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Effects and fate of metal-based engineered nanomaterials in soil ecosystem: A review

Pedosphere 2024年第5期34卷 843-852页

作者： Qibin WANG Peng ZHANG Weichen ZHAO Shakoor NOMAN Adeel MUHAMMAD Guikai ZHU yi SUN Quanlong WANG Yaqi jiang Yukui RUI Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation College of Resources and Environmental Sciences China Agricultural University Department of Environmental Science and Engineering University of Science and Technology of China School of Geography Earth and Environmental Sciences University of Birmingham BNU-HKUST Laboratory of Green Innovation Advanced Institute of Natural Sciences Beijing Normal University at Zhuhai China Agricultural University Professor Workstation of Yuhuangmiao Town China Agricultural University Professor Workstation of Sunji Town

Metal-based engineered nanomaterials (MENMs) are increasingly being used in people’s working lives. Although MENMs have important effects on soil ecosystem and play an important role in solving soil environmental problems, the hazards associated with MENMs cannot be ignored. Therefore, more and more scholars have studied the behavior and effects of nanomaterials in soils in recent years. In this review, we explore the articles on MENMs and soil ecosystem retrieved from various databases from 2013 to 2022. We discuss the mechanisms of MENM toxicity, the current state of soil ecosystem, the ecological effects of MENMs on soil microbes, earthworms, and plants, and the ways by which soil organisms take up MENMs. We now know that although MENMs have positive effects on soil ecosystem, their potential hazards are not negligible. Therefore, it is necessary to investigate the effects of MENMs on soil organisms. Meanwhile, we should pay more attention to the negative effects of MENMs on soil ecosystem while exploring their positive effects on soil ecosystem in future research.

关键词： earthworm nanomaterial migration and transformation nanotechnology plant soil microorganism toxicity

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Asymptomatic low-grade appendiceal mucinous neoplasm:A case report

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World Journal of Clinical Cases 2024年第2期12卷 361-366页

作者： Min-Quan Yao Yu-Peng jiang Yuan-Yu Wang yi-Ping Mou Jin-Xing Fan Department of Gastrointestinal Surgery Tongxiang First People’s HospitalJiaxing 314500Zhejiang ProvinceChina Department of General Surgery Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Endoscopy Center Tongxiang First People’s HospitalJiaxing 314500Zhejiang ProvinceChina

BACKGROUND Low-grade appendiceal neoplasms(LAMN)are characterized by low incidence and atypical clinical presentations,often leading to misdiagnosis as acute or chronic appendicitis before *** primary diagnostic tool for LAMN is abdominal computed tomography(CT)*** resection remains the cornerstone of LAMN management,necessitating en bloc tumor excision to minimize the risk of iatrogenic ***,known for its minimal invasiveness,reduced postoperative discomfort,and expedited recovery,is a safe and reliable approach for LAMN *** the possibility of pseudomyxoma peritonei development,appendectomy and partial appendectomy generally result in negative tumor margins and favorable outcomes,which can be attributed to the disease’s slow growth and lower *** SUMMARY A 71-year-old male patient was admitted to our hospital with a pelvic spaceoccupying lesion detected 1 mo *** examination showed a soft abdomen without tenderness or rebound and no palpable *** shifting dullness was noted,and digital rectal examination revealed no palpable *** revealed a raised,smooth-surfaced mass measuring 3.0 cm in the *** contrast-enhanced CT showed a markedly thickened and dilated appendix with visible cystic *** surgery was performed and revealed a significantly dilated appendix,leading to laparoscopic resection of the appendix and part of the ***-surgical pathologic analysis confirmed *** patient received symptomatic and supportive post-operative care and was discharged on postoperative day 4 without complications such as abdominal bleeding,intestinal obstruction,or incision *** tumor recurrence was observed during a 7-mo follow-up *** LAMN is a rare disease that lacks specific clinical *** CT plays a crucial role in diagnosing LAMN,and laparoscopic surgery is a safe and effective diagnostic and therapeutic approach.

