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Effect of RE addition on solidification process and high-temperature strength of Al-12%Si-4%Cu-1.6%Mn heat-resistant alloy

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Transactions of Nonferrous Metals Society of China 2019年第6期29卷 1117-1126页

作者： Heng-cheng LIAO He-ting XU yi-yun hu Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Nanjing 211189 China

The effect of RE addition on solidification process and high-temperature strength of Al-12%Si-4%Cu-1.6%Mn(in wt.%)heat-resistant alloy was investigated by microstructure observation and tensile test.A great number of fine needle-like RE-rich phases are observed in the alloys with RE addition. Solutionizing treatment does not change their morphologies and sizes, indicating that they have good thermal stability. The addition of RE totally alters the solidification process of eutectic CruAl2 phase, from network-like phase in the form of segregation at the final eutectic grain boundaries to discretely blocky phase growing on the hair-filamentous RE-rich needles. In the alloys with Ce addition, blocky CuAl2, particulate Al15Mn3Si2 and needle-like RE-rich needle phases grow together, but they did not occur in the alloy with only La addition. The addition of RE does not considerably improve the strength of the alloy at high temperatures. The formation of RE-rich phases also does not significantly alter the originating and propagating of micro-cracks in the alloy during tensile test.

关键词： Al-Si-Cu-Mn heat-resistant alloy rare earth solidification process high-temperature strength

Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis

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World Journal of Gastroenterology 2021年第46期27卷 7982-7994页

作者： Li-Chao Zhang Xiao-ying Wu Rui-Bing Yang Fang Chen Jia-hua Liu yun-yi hu Zhong-Dao Wu Li-Fu Wang Xi Sun Department of Parasitology of Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Gastroenterology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina School of Medicine South China University of TechnologySouth China University of TechnologyGuangzhou 510000Guangdong ProvinceChina Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)affects millions of people worldwide and has emerged as a growing problem in industrialized *** lack of therapeutic targets has limited the treatment of *** found that parasitic nematode infections can ameliorate clinical and experimental *** previous study found that rSj16,a 16-kDa secreted protein of Schistosoma japonicum produced by Escherichia coli,has protective effects on dextran sulfate sodium(DSS)-induced colitis in *** is an important factor in the pathogenesis of ***,it is not clear whether the effect of rSj16 on colitis is related to *** To investigate whether the protective effects of rSj16 on colitis is related to apoptosis and its *** In-vivo,colitis was induced by *** severity of colitis was *** was used to detect the changes of apoptosis-related genes in colon tissues.Q-PCR was used to detect the changes of miRNA-217-5p and ***-vitro,WB was used to detect the changes of apoptosis-related genes in intestinal epithelial *** staining and flow cytometry were used to detect cell *** rSj16 attenuates clinical activity in DSS-induced colitis *** staining and WB results showed that apoptosis was increased in colon tissue after treatment with DSS,and the apoptosis of colon tissue was significantly reduced after treatment with *** with normal mice,the expression of miR-217-5p was increased in colon tissue of DSS-induced colitis *** addition,the miR-217-5p target gene hnf1b was decreased after administration of *** treatment with rSj16,the expression of miR-217-5p was decreased and the expression of HNF1B was increased compared with the DSS-treated *** Etoposide was used in combination with miR-217-5p mimic on MODE-K cells,the expression of cleaved-Caspase-3 and Bax was increased,and Bcl-2 was decreased compared with only Etoposide treatment,the expression of HNF1B was signif

关键词： Schistosoma japonicum rSj16 Inflammatory bowel disease Apoptosis miRNA-217-5p

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： yi Ji Chaoyi Yang Xuerui Pang yibing Yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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分块杯形砂轮磨削高硬度涂层球面温度

上海交通大学学报 2011年第11期45卷 1647-1652页

作者：蒋天一侯海云胡德金许开州上海交通大学机械与动力工程学院上海200240

针对分块杯形砂轮磨削高硬度涂层球面的实际工况,计算移动热源的有效宽度,并使用三角形移动热源模型对磨削温度场进行理论建模.分析了磨削运动对传热过程的影响,结合磨粒端面温度和一维导热模型计算热量传入工件比率.通过实验比较了分... 详细信息

针对分块杯形砂轮磨削高硬度涂层球面的实际工况,计算移动热源的有效宽度,并使用三角形移动热源模型对磨削温度场进行理论建模.分析了磨削运动对传热过程的影响,结合磨粒端面温度和一维导热模型计算热量传入工件比率.通过实验比较了分块杯形砂轮和普通杯形砂轮的磨削温度及磨后表面形貌,同时,分析了磨削参数对磨削温度的影响.结果表明:分块杯形砂轮磨削高硬度涂层球面较普通杯形砂轮具有更低的磨削温度和更好的磨削条件.

