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Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： ying-ying Tan ying-ying Liu yi-yan zhai yi-Xuan Wang Zhi-Shan Wu Antony Stalin Guo-Liang Cheng Bing Li Chao Wu Zhi-Hong Huang Shan Lu Xiao-Tian Fan Zheng Zhao Jia-Rui Wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

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Effect of Low-temperature Imidization on Properties and Aggregation Structures of Polyimide Films with Different Rigidity

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Chinese Journal of Polymer Science 2024年第8期42卷 1134-1146页

作者： yan Jia Lei zhai Song Mo yi Liu Li-Xin Liu Xin-Yu Du Min-Hui He Lin Fan Key Laboratory of Science and Technology on High-tech Polymer Materials Institute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

The traditional high-temperature preparation process of polyimide can cause many problems and limits the wider application in extreme *** important challenge to be solved urgently is the reduction of imidization *** this work,twelve kinds of polyimide films with different chain rigidity were prepared at low temperature of 200℃,in the absence or presence of imidazole used as the *** molecular rigidity and free volume were theoretically calculated,and relationship between structure and properties were systematically *** results show that imidization reaction under low temperatures is significantly affected by the rigidity of molecula r *** rigid structure of polyimide is not conducive to the low-temperature imidization,but this adverse effect can be eliminated by adding catalyst,resulting the notably increased imidization *** optical and thermal properties can be improved to a certain extent for the chemically catalyzed system,resulting in relatively higher heat resistance and thermal *** the mechanical performance could be determined by com plicating factors,greatly different from polyimide films prepa red by high temperature *** investigate aggregation structures of film s,the effect of chain rigidity and catalyst on the stacking or orientation of molecular chains was further *** wo rk can contribute to the understanding of chemically catalyzed imidization that is rarely reported in the existing research,and will provide guidance for the low-temperature preparation of high-performance polyimides.

关键词： Polyimide Imidization Catalyst Structure and properties Aggregation structures

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Measurement,Modelling and Analysis of Residence Time Distribution Characteristics in a Continuous Hydrothermal Reactor

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Journal of Thermal Science 2024年第4期33卷 1301-1311页

作者： LI yi zhai Binjiang WANG Junying WANG Weizuo JIN Hui State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China

Understanding the residence time distribution(RTD)of a continuous hydrothermal reactor is of great significance to improve product quality and reaction *** this work,an on-line measurement system is attached to a continuous reactor to investigate the characteristics of *** approach that can accurately fit and describe the experimental measured RTD curve by finding characteristic values is proposed for analysis and *** RTD curves of three experiment groups are measured and the characteristic values are *** show that increasing total flow rate and extending effective reactor length have inverse effect on average residence time,but they both cause the reactor to approach a plug flow reactor and improve the materials *** branch flow rate fraction has no significant effect on RTD characteristics in the scope of the present work except the weak negative correlation with the average residence ***,the natural convection stirring effect can also increase the average residence time,especially when the forced flow is *** analysis reveals that it is necessary to consider the matching of natural convection,forced flow and reactor size to control RTD when designing the hydrothermal reactor and working conditions.

关键词： continuous reactor residence time distribution modelling

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Enhanced nitrite electroreduction to ammonia via interfacial dual-site adsorption

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Journal of Energy Chemistry 2024年第9期96卷 328-335页

作者： Xiaokang Chen Shengliang zhai yi Tan Le Su Dong zhai Wei-Qiao Deng Hao Wu Institute of Frontier Chemistry School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266071ShandongChina College of Physics and Information Engineering Shanxi Normal UniversityTaiyuan 030031ShanxiChina Suzhou Research Institute of Shandong University Suzhou 215123JiangsuChina

The nitrite(NO_(2)^(−))to ammonia(NH3)electroreduction reaction(NO_(2)^(−)RR)would be impeded by sluggish proton-coupled electron transfer kinetics and competitive hydrogen evolution reaction(HER).A key to improving the NH_(3) selectivity is to facilitate adsorption and activation of NO_(2)^(−),which is generally undesirable in unitary *** this work,an efficient NO_(2)^(−)RR catalyst is constructed by cooperating Pd with In2O3,in which NO_(2)^(−)could adsorb on interfacial dual-site through“Pd–N–O–In”linkage,leading to strengthened NO_(2)^(−)adsorption and easier N=O bond cleavage than that on unitary Pd or ***,the Pd/In_(2)O_(3)composite exhibits moderate H^(*)adsorption,which may facilitate protonation kinetics while inhibiting competitive *** a result,it exhibits a fairly high NH_(3)yield rate of 622.76 mmol h^(−1)g^(−1)cat with a Faradaic efficiency(FE)of 95.72%,good selectivity of 91.96%,and cycling stability towards the NO_(2)^(−)RR,surpassing unitary In_(2)O_(3)and Pd/C ***,computed results indicate that NH_(3)production on Pd/In_(2)O_(3)follows the deoxidation to hydrogenation *** work highlights the significance of H^(*)and NO_(2)^(−)adsorption modulation and N=O activation in NO_(2)^(−)RR electrochemistry by creating synergy between a mediocre catalyst with an appropriate cooperator.

