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Hepatocellular carcinoma with biliary and neuroendocrine differentiation: A case report

World Journal of Clinical Oncology 2021年第4期12卷 262-271页

作者： yiannis petros dimopoulos Emily R Winslow Aiwu Ruth He Metin Ozdemirli Department of Pathology and Laboratory Medicine Medstar Georgetown University HospitalWashingtonDC 20007United States Medstar Center for Liver and Pancreas Surgery Medstar Georgetown University HospitalWashingtonDC 20007United States Lombardi Comprehensive Cancer Center Medstar Georgetown University HospitalWashingtonDC 20007United States

BACKGROUND Liver tumors with dual differentiations[combined hepatocellular carcinoma(HCC)and cholangiocarcinoma]are ***,liver tumors that exhibit hepatocellular,biliary,and neuroendocrine differentiation are exceedingly rare,with only three previous case reports in the *** SUMMARY A 65-year-old female with a previous history of hepatitis C and a distant history of low grade,well-differentiated rectal neuroendocrine tumor was found to have two liver lesions in segment 4 and segment 7 on *** alpha-fetoprotein and chromogranin A were *** of the larger lesion in segment 4 revealed a high-grade tumor,with morphologic and immunohistochemical features of a neuroendocrine *** the previous history of rectal neuroendocrine tumor,imaging investigation,serologic markers,and biopsy findings,metastatic neuroendocrine tumor was *** regional resection of these hepatic lesions revealed the segment 4 lesion to be a HCC with additional biliary and neuroendocrine differentiation and the segment 7 lesion to be a cholangiocarcinoma with neuroendocrine ***-up of the patient revealed disease recurrence in the dome of the liver and metastasis in retro-pancreatic lymph *** patient eventually expired due to complications of *** HCC cases with additional biliary and neuroendocrine differentiation are exceedingly rare,posing a diagnostic challenge for clinicians and pathologists.

关键词： Mixed liver tumor Hepatocellular Biliary Neuroendocrine Triple differentiation Case report

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In vitro calcification studies on bioprosthetic and decellularized heart valves under quasi-physiological flow conditions

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Bio-Design and Manufacturing 2021年第1期4卷 10-21页

作者： Cristian C.D’Alessandro Andreas dimopoulos Sofia Andriopoulou Gerasimos A.T.Messaris Sotirios Korossis petros Koutsoukos Dimosthenis Mavrilas Laboratory of Biomechanics and Biomedical Engineering Department of Mechanical Engineering and AeronauticsUniversity of PatrasPatrasGreece Department of Cardiothoracic Transplantation and Vascular SurgeryHannover Medical SchoolHannoverGermany Department of Medical Physics University Hospital of PatrasPatrasGreece Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughUK Department of Chemical Engineering University of PatrasPatrasGreece FORTH-Institute of Chemical Engineering Sciences PatrasGreece

The lifespan of biological heart valve prostheses available in the market is limited due to structural alterations caused by calcium phosphate deposits formed from blood plasma in contact with the *** objective of this work is to present a comparative methodology for the investigation of the formation of calcium phosphate deposits on bioprosthetic and tissue-engineered scaffolds in vitro and the influence of mechanical forces on tissue *** on earlier investigations on biological mineralization at constant supersaturation,a circulatory loop simulating dynamic blood flow and physiological pressure conditions was *** system was appropriately adapted to evaluate the calcification potential of decellularized(DCV)and glutaraldehyde-fixed(GAV)porcine aortic *** indicated that DCV calcified at higher,statistically nonsignificant,rates in comparison with *** difference was attributed to the tissue surface modifications and cell debris leftovers from the decellularization *** analysis of the solids deposited after 20 h by scanning electron microscopy in combination with chemical microanalysis electron-dispersive spectroscopy identified the solid formed as octacalcium phosphate(Ca8(PO4)6H2·5H2O,OCP).OCP crystallites were preferentially deposited in high mechanical stress areas of the test ***,GAV tissues developed a significant transvalvular pressure gradient increase past 36 h with a calcium deposition distribution similar to the one found in explanted *** conclusion,the presented in vitro circulatory model serves as a valuable prescreening methodology for the investigation of the calcification process of bioprosthetic and tissue-engineered valves under physiological mechanical load.

关键词： Reactors Calcification Constant composition reactor Heart valve In vitro Mechanical load Tissue engineering

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