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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： ZHONG yi LI Xin-yue LIANG Tian-jun DING Bao-zhu MA Ke-xin REN Wen-xuan LIANG Wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and *** RNAs(nc RNAs)are important regulatory *** Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting *** mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator *** NLRP3 protein is an important regulatory target for CVD prevention and treatment with *** the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms

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Deciphering the population structure and genetic basis of growth traits from whole-genome resequencing of the leopard coral grouper(Plectropomus leopardus)

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Zoological Research 2024年第2期45卷 329-340页

作者： Shao-xuan Wu Qi-Fan Zeng Wen-Tao Han Meng-Ya Wang Hui Ding Ming-xuan Teng Ming-yi Wang Pei-Yu Li Xin Gao Zhen-Min Bao Bo Wang Jing-Jie Hu MOE Key Laboratory of Marine Genetics and Breeding College of Marine Life Sciences/Key Laboratory of Tropical Aquatic Germplasm of Hainan ProvinceSanya Oceanographic InstitutionOcean University of ChinaQingdaoShandong/SanyaHainan 266100/572025China Hainan Seed Industry Laboratory SanyaHainan 572025China Southern Marine Science and Engineer Guangdong Laboratory GuangzhouGuangdong 511458China

The leopard coral grouper(Plectropomus leopardus)is a species of significant economic *** artificial cultivation of *** has thrived in recent decades,the advancement of selective breeding has been hindered by the lack of comprehensive population genomic *** this study,we identified over 8.73 million single nucleotide polymorphisms(SNPs)through whole-genome resequencing of 326 individuals spanning six distinct ***,we categorized 226 individuals with high-coverage sequencing depth(≥14×)into eight clusters based on their genetic profiles and phylogenetic ***,four of these clusters exhibited pronounced genetic differentiation compared with the other *** identify potentially advantageous loci for ***,we examined genomic regions exhibiting selective sweeps by analyzing the nucleotide diversity(θπ)and fixation index(FST)in these four *** these high-coverage resequencing data,we successfully constructed the first haplotype reference panel specific to *** achievement holds promise for enabling high-quality,***,we combined low-coverage sequencing data with imputation techniques for a genome-wide association study,aiming to identify candidate SNP loci and genes associated with growth traits.A significant concentration of these genes was observed on chromosome 17,which is primarily involved in skeletal muscle and embryonic development and cell ***,our detailed investigation of growth-related SNPs across the eight clusters revealed that cluster 5 harbored the most promising candidate SNPs,showing potential for genetic selective breeding *** findings provide a robust toolkit and valuable insights into the management of germplasm resources and genome-driven breeding initiatives targeting ***.

关键词： Plectropomus leopardus Whole-genome resequencing Growth Haplotype reference panel Single nucleotide polymorphisms

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Enterococcus faecalis provides protection during scavenging in carrion crow (Corvus corone)

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Zoological Research 2024年第3期45卷 451-463页

作者： Bin Hu Jia-Min Wang Qing-Xun Zhang Jing Xu Ya-Nan Xing Bo Wang Shu-yi Han Hong-xuan He CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Beijing Milu Ecological Research Center Beijing 102600China Beijing Capital International Airport Co. Ltd.Beijing 101300China

The gut microbiota significantly influences host physiology and provides essential ecosystem *** diet can affect the composition of the gut microbiota,the gut microbiota can also help the host adapt to specific dietary *** carrion crow(Corvus corone),an urban facultative scavenger bird,hosts an abundance of pathogens due to its scavenging *** this,carrion crows infrequently exhibit illness,a phenomenon related to their unique physiological *** present,however,the role of the gut microbiota remains incompletely *** this study,we performed a comparative analysis using 16S rRNA amplicon sequencing technology to assess colonic content in carrion crows and 16 other bird species with different diets in Beijing,*** findings revealed that the dominant gut microbiota in carrion crows was primarily composed of Proteobacteria(75.51%)and Firmicutes(22.37%).Significant differences were observed in the relative abundance of Enterococcus faecalis among groups,highlighting its potential as a biomarker of facultative scavenging behavior in carrion ***,*** isolated from carrion crows was transplanted into model mice to explore the protective effects of this bacterial community against Salmonella enterica *** showed that *** down-regulated the expression of pro-inflammatory cytokines tumor necrosis factor alpha(TNF-α),interferon gamma(IFN-γ),and interleukin 6(IL-6),prevented *** colonization,and regulated the composition of gut microbiota in mice,thereby modulating the host’s immune regulatory ***,*** exerts immunoregulatory and anti-pathogenic functions in carrion crows engaged in scavenging behavior,offering a representative case of how the gut microbiota contributes to the protection of hosts with specialized diets.

