要基于测距技术,并根据安全距离判断障碍影响行动与否,可以有效地避免摔倒,减少跌倒损伤。该文基于测距传感器的不同介绍了超声波避障、红外避... 详细信息

各种障碍物对盲人和视障患者出行带来极大的不便,安全避障成为重要研究课题之一。避障方法主要基于测距技术,并根据安全距离判断障碍影响行动与否,可以有效地避免摔倒,减少跌倒损伤。该文基于测距传感器的不同介绍了超声波避障、红外避障和激光雷达避障三类避障方法。然后分别介绍了其最新研究及应用现状,并对不同方法的优缺点进行了比较分析,最后展望了盲人和视障患者避障方法的发展方向。

关键词：测距超声波避障红外避障激光雷达避障

基于多维感知的城市广场景观要素优化策略研究

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山东林业科技 2021年第2期51卷 31-35,39页

作者：唐新蔚郭渲熊义超阙晨曦福建农林大学园林学院福建福州350002

在健康人居环境建设的背景下,城市广场景观要素对城市居民生活环境质量有重要影响。本研究的目的是分析城市广场景观要素的居民感知评价,提出相应的景观要素优化策略。以福州五一广场为例,基于多维感知的理论方法提取广场的23项景观要... 详细信息

在健康人居环境建设的背景下,城市广场景观要素对城市居民生活环境质量有重要影响。本研究的目的是分析城市广场景观要素的居民感知评价,提出相应的景观要素优化策略。以福州五一广场为例,基于多维感知的理论方法提取广场的23项景观要素作为广场使用者的评价对象,采用Kano-IPA景观要素评价问卷调查获取了使用者的主观评价数据。结果表明:广场使用者对声景要素和基础设施要素更为关注;机械声源的评价最低,是首要的景观优化对象,自然声景的营造有利于提升广场使用体验;基础设施是其次需要优化和维持其基本使用功能的对象;广场景观规划中资源分配的比重需要根据其优化后是否能提升使用体验而进行调整。该研究有利于指导城市广场的景观规划与设计,并为今后研究的开展提供新的思路。

关键词：多维感知城市广场声景景观要素优化 Kano模型 IPA分析法

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城市广场声景感知对游览体验的影响研究

西部人居环境学刊 2021年第1期36卷 128-134页

作者：唐新蔚熊义超杨玲刘江阙晨曦福建农林大学艺术学院、园林学院福州大学建筑与城乡规划学院

研究以福州仓山万达广场为例,通过实地调查以及针对广场使用者的问卷调查等方式研究声景感知对游览体验的影响。研究结果显示游览满意度评价与景观美景度和声景安静度均显著相关,相关系数分别为0.577和0.368。声源优势度对景观美景度影... 详细信息

研究以福州仓山万达广场为例,通过实地调查以及针对广场使用者的问卷调查等方式研究声景感知对游览体验的影响。研究结果显示游览满意度评价与景观美景度和声景安静度均显著相关,相关系数分别为0.577和0.368。声源优势度对景观美景度影响最大,而声源偏好度对游览满意度影响最大。城市交通声是对游览体验产生消极影响的最主要因素,鸟叫声和游乐设施声也是影响游览体验的关键声源。使用者社会、人口及行为学特征对声景感知和游览体验的影响主要体现为,偏好度与使用者特征关系最密切;年龄对声景感知的影响最大;来访频率和受教育程度对游览体验的影响最大。研究结论可以为提升城市广场视听综合感受的设计提供理论依据。

关键词：城市广场声景感知景观美景度声景安静度游览满意度

A ZMP and CoM Online Replanning Method for Stable Walking of Bipedal Robots

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A ZMP and CoM Online Replanning Method for Stable Walking of...

High selective epoxidation of 2-methylpropene over a Mo-based oxametallacycle reinforced nano composite

第25届中国控制与决策会议

作者： Jianbo Zhan Rong xiong yichao Sun State Key Lab. of Industrial Control Technology Zhejiang University

ISBN: (纸本)9781467355339

Recent developed humanoid robots have had the capability to demonstrate fast and stable walking, while it is still a challenge for those robots to walk stably and flexibly in complex environments. A common solution is to search for appropriate footsteps either from a predefined motion set or not. However, the inaccuracy in models and external perturbation during implementation will make the robot fail to follow such footsteps. This paper proposes a solution to replan motions online, which promises the robot closely follow the given footsteps as well as keep stable. With analysis of the dynamics and kinematics of the humanoid robot, the proposed method replans the desired ZMP （Zero Moment Point） for the preview control based stable biped walking by combining the analysis on CoM （Center of Mass） state transition and the adjustment of supporting time. Then the desired ZMP is slightly regulated within its stable region to achieve a smooth CoM trajectory. Through the dynamic planning process in each control cycle, the robot can perform flexible motions with balance maintained. The simulation results indicate that the method proposed can effectively overcome external disturbances and provide better support during biped walking. The time cost also meets demands of online control.

