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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi qun yi Yao Liu yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationHubei Key Laboratory of Novel Reactor and Green Chemical TechnologySchool of Chemical Engineering&PharmacyWuhan Institute of TechnologyWuhan 430205HubeiChina Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079HubeiChina College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108FujianChina

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction(OER).Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER ***,most of them undergo incomplete reconstruction with limited thickness of reconstruction layer,leading to low component utilization and arduous exploration of real catalytic ***,we identify the dynamic behaviors in complete reconstruction of Co-based complexes during *** hollow phytic acid(PA)cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability,in favor of the fast and complete reconstruction.A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co(Fe)(OH)xand subsequent potential-driven oxidation to Co(Fe)*** obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm^(-2)and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER *** work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng Liao Sha Liao Yu-Jiao Gao Xi Wang Li-Hong Guo Su Zheng Wu Yang yi-Nan dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

Chinese Medicine for Treatment of COVID-19:A Review of Potential Pharmacological Components and Mechanisms

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Chinese Journal of Integrative Medicine 2025年第1期31卷 83-95页

作者： XU Qian-qian YU Dong-dong FAN Xiao-dan CUI He-rong dai Qian-qian ZHONG Xiao-ying ZHANG Xin-yi ZHAO Chen YOU Liang-zhen SHANG Hong-cai Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China The Geriatrics Center First Affiliated HospitalAnhui University of Chinese MedicineHefei230031China School of Medical Information Engineering Guangzhou University of Chinese MedicineGuangzhou51006China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China

Coronavirus disease 2019(COVID-19)is an acute infectious respiratory disease that has been prevalent since December *** medicine(CM)has demonstrated its unique advantages in the fight against COVID-19 in the areas of disease prevention,improvement of clinical symptoms,and control of disease *** review summarized the relevant material components of CM in the treatment of COVID-19 by searching the relevant literature and reports on CM in the treatment of COVID-19 and combining with the physiological and pathological characteristics of the novel *** the basis of sorting out experimental methods in vivo and in vitro,the mechanism of herb action was further clarified in terms of inhibiting virus invasion and replication and improving related *** aim of the article is to explore the strengths and characteristics of CM in the treatment of COVID-19,and to provide a basis for the research and scientific,standardized treatment of COVID-19 with CM.

关键词： Chinese medicine COVID-19 SARS-CoV-2 substance component mechanism experimental method

Identification of common genetic variants in KCNQ family genes associated with gastric cancer survival in a Chinese population

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Journal of Biomedical Research 2025年第1期39卷 76-86页

作者： Yuetong Chen Chen Li yi Shi Jiali dai yixuan Meng Shuwei Li Cuiju Tang Dongying Gu Jinfei Chen Department of Radiation Oncology the Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215008China Department of Oncology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Department of Oncology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325015China Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

The KCNQ family of genes(KCNQ1–KCNQ5),encoding voltage-gated K+(Kv)channels,have been demonstrated to play potential pathophysiological roles in ***,the associations between genetic variants located in KCNQ family genes and gastric cancer survival remain *** this study,a large-scale cohort comprising 1135 Chinese gastric cancer patients was enrolled to identify genetic variants in KCNQ family genes associated with overall survival(OS).Based on the survival evaluation of all five KCNQ family genes,KCNQ1 was selected for subsequent genetic *** both Cox regression model and stepwise Cox regression model used to evaluate survival-related genetic variants,we found that KCNQ1 rs10832417G>T was associated with an increased OS in gastric cancer patients(adjusted hazards ratio[HR]=0.84,95%confidence interval[CI]:0.72–0.98,P=0.023).Subsequently,a nomogram was constructed to enhance the prognostic capacity and clinical translation of rs10832417 *** rs10832417 T allele was predicted to increase the minimum free energy of the secondary ***,we observed that gastric cancer patients with downregulated KCNQ1expression had a poorer survival across multiple public *** findings of the present study indicate that KCNQ1 rs10832417 may serve as an independent prognostic predictor of gastric cancer,providing novel insights into the progression and survival of the disease.

