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O-glycosylation in viruses:A sweet tango

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mLife 2024年第1期3卷 57-73页

作者： Annan Ming Jianxin Zhao Yihan Liu yibo wang Xiaohui wang Jing Li Leiliang Zhang Shandong Provincial Hospital Afiliated to Shandong First Medical University JinanChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina Bejing Key Laboratory of DNA Damage Response and College of Life Sciences Capital Normal UniversityBeijingChina Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiChina Bejing National Laboratory for Molecular Sciences BeijingChina

O-glycosylation is an ancient yet underappreciated protein posttranslational modification,on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseases or even cancer.But due to the innate complexity of O-glycosylation,research techniques have been limited to study its exact role in viral attachment and entry,assembly and exit,spreading in the host cells,and the innate and adaptive immunity of the host.Recently,the advent of many newly developed methodologies(e.g.,mass spectrometry,chemical biology tools,and molecular dynamics simulations)has renewed and rekindled the interest in viral-related O-glycosylation in both viral proteins and host cells,which is further fueled by the COVID-19 pandemic.In this review,we summarize recent advances in viral-related O-glycosylation,with a particular emphasis on the mucin-type O-linkedα-N-acetylgalactosamine(O-GalNAc)on viral proteins and the intracellular O-linkedβ-N-acetylglucosamine(O-GlcNAc)modifications on host proteins.We hope to provide valuable insights into the development of antiviral reagents or vaccines for better prevention or treatment of infectious diseases.

关键词： immune response O-GalNAc O-GlcNAc O-glycosylation virus

Rational design of vitamin C/defective carbon van der Waals heterostructure for enhanced activity,durability and storage stability toward oxygen reduction reaction

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Journal of Energy Chemistry 2024年第1期88卷 103-111,I0003页

作者： Ruiqi Cheng Kaiqi Li Huanxin Li Tianshuo Zhao yibo wang Qingyue Xue Jiao Zhang Chaopeng Fu Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Christopher Ingold Laboratory Department of ChemistryUniversity College LondonLondon WC1H 0AJUK Department of Chemistry Physical&Theoretical Chemistry LaboratoryUniversity of OxfordSouth Parks RoadOxford OX13QZUK

Metal-free defective carbon materials with abundant active sites have been widely studied as low-cost and efficient oxygen reduction reaction(ORR)electrocatalysts in metal-air batteries.However,the active sites in defective carbon are easily subjected to serious oxidation or hydroxylation during ORR or storage,leading to rapid degradation of activity.Herein,we design a van der Waals heterostructure comprised of vitamin C(VC)and defective carbon(DC)to not only boost the activity but also enhance the durability and storage stability of the DC-VC electrocatalyst.The formation of VC van der Waals between DC and VC is demonstrated to be an effective strategy to protect the defect active sites from oxidation and hydroxylation degradation,thus significantly enhancing the electrochemical durability and storage anti-aging performance.Moreover,the DC-VC van der Waals can reduce the reaction energy barrier to facilitate the ORR.These findings are also confirmed by operando Fourier transform infrared spectroscopy and density functional theory calculations.It is necessary to mention that the preparation of this DC-VC electrocatalyst can be scaled up,and the ORR performance of the largely produced electrocatalyst is demonstrated to be very consistent.Furthermore,the DC-VC-based aluminum-air batteries display very competitive power density with good performance maintenance.

关键词： Van der Waals heterostructure Oxygen reduction reaction Stability Scalable production Aluminum-air battery

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Suppressing the lattice oxygen diffusion via high-entropy oxide construction towards stabilized acidic water oxidation

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Nano Research 2024年第3期17卷 1107-1113页

作者： Jing Ni Zhaoping Shi yibo wang Jiahao Yang Hongxiang Wu Pengbo wang Kai Li Meiling Xiao Changpeng Liu Wei Xing State Key Laboratory of Electroanalytic Chemistry Jilin Province Key Laboratory of Low Carbon Chemistry PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The scale-up deployment of ruthenium(Ru)-based oxygen evolution reaction(OER)electrocatalysts in proton exchange membrane water electrolysis(PEMWE)is greatly restricted by the poor stability.As the lattice-oxygen-mediated mechanism(LOM)has been identified as the major contributor to the fast performance degradation,impeding lattice oxygen diffusion to inhibit lattice oxygen participation is imperative,yet remains challenging due to the lack of efficient approaches.Herein,we strategically regulate the bonding nature of Ru–O towards suppressed LOM via Ru-based high-entropy oxide(HEO)construction.The lattice disorder in HEOs is believed to increase migration energy barrier of lattice oxygen.As a result,the screened Ti_(23)Nb_(9)Hf_(13)W_(12)Ru_(43)O_(x) exhibits 11.7 times slower lattice oxygen diffusion rate,84%reduction in LOM ratio,and 29 times lifespan extension compared with the state-of-the-art RuO_(2) catalyst.Our work opens up a feasible avenue to constructing stabilized Ru-based OER catalysts towards scalable application.

