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Analysis of lycopodiastrum casuarinoides transcriptome discovers lycodine-type alkaloid biosynthetic genes and genetic markers

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中国药理学与毒理学杂志 2018年第4期32卷 274-275页

作者： Gang CHEN Qiu-mei LIN Lin ZENG yi-ping zou Key Laboratory of Natural Active Pharmaceutical Constituents Yichun University Yichun 336000 China College of Chemistry and Bioengineering Yichun University Yichun 336000 China

OBJECTIVE o facilitate the basic acquaintance with the bioactive lycodine-type alkaloids biosynthetic pathways,we conducted the transcriptome analysis of *** by illumina *** The plant of *** was collected and was subjected to RNA isolation,cDNA library construction,and illumina sequencing before bioinformatics *** sequencing,the clean reads were obtained for de novo assembly by using Trinity software,and then further processed with TGICL sequencing clustering software to generate unigenes,The unigenes are aligned by Blast X alignment to six public protein *** addition,all unigenes are functionally annotated by GO,KEGG and characterized putative genes involved in lycopodium alkaloids *** In total,124,524 high-quality unigenes were obtained with an average sequence length of 601 *** the *** transcripts,61,304 showed significant similarity(E-value<1 e-5) to the known proteins in the public *** the total 124 524 unigenes,47,538 open reading frame(ORFs) were *** on the bioinformatics analysis,all possible enzymes involved in the Lycodine-type alkaloids biosynthetic pathway of *** were identified,including primary amine oxidase(PAO),and Malonly-CoA *** addition,a total of 64 putative cytochrome P450(CYP450) and 827 transcription factors were selected as the candidates of Lycodine-type *** ***,a total of 13 352 simple sequence repeats(SSRs) were identified from the 124,524 unigenes,of which dinucleotide motifs AG/CT(50.1%),were the most *** This transcriptome analysis of ***,provides many valuable candidate genes *** in the biosynthesis of novel secondary metabolites but also lays the foundation for genetic diversity analysis via SSRs markers in ***.

关键词：番茄碱生物碱生物活性药物分析

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Black hairy tongue associated with allo peripheral blood hematopoietic stem cell transplantation

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Chinese Medical Journal 2010年第13期123卷 1807-1808页

作者： LUO yi zou ping LI Qiu-bai YOU Yong Institute of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Tongue lesions resulting from mucositis are a frequent complication of high-dose chemotherapy and irradiation. They are very common in patients with hematopoiefic stem cell transplantation, and tongue lesions due to other causes have also been reported. Black hairy tongue （BHT） is a special tongue lesion, not rare in the population with tobacco abuse, but so far it has not been reported after allo peripheral blood hematopoietic stern cell transplantation （allo-PBHST）. Here we presented a patient who developed BHT after allo-PBHST and discussed the factors that may cause this condition.

关键词： tongue, hairy oral hygiene graft vs host disease

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Functional anatomical hepatectomy guided by indocyanine green fluorescence imaging in patients with localized cholestasis:Report of four cases

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World Journal of Gastrointestinal Surgery 2021年第3期13卷 323-329页

作者： Hong-Wei Han Ning Shi yi-ping zou Yuan-Peng Zhang Ye Lin Zi yin Zhi-Xiang Jian Hao-Sheng Jin The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Liver cancer is a malignant tumor with a high *** present,the most effective treatment is laparoscopic hepatectomy(LH).Indocyanine green fluorescence imaging(ICG-FI)has become an important tool in LH,and the most common fluorescent types of tumors are total fluorescence,partial fluorescence,and rim *** SUMMARY We presented four cases of LH guided by ICG-FI in which we also observed the fourth special fluorescent *** the tumor or intrahepatic stone compresses the adjacent bile duct to cause local cholestasis,the liver segment or subsegment with obstructed bile drainage will show strong *** removal of the lesion together with the fluorescent liver parenchyma may help reduce the risk of tumor or stone *** This type of partial fluorescence can indicate local biliary compression,and the resection method is related to bile drainage,which may be called functional anatomical hepatectomy and ensures radical resection of the lesion.

