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Down-regulation of histone deacetylase 7 reduces biological activities of retinal microvascular endothelial cells under high glucose condition and related mechanism

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1210-1217页

作者： Jia-yi Ning Han-yi Yang Ting-Ke Xie yi-xuan chen Jing Han Xi’an Medical University Xi’an 710021Shaanxi ProvinceChina Department of Ophthalmology Tangdu Hospitalthe Air Force Military Medical UniversityXi’an 710038Shaanxi ProvinceChina

AIM:To investigate the expression and effect of histone deacetylase 7(HDAC7)in human retinal microvascular endothelial cells(HRMECs)under high glucose condition and related mechanism,and the expression of HDAC7 in the retinal tissue in diabetic ***:The expression of HDAC7 in HRMECs under high glucose and the retinal tissue from normal or diabetic rats were detected with immunohistochemistry and Western ***-shHDAC7 HRMECs were used to study the effect of HDAC7 on cell *** count kit-8(CCK-8),5-ethynyl2’-deoxyuridine(EdU),flow cytometry,scratch test,Transwell test and tube formation assay were used to examine the ability of cell proliferation,migration,and ***,a preliminary exploration of its mechanism was performed by Western ***:The expression of HDAC7 was both upregulated in retinal tissues of diabetic rats and high glucosetreated ***-regulation of HDAC7 expression significantly reduced the ability of proliferation,migration,and tube formation,and reversed the high glucose-induced high expression of CDK1/Cyclin B1 and vascular endothelial growth factor in high glucose-treated ***:High glucose can up-regulate the expression of HDAC7 in ***-regulation of HDAC7 can inhibit HRMECs ***7 is proposed to be involved in pathogenesis of diabetic retinopathy and a therapeutic target.

关键词： human retinal microvascular endothelial cells histone deacetylase 7 high glucose diabetic rat vascular endothelial growth factor

Total-factor energy efficiency of ten major global energy-consuming countries

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Journal of Environmental Sciences 2024年第3期137卷 41-52页

作者： xuan Wang Yonglong Lu Chunci chen Xiaojie yi Haotian Cui State Key Laboratory of Urban and Regional Ecology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Marine Environmental Science and Key Laboratory of the Ministry of Education for Coastal Wetland Ecosystems College of the Environment and EcologyXiamen UniversityFujian 361102China University of Chinese Academy of Sciences Beijing 100049China

Improving energy efficiency is regarded as a key path to tackling global warming and achieving the Sustainable Development Goals(SDGs).In 2020,the energy consumption of the world's ten major energy-consuming countries accounted for 66.8%of the global *** paper applied data envelopment analysis(DEA)to calculate these ten major energyconsuming countries'total-factor energy efficiency(TFEE)at national and sectoral levels from 2001-2020,and explored the infuencing factors of total-factor energy efficiency with the Tobit regression *** results showed significant difference in the ten countries'energy *** United States and Germany topped the list for total-factor energy efficiency,while China and India were at the ***,the energy efficiency of the industrial subsector has increased significantly over the past two decades,while that of the other subsectors has been relatively *** industrial structure upgrading,per capita GDP,energy consumption structure,and foreign direct investment had significant impacts on energy efficiency with national *** consumption structure and GDP per capita were determinative factors of energy efficiency.

关键词： Total-factor energy efficiency SBM-UN model Major energy-consuming country Carbon emission reduction

Lipase and photodecarboxylase coexpression: A potential strategy for alkane-based biodiesel production from natural triglycerides

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Chinese Journal of Chemical Engineering 2024年第3期67卷 238-246页

作者： Yong-yi Zeng Xin-yi Xu Jin-xuan Xie Wen-Li chen Lan Liu Xin-Jian yin Bi-Shuang chen School of Marine Sciences Sun Yat-Sen UniversityZhuhai 519080China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Alkane-based biodiesel is considered the next generation of biodiesel owing to its potential environmental benefits and the fact that it exhibits much higher specific caloric values than traditional ***,the formidable obstacle impeding the commercialization of this cutting-edge fuel alternative lies in the cost associated with its *** this study,an engineered strain Escherichia coli(***)showcasing harmonized coexpression of a lipase(from Thermomyces lanuginosus lipase,TLL)and a fatty acid photodecarboxylase(from Chlorella variabilis,CvFAP)was first constructed to transform triglycerides into *** potential of *** BL21(DE3)/pRSFDuet-1-TLL-CvFAP for alkane synthesis was evaluated with tripalmitin as a model substrate under various process *** a comprehensive examination of the reaction parameters,the scope of the biotransformation was expanded to‘real’substrates(vegetable oils).The results showed that bioderived oils can be transformed into alkanes with high yields(0.80-10.20 mmol·L^(-1))under mild conditions(35℃,pH 8.0,and 36 h)and blue light *** selected processes were performed on an increased lab scale(up to 100 ml)with up to 24.77 mmol·L^(-1) tripalmitin,leading to a yield of 18.89 mmol·L^(-1) *** the employment of a method for efficiently producing alkanes under mild conditions and a simple procedure to isolate alkanes from the reaction system,the utilization of sustainable biomass as a fundamental feedstock emerges as the primary solution to lower the cost of alkane-based ***,this study proposes a readily implementable and highly effective approach for alkane-based biodiesel production.