关键词： ruthenium-based high-entropy oxide suppressing the lattice oxygen diffusion acidic oxygen evolution reaction

Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第2期15卷 878-897页

作者： Chang Cui Yulong Wei yibo wang Wen Ma Xiaoyu Zheng Jun wang Ziwei Ma Caichi Wu Licui Chu Shihai Zhang Wutai Guan Fang Chen Guangdong Provincial Key Laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China

Background The benefits of combining benzoic acid and essential oils(BAO)to mitigate intestinal impairment during the weaning process have been well established,while the detailed underlying mechanism has not been fully elucidated.Previous research has primarily focused on the reparative effects of BAO on intestinal injury,while neglecting its potential in enhancing intestinal stress resistance.Methods In this study,we investigated the pre-protective effect of BAO against LPS-induced stress using a modified experimental procedure.Piglets were pre-supplemented with BAO for 14 d,followed by a challenge with LPS or saline to collect blood and intestinal samples.Results Our findings demonstrated that BAO supplementation led to significant improvements in piglets’final weight,average daily gain,and feed intake/body gain ratio.Additionally,BAO supplementation positively influenced the composition of intestinal microbiota,increasing beneficial Actinobacteriota and Alloprevotella while reducing harmful Desulfobacterota,Prevotella and Oscillospira.Furthermore,BAO supplementation effectively mitigated oxidative disturbances and inflammatory responses induced by acute LPS challenge.This was evidenced by elevated levels of T-AOC,SOD,and GSH,as well as decreased levels of MDA,TNF-α,and IL-6 in the plasma.Moreover,piglets subjected to LPS challenge and pre-supplemented with BAO exhibited significant improvements in intestinal morphological structure and enhanced integrity,as indicated by restored expression levels of Occludin and Claudin-1 compared to the non-supplemented counterparts.Further analysis revealed that BAO supplementation enhanced the jejunal antioxidative capacity by increasing GSH-Px levels and decreasing MDA levels under the LPS challenge and stimulated the activation of the Nrf2 signaling pathway.Additionally,the reduction of TLR4/NF-κB/MAPK signaling pathways activation and proinflammatory factor were also observed in the jejunal of those piglets fed with BAO.Conclusions In summary,our study demonstrates that

关键词： Anti-stress Benzoic acid Essential oils Intestine LPS Weaned piglets

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Stabilizing high-efficiency iridium single atoms via lattice confinement for acidic oxygen evolution

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Nano Research 2024年第4期17卷 2492-2498页

作者： yibo wang Jiadong Jiang Zhaoping Shi Hongxiang Wu Jiahao Yang Pengbo wang Shuai Hou Meiling Xiao Junjie Ge Changpeng Liu Wei Xing Laboratory of Advanced Power Sources Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026.China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Jilin Province Key Laboratory of Low Carbon Chemical Power Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Key Laboratory of Physics and Technology for Advanced Batteries Ministry of EducationCollege of PhysicsJilin UniversityChangchun 130012China

Stable and efficient single atom catalysts(SACs)are highly desirable yet challenging in catalyzing acidic oxygen evolution reaction(OER).Herein,we report a novel iridium single atom catalyst structure,with atomic Ir doped in tetragonal PdO matrix(IrSAs-PdO)via a lattice-confined strategy.The optimized IrSAs-PdO-0.10 exhibited remarkable OER activity with an overpotential of 277 mV at 10 mA·cm^(-2) and long-term stability of 1000 h in 0.5 M H_(2)SO_(4).Furthermore,the turnover frequency attains 1.6 s^(-1) at an overpotential of 300 mV with a 24-fold increase in the intrinsic activity.The high activity originates from isolated iridium sites with low valence states and decreased Ir–O bonding covalency,and the excellent stability is a result of the effective confinement of iridium sites by Ir–O–Pd motifs.Moreover,we demonstrated for the first time that SACs have great potential in realizing ultralow loading of iridium(as low as microgram per square center meter level)in a practical water electrolyzer.