关键词： Carrion crow Facultative scavenger Gut microbiota Enterococcus faecalis 16S rRNA sequencing

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Holographic Polymer Nanocomposites with High Refractive Index Modulation by Doping Liquid Crystal E6M

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Chinese Journal of Polymer Science 2024年第7期42卷 926-935,I0006页

作者： Meng-Yun Wang Yue Zhang Dan Wang Ming Yao yi-xuan Wang Xing-Ping Zhou Hai-Yan Peng Xiao-Lin Xie Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China National Anti-counterfeit Engineering Research Center Huazhong University of Science and TechnologyWuhan430074China

Holographic optical elements(HOEs)based on polymer composites have become a research hot spot in recent years for augmented reality(AR)due to the significant improvement of optical performance,dynamic range,ease of processing and high yield ***,it remains a formidable challenge to obtain a large field of view(FOV)and brightness due to the limited refractive index ***,we report an effective method to tackle the challenge by doping an epoxy liquid crystal termed E6M,which enables a large refractive index modulation of 0.050@633 nm and low haze of 5.0%at a doping concentration of 5 wt%.This achievement may be ascribed to the improved molecular ordering of liquid crystals within the holographic polymer *** high refractive index modulation can endow transmission-type holographic polymer composites with a high diffraction efficiency of 96.2%at a small thickness of 5μm,which would promise the design of thin and lightweight AR devices.

关键词： Polymer nanocomposites Holography AR/VR Refractive index modulation Liquid crystal

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Lactobacillus plantarum and quercetin synergistically ameliorate hyperuricemia through targeting multiple pathways

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Food Science and Human Wellness 2024年

作者： Lin-Yan Zhu Meng-Yue Zhang Juan-Cheng yi-xuan Zhang School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University

Hyperuricemia is a prevalent metabolic disorder resulting from dysregulation of purine metabolism， often accompanied by inflammation. It is characterized by an abnormal elevation in uric acid levels. In our investigation， the combined treatment with Lactobacillus plantarum DY1 and quercetin suppressed the activity of xanthine oxidase and adenosine deaminase， decreased the levels of uric acid， TNF-α and IL-β， downregulated gene expression of URAT1 and GLUT9， and upregulated OAT1 and ABCG2. The combination increased the abundance of Lactobacillus and decreased the abundance of norank＿f＿norank＿o＿Clostridia＿UCG-014 and Roseburia. Metabolomics analysis revealed that the combination of probiotics and quercetin exhibited distinct metabolic pathways compared to their individual administrations. When compared to probiotics alone， the combination led to alterations in glutathione metabolism (oxidized glutathione and glutathione) as well as sphingolipid metabolism (sphingosine and sphinganine). When compared to quercetin alone， the combination resulted in variations in tryptophan metabolism (indole-3-acetamide， 5-hydroxy-L-tryptophan， indoleacetaldehyde， 3-(3-Indolyl)-2-oxopropanoic acid， 3-indoleacetic acid and 3-methylindole) along with purine metabolism (UA， xanthosine， cAMP， ADP and adenosine monophosphate). The subsequent fecal microbiota transplantation proved that the effect of the combination on reducing uric acid levels was mediated by the gut microbiota. Therefore， this new combination can be considered a promising adjuvant therapy capable of synergistically alleviating hyperuricemia.