关键词： Indocyanine green Localized cholestasis Laparoscopic hepatectomy Unique fluorescent phenomenon Functional anatomical hepatectomy Case report

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Pancreatic neuroendocrine tumors:A review of serum biomarkers,staging,and management

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World Journal of Gastroenterology 2020年第19期26卷 2305-2322页

作者： Zu-yi Ma Yuan-Feng Gong Hong-Kai Zhuang Zi-Xuan Zhou Shan-Zhou Huang yi-ping zou Bo-Wen Huang Zhong-Hai Sun Chuan-Zhao Zhang Yun-Qiang Tang Bao-Hua Hou Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Shantou University of Medical College Shantou 515000Guangdong ProvinceChina Department of Hepatobiliary Surgery the Affiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhou 510080Guangdong ProvinceChina

Pancreatic neuroendocrine tumors(pNETs)are a heterogeneous group of tumors with complicated treatment options that depend on pathological grading,clinical staging,and presence of symptoms related to hormonal *** regard to diagnosis,remarkable advances have been made:Chromogranin A is recommended as a general marker for *** other new biomarker modalities,like circulating tumor cells,multiple transcript analysis,microRNA profile,and cytokines,should be clarified in future investigations before clinical ***,the currently available serum biomarkers are insufficient for diagnosis,but reasonably acceptable in evaluating the prognosis of and response to treatments during follow-up of *** resection is still the only curative therapeutic option for localized ***,a debulking operation has also been proven to be effective for controlling the *** for drug therapy,steroids and somatostatin analogues are the first-line therapy for those with positive expression of somatostatin receptor,while everolimus and sunitinib represent important progress for the treatment of patients with advanced *** progress has been achieved in the combination of systematic therapy with local control *** optimal timing of local control intervention,planning of sequential therapies,and implementation of multidisciplinary care remain pending.

关键词： Pancreatic neuroendocrine tumor Serum biomarkers Staging Grading Management Therapy

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Mining lycodine-type alkaloid biosynthetic genes and genetic markers from transcriptome of Lycopodiastrum casuarinoides

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Chinese Herbal Medicines 2020年第2期12卷 133-141页

作者： Gang Chen Qiu-mei Lin Lin Zeng yi-ping zou Key Laboratory of Natural Active Pharmaceutical Constituents College of Chemistry and Biology EngineeringYichun UniversityYichun 336000China College of Life Sciences and Resource Environment Yichun UniversityYichun 336000China

Objective:Lycopodiastrum casuarinoides,a fern of the Lycopodiaceae family,is a traditional Chinese medicine,which has similar efficacy to that of Huperzia serrata in treating rheumatoid arthritis(RA).However,they are different in the contents and compositions of lycopodium *** this study,the biosynthesis related genes of lycopodium alkaloids and genetic markers are discovered in *** ***:The plant of *** was collected and was subjected to the RNA isolation,c DNA library construction,high throughput RNA sequencing and bioinformatics ***:Totally 124,524 high-quality unigenes were assembled from RNA sequencing reads,with an average sequence length of 601 *** the *** transcripts,61,304 shared the significant similarity(E-value<10-5)with existing protein sequences in the public *** 124,524 unigenes,47,538 open reading frames(ORFs)were *** on the bioinformatics analysis,all possible enzyme genes involved in the lycodine-type alkaloids biosynthetic pathway of *** were identified,including lysine decarboxylase(LDC),primary amine oxidase(PAO),malonyl-Co A decarboxylase,***-four putative cytochrome p450(CYP)and 827 putative transcription factors were selected from the transcriptome unigenes as the candidates of lycodine-type alkaloids biosynthesis ***,13,352 simple sequence repeats(SSRs)were identified from 124,524 unigenes,of which dinucleotide motifs AG/CT were the most abundant(50.1%).Meanwhile,we confirmed the amplification effectiveness of25 PCR primer pairs for randomly selected ***:We obtained the comprehensive transcriptomic information from the high throughput RNA sequencing and bioinformatics analysis,which provided a valuable resource of transcript sequences of *** in public databases.