关键词： Dual-site adsorption Nitrite electroreduction Ammonia Pd Hydrogenation

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Cucurbit[8]uril-regulated face-to-face dimerization assembly enhanced photosensitization and photocatalysis

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Science China Chemistry 2024年第5期67卷 1605-1612页

作者： Haigen Nie Die Hu Zhiyao Zeng yan Fan Yaxin zhai Xin-Long Ni Key Laboratory of Chemical Biology and Traditional Chinese Medicine Ministry of Educational of ChinaKey Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangsha 410081China

In water, N,N′-diarylpyridinium thiazolo[5,4-d]thiazole guests(G1–G3) were encapsulated by cucurbit[8]uril(Q[8]) to construct Q[8]_(3)/G_(2) complexes, in which the encapsulated G molecules exist as an exact face-to-face dimer. These complexation behaviors have been indicated by proton nuclear magnetic resonance(~1H NMR) spectroscopy and isothermal titration calorimetry(ITC),and have been confirmed by X-ray single crystal structural analysis of Q[8]_(3)/G2_(2). While free guests G1–G3 have no ability to sensitize singlet oxygen, they all become effective singlet oxygen sensitizers when complexed with Q[8]. By irradiation of white light, Q[8]_(3)/G_(2) complexes induced selective oxidation of aryl sulfide to aryl sulfoxide in good yields and selective oxidation of dimethyl sulfide(DMS) to dimethyl sulfoxide(DMSO) in excellent yields without over-oxidation to dimethyl sulfone(DMSO_(2))even for elongated irradiation. High-yield photo-oxidation of DMS to DMSO_(2) was only achieved by irradiation of blue light in the presence of Q[8]_(3)/G1_(2), which was also effective in photobleaching of Rhodamine B in water. The higher photo-oxidation power of Q[8]_(3)/G1_(2) has been ascribed to an additional generation of reactive oxygen species besides singlet oxygen.

关键词： host-guest interaction dimerization macrocycles photosensitization

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Dynamic Treatment Strategy of Chinese Medicine for Metastatic Colorectal Cancer Based on Machine Learning Algorithm

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Chinese Journal of Integrative Medicine 2024年第11期30卷 993-1000页

作者： XU Yu-ying LI Qiu-yan yi Dan-hui CHEN Yue zhai Jia-wei ZHANG Tong SUN Ling-yun yanG Yu-fei Department of Oncology Xiyuan Hospital China Academy of Chinese Medical Sciences School of Statistics Renmin University of China Graduate School Beijing University of Chinese Medicine

Objective: To establish the dynamic treatment strategy of Chinese medicine(CM) for metastatic colorectal cancer(m CRC) by machine learning algorithm, in order to provide a reference for the selection of CM treatment strategies for m CRC. Methods: From the outpatient cases of m CRC in the Department of Oncology at Xiyuan Hospital, China Academy of Chinese Medical Sciences, 197 cases that met the inclusion criteria were screened. According to different CM intervention strategies, the patients were divided into 3 groups: CM treatment alone, equal emphasis on Chinese and Western medicine treatment(CM combined with local treatment of tumors, oral chemotherapy, or targeted drugs), and CM assisted Western medicine treatment(CM combined with intravenous regimen of Western medicine). The survival time of patients undergoing CM intervention was taken as the final evaluation index. Factors affecting the choice of CM intervention scheme were screened as decision variables. The dynamic CM intervention and treatment strategy for m CRC was explored based on the cost-sensitive classification learning algorithm for survival(CSCLSurv). Patients' survival was estimated using the Kaplan-Meier method, and the survival time of patients who received the model-recommended treatment plan were compared with those who received actual treatment plan. Results: Using the survival time of patients undergoing CM intervention as the evaluation index, a dynamic CM intervention therapy strategy for m CRC was established based on *** CM intervention strategies for m CRC can be selected according to dynamic decision variables, such as gender, age, Eastern Cooperative Oncology Group score, tumor site, metastatic site, genotyping, and the stage of Western medicine treatment at the patient's first visit. The median survival time of patients who received the modelrecommended treatment plan was 35 months, while those who receive the actual treatment plan was 26.0 months(P=0.06). Conclusions:

