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CT whole lung radiomic nomogram:a potential biomarker for lung function evaluation and identification of COPD

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Military Medical Research 2025年第1期12卷 36-47页

作者： Tao-Hu Zhou Xiu-Xiu Zhou Jiong Ni Yan-qing Ma Fang-yi Xu Bing Fan Yu Guan Xin-Ang Jiang xiao-qing Lin Jie Li yi xia xiang Wang Yun Wang Wen-Jun Huang Wen-Ting Tu Peng Dong Zhao-Bin Li Shi-Yuan Liu Li Fan Department of Radiology the Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China School of Medical Imaging Shandong Second Medical UniversityWeifang 261053ShandongChina Department of Radiology School of MedicineTongji HospitalTongji UniversityShanghai 200065China Department of Radiology Zhejiang Province People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Department of Radiology Sir Run Run Shaw HospitalZhejiang 310018China Jiangxi Provincial People’s Hospital the First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China College of Health Sciences and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Radiology the Second People’s Hospital of DeyangDeyang 618000SichuanChina Department of Radiation Oncology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Background:Computed tomography(CT)plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease(COPD).This study aimed to explore the performance of CT-based whole lung radiomic in discriminating COPD patients and non-COPD ***:This retrospective study was performed on 2785 patients who underwent pulmonary function examination in 5 hospitals and were divided into non-COPD group and COPD *** radiomic features of the whole lung volume were *** absolute shrinkage and selection operator(LASSO)logistic regression was applied for feature selection and radiomic signature construction.A radiomic nomogram was established by combining the radiomic score and clinical *** operating characteristic(ROC)curve analysis and decision curve analysis(DCA)were used to evaluate the predictive performance of the radiomic nomogram in the training,internal validation,and independent external validation ***:Eighteen radiomic features were collected from the whole lung volume to construct a radiomic *** area under the curve(AUC)of the radiomic model in the training,internal,and independent external validation cohorts were 0.888[95%confidence interval(CI)0.869–0.906],0.874(95%CI 0.844–0.904),and 0.846(95%CI 0.822–0.870),*** were higher than the clinical model(AUC were 0.732,0.714,and 0.777,respectively,Pying COPD in this multicenter study.

关键词： Chronic obstructive pulmonary disease(COPD) Computed tomography(CT) Radiomic

黄河流域生态系统服务权衡协同关系及其时空异质性

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环境科学 2025年第2期46卷 972-989页

作者：王奕淇孙学莹长安大学经济与管理学院西安710064

探析生态系统服务之间权衡协同关系及其内在影响机制,对提高生态系统的整体效益,保障生态系统服务的可持续供给至关重要.以黄河流域499个县域为研究对象,在测度黄河流域各县域生态系统服务价值的基础上,采用Pearson相关系数法测度各县... 详细信息

探析生态系统服务之间权衡协同关系及其内在影响机制,对提高生态系统的整体效益,保障生态系统服务的可持续供给至关重要.以黄河流域499个县域为研究对象,在测度黄河流域各县域生态系统服务价值的基础上,采用Pearson相关系数法测度各县域的权衡与协同关系,并构建地理加权逻辑回归(GWLR)模型考察权衡协同与各影响因素之间的时空异质性.结果表明:(1)2001~2021年黄河流域生态系统服务价值先上升再下降最后上升,呈现“下游低、中上游高”的空间分布格局.(2)通过对生态系统服务进行权衡与协同分析,发现研究期内黄河流域各生态系统服务之间的权衡关系存在于食物生产与调节服务和支持服务之间,协同关系存在于调节服务和支持服务内部及其二者之间.(3)通过对潜在因子进行初次筛选和二次筛选,得到建设用地占比变化、年均归一化植被指数(NDVI)变化、年均降水量变化、年均温度变化、人口密度变化和GDP变化6个自变量对6组生态系统服务之间的关系影响较为显著.(4)与其他因子相比,建设用地占比变化和年均温度变化,对生态系统服务权衡协同的时空非平稳响应更强烈.研究结果有利于优化黄河流域生态系统服务效益,为制定精细化的管理措施和政策提供支持.

