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The potential value of microRNA-4463 in the prognosis evaluation in hepatocel.ular carcinoma

Genes & Diseases 2017年第2期4卷 116-122页

作者： Tian Hu Jincheng li Chuhong Zhang Xiu lv Sai li Sha He Hanxing Yan yixi Tan Mingsheng lei Meiling Wen Jianhong Zuo The Affiliated Nanhua Hospital University of South ChinaHengyangHunan421001China School of Medicine University of South ChinaHengyangHunan421001China Medical School Shaoyang UniversityShaoyangHunan422000China Department of Respiratory and Critical Care Medicine Zhangjiajie City HospitalZhangjiajieHunan427000China

The purpose of this study is to measure the expression of microRNA-4463 and microRNA-6087 between normal persons and patients with hepatocel.ular carcinoma(HCC),and to clarify the meaning of them in the prognosis evaluation in ***-five samples from healthy people and patients,who had been diagnosed with hepatocel.ular carcinoma before any treatment,were collected to study ***-time PCR was used to detect the expression of miRNA-4463 and miRNA-6087 in the serum of control group and hepatocel.ular carcinoma *** expression of miR-4463 in the serum of HCC patients was significantly higher than that in control group(Plevel was independent of gender,tumor size,cell types,stages,alanine aminotransferase(AlT),aspartate aminotransferase(AST),total bilirubin(TBIl)and HBsAg status(P>0.05).But there was a significant difference of different level of AFP in HCC(Pup of AFP lower than 400 ug/l and the control group is statistically significant(Purvival time had showed a significant difference at the high and low expression levels(Put the expression level of miRNA-6087 was no difference in HCC and control *** disorder of miRNA-4463 occurred in HCC,even the AFP level doesn’t ***’s more,patients who get the high level of miRNA-4463 seem to have a shorter survival *** it contributes great to the prognostic *** is the first study to il.ustrate the potential significance of miRNA-4463 in the prognosis in HCC.

关键词： Hepatocel.ular carcinoma malignant tumors microRNA-4463 microRNA-6087 miR-4463 Prognostic

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Counting Formulas for Restricted Matrix of Set

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Chinese Quarterly Journal of Mathematics 2009年第2期24卷 168-172页

作者： l.u Qing-lin School of Mathematical Science Xuzhou Normal University Xuzhou 221116 China

In this paper, we consider the counting problem of matrix of set （Aij）kxn which satisfies ui=1^k uj=1 ^n Aij={α1,α2,…αm} and other conditions, and obtain some computational formulas which extend all the results... 详细信息

关键词： counting matrix of set exponential generating function

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Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-lópez Iva Tic David Valle-García Marta Ribalta-Vilella luis labrador Deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer lyon Universitéde LyonLyonFrance Inserm u1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS uMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-uTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cul.ures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

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A comparison of animal color measurements using a commercially available digital color sensor and photograph analysis

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Current Zoology 2020年第6期66卷 601-606页

作者： Alex D.Potash Daniel.u.Greene Gabrielle A.Foursa Verity l.Mathis l.Mike Conner Robert A.McCleery Department of Wildlife Ecology and Conservation University of Florida Institute of Food and Agricultural ScienceGainesvilleFL 32611USA Weyerhaeuser Company Environmental Research SouthColumbusMS 39701USA Department of Biology University of FloridaGainesvilleFL 32611USA Florida Museum of Natural History University of FloridaGainesvilleFL 32611USA The Jones Center at Ichauway NewtonGA 39870USA

