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一种特异性靶向上皮细胞黏附分子EpCAM的小肽的鉴定

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中国医药导报 2019年第10期16卷 4-6,29,F0003,F0004页

作者：朱一超马晓雯何磊周继明逄志俊张鑫磊毛壮李萌空军军医大学学员旅陕西西安710032 空军军医大学药学系陕西西安710032 解放军济南军区总院药理科山东济南250000 解放军第一五三中心医院心血管内科河南郑州450000

目的鉴定前期获得的一个食管腺癌特异性靶向小肽的靶分子。方法小肽Pull Down和质谱筛选该小肽的可能靶分子;计算机模拟分子对接、Western blot、激光共聚焦显微镜、流式细胞术、siRNA干扰、基因转染等方法确认靶分子的正确性。结果上... 详细信息

目的鉴定前期获得的一个食管腺癌特异性靶向小肽的靶分子。方法小肽Pull Down和质谱筛选该小肽的可能靶分子;计算机模拟分子对接、Western blot、激光共聚焦显微镜、流式细胞术、siRNA干扰、基因转染等方法确认靶分子的正确性。结果上皮细胞黏附分子(EpCAM)是该小肽的特异性结合靶分子,且该小肽可特异性结合EpCAM高表达的结肠癌细胞和组织。结论除了食管腺癌,该小肽在EpCAM高表达的结肠癌中也具有早期诊断和靶向治疗的潜在应用价值。

关键词： EpCAM 多肽分子成像肿瘤靶向治疗

A Giant Right Atrial Myxoma with Blood Supply from the Left and Right Coronary Arteries:Once in a Blue Moon

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Cardiovascular Innovations and Applications 2020年第1期4卷 201-204页

作者： yichao Xiao Zhenfei Fang Xinqun Hu Qiming Liu Zhaowei zhu Na Liu Xiaofan Peng Shenghua Zhou Department of Cardiology The Second Xiangya Hospital of Central South UniversityChangsha410011 HunanPeople’s Republic of China

Cardiac myxomas,the commonest primary benign cardiac tumors,are extremely rare,with an incidence ranging from 0.0017 to 0.19%and only about one-fi fth of them originating from the right chambers of the heart.A 60-year-old woman was admitted because of recurrent attacks of chest tightness and shortness of *** echocardiography detected a giant mass in the right atrium;myxoma was indicated by[18 F]fl uorodeoxyglucose PET/*** selective coronary angiography was performed to assess the extent and severity of coronary stenosis,and showed a strongly neovascularized right atrial mass supplied by two feeding vessels with multiple branches from the left and right coronary *** myxoma was successfully excised with open heart surgery and the patient was free of myxoma recurrence during the 3-year follow-up.

关键词： cardiac myxomas coronary angiography neovascularization

A cabazitaxel liposome for increased solubility, enhanced antitumor effect and reduced systemic toxicity

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 658-667页

作者： Xiaoyi Yin Lihua Luo Wei Li Jie Yang Chunqi zhu Mengshi Jiang Bing qin Xiaoling Yuan Hang Yin yichao Lu Yongzhong Du Dawei Chen Jian You College of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China

The potential side effects of cabazitaxel(CBZ)in the field of cancer treatment have become a great limitation to its further clinical *** delivery is a well-established approach to increase the therapeutic index of hydrophobic *** this study,a PEGmodified liposome was developed for efficiently encapsulating CBZ,thus enhancing its specific tumor inhibition effect and reducing the systemic *** was found that the loading efficiency of CBZ into the liposome could be improved with the increase of lipophilic materials,as it could be over 80%under the weight ratio of 20:1(total lipid:CBZ).The diameter of CBZ loaded liposome(CBZ@Lipo)was^100 *** the liposome suspending in aqueous medium was stable at 4°C for at least one month,according to the change of its size *** killing ability of CBZ@Lipo to cancer cells was significantly lower comparing to that of CBZ solution,which could be attributed to the slow release of CBZ from the ***,CBZ@Lipo could induce an obvious apoptosis of the cancer cells at low ***,CBZ@Lipo exhibited an expressively enhanced tumor growth inhibition effect comparing to CBZ *** importantly,CBZ@Lipo showed an obviously higher biosafety proved by lower hemolysis probability,stable body weight of mice during the whole experiment and no obvious lesion in histology *** work provided a useful reference of the formulation of CBZ,which had potential for greater clinical application.

