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Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

Zoological Research 2024年第4期45卷 747-766页

作者： Hong-yi Zheng Tian-Zhang Song Yong-tang Zheng State Key Laboratory of Genetic Evolution&Animal Models KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole ***,developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** review summarizes current progress related to COVID-19 animal models,including non-human primates(NHPs),mice,and hamsters,with a focus on their roles in exploring the mechanisms of immunopathology,immune protection,and long-term effects of SARS-CoV-2 infection,as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 *** among these animal models and their specific applications are also highlighted,as no single model can fully encapsulate all aspects of *** effectively address the challenges posed by COVID-19,it is essential to select appropriate animal models that can accurately replicate both fatal and non-fatal infections with varying courses and *** animal model libraries and associated research tools is key to resolving the global COVID-19 pandemic,serving as a robust resource for future emerging infectious diseases.

关键词： SARS-CoV-2 COVID-19 Animal models Infection immunology Immunotherapy

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Bortezomib depended on PRDM1 and TP53 to exert therapeutic effect in activated B-cell-like diffuse large B-cell lymphoma

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Genes & Diseases 2024年第2期11卷 550-553页

作者： Jing tang Yue Li Jiazhu Wu Haorui Shen Hua yin Jinhua Liang Li Wang Jianyong Li yi Xia wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

PR/SET domain 1(PRDM1)gene is located on chromosome 6q21,encoding the B lymphocyte-induced maturation protein 1(BLIMP1).1 It is reported that loss of PRDM1 function is exacerbated in activated B-cell-like(ABC)-diffuse large B cell lymphoma(DLBCL)and associated with inferior ***,it remains unclear what leads to PRDM1 inactivation and the drug resistance mechanism caused by abnormal inactivation of *** investigated the contribution of PRDM1 gene as a prognosis and potential therapeutic target for ABC-DLBCL patients and further clarified the possible mechanism of PRDM1 abnormal *** first proposed that TP53 could regulate PRDM1 by histone ubiquitination modification at the post-transcriptional level.

关键词： PRDM1 TP53 therapeutic

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Visualisation and Heat Transfer Performance of Mini-Channel Flat Heat Pipe with a Binary Mixture

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Journal of Thermal Science 2024年第5期33卷 1712-1725页

作者： FAN Gaoting tang Aikun CAI Tao SHAN Chunxian PAN Jun JIN yi School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Jiangsu Jinhe Energy Technology Co.Ltd Zhenjiang 212400China

To unravel the intricacies of two-phase gas-liquid flow characteristics and heat transfer behavior,an array mini-channel gravity plate heat pipe(AMGPHP)is proposed in this work,which allows for observing the internal changes in the state of the working *** flow patterns such as pool flow,columnar flow,and slug flow,are experimentally explored and analyzed in *** is found that the optimal volume fill ratio is 20%by utilizing start-up time and thermal resistance as performance evaluation *** this fill ratio,a medium optimization strategy by blending ethanol within R141b is proposed and *** comparison to pure working fluids,the heat transfer performance of AMGFHP in the binary fluid has been significantly augmented due to temperature and concentration shifts resulting from disparate boiling *** the 10%volume fraction ethanol blending condition,the equivalent thermal conductivity of the heat pipe is dramatically elevated,with a value of 3110 W/(m·℃),along with the reduction of the minimum start-up power to 4 *** general,applying such a medium to heat pipes has considerable potential in practical applications.

关键词： flat heat pipe mini-channel visualisation two-phase flow binary mixtures thermal performance

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Conceptual design of a 714-MHz RFQ for compact proton injectors and development of a new tuning algorithm on its aluminium prototype

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Nuclear Science and Techniques 2024年第1期35卷 45-58页

作者： yi-Xing Lu Wen-Cheng Fang Yu-Sen Guo Zhen-tang Zhao Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800China University of Chinese Academy of Sciences Beijing 101408China Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201204China Shanghai Key Laboratory of Cryogenics&Superconducting RF Technology Shanghai 201800China ShanghaiTech University Shanghai 201210China

Radio frequency quadrupoles(RFQs),which are crucial components of proton injectors,significantly affect the performance of proton accelerator *** RFQ with a high frequency of 714 MHz dedicated to compact proton injectors for medi-cal applications is designed in this *** RFQ is designed to accelerate proton beams from 50 keV to 4 MeV within a short length of 2 m and can be matched closely with the downstream drift tube linac to capture more particles through a preliminary *** develop an advanced RFQ,challenging techniques,including fabrication and tuning method,must be evaluated and verified using a *** aluminium prototype is derived from the conceptual design of the RFQ and then redesigned to confirm the radio frequency performance,fabrication procedure,and feasibility of the tuning ***,a new tuning algorithm based on the response matrix and least-squares method is developed,which yields favorable results based on the prototype,i.e.,the errors of the dipole and quadrupole components reduced to a low level after several tuning *** from the conceptual design and techniques obtained from the prototype,the formal mechanical design of the 2-m RFQ is ready for the next manufacturing step.