An animal's pelage,feather,or skin color can serve a variety of functions,so it is important to have multiple standardized methods for measuring *** of the most common and reliable methods for measuring animal coloration is the use of standardized digital photographs of *** tech no logy in the form of a commercially available handheld digital color sensor could provide an alter native to photography-based animal color *** determine whether a digital color sensor could be used to measure animal coloration,we tested the ability of a digital color sensor to measure coloration of mammalian,avian,and lepidopteran museums *** compared results from the sensor to measurements taken using traditional photography *** study yielded significant differences between photography-based and digital color sensor measurements of brightness(light to dark)and colors along the green to red *** was no difference between photographs and the digital color sensor measurements for colors along the blue to yellow *** average difference in recorded color(AE)by the 2 methods was above the threshold at which humans can perceive a *** were sign讦icant correlations between the sensor and photographs for all measurements indicating that the sensor is an effective animal coloration measuring ***,the sensor's small aperture and narrow light spectrum range designed for human-vision limit its value for ecological *** discuss the conditions in which a digital color sensor can be an effective tool for measuring animal coloration in both laboratory settings and in the field.

关键词： animal coloration color measurement comparative method digital photography museum specimens Nix color sensor

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Physics-based,data-driven approach for predicting natural ventilation of residential high-rise buildings

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Building Simulation 2022年第1期15卷 129-148页

作者： Vincent J.l.Gan Boyu Wang C.M.Chan A.u.Weerasuriya Jack C.P.Cheng Department of Building School of Design and EnvironmentNational University of SingaporeSingapore117566 Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Natural ventilation is particularly important for residential high-rise buildings as it maintains indoor human comfort without incurring the energy demands that air-conditioning *** improve a building’s natural ventilation,it is essential to develop models to understand the relationship between wind flow characteristics and the building's *** more effort is still needed for developing such reliable,accurate,and computationally economical models instead of currently the most popular physics-based models such as computational fluid dynamics(CFD)*** paper,therefore,presents a novel model developed based on physics-based modelling and a data-driven approach to evaluate natural ventilation in residential high-rise *** model first uses CFD to simulate wind pressures on the exterior surfaces of a high-rise *** the surface pressures have been obtained,multizone modelling is used to predict the air change per hour(ACH)for different flats in various ***-driven prediction models are then developed using data from the simulation and deep neural networks that are based on mean absolute error,mean absolute percentage error,and a fusion algorithm *** data-driven models are used to predict the ACH of 25 *** results from multizone modelling and data-driven modelling are *** results imply a high accuracy of the data-driven prediction in comparison with physics-based *** fusion algorithm-based neural network performs best,achieving 96%accuracy,which is the highest of all models *** study contributes a more efficient and robust method for predicting wind-induced natural *** findings describe the relationship between building design(e.g.,plan layout),distribution of surface pressure,and the resulting ACH,which serve to improve the practical design of sustainable buildings.

关键词： computational fluid dynamics data-driven prediction machine learning multizone model natural ventilation residential building

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The AlMaQuEST Survey ⅩⅤ:The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 174-196页

作者： Niankun Yu Zheng Zheng Chao-Wei Tsai Pei Zuo Sara l.Ellison David V.Stark Di li Jingwen Wu Karen l.Masters Ting Xiao Yinghui Zheng Zongnan li Kai Zhang Hongying Chen Shu l.u Sihan Jiao Fanyi Meng National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Department of Physics&Astronomy University of VictoriaVictoriaV8P 1A1Canada Departments of Physics and Astronomy Haverford CollegeHaverford19041USA Space Telescope Science Institute San Martin Dr.Baltimore 21218USA Zhejiang laboratory Hangzhou 311121China New Cornerstone Science laboratory Shenzhen 518054China School of Physics Zhejiang UniversityHangzhou 310058China