关键词： gastric cancer survival genetic variants ionic channels

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China(Life Sciences) 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastroenterology Gansu Wuwei Tumor HospitalWuwei 730000China Cixian Cancer Institute Handan 056500China Linzhou Cancer Hospital Linzhou 456550China Center for Disease Control and Prevention of Sheyang County Yancheng 224499China Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410029China Luoshan Center for Disease Control and Prevention Xinyang 464299China Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150081China

Surveillance recommendations for gastric cancer(GC)in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline *** aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool,and assessed whether mild-precursor-lesion patients can be safely exempt from *** the multicenter communitybased cohort,75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until *** incidence rates(CIRs)of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank *** Cox regression models were used to detect potential factors for progression towards GC.A risk score was calculated as counts of selected *** independent cohort,including 26,586 participants was used for external *** a median follow-up of 6.25 years,CIRs of GC were 0.302%,0.436%,and 4.756%for normal group,non-neoplastic(atrophic gastritis/intestinal metaplasia)and neoplastic lesions(low-grade/high-grade dysplasia),respectively(Ptrend<0.001).Four predictors,including male,≥60 years,smoking,and limited vegetable consumption,were selected for ***-risk patients(≥3 risk factors)with non-neoplastic lesions showed higher GC risks(adjusted HR=7.73,95%CI:4.29–13.92),and their four-year CIR reached the one-year CIR of neoplastic *** categorizing non-neoplastic lesions by histological grade,both patients with moderate-to-severe lesions(aHR=3.07,95%CI:1.67–5.64)and high-risk patients with mild lesions(aHR=7.29,95%CI:3.58–14.86)showed higher *** trends were observed in validation ***-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline *** study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

Hewei Jiangni granule(和胃降逆颗粒) alleviates visceral hypersensitivity of non-erosive reflux disease via stromal interaction molecule 1/transient receptor potential vanilloid subfamily member 1 pathway

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Journal of Traditional Chinese Medicine 2025年第1期45卷 1-12页

作者： CHENG Yuan ZHANG Xiaosi LI Junxiang ZHANG Liming dai yi XIE Chune SHI Lei LI Xiaohong KOU Fushun School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine Nanjing University of Chinese Medicine Gastroenterology Department Dongfang HospitalBeijing University of Chinese Medicine Department of Pharmacotherapy and Oriental Medicine School of PharmacyHyogo University of Health Sciences Center for IBD Research Department of GastroenterologyShanghai Tenth People's HospitalTongji University School of Medicine

OBJECTIVE: To explore if Hewei Jiangni granule（和胃降逆颗粒, HWJNG） could regulate esophageal hypersensitivity via stromal interaction molecule 1（STIM1）/transient receptor potential vanilloid subfamily member 1（TRPV1） pathway. METHODS: Qualitative analysis of HWJNG was analysis by high performance of liquid and gas chromatography. In vivo, animal model of non-erosive reflux disease（NERD） was established by fructose intake and restraint stress. HWJNG and Omeprazole were administered by gavage to the drug intervention group. Reflux and visceral hypersensitivity were analyzed by pathological changes, PH value test, mechanical paw withdrawal threshold, thermal withdrawal latency and mast cells（MCs） degranulation. In vitro, substance P（SP）-induced P815 cells and dorsal root ganglion（DRG） cells were cocultured. Expression in both mice and cells of STIM1, TRPV1, and esophageal visceral hypersensitivity-related gastrointestinal neurochemicals were validated by enzyme linked immunosorbent assays, quantitative realtime polymerase chain reaction（qRT-PCR） and Western blot. Moreover, overexpression and small interfering RNA against STIM1 were utilized to verify of the role of HWJNG in DRG cells. RESULTS: HWJNG significantly suppressed intercellular space widening, injury of mitochondrial, MCs degranulation, mechanical allodynia and heat neuropathic sensory and increased pH value of esophageal mucosa in NERD mice. HWJNG inhibited expression of visceral hypersensitivityrelated gastrointestinal neurochemicals in esophageal mucosa and activated P815 cells, and expression of the STIM1, TRPV1 and related neurotransmitters in DRG and DRG cells. STIM1 siRNA and HWJNG both reduced P815 cells adhesion to DRGs cells and Ca2+flow into the cytoplasmic space of DRG cells. Furthermore, HWJNG could reversed STIM1 overexpression induced upregulation of TRPV1. CONCLUSION: HWJNG suppressed intercellular space widening in NERD mice, stabilized MCs and restored neuronal hyperexcitability by regulating vis