关键词： Low-grade appendiceal mucinous neoplasm Pseudomyxoma peritonei Computed tomography Laparoscopy appendectomy Case report

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Hydrogel dressings on neurotrophic keratitis in an experimental animal model

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1396-1402页

作者： Hua-Qin Xia Xiao-Dan jiang yi-Fan Song Xue-Min Li Yan-Jie Tian Department of Ophthalmology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third HospitalBeijing 100191China

AIM:To investigate the therapeutic effects of hydrogel dressings on neurotrophic keratitis in ***:Male Wistar rats,aged 42–56d,were randomly divided into control,experimental,and treatment groups,each consisting of five *** experimental and treatment groups underwent neurotrophic keratitis modeling in both *** successful modeling,biomedical hydrogels formed with polyvinyl alcohol and polyvinyl pyrrolidone were used in treatment group for *** irritation response and keratitis index scores,Schirmer’s test,tear film break-up time(BUT),sodium fluorescein staining,and hematoxylin and eosin(HE)staining were used to evaluate the effectiveness of the ***:The neurotrophic keratitis model was successfully established in rats with severe ophthalmic nerve injury,characterized by keratitis,ocular irritation,reduced tear secretion measured by decreased BUT and Schirmer test values,corneal epithelial loss,and disorganized collagen fibers in the stromal *** treatment with hydrogel dressings,significant improvements were observed in keratitis scores and ocular irritation symptoms in model *** the recovery of tear secretion,as measured by the Schirmer’s test,did not show statistical differences,BUT was significantly *** staining confirmed a reduction in the extent of corneal epithelial loss after *** staining revealed the restoration of the structural disorder in both the epithelial and stromal layers to a certain ***:Hydrogel dressing reduces ocular surface irritation,improves tear film stability,and promotes the repair and restoration of damaged epithelial cells by maintaining a moist and clean environment on the ocular surface in the rat model.

关键词： neurotrophic keratitis hydrogel corneal epithelial cells rat

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Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 751-764页

作者： Wen Li Jiali Huang Chen Shen Weiye jiang Xi Yang Jingxuan Huang Yueqing Gu Zhiyu Li yi Ma Jinlei Bian State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China jiangsu Key Laboratory of Drug Design and Optimization Department of Medicinal ChemistrySchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such *** address this challenge,we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug,specifically 6-diazo-5-oxo-L-norleucine(DON),using a thioketal linkage(TK).This system enables imaging,chemotherapy,photodynamic therapy,and on-demand drug release upon radiation *** optimized prodrug,DON-TK-BM3,incorporating cyanine dyes as the fluorophore,displayed potent reactive oxygen species release and efficient tumor cell *** the parent drug DON,DON-TK-BM3 exhibited no toxicity toward normal ***,DON-TK-BM3 demonstrated high tumor accumulation and reduced side effects,including gastrointestinal toxicity,in *** study provides a practical strategy for designing prodrugs of metabolic inhibitors with significant toxicity stemming from their lack of tissue selectivity.

关键词： Smart prodrug system Glutamineantagonists Immunotherapy Photodynamictherapy Reactive oxygen species Metabolicinhibitor Cyaninedye Non-small-cell lung cancer(NSCLC)

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Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer’s Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice

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Neuroscience Bulletin 2024年第2期40卷 182-200页

作者： Yang Zhu Hao Huang Zhi Chen Yong Tao Ling-yi Liao Shi-Hao Gao Yan-jiang Wang Chang-Yue Gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqing 400042China Department of Neurology and Center for Clinical Neuroscience Daping HospitalArmy Medical UniversityChongqing 400042China Department of Special Medicine Daping HospitalArmy Medical UniversityChongqing 400042China

Intermittent theta burst stimulation(iTBS),a time-saving and cost-effective repetitive transcranial magnetic stimulation regime,has been shown to improve cognition in patients with Alzheimer’s disease(AD).However,the specific mechanism underlying iTBS-induced cognitive enhancement remains *** studies suggested that mitochondrial functions are modulated by magnetic ***,we showed that iTBS upregulates the expression of iron-sulfur cluster assembly 1(ISCA1,an essential regulatory factor for mitochondrial respiration)in the brain of APP/PS1 *** vivo and in vitro studies revealed that iTBS modulates mitochondrial iron-sulfur cluster assembly to facilitate mitochondrial respiration and function,which is required for ***,iTBS rescues cognitive decline and attenuates AD-type pathologies in APP/PS1 *** present study uncovers a novel mechanism by which iTBS modulates mitochondrial respiration and function via ISCA1-mediated iron-sulfur cluster assembly to alleviate cognitive impairments and pathologies in *** provide the mechanistic target of iTBS that warrants its therapeutic potential for AD patients.

