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IL-13 R110Q, a naturally occurring IL-13 polymorphism, correlateswith enhanced functional activity in cultured human bronchial smooth muscle cells

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IL-13 R110Q, a naturally occurring IL-13 polymorphism, corre...

Review of Cement Concrete Pavement Preventive Maintenance in High Grade Highway

2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班

作者： Ya-fang He Li Hua yi-xiao bao Quan-hua Liu yi Chu Ding-zhu Fang 新华医院小儿呼吸科

Objective IL-13, a Th2-type cytokine, has been reported to play a pivotal role in the pathogenesis of asthma. It has been shown to exert detrimental effects on asthma by acting directly on airway smooth muscle. IL-13 R110Q, a naturally occurring IL-13 polymorphism, has been shown to be strongly associated with increased total serum IgE levels and asthma. In the present study, we aimed to determine if this IL-13 variant displays

关键词： IL-13 R110Q a naturally occurring IL-13 polymorphism correlateswith enhanced functional activity in cultured human bronchial smooth muscle cells

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Review of Cement Concrete Pavement Preventive Maintenance in...

IL-13 R110Q,a naturally occurring IL-13 polymorphism,correlates with enhanced functional activity in cultured human bronchial smooth muscle cells

4～(th) International Conference on Road & Airfield Pavement Technology

作者： Tanglin xiao yi-ming bao chuan-fu zhanghongAnhni province Expressway General Corp CHN

＜正＞ From the point of view of preventive maintenance, combining the technical features of cement concrete pavement maintenance, this paper proposes processing measurements for common distresses of cement concrete p... 详细信息

关键词： cement concrete pavement preventive maintenance pavement distress pavement drainage slab jacking

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IL-13 R110Q,a naturally occurring IL-13 polymorphism,correla...

Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition)

中华医学会第十七次全国儿科学术大会

作者： Yafang He,Li Hua,Quan-hua Liu,yi Chu,yi-xiao bao. Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine

Background and purpose IL-13,a Th2-type cytokine,has been reported to play a pivotal role in the pathogenesis of *** has been shown to exert detrimental effects on asthma by acting directly on airway smooth muscle(ASM).IL-13 R110Q,a naturally occurring IL-13 polymorphism, has been shown to be strongly associated with increased total serum IgE levels and *** the

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World Journal of Pediatrics 2018年第5期14卷 437-447页

作者： Xing-Wang Li Xin Ni Su-Yun Qian Quan Wang Rong-Meng Jiang Wen-Bo Xu Yu-Cai Zhang Guang-Jun Yu Qiang Chen Yun-xiao Shang Cheng-Song Zhao Hui Yu Ting Zhang Gang Liu Hui-Ling Deng Jie Gao Xian-Gui Ran Qiao-Zhi Yang Bian-Li Xu Xue-Yong Huang Xing-Dong Wu yi-xiao bao yi-Ping Chen Zhi-Hai Chen Qing-Quan Liu Guo-Ping Lu Chun-Feng Liu Rong-Bing Wang Guo-Liang Zhang Fang Gu Hong-Mei Xu ying Li Tao Yang Infectious Disease Diagnosis and Treatment Center Beijing Ditan Hospital Capital Medical UniversityBeijingChina Otorhinolaryngology Head andN eck Surgery Beijing Children’s HospitalCapital Medical UniversityBeijingChina Prediatric Intensive Care Unit Beijing Children’s Hospital of Capit al Medical UniversityBeijingChina National Institute For Viral Disease Control and Prevention Chinese Center for Disease Control and Pre ventionBeijingChina Children’s Hospital ofShanghai Jiaotong University ShanghaiChina Pneumology department Jiangxi Provincial Children’s HospitalNanchangChina Department of P ediatric Pneumology Shengjing Hospital of China Medical UniversityShenyangChina Department of Inf ectious Diseases Beijing Children’s HospitalCapital Medical UniversityBeijingChina Department of Inf ectious Diseases Children’s Hospital of Fudan UniversityShanghaiChina Digestive Department Children’s Hospital of Shanghai Jiaotong UniversityShanghaiChina Department of Inf ectious Diseases The Children’s Hospital of Xi'anXi’anChina Infection Control Offi ce Children’s Hospital ofShanghai Jiaotong UniversityShanghaiChina Department ofR espiratory Medicine People’s Hospital ofFuy ang CityFuyangChina Department of P ediatrics People’s Hospital of Liaoc heng CityLiaochengChina

