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A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertility

Asian Journal of Andrology 2023年第5期25卷 643-645页

作者： si-yi zhao Lan-Lan Meng zhao-Li Du Yue-Qiu Tan Wen-Bin He Xiong Wang The First Clinical College of Guangzhou Medical University Guangzhou 511436China National Engineering and Research Center of Human Stem Cells and Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410008China Reproductive and Genetic Hospital of CITIC-Xiangya and Clinical Research Center For Reproduction and Genetics in Hunan Province Changsha 410008China yinfeng Gene Technology Co. Ltd.Jinan 250000China Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000China

Male infertility is a major reproductive disorder,which is clinically characterized by highly heterogeneous phenotypes of abnormal sperm count or *** date,five male patients with biallelic loss-of-function(LOF)variants of PARN-like ribonuclease domain-containing exonuclease 1(PNLDC1)have been reported to experience infertility with nonobstructive *** aim of this study was to identify the genetic cause of male infertility with oligo-astheno-teratozoospermia(OAT)in a patient from a Chinese Han ***-exome and Sanger sequencing analyses identified a homozygous LOF variant(NM_173516.2,c.l42C>T,***48Ter)in *** and eosin staining revealed that the spermatozoa of the patient with OAT had an irregular head phenotype,including microcephaly,head tapering,and ***,peanut agglutinin staining of the spermatozoa revealed a complete or partial loss of the ***,the disomy rate of chromosomes in the patient’s spermatozoa was significantly increased compared with that of a fertile control *** reported an LOF variant of the PNLDC1 gene responsible for OAT.

关键词： loss-of-function variant male infertility oligo-astheno-teratozoospermia PARN-like ribonuclease domain-containing exonuclease 1

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An efficient and coordinated mapping algorithm in virtualized SDN networks

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Frontiers of Information Technology & Electronic Engineering 2016年第7期17卷 701-716页

作者： Shui-qing GONG Jing CHEN Qiao-yan KANG Qing-wei MENG Qing-chao ZHU si-yi zhao College of Information and Navigation Air Force Engineering University

Software-defined networking(SDN) enables the network virtualization through SDN hypervisors to share the underlying physical SDN network among multiple logically isolated virtual SDN networks(v SDNs),each with its own *** v SDN embedding,which refers to mapping a number of v SDNs to the same substrate SDN network,is a key problem in the SDN virtualization ***,due to the distinctions of the SDN,such as the logically centralized controller and different virtualization technologies,most of the existing embedding algorithms cannot be applied directly to SDN *** this paper,we consider controller placement and virtual network embedding as a joint vS DN embedding problem,and formulate it into an integer linear programming with objectives of minimizing the embedding cost and the controller-to-switch delay for each v ***,we propose a novel online vS DN embedding algorithm called CO-v SDNE,which consists of a node mapping stage and a link mapping *** the node mapping stage,CO-vS DNE maps the controller and the virtual nodes to the substrate nodes on the basis of the controller-to-switch delay and takes into account the subsequent link mapping at the same *** the link mapping stage,CO-v SDNE adopts the k-shortest path algorithm to map the virtual *** evaluation results with simulation and Mininet emulation show that the proposed CO-v SDNE not only significantly increases the long-term revenue to the cost ratio and acceptance ratio while guaranteeing low average and maximum controller-to-switch delay,but also achieves good v SDN performance in terms of end-to-end delay and throughput.

关键词： Software-defined networking(SDN) Network virtualization Controller placement Virtual network embedding Coordination

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The impact of Internet access on household dietary quality:Evidence from rural China

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Journal of Integrative Agriculture 2024年第2期23卷 374-383页

作者： yi Cui Qiran zhao Thomas Glauben Wei si College of Economics and Management China Agricultural UniversityBeijing 100083China Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China Leibniz Institute of Agricultural Development in Transition Economies(IAMO) Halle(Saale)06120Germany

Over the past few decades,the Internet has rapidly diffused across *** spread of the Internet has had a profound economic and social impact on Chinese rural *** research shows that Internet access significantly impacts agricultural production and improves smallholder farmers’*** these,the Internet can affect other dimensions of social ***,research about the impact of Internet access on dietary quality in rural China remains *** study utilizes multi-period panel data from Fixed Observation Point in rural China from 2009 to 2015 to estimate the impact of Internet access on dietary quality and food consumption of rural households and conducts a causal *** models with time and household fixed effects allow robust estimation while reducing potential issues of unobserved *** estimates show that Internet access has significantly increased rural household dietary quality(measured by the Chinese Diet Balance Index).Further research finds that Internet access has increased the consumption of animal products,such as aquatic and dairy *** also examine the underlying *** access improves dietary quality and food consumption mainly through increasing household income and food *** results encourage the promotion of Internet access as a valuable tool for nutritional improvements,especially in rural areas.