关键词： Hewei Jiangni granule non-erosive reflux disease stromal interaction molecule 1 transient receptor potential channels visceral hypersensitivity

Get More Acids for More Iron： A New Regulatory Pathway for Iron Homeostasis

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Molecular Plant 2016年第4期9卷 498-500页

作者： Gao, yi-qun Chao, dai-yin Chinese Acad Sci Natl Key Lab Plant Mol Genet CAS Ctr Excellence Mol Plant Sci Inst Plant Physiol & EcolShanghai Inst Biol Sci 300 Fenglin Rd Shanghai 200032 Peoples R China

Iron is an essential element for most living organisms including plants,playing a vital role in key biological processes such as respiration and ***,as a heavy metal,excess iron is also toxic for ***,the iron concentr... 详细信息

关键词： essential element organisms

Knoevenagel condensation catalysed by poly(vinyl chloride) supported tetraethylenepentamine (PVC-TEPA)

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Chinese Chemical Letters 2007年第3期18卷 266-268页

作者： Fen Dong yi qun Li Rong Feng dai Department of Chemistry Jinan University Guangzhou 510632 China

Poly（vinyl chloride） supported tetraethylenepentamine （PVC-TEPA） has been found to be an efficient catalyst for the Knoevenagel condensation. A wide range of aromatic aldehydes easily undergo condensations with ethyl cyanoacetate and malononitrile in the commercial 95% ethanol in refluxing using PVC-TEPA as catalyst to afford the desired products of good purity in moderate to excellent yields. A recycling study confirmed that the catalyst could be reused, the yield of the desired condensation product were not reduced. The merits of this protocol are environmentally benign, simple operation, convenient work-up and good yields. Furthermore, the catalyst can easily be recovered and reused at five times with comparable yields.

关键词： Knoevenagel condensation PVC-supported tetraethylenepentamine Catalysis

长循环双靶向重组蛋白药物偶联体用于抗肿瘤治疗

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高分子学报 2025年第2期56卷 266-277页

作者：袁洋蒋惠忆陈伟芝蒋锡群南京大学化学化工学院、高性能高分子材料与技术教育部重点实验室南京210023

药物的靶向性以及体内长效循环特性对于药物在病灶部位的累积和疗效发挥着至关重要的作用.本研究设计合成了长循环双靶向重组蛋白药物偶联体RPDC-L(long-circulated dualtargeted recombinant protein drug conjugate),用于抗肿瘤治疗.R... 详细信息

药物的靶向性以及体内长效循环特性对于药物在病灶部位的累积和疗效发挥着至关重要的作用.本研究设计合成了长循环双靶向重组蛋白药物偶联体RPDC-L(long-circulated dualtargeted recombinant protein drug conjugate),用于抗肿瘤治疗.RPDC-L包含4个部分,分别是靶向人表皮生长因子受体2(HER2)的anti-HER2纳米抗体、整合素受体αvβ_(3)的多肽配体RGD、白蛋白结合域以及小分子化疗药物阿霉素.其中,anti-HER2纳米抗体和RGD多肽提供肿瘤靶向功能;白蛋白结合域通过结合血液中的白蛋白,赋予药物较长的体内循环时间;化疗药物阿霉素通过酸响应聚乙二醇-腙键连接子与重组蛋白偶联,在微酸性的肿瘤微环境中通过pH响应性释放,进行肿瘤杀伤.与非长循环双靶向重组蛋白相比,融合表达白蛋白结合单元后,长循环双靶向重组蛋白在小鼠体内的半衰期时间提升到了1.51倍.与抗肿瘤药物阿霉素偶联后,药物在肿瘤组织中的累积提升到了1.6倍.体内抗肿瘤试验表明,RPDC-L实现安全高效的抗肿瘤效果,肿瘤抑制率达到78.4%,是非长循环双靶向重组蛋白药物偶联体的1.50倍.

关键词：药物递送大分子药物双靶向重组蛋白药物偶联体长循环