关键词： Alkane-based biodiesel Renewable biomass Co-overexpression Lipase Photodecarboxylase

Chiral thermally activated delayed fluorescence materials for circularly polarized organic light-emitting diodes

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Science China Chemistry 2024年第4期67卷 1097-1116页

作者： Li Yuan yi-Pin Zhang You-xuan Zheng State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresJiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Chirality is an important natural characteristic of organic molecules,and chiral organic molecules have shown extensive application in areas such as pharmaceutical development and material *** from the ability to achieve circularly polarized luminescence(CPL),chiral luminescent materials have shown potential applications in anti-glare display,optical communication and,3D display,*** to the ability to harvest both singlet and triplet excitons by a fast reverse intersystem crossing process without involving noble metals,chiral thermally activated delayed fluorescence(TADF)materials with point chirality,axial chirality,planar chirality and helical chirality are regarded as the state-of-the-art materials for circularly polarized organic light-emitting diodes(CP-OLEDs).In recent years,the chiral TADF materials and CP-OLEDs have rapidly developed,but unfortunately,the dissymmetry factors(g)are far from the requirement of practical *** ideal emitters and devices should have both high efficiency and a g factor,or at least a balance between these two *** review gives an overview of recent progress in chiral TADF materials,with a particular focus on the chiral skeleton,CPL property and device ***,the molecular design concept,device structure and methods to improve the g factors of chiral materials and CP-OLEDs are also discussed.

关键词： chiral thermally activated delayed fluorescence material chiral skeleton circularly polarized luminescence circularly polarized organic light-emitting diodes dissymmetry factor

Reference values of gait parameters in healthy Chinese university students: A cross-sectional observational study

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World Journal of Clinical Cases 2023年第29期11卷 7061-7074页

作者： Jin-Sheng Yu chen Zhuang Wen-xuan Guo Jun-Jie chen Xiang-Ke Wu Wei Xie Xing Zhou Hui Su yi-xuan chen Li-Kang Wang Wen-Kai Li Kun Tian Ru-Jie Zhuang The First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310003Zhejiang ProvinceChina Alberta Institute Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Gait is influenced by race,age,and diseases *** values for gait are closely related to numerous health *** gain a comprehensive understanding of gait patterns,particularly in relation to race-related pathologies and disorders,it is crucial to establish reference values for gait in daily life considering sex and ***,our objective was to present sex and age-based reference values for gait in daily life,providing a valuable foundation for further research and clinical *** To establish reference values for lower extremity joint kinematics and kinetics during gait in asymptomatic adult women and *** Spatiotemporal,kinematics and kinetics parameters were measured in 171 healthy adults(70 males and 101 females)using the computer-aided soft tissue foot *** curve statistical parametric mapping was performed using independent and paired-samples *** Compared with females,males required more time(cycle time,double-limb support time,stance time,swing time,and stride time),and the differences were statistically *** addition,the step and stride lengths of males were *** to males,female cadence was faster,and statures-per-second and stride-per-minute were *** were no statistical differences in speed and stride width between the two *** adjusting for height,it was observed that women walked significantly faster than men,and they also had a higher ***,in terms of step length,stride length,and stride width,both genders exhibited *** We established reference values for gait speed and spatiotemporal gait parameters in Chinese university *** contributes to a valuable database for gait assessment and evaluation of preventive or rehabilitative programs.

关键词： Gait analysis Gait Reference values Spatiotemporal parameters Kinematics Chinese

Free radicals trigger the closure of open pores in lignin-derived hard carbons toward improved sodium-storage capacity

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Journal of Energy Chemistry 2024年第7期94卷 551-559页

作者： Wen-Jun Ji Zong-Lin yi Ming-Xin Song Xiao-Qian Guo yi-Lin Wang yi-xuan Mao Fang-Yuan Su Jing-Peng chen Xian-Xian Wei Li-Jing Xie cheng-Meng chen CAS Key Laboratory of Carbon Materials Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001ShanxiChina University of Chinese Academy of Sciences Beijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030001ShanxiChina

The chemical activation of various precursors is effective for creating additional closed pores in hard carbons for sodium ***,the formation mechanism of closed pores under the influence of pore-forming agents is not well ***,an effective chemical activation followed by a high-temperature self-healing strategy is employed to generate interconnected closed pores in lignin-derived hard carbon(HCs).By systematic experimental design combined with electron paramagnetic res-onance spectroscopy,it can be found that the content of free radicals in the carbon matrix influences the closure of open pores at high *** high activation temperature(>700 C)leads to a low free radical concentration,making it difficult to achieve self-healing of open pores at high *** activation at 700°C,a balance between pore making and self-healing is achieved in the final hard carbon.A large number of free radicals triggers rapid growth and aggregation of carbon microcrys-tals,blocking pre-formed open micropores and creating additional interconnected closed pores in as-obtained hard *** a result,the optimized carbon anode(LK-700-1300)delivers a high reversible capacity of 330.8 mA h g^(-1) at 0.03 A g^(-1),which is an increase of 86 mA h g^(-1) compared to the pristine lignin-derived carbon anode(L-700-1300),and exhibits a good rate performance(202.1 mA h g^(-1) at 1 A g^(-1)).This work provides a universal and effective guidance for tuning closed pores of hard carbons from otherprecursors.