The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies,which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar *** compiled a sample of 94 nearby galaxies with observations of multi-phase gas contents by utilizing public H_(Ⅰ),CO,and optical IFu data from the Ma NGA survey together with new FAST H_(Ⅰ)*** agreement with previous results,our sample shows that the global molecular-to-atomic gas ratio(R_(mol)≡log M_(H2)/M_(H_(Ⅰ)))is correlated with the global stellar mass surface densityμ_*with a Kendall'sτcoefficient of 0.25 and pless tightly but still correlated with stellar mass and NuV-r color,and not related to the specific star formation rate(sSFR).The cold gas distribution and kinematics inferred from the H_(Ⅰ)and CO global profile asymmetry and shape do not significantly rely on R_(mol).Thanks to the availability of kpc-scale observations of MaNGA,we decompose galaxies into H_(Ⅱ),composite,and AGN-dominated regions by using the BPT *** increasing R_(mol),the fraction of H_(Ⅱ)regions within 1.5 effective radius decreases slightly;the density distribution in the spatially resolved BPT diagram also changes significantly,suggesting changes in metallicity and ionization *** with high R_(mol)tend to have high oxygen abundance,both at one effective radius with a Kendall'sτcoefficient of 0.37(pl *** all parameters investigated here,the oxygen abundance at one effective radius has the strongest relation with global R_(mol).The dependence of gas conversion on gas distribution and galaxy ionization states is *** contrast,the observed positive relation between oxygen abundance(μ_(*))and R_(mol)indicates that the gas conversion is efficient in regions of high metallicity(density).

关键词： Galaxies baryon cycle radio lines H_(Ⅰ)21 cm atomic-to-molecular gas conversion

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A Statistical Mechanical Analysis on the Bound State Solution of an Energy-Dependent Deformed Hulthén Potential Energy

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Communications in Theoretical Physics 2019年第9期71卷 1127-1138页

作者： B.C.lütfüoglu A.N.Ikot u.S.Okorie A.T.Ngiangia Department of Physics Faculty of ScienceAkdeniz University07058AntalyaTurkey Department of Physics Faculty of ScienceUniversity of Hradec KraloveRokitanskeho6250003Hradec KraloveCzechia Department of Physics Theoretical Physics GroupUniversity of Port HarcourtChobaPort HarcourtNigeria Department of Physics Akwa Ibom State UniversityIkot AkpadenP.M.B.1167UyoNigeria

In this article, we investigate the bound state solution of the Klein Gordon equation under mixed vector and scalar coupling of an energy-dependent deformed Hulthén potential in D dimensions. We obtain a transcendental equation after we impose the boundary conditions. We cal.ulate energy spectra in four different limits and in arbitrary dimension via the Newton-Raphson method. Then, we use a statistical method, namely canonical partition function, and discuss the thermodynamic properties of the system in a comprehensive way. We find out that some of the thermodynamic properties overlap with each other, some of them do not.

关键词： Klein-Gordon equation energy-dependent deformed Hulthén potential energy bound state solution thermodynamic properties

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Risk of New-Onset Atrial Fibrillation in Elderly Patients with the Overlap Syndrome: A Retrospective Cohort Study

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Journal of Geriatric Cardiology 2013年第2期10卷 129-134页

作者： Harsha V. Ganga Sanjeev u. Nair Venkata K. Puppala Wayne l. Miller The Henry low Heart Center Hartford Hospital B-1010 80 Seymour Street Hartford CT 06102 USA St. Joseph's Hospital 45 W 10th St St. Paul MN 55102 USA Division of Cardiovascular Diseases Mayo Clinic Rochester MN 55905 USA

Background Co-existence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) is referred to as overlap syndrome. Overlap patients have greater degree of hypoxia and pulmonary hypertension than patients with OSA or COPD alone. Studies showed that elderly patients with OSA alone do not have increased risk of atrial fibrillation (AF) but it is not known if overlap patients have higher risk of AF. Objective To determine whether elderly patients with overlap syndrome have an increased risk of AF. Methods In this single center, community-based retrospective cohort analysis, data were collected on 2,873 patients > 65 years of age without AF, presenting in the year 2006. Patients were divided into OSA group (n = 60), COPD group (n = 416), overlap syndrome group (n = 28) and group with no OSA or COPD(n = 2369). The primary endpoint was incidence of new-onset AF over the following two years. logistic regression was performed to adjust for heart failure (HF), coronary artery disease, hypertension (HTN), cerebrovascular disease, cardiac valve disorders, diabetes mellitus, hyperlipidemia, chronic kidney disease (CKD) and obesity. Results The incidence of AF was 10% in COPD group, 6% in OSA group and 21% in overlap syndrome group (P usting for age, sex, HF, CKD, and HTN, patientswith overlap syndrome demonstrated a significant association with new-onset AF (OR = 3.66, P = 0.007). HF, CKD and HTNwere also significantly associated with new-onset AF (P lusion Among elderly patients, the presence of overlap syndrome is associatedwith a marked increase in risk of new-onset AF as compared to the presence of OSA or COPDalone.

