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The History of Controlling and Treating Infectious Diseases in Ancient China

Current Medical Science 2024年第1期44卷 64-70页

作者： Cui-ling LIU Tao ZHOU Liang-bin CHENG David FISHER Khrystyna PRONYUK Erkin MUSABAEV yi-ping dang Lei ZHAO Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Gastroenterology and Hepatology Huanggang Hospital of Traditional Chinese MedicineHubei University of Chinese MedicineHuanggang 438000China Clinical College of Traditional Chinese Medicine Hubei University of Chinese MedicineWuhan 430065China Department of Liver Diseases Hubei Hospital of Traditional Chinese MedicineWuhan 430061China Department of Medical Biosciences Faculty of Natural SciencesUniversity of the Western CapeBellvilleCape Town 7535South Africa Department of Infectious Diseases Bogomolets National Medical UniversityKyiv 02132Ukraine The Research Institute of Virology Ministry of HealthTashkent 100122Uzbekistan Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Infectious diseases are the common enemies of *** the course of historical development,they persistently threaten human health and *** today,despite the developments in medical science,we cannot escape the fear and suffering caused by infectious *** in ancient or modern times,the source of infection,route of transmission,and a susceptible population are the three key conditions for the prevalence and spread of infectious *** factors closely related to these three conditions can affect the prevalence of infectious *** is one of the cradles of world *** ancient people accumulated a great deal of experience and lessons in the long struggle against infectious *** the face of the current threat posed by widespread infectious disease,it is imperative to review and summarize ancient Chinese ideas and health policies on epidemic prevention and control to inspire contemporary efforts in the prevention and control of infectious *** combination of prevention-oriented epidemic prevention ideology and traditional medicine provides valuable insights,especially for impoverished and medically underserved regions.

关键词： infectious diseases Chinese medicine public health historical review

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黄芪注射液对肺结核近期疗效、纤维化和炎症细胞因子表达的影响

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陕西中医 2017年第5期38卷 583-585页

作者：王建梅李毅党萍王丽娟刘宁河北省胸科医院结核科石家庄050041

目的:分析肺结核(TB)治疗中黄芪注射液的应用效果及对疾病相关细胞因子的影响。方法:将68例初治TB患者随机分为对照组及治疗组两组,对照组接受单纯西药治疗,治疗组接受西药联合黄芪注射液治疗,每组34例。对比两组近期疗效,并分析两组治... 详细信息

目的:分析肺结核(TB)治疗中黄芪注射液的应用效果及对疾病相关细胞因子的影响。方法:将68例初治TB患者随机分为对照组及治疗组两组,对照组接受单纯西药治疗,治疗组接受西药联合黄芪注射液治疗,每组34例。对比两组近期疗效,并分析两组治疗前后疾病相关细胞因子变化情况。结果:治疗组治疗总有效率高于对照组,差异具有统计学意义,而两组治疗期间不良反应发生率比较,差异无统计学意义。同时,两组入组时HA、PC-Ⅲ、MMP-9、IL-6及IL-8比较,差异未见统计学意义,而180d治疗后,治疗组HA、PC-Ⅲ、IL-6及IL-8均低于对照组(P<0.05),治疗组MMP-9高于对照组(P<0.05)。结论:黄芪注射液可有效提高TB患者的近期治疗效果,其治疗机制可能与调节纤维化因子及炎症细胞因子有关。

关键词：结核,肺/中西医结合疗法纤维化黄芪注射液/治疗应用

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升降散改善MNNG诱导的胃黏膜损伤及其机制

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中国药理学通报 2025年第1期41卷 178-185页

作者：刘轶璜张思佳刘菲陈苹苹河北中医药大学药学院河北石家庄050091 河北省离子通道功能与创新中药国际联合研究中心河北石家庄050091 河北中医药大学中西医结合学院河北石家庄050091

目的确定升降散对胃黏膜损伤的改善作用并探讨其机制。方法通过文献计量学研究了解升降散的研究现状。采用液质联用技术获取升降散主要药效成分,通过网络药理学分析预测机制。对胃黏膜损伤大鼠灌胃给予阳性药及不同剂量升降散,通过HE染... 详细信息

