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Paraventricular Thalamus as A Major Thalamic Structure for Wake Control

Neuroscience Bulletin 2019年第5期35卷 946-948页

作者： Yu-Feng Shao Jian-Sheng Lin yi-ping hou Departments of Neuroscience Anatomy Histology and Embryology Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University Lanzhou 730000 China Integrative Physiology of the Brain Arousal Systems Lyon Neuroscience Research Center Lyon 69373 France

The thalamus is the gate of the cerebral cortex, the ultimate target for the neural networks controlling behavioral states and cognitive functions. According to the reticular theory initially proposed by Moruzzi and Magoun, excitatory inputs from large reticular zones of the brainstem via widespread intra- and extra-thalamocortical systems finally activate the cerebral cortex to cause generalized cortical activation and wakefulness [1]. This theory proposes a central relay role to the thalamus for cortical activation as supported by early studies using neurodegeneration techniques and by the elegant work of Steriade’s group and other investigators illustrating the electrophysiological mechanisms of the thalamocortical system at the cellular level during wakefulness, rapid eye-movement sleep (REMs) and non-REM sleep (NREMs)[2].

关键词： Paraventricular Thalamus Thalamic Structure Wake Control

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Role of neuropeptide S in sleep-wake regulation

Role of neuropeptide S in sleep-wake regulation

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中国神经科学学会第十届全国学术会议

作者： yi-ping hou Peng ZHAO Yu-Feng SHAO Xiang-Pan KONG Department of Neuroscience AnatomyHistology and EmbryologyKey Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical SciencesLanzhou University

Objective Neuropeptide S（NPS） is a newly identified neuromodulator located in the *** selectively binds with high affinity to its receptor（NPSR）,involving in the regulation of multiple central *** NPS-NPSR system is proposed as a new arousal ***,the effects of NPS on the architectures of sleep-waking states and the mechanisms involved remain *** study is to explore the effects and mechanisms of NPS-NPSR system on sleep-wake *** Firstly,the sleep-waking states and related EEG power spectra were defined by the electroencephalogram（EEG） and electromyogram（EMG） signal recordings during light-phrase（8:00-20:00 h） in freely moving rats following intracerebroventricular（i.c.v.） injection of NPS,and ex-vivo Fos immunohistochemistry was made to identify the potential neuronal targets for NPS in the brain involved in ***,according to primary results,the distribution of NPSR mRNA was revealed by quantitative real-time PCR（RT-PCR） and dual-immunofluorescences *** sleep-waking profiles following bilateral microinjections of NPS into the tuberomammillary nucleus（TMN） were studied for comprehensive understanding NPS-NPSR system in regulating sleep-wake ***,the neuropharmacology assays were made to identify whether the antagonists of NPSR,H1R and H2R receptors block the arousal effect of ***（1） Central administration of NPS（0.1-1 nmol）increased significantly wakefulness（W） during the first 2 h,accompanied by an increase in EEG high frequency activities（14.5-60 Hz）.In the meanwhile,slow wave sleep（SWS） and paradoxical sleep（PS） decreased significantly,and accompanied by a suppression in EEG delta（0.5-4 Hz） and theta（4.5-8.5 Hz） *** W-increasing effect was because of a significant increase in the mean duration of wake episode.（2） Fos immunohistochemistry in the posterior hypothalamus revealed that,as compared with saline-treated rats,NPS enhanced c-Fos expression in histaminergic n

关键词： neuropeptide S neuropeptide S receptor sleep-wake states tuberomammillary nucleus histaminergic neurons orexinergic neurons histamine receptor antagonist

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The hypnotic effect of lavender essential oil

The hypnotic effect of lavender essential oil

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中国睡眠研究会第九届学术年会

作者： Yu-Feng SHAO Le XIN Can WANG Jun-Fan XIE Min hou Guang-Fu CUI Lin-Xin WANG yi-ping hou Department of Neuroscience AnatomyHistology and EmbryologyKey Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical SciencesLanzhou University