关键词： Chinese medicine cost sensitive classification learning for survival dynamic treatment strategy metastatic colorectal cancer

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The Application of Permanent Magnet Synchronous Motor with Small Electrical Time Constant in Fiber Positioner

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Research in Astronomy and Astrophysics 2024年第1期24卷 212-222页

作者： Shaoxiong Guo yan yang yanbin yin yihu Tang yang Tian Chao zhai Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230026China School of Biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Experiment Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

With the development of cutting-edge multi-object spectrographs,fiber positioners located in the focal plane are being scaled down in size,and miniature hollow-cup Permanent Magnet motors are now being considered as a suitable replacement for Faulhaber Precistep stepper ***,the small electrical time constant of such coreless motors poses a challenge,as the problem of severe commutation torque ripple in a fiber positioner running a position loop has been *** overcome this challenge,it is advised to increase the Pulse Width Modulation(PWM)frequency as much as possible to mitigate the effects of the current *** must be done while ensuring adequate resolution of the PWM *** employing a voltage open-loop field-oriented control based on a modulation frequency of 1 MHz,the drive current only costs 25 m A under a 3.3 V power *** sine degree of phase current is immaculate,and the repeat positioning accuracy can reach 2μ***,it is possible to further shrink the bill of devices and the layout area of the Printed Circuit Board,especially in sizesensitive *** device has been developed under the new generation of The Large Sky Area MultiObject Fiber Spectroscopic Telescope.

关键词： instrumentation:adaptive optics instrumentation:spectrographs proper motions reference systems

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： yi-Qun Li Fang-Zhou Sun Chun-Xiao Li Hong-Nan Mo yan-Tong Zhou Dan Lv Jing-Tong zhai Hai-Li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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The Contributions of Thrombospondin-1 to Epilepsy Formation

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Neuroscience Bulletin 2024年第5期40卷 658-672页

作者： Yao Cheng Yujie zhai yi Yuan Qiaoyun Wang Shucui Li Hongliu Sun School of Pharmaceutical Sciences Binzhou Medical UniversityYantai264003China

Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory *** synaptogenesis plays a vital role in the formation of overexcited *** evidence has confirmed that thrombospondin-1(TSP-1),mainly secreted by astrocytes,is a critical cytokine that regulates synaptogenesis during ***,numerous studies have reported that TSP-1 is also involved in other processes,such as angiogenesis,neuroinflammation,and regulation of Ca^(2+)homeostasis,which are closely associated with the occurrence and development of *** this review,we summarize the potential contributions of TSP-1 to epilepsy development.

关键词： Thrombospondin-1 Epileptogenesis Synaptogenesis Hyperexcitability

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Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish

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Zoological Research 2024年第2期45卷 355-366页

作者： Jing-yi Jia Guang-Hui Chen Ting-Ting Shu Qi-Yong Lou Xia Jin Jiang-yan He Wu-Han Xiao Gang zhai Zhan yin College of Fisheries Huazhong Agriculture UniversityWuhanHubei 430070China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Chinese Sturgeon Research InstituteChina Three Gorges CorporationYichangHubei 443100China Hubei Hongshan Laboratory Huazhong Agriculture UniversityWuhanHubei 430070China Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100049China

Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in ***,the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood,especially in *** this study,cyp17a1-/-zebrafish(Danio rerio)exhibited excessive visceral adipose tissue(VAT),lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis(DNL)*** assay for transposase accessible chromatinwithsequencing(ATAC-seq)results demonstrated that chromatin accessibility of DNL genes was increased in cyp17a1-/-fish compared to cyp17a1+/+male fish,including stearoyl-CoA desaturase(scd)and fatty acid synthase(fasn).Androgen response element(ARE)motifs in the androgen signaling pathway were significantly enriched in cyp17a1+/+male fish but not in cyp17a1-/-*** androgen receptor(ar)-/-and wildtype(WT)zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue,lipid content,and up-regulated expression and activity of hepatic de novo lipogenesis *** Ar agonist BMS-564929 reduced the content of VAT and lipid content,and down-regulated acetyl-CoA carboxylase a(acaca),fasn,and scd ***,the rescue effect of testosterone on cyp17a1-/-fish in terms of phenotypes was abolished when ar was additionally ***,these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish,thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.

关键词： Cyp17a1 Testosterone Androgen receptor De novo lipogenesis Fatty acid synthesis

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