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The homogenous growth of Co-based coordination compound on graphene nanosheet for high-performance K-organic battery and its reaction mechanism

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Rare Metals 2024年第4期43卷 1622-1634页

作者： Qian-Qian Peng yi-ting wang Shuo Qi Yao Xiao Yong wang Shuang-Qiang Chen School of Environmental and Chemical Engineering Shanghai UniversityShanghai200444China School of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China

Metal coordination compounds(MCCs)are gaining popularity for potassium-ion batteries(PIBs)owing to their tuneable structure,multiple reaction sites,low cost and unique ***,they are generally subjected to intrinsic features of the sluggish ionic diffusion coefficient,low electronic conductivity and slow ***,a new MCC material of cobalt-1,3,5-trioxy-2,4,6-triamino-benzo(Co-TB)coordination compound was synthesized and homogenously grown on the surface of graphene nanosheets(GNS),forming a Co-TB@GNS composite with enhanced electronic conductivity and flexible *** from the overall enhanced conductivity,high surface area and abundant activated K-storage sites,Co-TB@GNS electrodes have exhibited superior cycling performance with high reversible capacities(312 mAh·g^(-1)after 100 cycles at 100 mA·g^(-1),224 mAh·g^(-1)after 500 cycles at 1 A·g^(-1))and better rate performances compared with the pure Co-TB compound when served as PIB's ***,multiple in-situ measurement techniques have jointly confirmed that the organic functional groups(C=O,C=N and C=C of benzene rings)and Co^(2+)in Co-TB are the main reversible K-storage sites,including in-situ Fourier transform infrared spectroscopy(FTIR)and X-ray diffraction(XRD),and partial capacity contribution is originated from GNS by the apparent K-storage behavior in the in-situ XRD pattern,proving the possibility of K-storage for metal-organic materials.

关键词： Metal coordination compounds Potassiumion battery Cobalt coordination compound K-storage mechanism

Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

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World Journal of Gastroenterology 2024年第30期30卷 3584-3608页

作者： Meng-Yuan Niu Geng-ting Dong yi Li Qing Luo Liu Cao Xi-Min wang Qi-Wen wang yi-ting wang Zhe Zhang Xi-Wen Zhong Wei-Bo Dai Le-Yu Li Pharmacology Laboratory Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina Department of Endocrinology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan 528400Guangdong ProvinceChina

BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging *** has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical ***-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with ***,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further *** To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in *** HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell ***,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 *** FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in *** experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte *** FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD.

关键词： Fanlian Huazhuo Formula Nonalcoholic fatty liver disease Autophagy Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress

Multiple skin abscesses associated with bacteremia caused by Burkholderia gladioli:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2286-2293页

作者： yi-ting wang Xue-Wen Li Pan-Yang Xu Chun Yang Jian-Cheng Xu The First Hospital of Jilin University Laboratory MedicineChangchun 130021Jilin ProvinceChina

BACKGROUND Burkholderia gladioli(***)is regarded as a rare opportunistic *** a few patients with abscesses caused by *** infections have been reported,and these are usually abscesses at the incision caused by traumatic *** SUMMARY A 74-year-old male patient with abscesses and pain throughout his body for 1 mo was admitted to our *** of the abscesses had ruptured with purulent secretions on *** Doppler ultrasound examination of the body surface masses showed mixed masses 75 mm×19 mm,58 mm×17 mm,17 mm×7 mm,and 33 mm×17 mm in size in the muscle tissues of both the right and left forearms,the posterior area of the right knee and the left leg,*** secretions and blood cultures grew *** following 3 methods were used to jointly identify the bacterium:an automatic microbial identification system,matrix-assisted laser desorption/ionization time-of-flight mass spectrometry,and full-length 16 S rDNA *** 27 d of treatment with meropenem,etimicin,trimethoprim-sulfamethoxazole and other antibiotics,most of his skin abscesses were flat and he was discharged without any *** This is the first reported case of multiple skin abscesses associated with bacteremia caused by *** study provides important reference values for the clinical diagnosis and treatment of *** infections.