Lavender essential oil（LEO） has been used to improving sleep and alleviating symptoms of anxiety in clinic *** effective characteristics and mechanisms involved in LEO action on sleep-wake cycle remain *** present study was undertaken to investigate the effect of intranasal delivering saturated LEO steam（SLEOS） on sleep-wake states and EEG power spectrums for 24 h（08:00-08:00 h） in *** of delivery parameter at 10 s SLEOS and 110 s fresh air（20ml/min）,compared to control,immediately enhanced the non-REM（NREM） sleep for 20 min（08:00-08:20 h,from 7.40 ± 1.78 min to 12.05 ± 1.07 min,P ＜ 0.05）and simultaneously accompanying a reduction in wakefulness（from 11.95 ± 2.03 s to 6.70 ± 1.23 s,P ＜ 0.05）,and increased REM sleep during 08:40-09:00 h（from 0.65 ± 0.31 minto 2.10 ± 0.46 min,P ＜ 0.05）.Near the end of light period（17:00-18:00 h）,SLEOS significantly increased non-REM（NREM） sleep during17:00-17:20 h（from 8.90 ± 1.76 min to 13.45 ± 0.27 min,P ＜ 0.05）,and REM sleep during 17:40-18:00 h（from 0.60 ± 0.26 min to 2.40 ± 0.52 min,P ＜ 0.01,） ***-induced enhancement of NREM and REM sleep was due to the increase of NREM and REM episode number,and reduction of wakefulness was because of a decrease in waking episode *** of each state across24-h sleep-wake cycle showed that SLEOS significantly decreased wakefulness（from 311.60 ± 8.99 min to 283.85 ± 5.94 min,P ＜ 0.05）,and increased rapid eye movement（REM） sleep（from 46.40 ±3.44 minto 56.10 ± 2.98 min,P ＜ 0.05） during light（inactive）period（08:00-20:00） and 24-h TST（from 75.15 ± 3.03 min to 85.40 + 3.42 min,P ＜ 0.05）.SLEOS-induced sleep mainly occurred during08:00-09:00 h andl7:00-18:00 *** significantly reduced the sleep latency in cage change（22.08 ± 3.24 min vs.43.20 ± 6.33 min,P ＜ 0.05） compared with control ***,olfactory epithelium lesion by intranasal application of zinc sulfate abolished the effect of the ***,the primary results show that SLEOS through olf

关键词： lavender essential oil hypnotic wakefulness rapid eye movement sleep non-rapid eye movement sleep

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The brain histaminergic system and arousal mechanism

The brain histaminergic system and arousal mechanism

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： yi-ping hou Lab.Neurobiology,Department of Anatomy,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000, China

＜正＞Wakefulness is a functional brain state that allows the performance of several "high brain function",such as diverse behavioural,cognitive and emotional *** knowledge at the whole animal or cellular level suggests that the maintenance of the cerebral cortex in this highly complex state necessitates the convergent and divergent activity of an ascending network with a large reticular zone,extending from the medulla to the forebrain and involving four major subcortical structures（the thalamus,basal forebrain,posterior hypothalamus and brainstem monoaminergic nuclei）,their integral interconnections and several neurotransmitters,such as glutamate,acetycholine,histamine and *** this review,the importance of the thalamus,basal forebrain and brainstem monoaminergic neurons in wake control is briefly summarized,before turning our attention to the posterior hypothalamus and histaminergic neurons have been far less *** and recent experimental data are summarized,supporting the hypothesis that（1） the posterior hypothalamus constitutes one of the brain ascending activating systems and plays an important role in waking;（2） this function is mediated,in part,by histaminergic neurons,which constitute one of the excitatory sources for cortical activation during waking;（3） the mechanisms of arousal involve both the ascending and descending projection of histaminergic neurons and their interactions with diverse neuronal populations,such as neurons in the pre-optic area and cholinergic neurons;and（4） other widespread-projecting neurons in the hypothalamus also contribute to the tonic cortical activation during wakefulness and/or paradoxical *** the mammalian brain,histamine is synthesized from L-histidine by histidine decarboxylase and is predominantly inactivated by *** central actions of histamine are mediated by post-synaptic H1- and H2-receptors and by H3-receptors possessing characteristics of auto- and

关键词： histaminergic system sleep-wake cycle

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A Novel Missense Mutation(L296Q)in Cholesteryl Ester Transfer Protein Gene Related to Coronary Heart Disease

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Acta Biochimica et Biophysica Sinica 2004年第1期36卷 33-36页