关键词： Lycopodiastrum casuarinoides(spring)Holub ex Dixit llycodine-type alkaloids biosynthesis simple sequence repeat(SSR) transcriptome

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Laboratory scoring system to predict hepatic indocyanine green clearance ability during fluorescence imaging-guided laparoscopic hepatectomy

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1442-1453页

作者： Zhen-Rong Chen Qing-Teng Zeng Ning Shi Hong-Wei Han Zhi-Hong Chen yi-ping zou Yuan-Peng Zhang Fan Wu Lian-Qun Xu Hao-Sheng Jin Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Hepatobiliary Surgery Shenzhen Hospital of Traditional Chinese MedicineShenzhen 518000Guangdong ProvinceChina Medical College Shantou UniversityShantou 515000Guangdong ProvinceChina

BACKGROUND Indocyanine green(ICG)fluorescence played an important role in tumor localization and margin delineation in hepatobiliary ***,the preoperative regimen of ICG administration was still *** associated with tumor fluorescence staining effect were *** To investigate the preoperative laboratory indexes corelated with ICG fluorescence staining effect and establish a novel laboratory scoring system to screen specifical patients who need ICG dose *** To investigate the predictive indicators of ICG fluorescence characteristics in patients undergoing laparoscopic hepatectomy from January 2018 to January 2021 were *** laboratory tests were completed within 1 wk before *** patients received 5 mg ICG injection 24 h before surgery for preliminary tumor *** software was used to measure the fluorescence intensity values of regions of *** analysis was used to identify risk factors.A laboratory risk model was established to identify individuals at high risk for high liver background *** There were 110 patients who were enrolled in this study from January 2019 to January *** mean values of fluorescence intensity of liver background(FI-LB),fluorescence intensity of gallbladder,and fluorescence intensity of target area were 18.87±17.06,54.84±33.29,and 68.56±36.11,*** receiver operating characteristic(ROC)curve showed that FI-LB was a good indicator for liver clearance ability[area under the ROC curve(AUC)=0.984].Correlation analysis found pre-operative aspartate aminotransferase,alanine aminotransferase,gammaglutamyl transpeptidase,adenosine deaminase,and lactate dehydrogenase were positively associated with FI-LB and red blood cell,cholinesterase,and were negatively associated with *** laboratory risk score(TLRS)was calculated according to ROC curve(AUC=0.848,sensitivity=0.773,specificity=0.885).When TLRS was greater than 6.5,the liver

关键词： Indocyanine green Fluorescence Laparoscopic Hepatectomy Predictive biomarkers Blood index

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Intraoperative radiofrequency ablation combined with ^(125)iodine seed implantation for unresectable pancreatic cancer

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World Journal of Gastroenterology 2010年第40期16卷 5104-5110页

作者： yi-ping zou Wei-Min Li Fang Zheng Fu-Cheng Li Hui Huang Ji-Dong Du Hao-Run Liu Department of Hepatobiliary Surgery Chinese PLA 309 Hospital Beijing 100091China