关键词： Cabazitaxel Liposome Stability Apoptosis Biosafety

Clinical Signifi cance of Angiographically Detectable Neovascularity in Patients with Cardiac Myxoma

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Cardiovascular Innovations and Applications 2021年第4期6卷 99-108页

作者： Xiaofan Peng yichao Xiao Yanan Guo Zhaowei zhu Liyan Liao Xiaobo Liao Xinqun Hu Zhenfei Fang Xuping Li Shenghua Zhou Department of Cardiovascular Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Pathology The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Cardiovascular and Thoracic Surgery The Second Xiangya HospitalCentral South UniversityChangshaHunanChina

Background:Myxomas are the most common primary cardiac *** detectable neovascularity(ADN)of myxoma is increasingly being reported as a result of the use of coronary angiography(CAG)to detect coronary artery ***,the clinical signifi cance of these fi ndings is not fully ***:We enrolled 59 patients with cardiac myxoma who also underwent CAG between January 2013 and October *** were followed up for a mean of 28.9 months(range 1-69 months).The clinical features,echocardiography measurements,pathological examination fi ndings,CAG results,and outcomes during follow-up were compared between patients with ADN and patients without ***:ADN was found in 25 patients(42.4%).The arteries feeding the ADN included the right coronary artery(n=15),the left circumfl ex coronary artery(n=7),and both arteries(n=3).The patients with ADN had a higher proportion of eosinophils(3.2%vs.2.2%,P=0.03)and higher low-density lipoprotein cholesterol level(2.7 mmol/L vs.2.2 mmol/L,P=0.02).Myxoma pedicles were more likely to be located in the interatrial septum in patients with ADN(96%vs.73.5%,P=0.02).No signifi cant correlation was observed between the groups in clinical manifestations,atrial arrhythmia,myxoma size,cardiac chamber size,left ventricular ejection fraction,and the prevalence of complication with coronary artery disease[16%in the ADN group(n=4)vs.20.6%in the non-ADN group(n=7),P=0.66].However,patients with ADN tended to have a lower incidence of major adverse cardiac and cerebrovascular events on long-term follow-up(0%vs.14.7%,P=0.07).Conclusion:CAG-detected ADN in patients with cardiac myxoma is associated with a borderline lower rate of major adverse cardiac and cerebrovascular events.

关键词： Cardiac myxomas coronary angiography angiographically detectable neovascularity major adverse cardiac and cerebrovascular events

Unsteady Aerodynamics Modeling Using SVM and Artificial Neural Network

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Unsteady Aerodynamics Modeling Using SVM and Artificial Neur...

雄性毛白杨无性系苗期表型和生理变异的早期综合评价

2015年中国智能自动化学术会议

作者： yichao Jiang Qingjie Zhao Jihong zhu Beijing Lab of Intelligent Information Technology School of Computer ScienceBeijing Institute of Technology Department of Computer Science and Technology Tsinghua University

Recently, more and more attention has been drawn by the aircraft’s maneuvering problem. This problem is very significant for improving performance of the nonlinear and unsteady modeling methods used for aircrafts at high angles of attack. In this paper, support vector machine(SVM) and artificial neural network are introduced into unsteady aerodynamics modeling. The experimental results show that the generality and precision have been significantly improved using these two methods, which verifies that machine learning methods can be applied to unsteady aerodynamic modeling.

关键词： Unsteady aerodynamics Machine learning method System modeling

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东北林业大学学报 2023年第11期51卷 1-9页

作者：周炳秀刘勇彭玉信张劲赵建松朱轶超赵巧玲王硕陶靖孟路北京林业大学北京100083 北京市园林绿化科学研究院河南省林业生态建设发展中心

为探究雄性毛白杨(Populus tomentosa Carr.)无性系苗木表型及生理的变异规律,对其进行早期综合评价并初步筛选出优良无性系。以35个3年根2年干的雄性毛白杨无性系苗木为材料,测定表型及生理等12个相关性状,分析表型及生理的变异程度及... 详细信息

为探究雄性毛白杨(Populus tomentosa Carr.)无性系苗木表型及生理的变异规律,对其进行早期综合评价并初步筛选出优良无性系。以35个3年根2年干的雄性毛白杨无性系苗木为材料,测定表型及生理等12个相关性状,分析表型及生理的变异程度及相关性,并进行综合评价。结果表明:12个表型及生理性状在无性系间均存在极显著差异(P<0.01),变异系数为3.86%~30.16%,叶柄长度、叶面积、叶绿素质量分数、叶片磷质量分数、叶片钾质量分数的变异系数较大,均超过了11.00%。各性状的重复力在0.548~0.949,属高重复力。毛白杨无性系植株的苗高、胸径与叶片形态、叶绿素质量分数、叶片氮质量分数间均存在极显著或显著正相关关系,与w(叶绿素a)∶w(叶绿素b)存在极显著负相关关系。通过主成分分析提取了6个主成分,累积贡献率达到了84.851%。结合模糊隶属函数的综合评价,1705、1409、4801、1315这4个无性系的综合表现较突出,其苗高、胸径、叶柄长度、叶面积比无性系群体平均值高出6.71%、4.43%、10.39%、19.15%,遗传增益分别达到5.78%、3.51%、7.16%、12.06%,生长较好。35个雄性毛白杨无性系的表型和生理变异丰富,受中偏上的遗传控制,其表型、生理性状与生长间有较为紧密的相关性。通过构建毛白杨无性系表型及生理评价模型,初步筛选出4个生长好、不飞絮的优良无性系。