关键词： dietary quality fixed effect model Internet access rural China

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Coronavirus disease 2019(COVID-19):cytokine storms,hyper-inflammatory phenotypes,and acute respiratory distress syndrome

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Genes & Diseases 2020年第4期7卷 520-527页

作者： Shi-hui Lin yi-si zhao Dai-xing Zhou Fa-chun Zhou Fang Xu Department of Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Coronavirus Disease 2019(COVID-19)was first identified in China at the end of *** respiratory distress syndrome(ARDS)represents the most common and serious complication of *** storms are a pathophysiological feature of COVID-19 and play an important role in distinguishing hyper-inflammatory subphenotypes of ***,in this review,we focus on hyper-inflammatory host responses in ARDS that play a critical role in the differentiated development of ***,we discuss inflammationrelated indicators that have the potential to identify hyper-inflammatory subphenotypes of COVID-19,especially for those with a high risk of ***,we explore the possibility of improving the quality of monitoring and treatment of COVID-19 patients and in reducing the incidence of critical illness and mortality via better distinguishing hyper-and hypoinflammatory subphenotypes of COVID-19.

关键词： Acute respiratory distress syndrome COVID-19 Cytokine storm Hyper-inflammatory host response SARS-CoV-2

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Cordyceps as potential therapeutic agents for atherosclerosis

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Journal of Integrative Medicine 2024年第2期22卷 102-114页

作者： yi Zhang si-jing Liu School of Marxism Chengdu University of Traditional Chinese MedicineChengdu 61137Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Chongqing Key Laboratory of sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases with Integrated Chinese and Western Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina

Atherosclerosis is a leading cause of mortality and morbidity *** the challenges in managing atherosclerosis,researchers continue to investigate new treatments and complementary *** is a traditional Chinese medicine that has recently gained attention as a potential therapeutic agent for *** studies have demonstrated the effectiveness of cordyceps in treating atherosclerosis through various pharmacological actions,including anti-inflammatory and antioxidant activities,lowering cholesterol,inhibiting platelet aggregation,and modulating apoptosis or autophagy in vascular endothelial ***,the current misuse of the terms cordyceps and Ophiocordyceps sinensis has caused confusion among researchers,and complicated the current academic research on *** review focuses on the chemical composition,pharmacological actions,and underlying mechanisms contributing to the anti-atherosclerotic effects of cordyceps and the mycelium of Ophiocordyceps *** review provides a resource for the research on the development of new drugs for atherosclerosis from cordyceps.

关键词： Atherosclerosis Cordyceps Ophiocordyceps sinensis

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Properties of collective flow and pion production in intermediate-energy heavy-ion collisions with a relativistic quantum molecular dynamics model

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Nuclear Science and Techniques 2024年第1期35卷 155-169页

作者： si-Na Wei zhao-Qing Feng School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

The relativistic mean-field approach was implemented in the Lanzhou quantum molecular dynamics transport model(***). Using the ***, the properties of collective flow and pion production were investigated systematically for nuclear reactions with various isospin asymmetries. The directed and elliptic flows of the *** are able to describe the experimental data of STAR Collaboration. The directed flow difference between free neutrons and protons was associated with the stiffness of the symmetry energy, that is, a softer symmetry energy led to a larger flow difference. For various collision energies, the ratio between the π^(-) and π^(+) yields increased with a decrease in the slope parameter of the symmetry energy. When the collision energy was 270 MeV/nucleon, the single ratio of the pion transverse momentum spectra also increased with decreasing slope parameter of the symmetry energy in both nearly symmetric and neutron-rich ***, it is difficult to constrain the stiffness of the symmetry energy with the double ratio because of the lack of threshold energy correction on the pion production.

关键词： Heavy-ion collision Collective flow Pion production Symmetry energy Relativistic mean field

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Design and tailoring of patterned ZnO nanostructures for perovskite light absorption modulation

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 855-861页

作者： Haonan si Xuan zhao Qingliang Liao Yue Zhang Academy for Advanced Interdisciplinary Science and Technology Beijing Advanced Innovation Center for Materials Genome EngineeringUniversity of Science and Technology BeijingBeijing 100083China Key Laboratory of Advanced Materials and Devices for Post-Moore Chips Ministry of EducationBeijing Key Laboratory for Advanced Energy Materials and TechnologiesSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Lithography is a pivotal micro/nanomanufacturing technique,facilitating performance enhancements in an extensive array of devices,encompassing sensors,transistors,and photovoltaic *** key to creating highly precise,multiscale-distributed patterned structures is the precise control of the lithography ***,high-quality patterned ZnO nanostructures are constructed by systematically tuning the exposure and development times during *** optimizing these parameters,ZnO nanorod arrays with line/hole arrangements are successfully *** ZnO nanostructures with highly controllable morphology and structure possess discrete three-dimensional space structure,enlarged surface area,and improved light capture ability,which achieve highly efficient energy conversion in perovskite solar *** lithography process management for these patterned ZnO nanostructures provides important guidance for the design and construction of complex nanostructures and devices with excellent performance.