作者： Ke-Qin ZHENG, Si-Zhong ZHANG, Li ZHANG, De-Jia HUANG, Lin-Chuan LIAO, and yi-ping hou ( Department of Medical Genetics, West China Hospital Division of Human Morbid Genomics, Key Laboratory ofBiotherapy of Human Diseases of Ministry of Education, Sichuan University, Chengdu 610041, China Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China School of Basic and Forensic Medicine, Sichuan University, Chengdu 610041, China) Department of Medical Genetics West China Hospita Division of Human Morbid Genomics Key Laboratory of Biotherapy of Human Diseases of Ministry of Education Sichuan University Chengdu 610041 Chin

Cholesteryl ester transfer protein (CETP) is a key participant in the reverse transport of cholesterol from the peripheral tissues to the liver. To understand the role that CETP gene plays in the pathogenesis of coronary heart disease (CHD) , the promoter region, all 16 exons and adjacent intronic regions of CETP gene were screened for single nucleotide polymorphisms (SNPs) in 203 CHD patients and 209 controls by a combination of PCR, denaturing high performance liquid chromatography (DHPLC), molecular cloning, and DNA sequencing. A novel missense mutation in the CETP gene was identified. This mutation (L296Q) was a T-to-A conversion at codon 296 of exon 10 which replaced the codon for leucine (CTG) with the codon for glutamine (CAG). Association study revealed that L296Q mutation was associated with CHD with a significantly higher mutant allele frequency in the CHD patients than that in the controls (0. 160 vs. 0.091,x2= 9.014, P = 0.003), and that the odds ratio for the development of CHD was 1.83 for

关键词： cholesteryl ester transfer protein gene (CETP gene) coronary heart disease (CHD) missense mutation plasma lipids single nucleoti.de polymorphism (SNP)

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Regulative effect of endogenous cannabinoid receptor type 1 agonist(m)VD-hemopressin(α) on sleep-wake states

Regulative effect of endogenous cannabinoid receptor type 1 ...

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中国睡眠研究会第九届学术年会

作者： Wen-Ting REN Jun-Fan XIE Guang-Fu CUI Min hou Yu-Feng SHAO Can WANG Le XIN Lin-Xin WANG yi-ping hou Department of Neuroscience AnatomyHistology and EmbryologyKey Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical SciencesLanzhou University

The cannabinoids were reported to play important roles in the modulating of physiological functions,including sleep-wake cycle,olfaction,emotional state,learning and memory,and reward ***1(cannabinoid receptor type 1) and CB2(cannabinoid receptor type 2) receptors,the two major G protein-coupled receptors(GPCRs),have been reported to belong to the cannabinoid system.(m)VD-hemopressin(a)(VD-Hpα),an 11-residue peptide originating from the α chain of hemoglobin,was recently reported as a selective agonist of cannabinoid CB1 *** present study was undertaken to investigate the regulative effect of the intracerebroventricular(i.c.v.) action of(m)VD-Hpα on sleep-wake cycle in freely moving ***55,212-2,α CB1 agonist reported to promote sleep,was used as a positive control to compare the *** of c-Fos was employed to mark the active neurons in the brain after(m)VD-Hpα *** results demonstrated that paradoxical sleep(PS)time was increased,and PS latency was reduced following a range dose(13.4,20.1 and 40.2 nmol)of(m)VD-Hpα *** at 20:00 h during dark phase compared to saline *** the three doses,20.1 nmol of(m)VD-Hpα showed the best efficiency to promote PS during20:00-23:00 h and 6:00-7:00 *** amount induced by 20.1 nmol of(m)VD-Hpα was significantly enhanced in dark phase and 24-h TST through increasing PS episode number without ***,an increase of PS amount induced by WIN55,212-2(7.5 nmol) was delayed to light phase.(m)VD-Hpα-induced Fos-ir neurons were increased in the VLPO and PPT,and decreased in the LH,and not altered in the TMN and *** data suggest that endogenous peptide agonist of the cannabinoid CB1 receptor promote PS in sleep-wake regulation through activation of CB1 receptor in the VLPO,LH,and PPT.