关键词： lattice confinement iridium single atoms ultralow iridium loading acidic oxygen evolution proton exchange membrane water electrolysis

Thermal and mechanical characterization of under-2-μm-thick AlCrNbSiTi high-entropy thin film

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Energy Storage and Saving 2024年第1期3卷 52-59页

作者： yibo wang Xiaona Huang Yan Liu Xiangyu Zhang Bing Yang Yanan Yue School of Power and Mechanical Engineering Wuhan UniversityWuhan430072China

High-entropy alloys(HEAs)exhibit extraordinary physical properties such as superior strength-to-weight ratios and enhanced corrosion and oxidation resistance,making them potentially useful in energy storage and gener-ation industries.However,thermal and mechanical properties of HEAs with various compositions vary signifi-cantly.Furthermore,these properties have rarely been investigated simultaneously owing to material or instru-mentation limitations.Herein,we synthesize an HEA(AlCrNbSiTi)coating with a thickness of less than 2μm.We customize a frequency-domain photothermal testing system to characterize the thermal and mechanical proper-ties of the proposed coating with high accuracy.Owing to the large mixing enthalpy of the Al-Ti,Nb-Si,and Ti-Si pairs in the coating,its hardness and elastic modulus are 15.2 and 254.7 GPa,respectively,which are higher than those of previously reported HEAs.The thermal conductivity of the AlCrNbSiTi coating is characterized to be 2.90 W·m^(−1)·K^(−1),within the expected range and well explained by the free-electron consistency diversity and phonon scattering from the amorphous structure.Additionally,the coating exhibits adequate wear performance,with a wear rate of 5.4×10^(−8) mm^(3)·N^(−1)·m^(−1).This relatively low thermal conductivity,combined with extraordi-nary mechanical properties,makes the proposed material an excellent candidate as a protective coating material for nuclear reactor components which require high strength,irradiation resistance,and thermal protection.

关键词： High-entropy alloys Thin coating Thermal conductivity Mechanical properties Noncontact photothermal technique

Comparative Analysis of Noise Margin between Pure SET-SET and Hybrid SET-PMOS Inverters

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Chinese Journal of Electronics 2024年

作者： Fan ZHANG Yi LIU yibo wang Minghu WU Sheng HU Youli DONG Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of Technology School of Electrical and Electronic Engineering Hubei University of Technology

Single-electron transistor（SET） is considered as one of the promising candidates for future electronic devices due to its advantages of low power consumption and high integration. The comparative analysis of SETbased inverters, especially the noise margin, is carried out. Pure SET-SET and hybrid SET with p type metal oxide semiconductor（SET-PMOS） inverters are designed for investigation. The effects of SET supply voltage, junction resistance and junction capacitance on noise tolerance and power consumption of inverters are studied. For hybrid SET-PMOS inverters, the noise margin for a logic high（NMH） is less than 60 mV under various conditions, which may become the bottleneck of its application. For pure SET-SET inverters, both NMH and the noise margin for a logic low（NML） could reach 300 mV at a supply voltage of 0.8 V. The minimum power consumption of pure SETSET and hybrid SET-PMOS inverters is 2.85 nW and 58 nW, respectively. The pure SET-SET inverters have greater noise tolerance and lower power consumption, which is more conducive to large-scale integration. When junction capacitance CJ= 0.0273 aF and junction resistance V, the NMH and NML are not significantly affected by the junction resistance and the noise margin fluctuates at 300mV.

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Chemical composition and pharmacological activities of Atractylodes lancea:A review

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Asian Journal of Traditional Medicines 2024年第3期19卷 159-171页

作者： Shuo wanga Yunpeng Yang yibo wang Wenhan wang Meng Zhang Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Jiangxi Alpha Hi-Tech Pharmaceutical Co. LtdWuxi 214422China

Atractylodes lancea(called Cangzhu in China)is a medicinal plant that has long been used as tonic agent in various ethno-medical systems in East Asia,especially in China,for the treatment of gastrointestinal dysfunction,cancer,osteoporosis,obesity and fetal irritability.We used the TCMSP database to search for the main active ingredients and traditional Chinese medicine targets of Atractylodes macrocephala.There are a total of 38 related articles,of which 27 are closely related to chemical composition and activity.This study reviews the chemical components and pharmacological effects of A.lancea,aiming to provide reference for its further research and development.

关键词： Atractylodes lancea chemical composition pharmacological activities

Chemical constituents and pharmacological effects of Croton crassifolius

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Asian Journal of Traditional Medicines 2024年第2期19卷 99-114页

作者： Luyan Yang yibo wang Xinyao wang Xiaoxia Xu Yunpeng Yang Meng Zhang Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China School of Business Liaoning UniversityShenyang 110136China

Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.

关键词： Croton crassifolius chemical compositions pharmacological activities