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Copper-Free Click Chemistry-Mediated Assembly of Single Quantum Dot Nanosensor for Accurately Monitoring Locus-Specific m^(6)A in Cancer Cells

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Chinese Journal of Chemistry 2024年第5期42卷 499-504页

作者： Yue-ying Li Ning-Ning Zhao yi-xuan Geng Qian Han Jian-Ge Qiu Bing-Hua Jiang Zi-Yue Wang Chun-Yang Zhang Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityThe Academy of Medical SciencesHenan Institute of Medical and Pharmaceutical Sciences BGI CollegeZhengzhou UniversityZhengzhouHenan450052 China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandong250014 China School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu211189 China

N6-methyladenosine(m^(6)A)plays an important role in embryogenesis,nuclear export,transcription splicing,and protein translation ***,we demonstrate a copper-free click chemistry-mediated assembly of single quantum dot(QD)nanosensor for accurately monitoring locus-specific m^(6)A in cancer *** m^(6)A-sensitive endoribonuclease MazF can digest the unmethylated A-RNA,and the intact m^(6)A-RNA then hybridizes with DNA probes a and b to produce a sandwich hybrid,initiating the click chemistry to generate probe a–b ligation product via first tandem ligation detection reaction(LDR)***,DNA probes c and d can hybridize with the probe a–b ligation product to generate the probe c–d ligation product via second LDR *** LDR cycles can be repeated through denaturation and annealing reaction to generate abundant biotin-/fluorophore-modified probe c–d ligation products that can easily assemble on the QD surface to induce distinct fluorescence resonance energy transfer(FRET)between QD and *** assay can be homogenously performed without the involvement of copper catalyst,m^(6)A-specific antibody,radioactive labeling,ligase enzyme,enzymatic reverse transcription,and next-generation ***,it can discriminate even 0.01% m^(6)A level in complex samples and accurately measure cellular m^(6)A-RNA expression,providing a promising avenue for clinical diagnostics and biomedical research.

关键词： RNA methylation Click chemistry Förster resonance energy transfer Biosensor Cancer

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A Dielectric Ink Combining Acrylate and Cyanate Moieties for Inkjet 3D Printing with Good Thermal Stability

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Chinese Journal of Polymer Science 2024年第6期42卷 766-774页

作者： yi-xuan Li Liang-ying Wu Yan Yang Yao-Zhong Lu Zhong-ying Ji Yu-Xiong Guo Xiao-Long Wang Qiao-Sheng Pu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsLanzhou730000China Lanzhou Traditional Chinese Medicine Hospital of Orthopedics and Traumatology Lanzhou730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai264006China

Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and ***,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely *** ester(CE)polymers have excellent thermal stability,high strength,and low shrinkage compared to other common dielectric inks for inkjet 3D printing,but cannot be quickly shaped by ultraviolet(UV)irradiation or thermal *** CEs with UV-curable monomers may be a possible way to accelerate crosslinking,but there are challenges from the adverse effects of the dilution of both *** this study,dielectric inks with acrylate and cyanate moieties were *** low viscosity and surface tension of the CE precursor(Bisphenol E cyanate ester)were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D *** internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5%up to 326.69℃,hardness up to 431.84 MPa,dielectric constant of 2.70 at 8 GHz,and shrinkage of 1.64%.The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties.

关键词： Inkjet printing Cyanate ester resin 3D doubly cross-linked network Good thermal stability

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Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

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Chinese Chemical Letters 2024年第6期35卷 433-438页

作者： Boran Cheng Lei Cao Chen Li Fang-yi Huo Qian-Fang Meng Ganglin Tong xuan Wu Lin-Lin Bu Lang Rao Shubin Wang Department of Oncology Shenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchCancer InstitutePeking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China