AIM: To evaluate the feasibility, efficacy and safety of intraoperative radiofrequency ablation (RFA) combined with 125 iodine seed implantation for unresectable pancreatic cancer. METHODS: Thirty-two patients (21 males and 11 females) at the age of 68 years (range 48-90 years) with unresectable locally advanced pancreatic cancer admitted to our hospital from January 2006 to May 2008 were enrolled in this study. The tumor, 4-12 cm in diameter, located in pancreatic head of 23 patients and in pancreatic body and tail of 9 patients, was found to be unresectable during operation. Diagnosis of pancreatic cancer was made through intraoperative biopsy. Patients were treated with FRA combined with 125 iodine seed implantation. In brief, a RFA needle was placed, which was confirmed by intraoperative ultrasound to decrease the potential injury of surrounding vital structures, a 125 iodine seed was implanted near the blood vessels and around the tumor border followed by bypass palliative procedure (cholangio-jejunostomy and/or gastrojejunostomy) in 29 ***: The serum CA 19-9 level was decreased from 512 ± 86 U/mL before operation to 176 ± 64 U/mL, 108 ± 42 U/mL and 114 ± 48 U/mL, respectively, 1, 3 and 6 mo after operation (P < 0.05). The pain score on day 7 after operation, 1 and 3 mo after combined therapy was decreased from 5.86 ± 1.92 before operation to 2.65 ± 1.04, 1.65 ± 0.88 and 2.03 ± 1.16, respectively, after operation (P < 0.05). The rate of complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD) in 32 patients was 21.8% (7/32), 56.3% (18/32), 15.6% (5/32) and 6.3% (2/32), respectively, 6 mo after operation, with a median overall survival time of 17. 5 mo. The median survival time of patients at stage Ⅲ was longer than that of those at stage Ⅳ (19 mo vs 10 mo, P = 0.0026). The median survival time of patients who received and did not receive chemotherapy after operation was 20 mo and 16 mo, respectively (P = 0.0176).

关键词： Unresectable pancreatic cancer Radiofrequency ablation 125 iodine seed implantation

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Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

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Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng Li Chunyan Chen Zhenyang Li Peng yi Haihan zou Gao Deng Ming Fang Junzhe He Xin Sun Ronghai Yu Jianglan Shui Caofeng Pan Xiaofang Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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皮试和血特异性IgE检测探讨乳胶过敏

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上海免疫学杂志 2003年第2期23卷 104-107页

作者：李凝许以平邹寒冰上海第二医科大学附属仁济医院呼吸科上海200001

为了了解我国乳胶过敏的发病情况 ,以进一步研究其发病机制及危险因素 ,统计分析我院过敏性疾病防治中心 6 5 1例门诊病人常见过敏原皮肤点刺试验 (SPT )结果 ,再按照门诊号随机挑选 6 4例乳胶与粉尘螨同时阳性的患者 ,并以 30例无过敏... 详细信息

为了了解我国乳胶过敏的发病情况 ,以进一步研究其发病机制及危险因素 ,统计分析我院过敏性疾病防治中心 6 5 1例门诊病人常见过敏原皮肤点刺试验 (SPT )结果 ,再按照门诊号随机挑选 6 4例乳胶与粉尘螨同时阳性的患者 ,并以 30例无过敏性疾病及其家族史的正常人作为对照 ,采用ELISA法测定血清中乳胶及粉尘螨特异性IgE。结果显示乳胶SPT的阳性率较高 (37 5 % ) ,特异性IgE阳性率亦较高 (31 2 5 % ) ;在 11种常见变应原中 ,乳胶与粉尘螨合并阳性率最高 ,其次是狗的分泌物、皮屑和真菌 ;单独对乳胶发生过敏的阳性率极低 (1/ 6 5 1) ;乳胶阳性的SPT与临床相关症状 (OR =14 2 6 1)、过敏性疾病家族史 (OR =3 86 8)之间呈显著相关 (P均 0 0 5 ) ;乳胶与粉尘螨可相互抑制各自的特异性IgE。提示乳胶过敏在我国的发病率较高 ;

关键词：乳胶超敏反应发病机制交叉反应

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图像处理中消除噪声的方法

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计算机应用与软件 2003年第5期20卷 29-30,34页

作者：易平陈福生邹红艳复旦大学计算机与信息技术系上海200433 同济大学计算机科学系上海200092

本文首先讨论了常见的噪声模型,然后讲述了几种典型的去噪方法。最后介绍了几种较新的滤除噪声方法。

关键词：图像处理噪声模型消除噪声方法线性处理

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