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Telfairia occidentalis (Cucurbitaceae) pulp extract mitigates rifampicinisoniazid-induced hepatotoxicity in an in vivo rat model of oxidative stress

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Journal of Integrative Medicine 2019年第1期17卷 46-56页

作者： Lucky Legbosi Nwidu yibala ibor oboma Experimental Pharmacology and Toxicology Faculty of Pharmaceutical Sciences University of Port Harcourt Medical Laboratory Sciences Faculty of Basic Medical Sciences College of Health Sciences Niger Delta University

Objective: Drug-induced liver injury complicates antituberculosis drug treatment and is a leading cause of death worldwide. The aim of this study is to establish the ethnomedicinal claim of hepatoprotective effects of fruit pulp extract of Telfairia occidentalis against rifampicin(RIF) and isoniazid(INH)-induced oxidative stress in ***: T. occidentalis pulp extract(TOPE)(125–500 mg/kg) and silymarin(50 mg/kg) were evaluated in an induced hepatotoxicity model of oxidative stress in Wistar rats by intoxication with RIF and INH(100 mg/kg each) orally for 60 d. Markers indicating oxidative stress and hepatic damage such as alanine aminotransferase(ALT), aspartate aminotransferase(AST) and alkaline phosphatase(ALP) were *** of antioxidant status, including catalase, glutathione reductase, glutathione peroxidase and superoxide dismutase, and marker of lipid peroxidation, malondialdehyde(MDA), were assayed using standard procedures. The hematological profile, lipid profile, serum markers for kidney function and histopathological examination were also ***: Intoxication with RIF and INH markedly reduced the hematological indices and elevated the biochemical enzyme markers(AST, ALT and ALP, P < 0.001) and lipid profile(P < 0.001), while antioxidant biomarkers were significantly(P < 0.01) depressed and MDA was elevated. However, pretreatment with TOPE significantly(P < 0.001) alleviated this alteration and sustained the antioxidant potentials. The histopathological morphology supports the biochemical evidence of ***: Current study is indicative of potential antioxidant activity, hepatoprotective effects and plausible therapeutic alleviation of RIF-INH-induced hepatotoxicity of TOPE in laboratory animals.

关键词： Telfairia occidentalis Pulp extract Oxidative stress Antioxidant Lipid peroxidation Hepatoprotective

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