关键词： Compact proton injector RFQ IH-DTL High gradient Tuning

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Remarkable N_(2)-selectivity enhancement of NH_(3)-SCR over HPMo modified MnCo-BTC@SiO_(2) catalyst

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Journal of Environmental Sciences 2024年第4期138卷 482-495页

作者： Songjin Ko Xiaolong tang Fengyu Gao Honghong yi Hengheng Liu Ning Luo Department of Environmental Science and Engineering University of Science and Technology BeijingBeijing 100083China Department of Chemistry Pyongyang University of ArchitecturePyongyangDPR of Korea

In this work,the phosphomolybdate(HPMo)modification strategy was applied to improve the N_(2) selectivity of Mn Co-BTC@SiO_(2)catalyst for the selective catalytic reduction of NO_(x),and further,the mechanism of HPMo modification on enhanced catalytic performance was *** Mn Co-BTC@SiO_(2-x) catalysts with different HPMo concentrations,Mn CoBTC@SiO_(2)-0.75 catalyst exhibited not only the highest NH_(3)-SCR performance(95% at 200-300℃)but also the best N_(2)selectivity(exceed 80% at 100-300℃)due to the appropriate redox capacity,greater surface acidity.X-ray photoelectron spectrometer(XPS)and temperature programmed reduction of H_(2)(H_(2)-TPR)results showed that the modification with HPMo reduced the oxidation-reduction performance of the catalyst due to electron transfer from Mo^(5+)to Mn^(4+)/Mn^(3+)and prevent the excessive oxidation of ammonia adsorption ***_(3)temperature-programmed desorption of(NH_(3)-TPD)results showed that the modification with HPMo could significantly improve the surface acidity and NH_(3)adsorption,which enhance the catalytic activity and N_(2)***-situ diffused reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS)revealed that modification with HPMo increased significantly the amount of adsorbed NH_(3)species on the Bronsted acid site and C_(B)/C_(L),it suppressed the production of N_(2)O by inhibiting the production of NH species,the deep dehydrogenation of ammonia adsorption *** study provided a simple design strategy for the catalyst to improve the low-temperature catalytic performance and N_(2)selectivity.

关键词： Metal organic framework(MOF) MnCo-BTC@SiO_(2) NH_(3)-SCR HPMo N_(2)selectivity

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Clinical efficacy of femtosecond laser-assisted phacoemulsification in diabetic cataract patients

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World Journal of Clinical Cases 2024年第10期12卷 1733-1741页

作者： yi-Fei tang Zhi-Hui Duan Department of Glaucoma and Cataracts Han Yang Eyegood Ophthalmic HospitalWuhan 430056Hubei ProvinceChina

BACKGROUND Diabetic patients with cataracts encounter specific difficulties during cataract surgery due to alterations in microcirculation,blood supply,metabolism,and the *** phacoemulsification may not fully tackle these issues,especially in instances with substantial preoperative *** utilization of femtosecond laser-assisted phacoemulsification,in conjunction with Toric intraocular lens(IOL)implantation,offers a potentially more efficient *** research seeks to evaluate the efficacy and possible complications of this approach in diabetic cataract *** To investigate the clinical efficacy and complications of femtosecond laser-assisted phacoemulsification combined with Toric IOL implantation in diabetic cataract patients,comparing it with traditional phacoemulsification *** This retrospective study enrolled 120 patients with diabetes cataract from May 2019 to May *** patients were divided into two groups:the control group underwent traditional phacoemulsification and Toric IOL implantation,while the treatment group received Len Sx femtosecond laser-assisted *** measures included naked eye vision,astigmatism,high-level ocular phase difference detection,clinical efficacy,and *** There were no significant preoperative differences in astigmatism or naked eyesight between the two ***,postoperative improvements were observed in both groups,with the treatment group showing greater enhancements in naked eye vision and astigmatism six months after the ***-level corneal phase difference tests also indicated significant differences in favor of the treatment *** This study suggests that femtosecond laser-assisted phacoemulsification combined with Toric IOL implantation appears to be more effective in enhancing postoperative vision in diabetic cataract patients compared to traditional methods offering valuable insights for clinical practice.

关键词： Diabetic cataract Femtosecond laser-assisted phacoemulsification Toric intraocular lens implantation Naked vision

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A seismic elastic moduli module for the measurements of low-frequency wave dispersion and attenuation of fluid-saturated rocks under different pressures

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Petroleum Science 2024年第1期21卷 162-181页

作者： Yan-Xiao He Shang-Xu Wang Gen-Yang tang Chao Sun Hong-Bing Li San-yi Yuan Xian wei Li-Deng Gan Xiao-Feng Dai Qiang Ge Peng-Peng wei Hui-Qing Zhang National Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationCollege of GeophysicsChina University of Petroleum(Beijing)Beijing102249China School of Resources and Geosciences China University of Mining and TechnologyXuzhou221116JiangsuChina Research Institute of Petroleum Exploration and Development CNPCBeijing100083China Beijing Vocational College of Labour and Social Security Beijing100029China PetroChina Dagang Oilfield Exploration and Development Research Institute CNPCTianjin300280China