Background Hand, foot, and mouth disease (HFMD) is a common infectious disease in childhood caused by an enterovirus (EV), and which is principally seen in children under 5 years of age. To promote diagnostic awareness and effective treat-ments, to further standardize and strengthen the clinical management and to reduce the mortality of HFMD, the guidelines for diagnosis and treatment have been developed. Methods National Health Commission of China assembled an expert committee for a revision of the guidelines. The com-mittee included 33 members who are specialized in diagnosis and treatment of HFMD. Results Early recognition of severe cases is utmost important in diagnosis and treatment of patients with HFMD. The key to diagnosis and treatment of severe cases lies in the timely and accurate recognition of stages 2 and 3 of HFMD, in order to stop progression to stage 4. Clinicians should particularly pay attention to those EV-A71 cases in children aged less than 3 years, and those with disease duration less than 3 days. The following indicators should alert the clinician of possible deterioration and impending critical disease: (1) persistent hyperthermia;(2) involvement of nervous system;(3) worsening respiratory rate and rhythm;(4) circulatory dysfunction;(5) elevated peripheral WBC count;(6) elevated blood glucose and (7) elevated blood lactic acid. For treatment, most mild cases can be treated as outpatients. Patients should be isolated to avoid cross-infection. Intense treatment modalities should be given for those severe cases. Conclusion The guidelines can provide systematic guidance on the diagnosis and management of HFMD.

关键词： Diagnosis Guidelines HFMD Treatment

上海地区儿童哮喘易感基因单核苷酸多态性研究

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中华儿科杂志 2009年第4期47卷 303-304页

作者：华丽鲍一笑董晓艳吕婕洪建国上海交通大学医学院附属新华医院儿内科 200092 上海交通大学附属第一人民医院儿科

2007年3月-2008年3月，我们选取5个最常见哮喘相关基因（IL-13、IL-4、IL-4 RA、FcεRI、ADRβ2基因）的8个单核苷酸多态性（SNP）位点（IL-13 C-1112T、C1923T；IL-4 C-590T；IL-4RA I75V；FcεRIC-109T、E237G；ADRβ2R16G、Q27E），... 详细信息

关键词：单核苷酸多态性哮喘易感基因上海地区儿童哮喘 FcεRI IL-4 SNP位点相关基因

Tuning the interfacial reaction environment via pH-dependent and induced ions to understand C–N bonds coupling performance in NO3- integrated CO2 reduction to carbon and nitrogen compounds over dual Cu-based N-doped carbon catalyst

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Journal of Energy Chemistry 2025年第1期100卷 273-285页

作者： Tianhang Zhou Chen Shen Zhenghao Wu Xingying Lan yi xiao College of Carbon Neutrality Future Technology State Key Laboratory of Heavy Oil Processing China University of Petroleum (Beijing) Institute of Materials Science TU Darmstadt Department of Chemistry Xi'an Jiaotong-Liverpool University Department of Mechanical and Mechatronics Engineering and Waterloo Institute of Nanotechnology University of Waterloo Waterloo

