检索结果-南通市图书馆

Integrated ribosome and proteome analyses reveal insights into sevoflurane-induced long-term social behavior and cognitive dysfunctions through ADNP inhibition in neonatal mice

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第3期45卷 663-678页

作者： Li-Rong Liang Bing Liu Shu-Hui Cao You-yi Zhao Tian Zeng Mei-Ting Zhai Ze Fan Dan-yi He San-xin ma Xiao-Tong Shi Yao Zhang Hui Zhang State Key Laboratory of Oral&maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of AnesthesiologySchool of StomatologyAir Force Medical UniversityXi’anShaanxi 710032China Department of Anesthesiology 986th Air Force HospitalAir Force Medical UniversityXi’anShaanxi 710032China

A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive ***,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive ***,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly *** this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal *** neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral *** indicated that ADNP was significantly down-regulated following developmental exposure to *** adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine ***,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane ***-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by *** analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic *** of Wnt signaling was restored in the davunetide-treated ***,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general *** study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal

关键词： Davunetide Sevoflurane Abnormal social behaviors ADNP Neurotoxicity

Improved Reall-Santos method for AdS black holes in general 4-derivative gravities

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 74-86页

作者： Peng-Ju Hu Liang ma Hong Lü yi Pang Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China Peng Huanwu Center for Fundamental Theory Hefei 230026China

For asymptotically flat black holes,Reall-Santos method is a convenient tool to compute leading higher derivative corrections to the thermodynamic quantities without actually solving the modified field ***,there are subtleties in its generalization to asymptotically AdS black holes with general higher derivative *** of all,it is necessary to know all the higher derivative holographic counterterms and the surface terms implementing the variational principle and subtracting the *** then needs to solve for the modified AdS radius and rescale the time coordinate in an appropriate way such that the induced metric on the conformal boundary of AdS black hole is not *** observe that Reall-Santos method can be directly applied to a particular 4-derivative gravity model,known as the Einstein-Weyl gravity,which does not modify the AdS radius and requires only the Gibbons-Hawking-York term and holographic counterterms for the 2-derivative *** thus suggest that to compute the thermodynamic quantities of AdS black holes in general 4-derivative theories of gravity,one simply needs to transform it to a Einstein-Weyl gravity with identical thermodynamic variables by appropriate field *** explicitly verify this proposal with spherically-symmetric and static charged black holes in Einstein-maxwell theory extended with generic 4-derivative interactions.

关键词： black holes thermodynamics higher-derivative corrections effective theories higher dimensional black holes quantum gravity

Facile and effective synthesis strategy for terbium-doped hydroxyapatite toward photoelectric devices and flexible functional fibers

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第4期43卷 1713-1723页

作者： Xiao-Dong Zhang Kun Nie Zi-Yao Hu Ran-Ran Zhou Xiu-Qiang Duan Wu-Bin Dai Song-Song Nie Song-Jun Yao Luo-xin Wang Le-Fu Mei Hua Wang yi-yi Yao Xiao-Xue ma Hubei Key Laboratory for New Textile materials and Applications and State Key Laboratory of New Textile materials and Advanced Processing Technology School of Materials Science and EngineeringWuhan Textile UniversityWuhan430200China Key Laboratory of Testing and Tracing of Rare Earth Products for State market Regulation Jiangxi University of Science and TechnologyGanzhou341000China Hubei Key Laboratory of Plasma Chemistry and Advanced materials and Key Laboratory of Green Chemical Engineering Process of Ministry of Education Wuhan Institute of TechnologyWuhan430205China