关键词：球面磨削杯形砂轮涂层材料断续磨削磨削温度

医药零售行业经营困境和对策分析——以深圳市医药零售市场为研究背景

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学术交流 2004年第3期 87-91页

作者：朱毅朝胡运权哈尔滨工业大学黑龙江哈尔滨150001

近年深圳市的医药零售行业出现了前所未有的良好发展势头,医药零售连锁经营走在全国前面。但是,由于国家宏观政策等主客观因素,医药零售行业在发展中遭遇区域分割和地方保护主义壁垒、连锁经营的规模不经济、发展资金缺乏等经营困境。... 详细信息

近年深圳市的医药零售行业出现了前所未有的良好发展势头,医药零售连锁经营走在全国前面。但是,由于国家宏观政策等主客观因素,医药零售行业在发展中遭遇区域分割和地方保护主义壁垒、连锁经营的规模不经济、发展资金缺乏等经营困境。为有效解决这些问题,须从提升公司核心竞争能力,建立现代公司组织管理体系,重视无形资产的输出,重视定点药店的开发,整合外部资源,构筑公司联盟和加强政府部门监督着手。

关键词：医药零售经营困境核心竞争力

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong hu Wenyi Lian Kang hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

Fabrication and Mechano-sensing Characteristics of Bending Polypyrrole Actuator

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 240-245页

作者： CHEN Jinyou hu Wei School of Automotive Engineering Hunan Financial&Industrial Vocational-technical CollegeHengyang 421002China College of Mechanical and Electrical Engineering Hunan Agricultural UniversityChangsha 410128China

To prepare a conductive polymer actuator with decent performance,a self-built experimental platform for the preparation of polypyrrole film is *** of the essential goals is to examine the mechanical characteristics of the actuator in the presence of various combinations of process parameters,combined with the orthogonal test method of"four factors and three levels".The bending and sensing characteristics of actuators of various sizes are methodically examined using a self-made bending polypyrrole *** functional relationship between the bending displacement and the output voltage signal is established by studying the characteristics of the actuator sensor subjected to various degrees of *** experimental results reveal that the bending displacement of the actuator tip almost exhibits a linear variation as a function of length and *** the voltage reaches 0.8 V,the bending speed of the actuator tends to be ***,the mechanical properties of the self-assembled polypyrrole actuator are verified by the design and fabrication of the microgripper.

关键词： conductive polymer polypyrrole mechanical characteristics actuators sensing characteristics

Optimizing Fine-Tuning in Quantized Language Models:An In-Depth Analysis of Key Variables

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Computers, Materials & Continua 2025年第1期82卷 307-325页

作者： Ao Shen Zhiquan Lai Dongsheng Li Xiaoyu hu National Key Laboratory of Parallel and Distributed Computing National University of Defense TechnologyChangsha410073China Strategic Assessments and Consultation Institute Academy of Military ScienceBeijing100091China

Large-scale Language Models(LLMs)have achieved significant breakthroughs in Natural Language Processing(NLP),driven by the pre-training and fine-tuning *** this approach allows models to specialize in specific tasks with reduced training costs,the substantial memory requirements during fine-tuning present a barrier to broader ***-Efficient Fine-Tuning(PEFT)techniques,such as Low-Rank Adaptation(LoRA),and parameter quantization methods have emerged as solutions to address these challenges by optimizing memory usage and computational *** these,QLoRA,which combines PEFT and quantization,has demonstrated notable success in reducing memory footprints during fine-tuning,prompting the development of various QLoRA *** these advancements,the quantitative impact of key variables on the fine-tuning performance of quantized LLMs remains *** study presents a comprehensive analysis of these key variables,focusing on their influence across different layer types and depths within LLM *** investigation uncovers several critical findings:(1)Larger layers,such as MLP layers,can maintain performance despite reductions in adapter rank,while smaller layers,like self-attention layers,aremore sensitive to such changes;(2)The effectiveness of balancing factors depends more on specific values rather than layer type or depth;(3)In quantization-aware fine-tuning,larger layers can effectively utilize smaller adapters,whereas smaller layers struggle to do *** insights suggest that layer type is a more significant determinant of fine-tuning success than layer depth when optimizing quantized ***,for the same discount of trainable parameters,reducing the trainable parameters in a larger layer is more effective in preserving fine-tuning accuracy than in a smaller *** study provides valuable guidance for more efficient fine-tuning strategies and opens avenues for further research into optimizing LLM

关键词： Large-scale Language Model Parameter-Efficient Fine-Tuning parameter quantization key variable trainable parameters experimental analysis

均匀设计在蚕蛹虫草和冬虫夏草活性成分分析中的应用

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分析测试学报 2004年第2期23卷 35-37,40页

作者：周枝凤梁逸曾胡芸郭方遒中南大学化学化工学院中药现代研究中心湖南长沙410083

采用均匀实验设计方法快速找到蚕蛹虫草活性成分的高效液相色谱最优分离条件 ;将该优化条件用于蚕蛹虫草和冬虫夏草的水溶性成分的分离取得满意结果 ,并对部分组分进行了定性定量分析 ;均匀实验设计方法可较快找到复杂未知或半未知体系... 详细信息

采用均匀实验设计方法快速找到蚕蛹虫草活性成分的高效液相色谱最优分离条件 ;将该优化条件用于蚕蛹虫草和冬虫夏草的水溶性成分的分离取得满意结果 ,并对部分组分进行了定性定量分析 ;均匀实验设计方法可较快找到复杂未知或半未知体系的色谱分离条件。

关键词：蚕蛹虫草冬虫夏草活性成分成分分析均匀设计高效液相色谱