关键词： cannabinoid receptor type 1 agonist sleep-wake regulation c-Fos

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The arousal effects and neural circuits of alarm pheromones

The arousal effects and neural circuits of alarm pheromones

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第二届中国睡眠研究会青年学术论坛暨四川省医学会第四次睡眠医学学术会议

作者： Yu-Feng Shao Jian-ping Hong Can Wang Jun-Fan Xie Le Xin Ya-Ting Zhang Wen-Ting Ren Guang-Fu Cui yi-ping hou Departments of Neuroscience AnatomyHistologyand EmbryologyKey Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical SciencesLanzhou University

Abstract:Objective Alarm pheromones(APs)are very important communicating substances in species survival,which conducts hazards,***,distress,presence of predators,*** the individual survival,sufficiently sleep is *** order to avoided predators,are the APs able to waking up mice during sleep time until *** Spherical Treadmill Olfaction-Sleep Recording System(STOSRS)was employed in this study,the mouse(C57BL/6J)head was restrained by a head plate,and the animal was able to maneuver on the top surface of an air-supported floating Styrofoam ***(which collected during killing of mice with CO electrical stimulation after anesthesia)directional/quantitative delivered during non-rapid eye movement sleep(NREM)or rapid eye movement sleep(REM)which were determined by EEG/EMG and digital *** waking latency(WL)and EEG power analysis were used to reveal the EEG/EMG characteristics of the arousal induced by APs in ***(l)Animals were able to sleeping(NREM and REM)on the STOSRS after one week *** EEG/EMGcharacteristics of the NREM and REM sleep were similar as unrestrained ***,when the mouse was movement on the Styrofoam ball,the EEG display typical 9 wave(4.5-9.0 Hz)same as REM sleep,meanwhile,the EMG shown high activity.(2)Air delivered into nasal cavity at NREM sleep,the WL was randomly from 5 s to 116 s(n=11).APs delivered display steady WL(9.31±0.71 s,n=8)and the EEG characteristics were changed to movement wave(described above).(3)During the REM sleep,as the same effects of air,the WL was randomly from 7.5 s to 138 s(n=5)after APs delivered.(4)The distribution of Grueneberg ganglion was 3D reconstruction by using OMP-GFP *** APs can awake mice within the NREM sleep,this pivotal effect protects animals to avoided predators and contributed to species survival.

关键词： alarm pheromones non-rapid eye movement sleep rapid eye movement sleep arousal

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Effect of microinjecting GABAA-receptor antagonist into the tuberomammillary nucleus on the sleep-wakefulness cycle after lesion of the ventrolateral preoptic area in rats

Effect of microinjecting GABAA-receptor antagonist into the ...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xin ZHANG,yi-Na SUN,Peng XIE,Xu-Guang YANG,yi-ping hou~* Department of Neuroscience and Anatomy,Histology and Embryology,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000

Objective Recent evidences have demonstrated that the interaction between GABAergic neurons in the ventrolateral preoptic area(VLPO) and histaminergic(HA) neurons in the tuberomammillary nucleus(TMn) plays a key role for regulating sleep-wakefulness ***,GABAergic neurons in TMn have not received much attention for their role in sleep-wakefulness *** aim of this study is to investigate the effect of GABAergic neurons in the TMn on sleep-wakefulness *** Male SD rats(250-300 g,n=15) were randomized into 3 groups:before lesion group (n=5),VLPO lesion group(n=5) and VLPO lesion plus bicuculline treated group(n=5).The 4 EEG screw electrodes were implanted into the skull under anesthesia with pentobarbital(35 mg/Kg,ip),and three flexible EMG wire electrodes were placed into the nechal *** free ends of the leads were soldered into a *** cannular for microinjection were implanted into the adjacent of TMn(Aβ-4.2 mm,ML±1.3 mm,DV-7.4 mm).All implantations were affixed to the skull with dental cement,except the area(0.5 cm) around the bregma filling with bone wax that was *** week after surgery,the sockets were connected via flexible recording cables to EEG polygraph,signals were digitized by CED Micro 1401 and computer running the Spike 2 recording system.A 24 h basic wake-sleep states in before lesion group were recorded and analyzed by manually scored in 30 s epochs on the digitized EEG/*** the 8th day,a fine glass micropipette(10-20 mm tip diameter) containing ibotenic acid solution for specific cell damage(10 nM/0.5μ,Sigma) was injected into the VLPO on each side after bone wax removed under *** week after the second surgery,rats of VLPO lesion group were recorded for sleep-wakefulness *** the 10th day after lesion of VLPO,bicuculline(10 nM/0.5μ),a GABA-receptor antagonist,was microinjected into the TMn and recorded sleep-wakefulness states for 24 ***(1) The ratio during 24 h of wakefulness(

关键词： GABAergic neurons GABAA-receptor antagonist histaminergic neuron neurotoxic lesion tuberomammillary nucles ventrolateral preoptic area

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Estazolam reverses histamine in tuberomammillary nucleus induced arousal effect