关键词： Intermittent theta burst stimulation Alzheimer’s disease Iron-sulfur cluster assembly 1 Mitochondrial dysfunction Neurodegeneration

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Performance and enhanced oil recovery efficiency of an acid-resistant polymer microspheres of anti-CO2 channeling in low-permeability reservoirs

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Petroleum Science 2024年第4期21卷 2420-2432页

作者： Hai-Zhuang jiang Hong-Bin Yang Ruo-Sheng Pan Zhen-Yu Ren Wan-Li Kang Jun-yi Zhang Shi-Long Pan Bauyrzhan Sarsenbekuly State Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) School of Petroleum Engineering China University of Petroleum (East China) Oil and Gas Engineering Research Institute School of Energy and Petroleum Industry Kazakh-British Technical University

CO2flooding is a vital development method for enhanced oil recovery in low-permeability reservoirs,However,micro-fractures are developed in low-permeability reservoirs,which are essential oil flow channels but can also cause severe CO2gas channeling ***,anti-gas channeling is a necessary measure to improve the effect of *** kind of anti-gas channeling refers to the plugging of fractures in the deep formation to prevent CO2gas channeling,which is different from the wellbore *** microspheres have the characteristics of controllable deep plugging,which can achieve the profile control of low-permeability fractured *** acidic environments with supercritical CO2,traditional polymer microspheres have poor expandability and plugging *** on previous work,a systematic evaluation of the expansion performance,dispersion rheological properties,stability,deep migration,anti-CO2channeling and enhanced oil recovery ability of a novel acid-resistant polymer microsphere（DCNPM-A） was carried out under CQ oilifield conditions（salinity of85,000 mg/L,80℃,pH=3）.The results show that the DCNPM-A microsphere had a better expansion performance than the traditional microsphere,with a swelling rate of *** microsphere dispersion with a concentration of 0.1%-0.5% had the advantages of low viscosity,high dispersion and good injectability in the low permeability fractured *** the acidic environment of supercritical CO2,DCNPM-A microspheres showed excellent stability and could maintain strength for over 60 d with less *** core experiments,DCNPM-A microspheres exhibited delayed swelling characteristics and could effectively plug deep *** a plugging rate of 95%,the subsequent enhanced oil recovery of CO2flooding could reach 21.03%.The experimental results can provide a theoretical basis for anti-CO2channeling and enhanced oil recovery in low-permeability fractured reservoirs.

关键词： Low-permeability reservoir Anti-CO 2 channeling Polymer microsphere Acid resistance

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Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KONG Zi Qing LIU Li qun HUANG De Qin WANG Yu Tong LI Jing Jie ZHANG Zheng WANG Xi Xi LIU Chuan Ling ZHANG Ya Di SHAO Jia Kang ZHU yi Min CHEN yi Meng LIU Mei ZHAO Wei Hong Medical School of Chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(P<0.001).The rate of HER2-low status increased with increasing ER expression levels(Mantel-Haenszelχ^(2)test,P<0.001,Pearson’s R=0.159,P<0.001).Survival analysis revealed a significantly longer overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

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The First Reported Case of Co-Infection with Neisseria Meningitidis and Bordetella Pertussis in the Cerebrospinal Fluid Specimen of a Normal Four-Year-Old Child

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Biomedical and Environmental Sciences 2024年第4期37卷 432-435页

作者： XIA Xian LI Guo Ming TANG yi WANG Si Quan HE Fei jiang Yong Zhong YANG Hong Mei jiang Hong Lin LYU Jing MAO Ling Feng Hubei Key Laboratory of Edible Wild Plants Conservation&Utilization Hubei Normal UniversityHuangshi 430070HubeiChina Hubei Provincial Center for Disease Control and Prevention Wuhan 430079HubeiChina Joint Research Center for Molecular Diagnosis of Severe Infection in Children Binjiang Institute of Zhejiang UniversityHangzhou 310058ZhejiangChina

Pertussis is an acute and highly contagious respiratory disease caused by Bordetella pertussis(***),which occurs in people of all ages and is most dangerous for young children,especially *** introduction of whole-cell pertussis vaccines(wPVs)in the 1950s dramatically reduced the incidence of pertussis worldwide[1].However,over the past two decades,many studies have reported the resurgence of pertussis in different countries[2].Epidemiological surveillance in Hubei Province over the last 3 years revealed a clear increasing trend in the incidence of pertussis during the coronavirus disease 2019(COVID-19)epidemic.