关键词：生态系统服务价值权衡与协同时空非平稳响应 GWLR模型黄河流域

Effects of family cognitive therapy on aggressive behavior,family functioning,and marital quality in patients with major depression

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World Journal of Psychiatry 2025年第3期15卷 124-133页

作者： yi-Bing Wang Xin-xia Chen Song-Tao Li Hong-Ping Yan Department of Psychiatry Shaoxing 7th People's HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Depression is a prevalent mental health disorder with significant impacts on individuals and *** hypothesize that combining family cognitive therapy(FCT)with pharmacotherapy will be more effective in managing depression and improving family dynamics than pharmacotherapy *** To investigate the effects of FCT combined with sertraline on depression,aggressive behavior,and family functioning in patients with major depressive disorder(MDD).METHODS This study involved 178 patients diagnosed with MDD at the Shaoxing 7th People's Hospital from January 2022 to April *** were divided into two groups according to whether they received *** included both patientfocused cognitive therapy and family-focused psychological guidance over a 12-week *** The observation group receiving combined treatment showed significantly greater reductions in depressive symptoms(Beck Depression Inventory scores:27.4±4.7 to 18.6±5.2)compared to the control group(28.1±5.5 to 20.9±4.9),with P=0.031 for the difference between *** in family functioning and marital quality were also observed,with P<0.001 for key dimensions on the Family Assessment Device and Enrich Marital *** The combination of FCT with sertraline effectively reduces depressive symptoms and improves family dynamics in patients with MDD.

关键词： Major depressive disorder Family cognitive therapy Depressive symptoms Aggressive behavior Marital quality

中国省际旅游交通碳排放空间关联网络及影响因素

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环境科学 2025年第1期46卷 53-65页

作者：雷婷王奕淇王超长安大学经济与管理学院西安710064 山东大学蓝绿发展研究院威海264209

厘清旅游交通碳排放空间关联网络结构及其影响因素对中国旅游交通行业统筹规划碳减排治理工作,实现旅游交通产业可持续发展至关重要.基于2001~2021年省际面板数据,测算中国旅游交通碳排放量,利用修正后的空间引力模型构建中国省际旅游... 详细信息

厘清旅游交通碳排放空间关联网络结构及其影响因素对中国旅游交通行业统筹规划碳减排治理工作,实现旅游交通产业可持续发展至关重要.基于2001~2021年省际面板数据,测算中国旅游交通碳排放量,利用修正后的空间引力模型构建中国省际旅游交通碳排放空间关联网络,结合社会网络分析法和QAP模型对空间网络结构特征及其影响因素进行分析.结果表明:①中国旅游交通碳排放总量逐年缓慢增长,呈“东南高、西北低”的分布格局,地区差异明显.②中国旅游交通碳排放网络已形成“东密西疏”的多线程、复杂化的关联形态.空间网络中的“马太效应”较明显,北京、上海和广东等东部省份居于核心主导地位;新疆、青海、黑龙江和辽宁等西北和东北省份居于边缘位置.③中国旅游交通碳排放块模型划分结构明显,各板块关联关系较多且均接收来自其他板块的碳排放溢出.④交通能源强度和交通运输结构对空间关联网络具有显著的正向影响;空间地理距离、居民消费水平和旅游经济效益则对空间网络产生显著的负向影响.

关键词：旅游交通碳排放空间网络结构社会网络分析影响因素

Effect of pharmacological pupil changes on intraocular lens power calculation:a systematic review and Metaanalysis

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 518-525页

作者： Si-yi Tan Dian-Feng Liu Wei-qi Wang Bing-Song Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To investigate the effect of pharmacological pupil alterations on intraocular lens(IOL)power ***:A systematic review and Meta-analysis of studies published before December 2023 in the PubMed,Embase,and Cochrane library databases on the accuracy of pharmacological pupil changes on IOL power calculation was *** primary outcome was the results of IOL power calculations before and after the use of *** analyses were performed based on participants’basic characteristics,such as age,axial length(AL),and whether miosis or mydriasis were used as classification criteria for further *** eligible study was evaluated for potential risk of bias by the AHRQ assessment *** study was registered on PROSPERO(CRD 42024497535).RESULTS:A total of 3062 eyes from 21 studies were *** was no significant difference in the IOL power calculation before and after pharmacological pupil changes using any of the Hoffer Q(WMD=0.055,95%CI=-0.046–0.156;P=0.29),SRK/T(WMD=0.003,95%CI=-0.073–0.080;P=0.93),Haigis(WMD=-0.030,95%CI=-0.176–0.116;P=0.69),Holladay 2(WMD=-0.042,95%CI=-0.366–0.282;P=0.80),and Barrett Universal Ⅱ(WMD=0.033,95%CI=-0.061–0.127;P=0.49)*** the measurement of parameters related to IOL power calculation,for either miosis or mydriasis AL(P=0.98 and 0.29,respectively),lens thickness(P=0.96 and 0.13,respectively),and mean keratometry(P=0.90 and 0.86,respectively)did not present significant differences,while anterior chamber depth(P=0.07 and<0.01,respectively)and white-to-white distance(P=0.01 and 0.04,respectively)changed significantly between the two measurements prior and *** the same time,despite there being some participants with the difference between the before and after calculations greater than 0.5 diopter,there was no significant difference in the incidence rate between these ***:There is no significant effect of pharmacological pupil changes on the IOL power ***