关键词：雄性毛白杨无性系表型变异生理变异早期综合评价

TAL Effectors Enhance Disease Susceptibility to Xanthomonas citri Via Activation of Genes Associated with ABA Biosynthesis in Citrus

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TAL Effectors Enhance Disease Susceptibility to Xanthomonas ...

中国植物病理学会2023年学术年会

作者： YAN yichao zhu Zhongfeng YIN Ke ZOU Lifang CHEN Gongyou State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong University

Plants manipulate phytohormone levels to regulate development and response to *** have identified two secreted PthAl-like transcription activation-like( TAL) effectors,Tal003-44, and Tal086-36, from Xanthomonas citri *** strains Xcc003 and ***,Tal003-44 and Tal086-36 inhibited plant immunity to promote virulence via SA-and ABA-signaling ***003-44 and Tal086-36 directly activated host genes involved in ABA biosynthesis and inhibited the biotic stress-response *** induction of multiple genes associated with ABA biosynthesis leads to ABA accumulation, disease susceptibility, and the suppression of gene expression connected with SA biosynthesis and ***003-44 and Tal086-36 inhibited ABA catabolism to impair plant immunity and increase host *** demonstrates that AnnoTALE-predicted EBE sequences of target gene promoters interact uniquely with Tal003-44 and *** light of a comprehensive comprehension of ABA and SA functions, the functions of Tal003-44 and Tal086-36 appear to be more clearly defined.

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利用图像描述与知识图谱增强表示的视觉问答

清华大学学报（自然科学版） 2022年第5期62卷 900-907页

作者：王屹超朱慕华许晨张琰王会珍朱靖波东北大学计算机科学与工程学院自然语言处理实验室沈阳110000

视觉问答作为多模态任务,需要深度理解图像和文本问题从而推理出答案。然而在许多情况下,仅在图像和问题上进行简单推理难以得到正确的答案,事实上还有其他有效的信息如图像描述、外部知识等可以被利用。该文提出了利用图像描述和外部... 详细信息

视觉问答作为多模态任务,需要深度理解图像和文本问题从而推理出答案。然而在许多情况下,仅在图像和问题上进行简单推理难以得到正确的答案,事实上还有其他有效的信息如图像描述、外部知识等可以被利用。该文提出了利用图像描述和外部知识增强表示的视觉问答模型。该模型以问题为导向,基于协同注意力机制分别在图像和其描述上进行编码,并且利用知识图谱嵌入,将外部知识编码到模型当中,丰富了模型的特征表示,增强了模型的推理能力。在OKVQA数据集上的实验结果表明,该方法相比基线方法有1.71%的准确率提升,与已有的主流模型相比也有1.88%的准确率提升,证明了该方法的有效性。

关键词：视觉问答多模态融合知识图谱图像描述

基于Landsat-8 TIRS的防城港核电站温排水分布规律研究

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生态科学 2023年第5期42卷 25-30页

作者：朱欧娜田义超北部湾大学资源与环境学院钦州535000 北部湾大学海洋地理信息资源开发利用重点实验室钦州535000 桂林理工大学广西空间信息与测绘重点实验室桂林541004

利用夏季和冬季两幅Landsat-8 TIRS数据,通过辐射传输方程法对防城港核电站附近海域温度反演,结合潮汐数据分析防城港核电站温排水造成附近海域温度变化的影响规律。结果表明:冬季与夏季对低于4℃的温升变化范围影响不大,高于4℃的温升... 详细信息

利用夏季和冬季两幅Landsat-8 TIRS数据,通过辐射传输方程法对防城港核电站附近海域温度反演,结合潮汐数据分析防城港核电站温排水造成附近海域温度变化的影响规律。结果表明:冬季与夏季对低于4℃的温升变化范围影响不大,高于4℃的温升变化范围影响显著;潮汐运动对温排水扩散方向有明显影响,潮涨时温排水向东北方向扩散,潮落时向西南方向扩散。探索核电站温排水的分布状况及分布规律,对保护海洋生态环境具有重要意义。

关键词：温排水海表温度海洋环境 Landsat-8 TIRS 防城港核电站

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