关键词： Biped Motion CoM Planning ZMP Planning

来源： cnki会议评论

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Nano Research 2023年第1期16卷 209-218页

作者： Chao xiong Hao Liu Jie Zhou Dejing Xu yichao Liang Xiantai Zhou Can Xue Hongbing Ji Fine Chemical Industry Research Institute School of ChemistrySun Yat-Sen UniversityGuangzhou 510275China School of Chemical Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

Compared with the gas-solid phase reactions,the epoxidation of light olefins in the liquid phase could realize the highly selective preparation of epoxides at a lower ***,the C=C bond of light olefins is more difficult to activate,and it is still a challenge to realize the dual activation of the oxidant and light olefins in one reaction *** this contribution,an oxametallacycle reinforced nanocomposite(Mo(O_(2))_(2)@RT)is prepared via an oxidative pretreatment strategy,and its epoxidation performance to 2-methylpropene in liquid-phase with tert-butyl hydroperoxide(TBHP)as an oxidant is evaluated.A set of advanced characterizations including field emission scanning electron microscopy,X-ray photoelectron spectroscopy,in-situ Fourier transform infrared spectroscopy(FT-IR),electron spin-resonance spectroscopy,and high-resolution mass spectrometer are implemented to confirm the physicochemical properties and the catalytic behaviors of Mo(O_(2))_(2)@*** catalyst has a fast kinetic response and exhibits excellent catalytic activity in 2-methylpropene epoxidation to produce 2-methylpropylene oxide(MPO;select.:99.7%;yield:92%),along with good reusability and ***,the main epoxidation mechanism is deduced that TBHP is activated by Mo(O_(2))_(2)@RT to generate the highly active tert-butyl peroxide radical,which realizes the epoxidation of 2-methylpropene to yield MPO.

关键词： oxidative pretreatment Mo(O_(2))_(2)@RT composite 2-methylpropene epoxidation dual activation radical mechanism

Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

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Neural Regeneration Research 2024年第10期19卷 2249-2258页

作者： Kai Li Zhanpeng Feng Zhiwei xiong Jun Pan Mingfeng Zhou Weizhao Li yichao Ou Guangsen Wu Mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng Department of Neurosurgery Institute of Brain DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis.

关键词： arginine vasopressin growth hormone hypothalamo-neurohypophyseal system hypothalamus injury insulin-like growth factor 1 oxytocin regeneration

Prognostic value of serum carcinoembryonic antigen combined with nutritional status control score in patients with colorectal cancer

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Oncology and Translational Medicine 2022年第3期8卷 135-139页

作者： yichao Zhang Biao Wang Yongchuan Zhang Gang xiong Xiao Pang Department of Gastroenterology Dazhou Central HospitalDazhou 635000China

Objective To investigate the prognostic value of serum carcinoembryonic antigen(CEA)and controlling nutritional status(CONUT)score in patients with colorectal *** We retrospectively studied 261 patients with colorectal cancer in our *** patients were divided into two groups by CONUT=3 and CEA=5 ng/mL,and the effects of CONUT score and CEA level on the prognosis and clinicopathological parameters were statistically ***(1)Different CONUT scores were significantly correlated with age,tumor diameter,differentiation type,and T stage(P<0.05).The older the patient was,the larger the tumor diameter,undifferentiated tumor,and T stage were,the higher the CONUT score was.(2)Seventy-five patients died during the follow-up period,and 45 patients died of progression or recurrence of colorectal *** 5-year overall survival(OS)rate of the low CONUT score group was significantly higher than that of the high CONUT score group,and the 5-year OS rate of the low CEA group was significantly higher than that of the high CEA group;the difference was statistically significant(P<0.01).(3)According to the serum CEA level and CONUT score,the 5-year survival rates of CEAlow/CONUTlow,CEAlow/CONUThigh,CEAhigh/CONUTlow,and CEAhigh/CONUThigh were 84.7%,69%,55.3%,and 36.1%respectively,with statistical significance(P<0.01).(4)The Cox multivariate analysis showed that age,CONUT score,CEA combined with CONUT score,lymph node metastasis,and distant metastasis were independent risk factors for the prognosis of colorectal cancer ***:The combination of CEA detection and CONUT score can more accurately judge the prognosis of colorectal cancer patients.

关键词： colorectal cancer carcinoembryonic antigen nutritional status control score