关键词： ocular biometry intraocular lens power calculation cataract pharmacological pupil alterations

Precision storage lifetime measurements of highly charged heavy ions in the CSRe storage ring using a Schottky resonator

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Nuclear Science and Techniques 2025年第1期36卷 150-160页

作者： qian Wang Xin-Liang Yan Guang-Yu Zhu Shahab Sanjari Li-Jun Mao He Zhao Yuri ALitvinov Rui-Jiu Chen Meng Wang Yu-Hu Zhang You-Jin Yuan Jun-xia Wu Hong-Yang Jiao Yue Yu Zu-yi Chen yin-Fang Luo Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China GSI Helmholtzzentrum für Schwerionenforschung Planckstrasse 164291 DarmstadtGermany FH Aachen University of Applied Sciences Heinrich-Mussmann-Str.152428 JülichGermany

Schottky mass spectrometry utilizing heavy-ion storage rings is a powerful technique for the precise mass and decay half-life measurements of highly charged *** to the nondestructive ion detection features of Schottky noise detectors,the number of stored ions in the ring is determined by the peak area in the measured revolution frequency *** of their intrinsic amplitude-frequency characteristic(AFC),Schottky detector systems exhibit varying sensitivities at different *** low-energy electron-cooled stored ions,a new method is developed to calibrate the AFC curve of the Schottky detector system of the Experimental Cooler Storage Ring(CSRe)storage ring located in Lanzhou,*** the amplitude-calibrated frequency spectrum,a notable refinement was observed in the precision of both the peak position and peak *** a result,the storage lifetimes of the electron-cooled fully ionized^(56)Fe^(26+)ions were determined with high precision at beam energies of 13.7 and 116.4 MeV/u,despite of frequency drifts during the *** electron cooling was turned off,the effective vacuum condition experienced by the 116.4 MeV/u^(56)Fe^(26+)ions was determined using amplitude-calibrated spectra,revealing a value of 2×10^(−10)mbar,which is consistent with vacuum gauge readings along the CSRe *** method reported herein will be adapted for the next-generation storage ring of the HIAF facility under construction in Huizhou,*** can also be adapted to other storage ring facilities worldwide to improve precision and enhance lifetime measurements using many ions in the ring.

关键词： Lifetime measurement Schottky mass spectrometry Sensitivity response Highly charged heavy ion Resonator UH vacuum Nondestructive diagnostics

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China(Life Sciences) 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang yi Teng qianru Li Changfa xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastroenterology Gansu Wuwei Tumor HospitalWuwei 730000China Cixian Cancer Institute Handan 056500China Linzhou Cancer Hospital Linzhou 456550China Center for Disease Control and Prevention of Sheyang County Yancheng 224499China Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410029China Luoshan Center for Disease Control and Prevention Xinyang 464299China Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150081China

Surveillance recommendations for gastric cancer(GC)in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline *** aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool,and assessed whether mild-precursor-lesion patients can be safely exempt from *** the multicenter communitybased cohort,75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until *** incidence rates(CIRs)of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank *** Cox regression models were used to detect potential factors for progression towards GC.A risk score was calculated as counts of selected *** independent cohort,including 26,586 participants was used for external *** a median follow-up of 6.25 years,CIRs of GC were 0.302%,0.436%,and 4.756%for normal group,non-neoplastic(atrophic gastritis/intestinal metaplasia)and neoplastic lesions(low-grade/high-grade dysplasia),respectively(Ptrend<0.001).Four predictors,including male,≥60 years,smoking,and limited vegetable consumption,were selected for ***-risk patients(≥3 risk factors)with non-neoplastic lesions showed higher GC risks(adjusted HR=7.73,95%CI:4.29–13.92),and their four-year CIR reached the one-year CIR of neoplastic *** categorizing non-neoplastic lesions by histological grade,both patients with moderate-to-severe lesions(aHR=3.07,95%CI:1.67–5.64)and high-risk patients with mild lesions(aHR=7.29,95%CI:3.58–14.86)showed higher *** trends were observed in validation ***-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline *** study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

Improved chromosome-level donkey(Equus asinus)genome provides insights into genome and chromosome evolution

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Journal of Genetics and Genomics 2025年第2期52卷 269-272页

作者： Ge Yang Mian Gong qi-Meng Yang yi-Dan Li Halima Jafari Chu-Zhao Lei Yu Jiang Rui-Hua Dang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China

The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family *** first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strategy(Huang et al.,2015).Subsequently,the donkey genome showed greater improvement in continuity and chromosome length than a previous assembly(Renaud et al.,2018).

关键词： al. insight belongs