As a material with good biocompatibility,hydroxyapatite(HAP)can have optical properties after doping with various rare earth *** a biocompatible fluorescent material,doped HAP could have broad applications in biological probes,drug delivery,optoelectronic materials,fluorescence anti-counterfeiting,and other *** this paper,we put forward the preparation of HAP doped with terbium(Ⅲ)ions(Tb^(3+))by hydrothermal *** controlling the Tb^(3+)doping content in reaction and the reaction time,the changes in HAP's structure,morphology,and luminescence properties under different conditions were *** the doping amount of Tb^(3+)reached an optimal value,the dipole-quadrupole would occur and the concentration would be *** control experiment showed that the optimal Tb3+content was 7.5×10^(-5)mol,which showed the best fluorescence ***,a non-luminous material,was rarely used in the field of fluorescent anti-counterfeiting and photoelectric *** proposed to prepare a luminescent aramid/polyphenylene sulfide(ACFs/PPS)fiber paper and a new light-emitting diode(LED)using the Tb-doped HAP *** composite sample exhibited an excellent stability and fluorescence performance,which also demonstrated a possibility of HAP applications in anticounterfeiting and *** introduction of Tb3+dopant HAP was done to give HAP optical properties and broaden the application range of HAP.

关键词： Hydroxyapatite Rare earth luminescence Photoelectric device Aramid Polyphenylene sulfide fiber paper Luminescent fiber

Experimental investigation of dynamic characteristics of leaching tubing for solution mining of salt cavern carbon and energy storage

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第4期21卷 2703-2722页

作者： yin-Ping Li xin-Bo Ge Xi-Lin Shi Hong-Ling ma State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil Mechanics Chinese Academy of Sciences University of Chinese Academy of Sciences College of Energy and Mining Engineering Shandong University of Science and Technology State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology

Salt caverns are extensively utilized for storing various substances such as fossil energy, hydrogen,compressed air, nuclear waste, and industrial solid waste. In China, when the salt cavern is leached through single-well water solution mining with oil as a cushion, engineering challenges arise with the leaching tubing, leading to issues like damage and instability. These problems significantly hinder the progress of cavern construction and the control of cavern shape. The primary cause of this is the flowinduced vibration instability of leaching tubing within a confined space, which results in severe bending or damage to the tubing. This study presents a model experimental investigation on the dynamic characteristics of leaching tubing using a self-developed liquid-solid coupling physical model experiment apparatus. The experiment utilizes a silicone-rubber pipe(SRP) and a polycarbonate pipe(PCP) to examine the effects of various factors on the dynamic stability of cantilevered pipes conveying fluid. These factors include external space constraint, flexural rigidity, medium outside the pipe, overhanging length, and end conditions. The experiments reveal four dynamic response phenomena: water hammer, static buckling, chaotic motion, and flutter instability. The study further demonstrates that the length of the external space constraint has a direct impact on the flutter critical flow velocity of the cantilevered pipe conveying fluid. Additionally, the flutter critical flow velocity is influenced by the end conditions and different external media.

关键词： Salt cavern storage Solution mining Leaching tubing Experimental investigation Flutter instability

Deployment of Edge Computing Nodes in IoT:Effective Implementation of Simulated Annealing Method Based on User Location

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

China Communications 2024年第1期21卷 279-296页

作者： Junhui Zhao Ziyang Zhang Zhenghao yi Xiaoting ma Qingmiao Zhang School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Information Engineering East China Jiaotong UniversityNanchang 330013China

Edge computing paradigm for 5G architecture has been considered as one of the most effective ways to realize low latency and highly reliable communication,which brings computing tasks and network resources to the edge of *** deployment of edge computing nodes is a key factor affecting the service performance of edge computing *** this paper,we propose a method for deploying edge computing nodes based on user *** the combination of Simulation of Urban Mobility(SUMO)and Network Simulator-3(NS-3),a simulation platform is built to generate data of hotspot areas in Io T *** effectively using the data generated by the communication between users in Io T scenario,the location area of the user terminal can be *** this basis,the deployment problem is expressed as a mixed integer linear problem,which can be solved by Simulated Annealing(SA)*** analysis of the results shows that,compared with the traditional method,the proposed method has faster convergence speed and better performance.