关键词： Burkholderia gladioli Multiple skin abscesses Bacteremia Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Case report

Enriching Context Information for Entity Linking with Web Data

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Journal of Computer Science & Technology 2020年第4期35卷 724-738页

作者： yi-ting wang Jie Shen Zhi-Xu Li Qiang Yang An Liu Peng-Peng Zhao Jia-Jie Xu Lei Zhao Xun-Jie Yang Institute of Artificial Intelligence School of Computer Science and TechnologySoochou University Suzhou 215006China iFLYTEK Research Suzhou 215000China State Key Laboratory of Cognitive Intelligence iFLYTEKHefei 230000China Computer Electrical and Mathematical Sciences and EngineeringKing Abdullah University of Science and Technology Jeddah 23955Saudi Arabia Anhui Toycloud Technologg Co. Ltd.Hefei 230000Chira

Entity linking(EL)is the task of determining the identity of textual entity mentions given a predefined knowledge base(KB).Plenty of existing efforts have been made on this task using either"local"information(contextual information of the mention in the text),or"global"information(relations among candidate entities).However,either local or global information might be insufficient especially when the given text is *** get richer local and global information for entity linking,we propose to enrich the context information for mentions by getting extra contexts from the web through web search engines(WSE).Based on the intuition above,two novel attempts are *** first one adds web-searched results into an embedding-based method to expand the mention's local information,where we try two different methods to help generate high-quality web contexts:one is to apply the attention mechanism and the other is to use the abstract extraction *** second one uses the web contexts to extend the global information,i.e.,finding and utilizing more extra relevant mentions from the web contexts with a graph-based ***,we combine the two models we propose to use both extended local and global information from the extra web *** empirical study based on six real-world datasets shows that using extra web contexts to extend the local and the global information could effectively improve the F1 score of entity linking.

关键词： entity linking web search engine (WSE) attention mechanism abstract extraction

Tailoring minimalist self-assembling peptides for localized viral vector aene deliverv

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Nano Research 2016年第3期9卷 674-684页

作者： Alexandra L. Rodriguez ting-yi wang Kiara F. Bruggeman Rui Li Richard J. Williams Clare L. Parish David R. Nisbet Research School of Engineering The Australian National University Canberra ACT2601 Australia Florey Institute ofNeuroscience & Men tal Health The University of Melbourne Parkville VIC 3010 Australia Cen tre for Chemistry and Biotechnology Deakin University Waurn Ponds VIC 3217 Australia School of Aerospace Mechanical and Manufacturing Engineering and the Health Innovations Research Institute RMIT University Melbourne VIC 300 I Australia

Viral vector gene delivery is a promising technique for the therapeutic administra- tion of proteins to damaged tissue for the improvement of regeneration outcomes in various disease settings including brain and spinal cord injury, as well as autoimmune diseases. Though promising results have been demonstrated, limitations of viral vectors, including spread of the virus to distant sites, neutralization by the host immune system, and low transduction efficiencies have stimulated the investigation of biomaterials as gene delivery vehicles for improved protein expression at an injury site. Here, we show how N- fluorenylmethyloxycarbonyl （Fmoc） self-assembling peptide （SAP） hydrogels, designed for tissue-specific central nervous system （CNS） applications via incorporation of the laminin peptide sequence isoleucine-lysine-valine-alanine- valine （IKVAV）, are effective as biocompatible, localized viral vector gene delivery vehicles in vivo. Through the addition of a C-terminal lysine （K） residue, we show that increased electrostatic interactions, provided by the additional amine side chain, allow effective immobilization of lentiviral vector particles, thereby limiting their activity exclusively to the site of injection and enabling focal gene delivery in vivo in a tissue-specific manner. When the C-terminal lysine was absent, no difference was observed between the number of transfected cells, the volume of tissue transfected, or the transfection efficiency with and without the Fmoc-SAP. Importantly, immobilization of the virus only affected transfection cell number and volume, with no impact observed on transfection efficiency. This hydrogel allows the sustained and targeted delivery of growth factors post injury. We have established Fmoc-SAPs as a versatile platform for enhanced biomaterial design for a range of tissue engineering applications.

关键词： viral vectors gene therapy self-assembling peptides biomaterials

Probing cytotoxicity of CdSe and CdSe/CdS quantum dots

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Chinese Chemical Letters 2011年第7期22卷 843-846页

作者： Yan Jie Bao Jun Jun Li yi ting wang Lei Yu Lei Lou Wei Ji Du Zi Qiang Zhu Hui Peng Jian Zhong Zhu Institutes for Advanced Interdisciplinary Research East China Normal University Shanghai 200062 China

Toxicities of CdSe and CdSe/CdS quantum dots （QDs） synthesized by ultrasound-assisted methods were investigated in vitro and in vivo. Five human cell lines were used to assess the cytotoxicity of as-prepared CdSe and CdSe/CdS by assays of MTT viability, red blood cell hemolysis, flow cytometry, and fluorescence imaging. The results show that these QDs may be cytotoxic by their influence in S and G2 phases in cell cycles. The cytotoxicity of QDs depends on both the physicochemical properties and related to target cells.