Estazolam reverses histamine in tuberomammillary nucleus ind...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： yi-Na SUN Xin ZHANG Xu-Guang YANG Yan-Feng SONG yi-ping hou~* Department of Neuroscience and Anatomy Histology and Embryology School of Basic Medical Sciences Lanzhou University Lanzhou 730000 China

＜正＞Objective The effect of estazolam,a potential agonist for promoting gamma-aminobutyric acid（GABA） release, on histamine（HA） in tuberomammillary nucleus（TMn） induced arousal activity was *** interaction between TMn histaminergic and GABAergic neurons for modulating sleep-wakefulness cycle was further *** 30 male Sprague-Dawley rats were randomly divided into 6 groups:control group,saline group,sstazolam group,HA group,HA+estazolam（2.5 mg/kg） group,HA+estazolam（5 mg/kg） *** stainless steel screw electrodes（2 mm in diameter） were implanted into the skull to the surface of the cerebral dura mater for recording *** silver wire electrodes were inserted bilaterally into the dorsal neck muscles for recording *** stainless steel guide cannular （0.06 mm in diameter） was implanted into the adjacent of TMn for subsequent drug *** 7 d recovery,a basic sleep-wake cycle as control of EEG and EMG were recorded and every phase analyzed for 24 *** wake and sleep states including light slow wave sleep（SWS1）,deep slow wave sleep（SWS2） and paradoxical sleep（PS） were statistically calculated per 10 s epochs for 24 h,when saline and drugs were subsequently administered according to *** Microinjection HA（1μg/kg） into TMn increased the durational time of wake（P＜0.01） and reduced the S WS time,but did not effect on PS compared to saline microinjection into TMn for 24 ***（5 mg/kg,p.o） increased the total sleep time via increase of SWS2（P＜0.01） without SWS1 and PS time compared to control,and also reversed the HA-induced wakefulness into sleep（P＜0.01）.Conclusion Histaminergic neurons in the TMn play a key role in promoting and maintaining the *** induces an increase of the total sleep time,mainly through increasing SWS2,and reverses HA-induced wakefulness into sleep.

关键词： sleep-wakefulness cycle tuberomammillary nucleus histaminergic neurons estazolam GABAergic neurons

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Microinjection of muscimol into tuberomammillary nucleus promoting sleepδpower and suppressing wakefulnessβ2 power-induced by histamine in rats

Microinjection of muscimol into tuberomammillary nucleus pro...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Peng XIE,Kun FAN,Min ZHANG,Yan-Feng SONG,yi-ping hou~* Department of Neuroscience and Anatomy,Histology and Embryology,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000

Objective o investigate the effect of muscimol,a potent agonist of GABA-receptor,microinjected into tubermammillary nucleus(TMn) on the sleep-wakefulness cycle,EEG power spectrum and the wake-promoting of histamine in freely *** Male SD rats were randomly divided into control group(n=7),saline group(n=7),muscimol 0.5μgroup(n=6),muscimol 0.25μgroup(n=4),HA group(n=7) and HA plus muscimol group(n=5).Animals were implanted with 4 EEG electrodes,3 EMG electrodes and a pair of stainless steel guide cannular to the adjacent of TMn for subsequent drug *** one week recovery,a 24 h basal sleep-wakefulness cycle was recorded and analyzed by Spike 2.(1) Saline and muscimol(0.25 or 0.5μg/side) were respectively microinjected into bilateral TMn at 22:00 during dark period recording from 20:00 to 8:00.(2) Saline and HA(0.125μg/side) were respectively administered into TMn at 10:00 during light period recording from 8:00 to 20:00.(3) Muscimol(0.5μg/side) was injected at 12:00 following HA administration at 10:*** EEG power spectrum was analyzed for the frequency range of 1-60 Hz includingδ(1-4 Hz),θ(4.2-8 Hz),α(8.2-12 Hz),β1(12.2-20 Hz),β2(20.2-30 Hz) andγ(30.2-60 Hz) using aFFT ***(1) Muscimol given at 0.25 and 0.5(ig/side for 12 h induced a dose-dependent decrease in wake(W,P 240 s,but that decreased in <120 *** addition,the stage transition number during 4 h from W to SWS,SWS to W,SWS to PS and PS to W were not affected respectively by muscimol.(2) HA in

关键词： sleep-wakefulness stages power spectrum tuberomammillary nucleus histamine GABAA-receptor agonist

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