关键词： lithography patterned ZnO nanorod arrays light absorption perovskite solar cell

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Application of a microscopic optical potential of chiral effective field theory in (p, d) transfer reactions

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Nuclear Science and Techniques 2024年第1期35卷 134-144页

作者： yi-Ping Xu si-Lu Chen Dan-Yang Pang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China School of Physics Beihang UniversityBeijing 100191China

The microscopic global nucleon–nucleus optical model potential(OMP)proposed by Whitehead,Lim,and Holt,the WLH potential(Whitehead et al.,Phys Rev Lett 127:182502,2021),which was constructed in the framework of many-body per-turbation theory with state-of-the-art nuclear interactions from chiral effective field theory(EFT),was tested with(p,d)transfer reactions calculated using adiabatic wave *** target nuclei included both stable and unstable nuclei,and the incident energies reached 200 *** results were compared with experimental data and predictions using the phenomenological global optical potential of Koning and Delaroche,the KD02 ***,we found that the micro-scopic WLH potential described the(p,d)reaction angular distributions similarly to the phenomenological KD02 potential;however,the former was slightly better than the latter for radioactive *** average,the obtained spectroscopic factors(SFs)using both microscopic and phenomenological potentials were similar when the incident energies were below approxi-mately 120 ***,their difference tended to increase at higher incident energies,which was particularly apparent for the doubly magic target nucleus 40Ca.

关键词： Microscopic optical model potential (p,d)transfer Spectroscopic factors

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Nature-inspired design of droplet-synthesized polymeric nanoelectrode for photoelectrochemical microRNA sensing within single cells

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Science Bulletin 2024年第2期69卷 159-162页

作者： si-Yuan Yu yi-Li Liu Zheng Li Dechen Jiang Jing-Juan Xu Hong-Yuan Chen Wei-Wei zhao State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Nanoelectrodes have been shown to be powerful tools for nanoscopic research on single entities,deepening the understanding of heterogeneity and stochastics for single molecules,nanoparticles and cells[1–3].However,despite their importance,current nanoelectrode preparations are highly restrained to flame/electrochemical etching,metal sputtering,electrochemical deposition,etc.[3],resulting in a limited range of materials(mainly gold,platinum and carbon)for potential-resolved detection of redox-active species(Table S1 online).The enrichment of preparation methods to introduce novel materials and mechanisms should prove significant for the development of nanoelectrodes.

关键词： electrode deepening restrained

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Global Zero-relaxation Limit Problem of the Electro-diffusion Model Arising in Electro-Hydrodynamics

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Acta Mathematicae Applicatae sinica 2024年第1期40卷 241-268页

作者： Ming-hua Yang si-ming Huang Jin-yi Sun Department of Mathematics Jiangxi University of Finance and EconomicsNanchang330032China School of Public Administration Guangdong University of Foreign StudiesGuangzhou510006China College of Mathematics and Statistics Northwest Normal UniversityLanzhou730070China

In this paper,we study a global zero-relaxation limit problem of the electro-diffusion model arising in electro-hydrodynamics which is the coupled Planck-Nernst-Poisson and Navier-Stokes *** is,the paper deals with a singular limit problem of{u^(∈)_(t)+u^(∈)·▽u^(∈)-Δu^(∈)+▽P^(∈)=Δφ^(∈)▽φ^(∈),in R^(3)×(0,∞),▽·u^(∈)=0,in R^(3)×(0,∞),n^(∈)_(t)+u^(∈)·▽n^(∈)-Δn^(∈)=-▽·(n^(∈)▽φ^(∈)),in R^(3)×(0,∞),ct+u^(∈)·▽c^(∈)-Δc^(∈)=▽·(c^(∈)▽φ^(∈)),in R^(3)×(0,∞),∈^(-1)φ^(∈)_(t)=Δφ^(∈)-n^(∈)+c^(∈),in R^(3)×(0,∞),(u^(∈),n^(∈),c^(∈),φ^(∈))|t=0=(u0,n0,c0,φ0),in R^(3) involving with a positive,large parameter^(∈).The present work show a case that(u^(∈),n^(∈),c^(∈))stabilizes to(u^(∞),n∞,c∞):=(u,n,c)uniformly with respect to the time variable as^(∈)→+∞with respect to the strong topology in a certain Fourier-Herz space.

关键词： fourier-Herz space littlewood-Paley decomposition stability limit dissipative system

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