Dual atomic catalysts （DAC）,particularly copper （Cu2）-based nitrogen （N） doped graphene,show great potential to effectively convert CO2and nitrate （NO3-） into important industrial chemicals such as ethylene,glycol,acetamide,and urea through an efficient catalytical process that involves C–C and C–N ***,the origin of the coupling activity remained unclear,which substantially hinders the rational design of Cu-based catalysts for the N-integrated CO2reduction reaction （CO2RR）.To address this challenge,this work performed advanced density functional theory calculations incorporating explicit solvation based on a Cu2-based N-doped carbon (Cu2N6C10) catalyst for *** calculations are aimed to gain insight into the reaction mechanisms for the synthesis of ethylene,acetamide,and urea via coupling in the interfacial reaction *** to the sluggishness of CO2,the formation of a solvation electric layer by anions （F-,Cl-,Br-,and I-） and cations (Na+,Mg2+,K+,and Ca2+) leads to electron transfer towards the Cu *** process significantly accelerates the reduction of *** results reveal that*CO intermediates play a pivotal role in N-integrated ***,the Cu2-based N-doped carbon catalyst examined in this study has demonstrated the most potential for C–N coupling to *** findings reveal that through the process of a condensation reaction between*CO and NH2OH for urea synthesis,*NO3-is reduced to*NH3,and*CO2to*CCO at dual Cu atom *** dual-site reduction facilitates the synthesis of acetamide through a nucleophilic reaction between NH3and the ketene ***,we found that the I-and Mg2+ions,influenced by pH,were highly effective for acetamide and ammonia synthesis,except when F-and Ca2+were ***,the mechanisms of C–N bond formation were investigated via ab-initio molecular dynamics simulations,and we found that adjusting the micro-environment can change the dominant side reaction,shift

关键词： pH-dependent micro-environments C–N coupling Dual Cu-based nitrogen carbon catalysts Explicit solvation model Ion stabilizer AIMD

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-xiao yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

在UNIX支持下的一种定制与半定制VLSI设计及测试的CAD系统

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微电子学与计算机 1987年第6期5卷 15-24页

作者：尹小维鲍培琪美国南加州大学电机工程研究所

本文简述了—种用于VLSI 设计、模拟及测试的计算机辅助设计系统.该系统由使用UNIX 操作系统的VAX 计算机、若干软件以及一个用于测试已制成芯片的数字化微电路功能测试仪(DMFT)组成。该系统在美国喷气推进实验室(JPL)已成功地设计了许... 详细信息

本文简述了—种用于VLSI 设计、模拟及测试的计算机辅助设计系统.该系统由使用UNIX 操作系统的VAX 计算机、若干软件以及一个用于测试已制成芯片的数字化微电路功能测试仪(DMFT)组成。该系统在美国喷气推进实验室(JPL)已成功地设计了许多用在深空网络高级系统项目中的定制和半定制VLSI 芯片.

关键词：芯片 CAD 半定制 UNIX VLSI

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上海市三级医院麻醉专业技术人员现状研究

中国卫生资源 2017年第6期20卷 503-506页

作者：凤磊唐靖一鲍晓青朱梅萍上海中医药大学医院管理处上海201203 上海申康医院发展中心组织人事部上海200041 上海中医药大学附属曙光医院人力资源部上海201203

目的 :研究上海地区三级医院麻醉科人力资源配置现状及其业务开展情况。方法 :采用问卷法对上海地区三级医院麻醉学科的业务范围、人员比例、职称和学历结构等进行调查,并分析麻醉专业人力资源配置存在的主要问题。结果 :19所医院麻醉... 详细信息

目的 :研究上海地区三级医院麻醉科人力资源配置现状及其业务开展情况。方法 :采用问卷法对上海地区三级医院麻醉学科的业务范围、人员比例、职称和学历结构等进行调查,并分析麻醉专业人力资源配置存在的主要问题。结果 :19所医院麻醉科共有手术台420台、麻醉医师513人、麻醉护士99人、麻醉技师19人,手术台医师比为1∶1.22,手术台医护技比为1∶1.50;麻醉科主任具有硕士研究生及以上学历的占63.16%,具有正高级职称占73.68%。现有麻醉医师文化程度:博士19.70%,硕士43.96%、本科34.61%、大专及以下1.73%;现有麻醉医师职称:正高6.31%、副高20.45%、中级44.56%、初级及以下28.68%。结论 :上海地区三级医院麻醉专业技术人员仍需要优化结构、提升专业能力。

关键词：麻醉专业技术人员现状研究三级医院上海地区