关键词： deployment problem edge computing internet of things machine learning

Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： ZHANG Yue XIAO Yan-wei ma Jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and ***:HaCaT cells were treated with *** proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration *** mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,***_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with *** expression of circ_0084443 was detected by ***:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

Hyperspectral remote sensing identification of marine oil spills and emulsions using feature bands and double-branch dual-attention mechanism network

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第3期42卷 728-743页

作者： Ning ZHANG Junfang YANG Shanwei LIU yi ma Jie ZHANG College of Oceanography and Space Informatics China University of PetroleumQingdao 266580China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

The accurate identification of marine oil spills and their emulsions is of great significance for emergency response to oil spill *** selection of characteristic bands with strong separability helps to realize the rapid calculation of data on aircraft or in orbit,which will improve the timeliness of oil spill emergency *** the same time,the combination of spectral and spatial features can improve the accuracy of oil spill *** ground-based experiments were designed to collect measured airborne hyperspectral data of crude oil and its emulsions,for which the multiscale superpixel level group clustering framework(MSGCF)was used to select spectral feature bands with strong *** addition,the double-branch dual-attention(DBDA)model was applied to identify crude oil and its *** with the recognition results based on original hyperspectral images,using the feature bands determined by MSGCF improved the recognition accuracy,and greatly shortened the running ***,the characteristic bands for quantifying the volume concentration of water-in-oil emulsions were determined,and a quantitative inversion model was constructed and applied to the AVIRIS image of the deepwater horizon oil spill event in *** study verified the effectiveness of feature bands in identifying oil spill pollution types and quantifying concentration,laying foundation for rapid identification and quantification of marine oil spills and their emulsions on aircraft or in orbit.

关键词： hyperspectral image spectral analysis dimensionality reduction multiscale superpixel level group clustering framework(MSGCF) double-branch dual-attention(DBDA)

Cucurbit[n]uril-based nanostructure construction and modification

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第8期35卷 138-148页

作者： Lijun mao Shuo Li xin Zhang Zhan-Ting Li Da ma School of Pharmaceutical Engineering&Institute for Advanced Studies Taizhou UniversityJiaojiang 318000China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China

New fabrication method of nanostructures is of great importance for the applications of nanoscience and *** review summarizes cucurbit[n]uril(CB[n])-based nanostructure fabrication and modification *** strategies include the use of CB[n]s as building blocks and supramolecular crosslinkers to fabricate nanostructures,to surface modify nanostructures,and as gatekeepers to control the release of encapsulated *** nanostructures are used for drug delivery,bioimaging,chemical sensing,catalysis and other ***[n]s often play a vital role in the fabrication of these nanos-tructures,and the realization of the applications.

关键词： Cucurbit[n]uril Nanostructure Host-guest interaction Nanofabrication

Investigations of the mechanical response of dummy HTPB propellant grain under ultrahigh acceleration overload conditions using onboard flight-test measurements

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第2期32卷 473-484页

作者： yiming Zhang Ningfei Wang Weihua ma Ran Wang Long Bai yi Wu School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Beijing System Design Institute of Electro-mechanic Engineering Beijing 100854China Xi'an Changfeng Research Institute of Mechanism and Electricity Xi'an 710065China

In this paper,to study the mechanical responses of a solid propellant subjected to ultrahigh acceleration overload during the gun-launch process,specifically designed projectile flight tests with an onboard measurement system were *** projectiles containing dummy HTPB propellant grains were successfully recovered after the flight tests with an ultrahigh acceleration overload value of 8100 *** onboard-measured time-resolved axial displacement,contact stress and overload values were successfully obtained and *** compression tests of the dummy HTPB propellant used in the gunlaunched tests were carried out at low and intermediate strain rates to characterize the propellant's dynamic properties.A linear viscoelastic constitutive model was employed and applied in finite-element simulations of the projectile-launching *** the launch process,the dummy propellant grain exhibited large deformation due to the high acceleration overload,possibly leading to friction between the motor case and propellant *** calculated contact stress showed good agreement with the experimental results,though discrepancies in the overall displacement of the dummy propellant grain were *** dynamic mechanical response process of the dummy propellant grain was analysed in *** results can be used to estimate the structural integrity of the analysed dummy propellant grain during the gun-launch process.

关键词： Gun-launched flight test Dummy HTPB propellant Onboard measurements Utrahigh overload Mechanical response