Knowledge about the seismic elastic modulus dispersion,and associated attenuation,in fluid-saturated rocks is essential for better interpretation of seismic observations taken as part of hydrocarbon identification and time-lapse seismic surveillance of both conventional and unconventional reservoir and overburden performances.A Seismic Elastic Moduli Module has been developed,based on the forced-oscillations method,to experimentally investigate the frequency dependence of Young's modulus and Poisson's ratio,as well as the inferred attenuation,of cylindrical samples under different confining pressure *** with three standard samples showed that the measured elastic moduli were consistent with the published data,indicating that the new apparatus can operate reliably over a wide frequency range of f∈[1-2000,10^(6)]*** Young's modulus and Poisson's ratio of the shale and the tight sandstone samples were measured under axial stress oscillations to assess the frequency-and pressure-dependent *** dry condition,both samples appear to be nearly frequency independent,with weak pressure dependence for the shale and significant pressure dependence for the *** particular,it was found that the tight sandstone with complex pore microstructure exhibited apparent dispersion and attenuation under brine or glycerin saturation conditions,the levels of which were strongly influenced by the increased effective *** addition,the measured Young's moduli results were compared with the theoretical predictions from a scaled poroelastic model with a reasonably good agreement,revealing that the combined fluid flow mechanisms at both mesoscopic and microscopic scales possibly responsible for the measured dispersion.

关键词： Low-frequency measurements Dispersion and attenuation Rock physics Fluid flow

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A Heuristic Radiomics Feature Selection Method Based on Frequency Iteration and Multi-Supervised Training Mode

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Computers, Materials & Continua 2024年第5期79卷 2277-2293页

作者： Zhigao Zeng Aoting tang Shengqiu yi Xinpan Yuan Yanhui Zhu School of Computer Hunan University of TechnologyZhuzhou412007China Hunan Key Laboratory of Intelligent Information Perception and Processing Technology Zhuzhou412007China

Radiomics is a non-invasive method for extracting quantitative and higher-dimensional features from medical images for *** has received great attention due to its huge application prospects in recent *** can know that the number of features selected by the existing radiomics feature selectionmethods is basically about *** this paper,a heuristic feature selection method based on frequency iteration and multiple supervised training mode is *** on the combination between features,it decomposes all features layer by layer to select the optimal features for each layer,then fuses the optimal features to form a local optimal group layer by layer and iterates to the global optimal combination *** with the currentmethod with the best prediction performance in the three data sets,thismethod proposed in this paper can reduce the number of features fromabout ten to about three without losing classification accuracy and even significantly improving classification *** proposed method has better interpretability and generalization ability,which gives it great potential in the feature selection of radiomics.

关键词： Radiomics feature selection machine learning metaheuristic

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Genome mining of multi-substituted alkylresorcinols from a hybrid highly reducing-and typeⅢ-polyketide pathway

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Chinese Chemical Letters 2024年第7期35卷 345-349页

作者： Huaran Zhang Yuting Huang yingjie tang Dekun Kong yi Zou College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China

Fungal alkylresorcinols are a class of polyketides,which are commonly synthesized by the hybridization of highly reducing polyketide synthase(hrPKS)with non-reducing polyketide synthase(nrPKS).In this study,we identified and demonstrated a new assembly model for synthesizing alkylresorcinol(scirpilin A,1),which was accomplished by collaboration of a hrPKS(FscA)and a typeⅢPKS(FscB).Furthermore,three post-tailoring enzymes(FscC,FscD,and FscE)act iteratively on 1 skeleton,including successive 14e-oxidation of inert carbons,di-halogenation,and di-methylation,to form highly oxidized and multisubstituted *** work presents an unusual synthesis manner of alkylresorcinols,sheds light on the collaborative mechanism between hrPKS and typeⅢPKS and provides three valuable enzymatic catalysts for the tailoring of alkylresorcinol family natural products in future.

关键词： Genome mining Alkylresorcinol hrPKS TypeⅢPKS Iterative catalysis

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An integrated strategy of UPLC-Q-TOF/MS and HPTLC/PAD-DESI-MSI for the analysis of chemical variations:A case study of Tibetan medicine Tiebangchui

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Journal of Pharmaceutical Analysis 2024年第4期14卷 615-618页

作者： Yue Liu Mengjia Li Xing Fu yi Zhang Ce tang State Key Laboratory of Southwestern Chinese Medicine Resources School of Ethnic MedicineChengdu University of Traditional Chinese MedicineChengdu611137China Meishan Hospital of Chengdu University of Traditional Chinese Medicine MeishanSichuan620010China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China

The dried roots of Aconitum pendulum Busch are the major source of a commonly used Tibetan medicine,namely Tiebangchui(TBC)(Fig.S1).However,raw TBC contains a large amount of high toxic diester-diterpenoid alkaloids(DDAs),and the improper use would cause arrhythmia,irreversible cardiovascular damages,and even death.“Paozhi”,an appropriate processing method,is the essential prerequisite for the safe clinical application of ***-decocting and sand-frying are commonly used processing methods for toxicity attenuation and efficacy preservation for TBC.

关键词： dried irreversible roots

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