关键词： Hard carbon Chemical activation Free radical Self-healing Closed pores Sodium ion batteries

Influence of ecological function protection zone on the water conservation in Gansu-Qinghai Contiguous Region of the upper Yellow River

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Journal of Mountain Science 2024年第4期21卷 1345-1357页

作者： TONG Huali chen Qingbo ZHANG xuan College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China Gansu Province Land Use and Comprehensive Improvement Engineering Research Center Lanzhou 730070China

The implementation of Ecological Function Protection Zone(EFPZ)policy is significant for the ecological restoration and conservation of soil and water in the territory *** manuscript analyzed and quantified the impact of EFPZ on the regional water conservation function,based on land use data from 2005,2008,2010,2015 and 2020,by conducting a counterfactual simulation along with the GeoSOS-FLUS model and the InVEST *** results demonstrate that the delineation of EFPZ can significantly influence the water conservation.(1)From 2010 to 2020,as the EFPZ was implemented,the water conservation in the study area was increasing year by year,with a growth rate of 0.03×10^(8) m^(3)∙a^(-1).On the other hand,the simulated water conservation capacity without the implementation of EFPZ decreased year by year,with a decrease rate of 0.01×10^(8) m^(3)∙a^(-1).(2)The EFPZ accounts for only 23%of the total area,but the contribution rate of water conservation reaches 80%.The actual values of water conservation and average water yield per unit pixel in the EFPZ show an increasing trend both internally and externally,while the counterfactual simulation values exhibit a decreasing trend.(3)The water conservation is much higher within the EFPZ than without *** implementation of EFPZ has a significant effect on the improvement of the water conservation capacity in Maqu EFPZ and Yellow River Source *** protection effectiveness should be enhanced in Qilian Mountain EFPZ and afforestation activities need to be carefully considered in Loess Plateau EFPZ.

关键词： Water conservation function Ecological Function Protection Zone Counterfactual simulation Geo SOS-FLUS model InVEST model

Rts: learning robustly from time series data with noisy label

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Frontiers of Computer Science 2024年第6期18卷 186332-186332页

作者： ZHOU Zhi JIN yi-xuan Li Yu-Feng National Key Laboratory for Novel Software Technology Nanjing University

Significant progress has been made in machine learning with large amounts of clean labels and static data. However, in many real-world applications, the data often changes with time and it is difficult to obtain massive clean annotations, that is, noisy labels and time series are faced simultaneously. For example, in product-buyer evaluation, each sample records the daily time behavior of users, but the long transaction period brings difficulties to analysis, and salespeople often erroneously annotate the user’s purchase behavior. Such a novel setting, to our best knowledge, has not been thoroughly studied yet, and there is still a lack of effective machine learning methods. In this paper, we present a systematic approach RTS both theoretically and empirically, consisting of two components, Noise-Tolerant Time Series Representation and Purified Oversampling Learning. Specifically, we propose reducing label noise’s destructive impact to obtain robust feature representations and potential clean samples. Then, a novel learning method based on the purified data and time series oversampling is adopted to train an unbiased model. Theoretical analysis proves that our proposal can improve the quality of the noisy data set. Empirical experiments on diverse tasks, such as the house-buyer evaluation task from real-world applications and various benchmark tasks, clearly demonstrate that our new algorithm robustly outperforms many competitive methods.

关键词： weakly-supervised learning time-series classification class-imbalanced learning

Effects of dimethyl ether and ethanol additions on soot transition in ethylene counterflow diffusion flames

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Science China(Technological Sciences) 2024年第4期67卷 1094-1112页

作者： GUO LinGe yiNG YaoYao chen chen ZHAO xuan LIU Dong MIIT Key Laboratory of Thermal Control of Electronic Equipment School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Advanced Combustion Laboratory School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China

This paper investigates the effect of blending dimethyl ether(DME)and ethanol on the soot transition periods in ethylene counterflow diffusion flames by using a novel optical diagnostic *** soot critical transition point in different conditions is identified experimentally and *** kinds of flames are carried out to gain the soot critical transition point in counterflow diffusion flames by changing oxygen fraction(Xo)and changing volume flow rates of fuel and oxidizer(Qv).The red-green-blue(RGB)ratio method is used to precisely identify the soot critical transition point,and chemical kinetic simulations are performed to analyze the detailed reaction *** results show that compared to the ethylene flame,the soot critical transition point occurs at a higher Xoand a lower Qvwhen DME or ethanol is *** addition of DME and ethanol can inhibit soot formation,due to the degree of soot formation reaction being lower than the degree of the oxidation reaction in the blending flames.

关键词： optical diagnosis sooting tendency counterflow diffusion flame dimethyl ether ethanol