As a type of new carbon-based nanomaterials,carbon dots(CDs)possess exceptional optical properties,making them highly desirable for use in fluorescent ***,the CDs with deep-red(DR)or near-infrared(NIR)emission have rarely been *** this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-CDs)by introducing a precursor simultaneously containing fluorine and *** synergistic effect of nitrogen doping and D-π-A pattern production contributed to the maximum emission of F-CDs at 636 nm with an absolute quantum yield of 36.00%±0.68%.Moreover,we designed an F-CDs-based fluorescence assay to determine the content of hypochlorite(ClO^(-)),with a limit of detection(LOD)as low as 15.4 nmol/L,indicating the high sensitivity of F-CDs to ClO^(-).In real samples,the F-CDs-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO^(-),with an error below 2%,suggesting their great potential in daily *** cancer cell imaging,the F-CDs not only demonstrated high sensitivity to ClO^(-)but also exhibited excellent mitochondria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization *** work presented here suggests the great potential of replacing commercial dyes with F-CDs for highly specific mitochondria labeling and cell imaging.

关键词： Carbon dots Near-infrared Cell imaging Mitochondria labeling Hypochlorite determination

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Effect of forging on the microstructure and texture of a high Nb containing γ-TiAl alloy

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Journal of Central South University 2024年第6期31卷 1763-1773页

作者： TAO Hui LI Hui-zhong WANG Li ZHOU Rui CHE yi-xuan CHEN Yong-hui LIANG Xiao-peng School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Key Laboratory of Nonferrous Metal Materials Science and Engineering Central South UniversityChangsha 410083China Department of Materials Science and Engineering City University of Hong KongKowloon 999077Hong KongChina

The effect of forging on the microstructure and texture evolution of a high Nb containing Ti-45Al-7Nb-0.3W(at.%)alloy was investigated by X-ray diffractometer(XRD),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).The results show that the as-cast alloy is mainly composed of α_(2)/γ lamellar colonies with a mean size of 70μm,but the hot-forged pancake displays a near duplex microstructure(DP).Kinking and bending of lamellar colonies,deformation twinning and dynamic recrystallization(DRX)occur during hot ***,dense dislocations in theβphase after forging suggest that the high-temperature β phase with a disordered structure is favorable for improving the hot-workability of the *** the common TiAl casting texture,the solidification process of the investigated as-cast alloy with high Nb content is completely via the β phase region,resulting in the formation of aγ fiber texture where theγ aligns parallel to the heat-flow *** comparison,the relatively strongand weaktexture components in the as-forged alloy are attributed to the deformation *** annealing,static recrystallization occurs at the twin boundary and intersections,which weakens the deformation texture.

关键词： high Nb containing γ-TiAl alloy forging microstructure texture β phase

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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1479-1499页

作者： xuan-Zeng Pei Min Cai Da-Wei Jiang Song-Hai Chen Qing-Qing Wang Hui-Min Lu yi-Fan Lu Department of Hepatological Surgery The First Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Our study investigated the role of FAM53B in regulating macrophage M2 polarization and its potential mechanisms in promoting pancreatic ductal adenocarcinoma(PDAC)*** To further investigate the role of FAM53B in regulating macrophage M2 polarization and its potential mechanism in promoting PDAC *** goal is to determine how FAM53B affects macrophage M2 polarization and to define its underlying mechanism in PDAC *** Cell culture and various experiments,including protein analysis,immunohisto-chemistry,and animal model experiments,were *** compared FAM53B expression between PDAC tissues and healthy tissues and assessed the correlation of FAM53B expression with clinical *** study analyzed the role of FAM53B in macrophage M2 polarization in vitro by examining the expression of relevant ***,we used a murine model to study the role of FAM53B in PDAC metastasis and analyzed the potential underlying *** Our research showed that there was a significant increase in FAM53B levels in PDAC tissues,which was linked to adverse tumor *** findings indicated that FAM53B can enhance macrophage M2 polarization,leading to increased anti-inflammatory factor *** results from the mouse model further supported the role of FAM53B in PDAC metastasis,as blocking FAM53B prevented tumor cell invasion and *** FAM53B promotes PDAC metastasis by regulating macrophage M2 *** discovery could lead to the development of new strategies for treating *** example,interfering with the FAM53B signaling pathway may prevent cancer *** research findings also provide important information for expanding our understanding of PDAC pathogenesis.

关键词： FAM53B Pancreatic ductal adenocarcinoma Tumor metastasis Macrophage polarization

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