关键词： Pertussis dangerous Hubei

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Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1768-1776页

作者： Hang Chi Suo-qun Zhao Ru-yi Chen Xing-Xing Suo Rong-Rong Zhang Wen-Hui Yang Dong-Sheng Zhou Min Fang Bo ying Yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS100071BeijingChina College of Life Sciences Inner Mongolia Agricultural UniversityHohhot010018Inner MongoliaChina School of Life Sciences Henan UniversityKaifeng475004HenanChina Suzhou Abogen Biosciences Co. LtdSuzhou215123JiangsuChina Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071BeijingChina

The Orthopoxvirus genus,especially variola virus(VARV),monkeypox virus(MPXV),remains a significant public health threat *** development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing ***-encoded antibodies have emerged as a powerful and universal platform for rapid antibody ***,by using the established lipid nanoparticle(LNP)-encapsulated mRNA platform,we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against *** vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing *** importantly,mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus(VACV)lethal challenge mouse model,and a unique mRNA antibody cocktail,Mix2a,exhibited superior in vivo protection by targeting both intracellular mature virus(IMV)-form and extracellular enveloped virus(EEV)-form *** summary,our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform,highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as otheremerging viruses.

关键词： proof universal neutral

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Health risk ranking of antibiotic resistance genes in the Yangtze River

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Environmental Science and Ecotechnology 2024年第5期21卷 113-122页

作者： Chunxia jiang Zelong Zhao Hans-Peter Grossart Feng Ju yi Zhao Geoffrey Michael Gadd Ewa Korzeniewska Yuyi Yang Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan430074China University of Chinese Academy of Sciences Beijing100049China Danjiangkou Wetland Ecosystem Field Scientific Observation and Research Station Chinese Academy of Sciences&Hubei ProvinceWuhan430074China Liaoning Key Laboratory of Marine Fishery Molecular Biology Liaoning Key Lab of Germplasm Improvement and Fine Seed Breeding of Marine Aquatic AnimalsLiaoning Ocean and Fisheries Science Research InstituteDalian116023China Leibniz-Institute for Freshwater Ecology and Inland Fisheries(IGB) Neuglobsow16775Germany Institute for Biochemistry and Biology Potsdam UniversityPotsdam14469Germany Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou310030China School of Water Resources and Environment China University of Geosciences(Beijing)Beijing100083China Geomicrobiology Group School of Life SciencesUniversity of DundeeDundeeDD15EHScotlandUK State Key Laboratory of Heavy Oil Processing State Key Laboratory of Petroleum Pollution ControlChina University of PetroleumBeijing102249China Department of Water Protection Engineering and Environmental Microbiology Faculty of GeoengineeringUniversity of Warmia and Mazury in OlsztynOlsztyn10-720Poland

Antibiotic resistance is an escalating global health concern,exacerbated by the pervasive presence of antibiotic resistance genes(ARGs)in natural *** Yangtze River,the world's third-longest river,traversing areas with intense human activities,presents a unique ecosystem for studying the impact of these genes on human ***,we explored ARGs in the Yangtze River,examining 204 samples from six distinct habitats of approximately 6000 km of the river,including free-living and particle-associated settings,surface and bottom sediments,and surface and bottom bank *** shotgun sequencing,we generated an average of 13.69 Gb reads per *** findings revealed a significantly higher abundance and diversity of ARGs in water-borne bacteria compared to other habitats.A notable pattern of resistome coalescence was observed within similar habitat *** addition,we developed a framework for ranking the risk of ARG and a corresponding method for calculating the risk *** them,we identified water-borne bacteria as the highest contributors to health risks,and noted an increase in ARG risks in particle-associated bacteria correlating with heightened anthropogenic *** analysis using a weighted ARG risk index pinpointed the ChengdueChongqing and Yangtze River Delta urban agglomerations as regions of elevated health *** insights provide a critical new perspective on ARG health risk assessment,highlighting the urgent need for strategies to mitigate the impact of ARGs on human health and to preserve the ecological and economic sustainability of the Yangtze River for future human use.

关键词： Antibiotic resistance genes Yangtze River Habitat Coalescence Health risk

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