关键词： Cytotoxicity Quantum dots CdSe CdSe/CdS Cell

Combining single-cell RNA-sequencing and bulk data to reveal immunity-related genes expression pattern in the systemic lupus erythematosus and target organ kidney

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Medical Data Mining 2023年第1期6卷 1-9页

作者： ying Zhang Tong Zhou yi-ting wang Xiao-Xian Pei Zhe Sun Ming-Cheng Li Wen-Gang Song Department of Clinical Diagnosis School of Laboratory MedicineBeihua UniversityJilin 132013China Department of Medicine Beihua UniversityJilin 132013China

Background:Systemic lupus erythematosus(SLE)is a complex chronic autoimmune disease with no known ***,the regulatory mechanism of immunity-related genes is not fully understood in *** order to explore new therapeutic targets,we used bioinformatical methods to analyze a series of ***:After downloading and processing the data from Gene Expression Omnibus database,the differentially expressed genes of SLE were *** algorithm was used to analyze the immune infiltration of *** on single-cell RNA-sequencing data,the role of immune-related genes in SLE and its target organ(kidney)were *** transcription factors affecting immune-related genes were ***-cell communication networks in SLE were ***:In total,15 hub genes and 4 transcription factors were found in the bulk *** and macrophages in GSE81622(SLE)showed more *** were four cell types were annotated in scRNA sequencing dataset(GSE135779),as follows T cells,monocyte,NK cells and B ***-related genes were overexpressed in ***:The present study shows that immune-related genes affect SLE through monocytes and play an important role in target organ renal injury.

关键词： systemic lupus erythematosus single-cell RNA-sequencing data immunity-related genes Lupus nephritis monocytes

Identification of a novel hepacivirus in Mongolian gerbil(Meriones unguiculatus)from Shaanxi,China

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Virologica Sinica 2022年第2期37卷 307-310页

作者： Cui-hong An Juan Li yi-ting wang Shou-min Nie Wen-hui Chang Hong Zhou Lin Xu Yang-xin Sun Wei-feng Shi Ci-xiu Li Department of Plague and Brucellosis Shaanxi Center for Disease Control and PreventionXi’An 710054China Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan250021China Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian271000China Department of Pathogen Biology School of Basic MedicineShandong First Medical University&Shandong Academy of Medical SciencesTaian271000China Shaanxi Center for Disease Control and Prevention Xi’An710054China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesTaian271000China

Dear Editor,Hepaciviruses,members of the family Flaviviridae,are enveloped viruses containing a single-stranded positive-sense RNA genome of approximately 8.9-10.5 kb in size(Simmonds et al.,2017).To date,15species(Hepacivirus A-N,and P)have been documented within the Hepacivirus genus that show distinct host ranges,including primates,bats,horses,donkeys,cows,and various rodents(Hartlage et al.,2016).

关键词： unguiculatus stranded envelope

Novel astrovirus and paramyxovirus in Mongolian gerbils(Meriones unguiculatus)from China

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Zoological Research 2022年第3期43卷 418-422页

作者： Shou-Min Nie Juan Li yi-ting wang Cui-Hong An Hong Zhou Lin Xu Yang-Xin Sun Wen-Hui Chang Ci-Xiu Li Wei-Feng Shi Shaanxi Provincial Center for Disease Control and Prevention Xi’anShaanxi 710054China Shandong Provincial Hospital Affiliated to Shandong First Medical University JinanShandong 250021China Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaianShandong 271000China Department of Pathogen Biology School of Basic MedicineShandong First Medical University&Shandong Academy of Medical SciencesTaianShandong 271000China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesTaianShandong 271000China

DEAR EDITOR,Mongolian gerbils(Meriones unguiculatus)are small rodents belonging to the family Muridae and widely inhabit typical steppes and desert grasslands across northern ***,few viruses in wild *** have been *** ... 详细信息

关键词： unguiculatus China