关键词： Atrial arrhythmias Elderly patients Obstructive lung disease Sleep apnea

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Cal.ulation of stratosphere–troposphere exchange in East Asia cut-off lows:cases from the lagrangian perspective

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Atmospheric and Oceanic Science letters 2016年第1期9卷 31-37页

作者： Wu Xue lü Da-Ren Key laboratory for Atmosphere and Global environment Observation Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

In this study,the authors focus on the cut-off low pressure systems（COls）lingering over East Asia in late spring and early summer and quantify the two-way stratosphere–troposphere exchange（STE）by 3D trajectory integrations,achieved using a revised version of the uK universities Global Atmospheric Modelling Programme Offline Trajectory Code（Version 3）.By selecting 10 typical COls and cal.ulating the cross-tropopause air mass fluxes,it is found that stratosphere-to-troposphere transport（STT）fluxes exist in the center of COls;and in the periphery of the COl center,troposphereto-stratosphere transport（TST）fluxes and STT fluxes are distributed *** transport fluxes in COls are from stratosphere to troposphere,and the magnitude is about 10-4 kg m-2 *** ratio between the area-averaged STT and TST fluxes increases with increasing strength of the *** adopting appropriate residence time,the spurious transports are effectively ***,the authors compare the results with previous studies,and find that the cross-tropopause fluxes（CTFs）induced by COls are about one to two orders of magnitude larger than global *** play a significant role in local,rapid air mass exchanges,although they may only be responsible for a fraction of the total STE.

关键词： stratosphere–troposphere exchange cut-off low trajectory model

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基于背景噪声反演华南块体岩石圈三维S波速度结构

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北京大学学报（自然科学版） 2024年第3期60卷 442-452页

作者：吕杰陈永顺郭震北京大学地球与空间科学学院北京100871 南方科技大学海洋科学与工程系深圳518055

利用背景噪声方法,对布设在华南块体及其周边区域数个流动地震台阵中共704个地震台站的连续数据进行分析,反演得到华南岩石圈的三维S波速度结构。结果表明,地表附近S波速度结构与华南块体的地表构造高度相关,低速异常区集中在四川盆地... 详细信息

利用背景噪声方法,对布设在华南块体及其周边区域数个流动地震台阵中共704个地震台站的连续数据进行分析,反演得到华南岩石圈的三维S波速度结构。结果表明,地表附近S波速度结构与华南块体的地表构造高度相关,低速异常区集中在四川盆地和江汉盆地等沉积层较厚的区域。江南造山带的中上地壳呈现明显的高速异常,该高速异常即为华夏块体与扬子块体的分界区域。华夏块体中地壳低速异常区与该区域广泛分布的中生代花岗岩对应较好。华南上地幔岩石圈的东部与西部存在显著的速度差异,西部呈现显著的高速异常,反映西部四川盆地底部稳固的克拉通结构;上地幔的低速异常揭示华南东部岩石圈因太平洋板块俯冲的影响而明显减薄(<70km)。推测华夏块体以琼州海峡为中心的上地幔显著低速区可能对应海南地幔柱的热物质上涌。

关键词：华南块体 S波速度结构江南造山带板块俯冲

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