目的确定升降散对胃黏膜损伤的改善作用并探讨其机制。方法通过文献计量学研究了解升降散的研究现状。采用液质联用技术获取升降散主要药效成分,通过网络药理学分析预测机制。对胃黏膜损伤大鼠灌胃给予阳性药及不同剂量升降散,通过HE染色,观察胃组织形态。ELISA实验检测血清中TNF-α、IL-1β的水平。IHC实验评价胃黏膜MUC5AC、MUC6的表达。结果文献计量学分析表明,升降散在内外伤杂病治疗方面应用广泛。根据升降散主要药效成分中浓度前20位的化合物得到的作用靶点525个,与胃炎相关靶点相交集的129个;GO分析得条目数2127条,KEGG分析得通路140条;说明升降散具有多靶点多通路改善胃黏膜损伤的可能性。HE染色结果显示,升降散确能改善大鼠胃黏膜炎症。ELISA实验结果显示,升降散可有效下调大鼠血清中的TNF-α和IL-1β。IHC实验结果表明,升降散有效下调MUC5AC的表达、上调MUC6的表达。结论升降散能以缓解炎症、调节表面黏液屏障的方式改善胃黏膜损伤。

关键词：升降散慢性胃炎文献计量学网络药理学胃组织结构炎症因子免疫组织化学

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Effect of Ti content on microstructure and properties of TixZrVNb refractory high-entropy alloys

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International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1318-1325页

作者： Tian-dang Huang Shi-yu Wu Hui Jiang yi-ping Lu Tong-min Wang Ting-ju Li Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao 266590China

This study aimed to investigate the microstructure and mechanical properties of TixZrVNb(x=1,1.5,2)refractory high-entropy alloys at room and elevated *** TiZrVNb alloy consisted of the body-centered cubic(bcc)matrix with a small amount of V2Zr *** Ti1.5ZrVNb and Ti2ZrVNb alloys exhibited a single-phase bcc *** room temperature,the tensile ductility of the as-cast alloys increased from 3.5%to 12.3%with the increase in the Ti *** TixZrVNb alloys exhibited high yield strength at 600°C,and the ultimate yield strength was more than 900 *** occurred at 800°C,but the ultimate yield strength could still exceed 200 ***,the TixZrVNb alloys displayed low densities but high specific yield strengths(SYSs).The lowest density of TixZrVNb alloys was only 6.12 g/cm^3,but the SYS could reach about 180 MPa·cm^3·g^−1,which is better than those of most reported high-entropy alloys(HEAs).

关键词： high-entropy alloys mechanical properties low density elevated temperature

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Effect of Reduction and Carburization Pretreatment on Iron Catalyst for Synthesis of Light Olefins from CO Hydrogenation

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Chemical Research in Chinese Universities 2017年第4期33卷 672-677页

作者： AN Tong dang Dan CHENG yi Department of Chemical Engineering Tsinghua University Beijing 100084 P. R. China

Effect of reduction and carburization pretreatment on iron catalyst for CO hydrogenation to light olefins was investigated. The bulk structure and surface composition of the catalysts during pretreatment were characterized by means of X-ray diffraction（XRD）, X-ray photoelectron spectroscopy（XPS） and high-resolution transmission elec- tron microscopy（HRTEM）. The results indicated that phase transformation of iron phases involved a-Fe203---~Fe304 --,a-Fe both in the bulk and on the surface layers in hydrogen atmosphere. However, a-Fe203 was firstly transformed to Fe3C and then to Fe5C2 in CO atmosphere, while in syngas atmosphere directly to Fe5C2. As carburization pretreatment time was prolonged, the degree of carburization on the surface increased, and the increase degree of iron catalyst carburization in CO pretreatment was stronger than that in syngas pretreatment. It inferred that surface carbon species was more easily formed in syngas pretreatment instead of iron carbide in CO pretreatment. After hydrogen pretreatment, when the catalyst was reduced to a mixture of magnetite and metallic iron, the selectivity to light olefins was relatively low. Under the joint effects of the active sites from surface iron carbide and surface carbon layers blocking the active sites, longer CO pretreatment time resulted in higher methane selectivity and less light olefins. The selectivity to methane on H2-pretreated catalyst was lower than that of CO-pretreated catalyst.

关键词： Light olefin Fischer-Tropsch synthesis CO hydrogenation Iron catalyst Pretreatment

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Synthesis, Structure and Geometrical Calculation of a Novel Co-crystal of {[4-Bromo-2-(benzimidazol-2-yl)phenolato][2-(1-butylbenzimidazol-2-yl)phenolato]zinc(Ⅱ)] and Bis[μ-2-(1-butylbenzimidazol-2-yl)phenolato]-1κN^3:2κO;1κO:2κN^3-bis{[2-(1-butylbe

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Chinese Journal of Structural Chemistry 2007年第2期26卷 143-148页

作者： TONG yi-ping Department of Chemistry Hanshan Normal University Chaozhou 521041 China

The title compound has been synthesized and characterized crystallographicaUy. It is a co-crystal consisting of two different neutral zinc（H） complexes with Hbpbm （Hbpbm = 4- bromo-2-（benzimidazol-2-yl）phenol） and Hnpbm （Hnpbm = 2-（1-butylbenzimidazol-2-yl）phenol）. One is a monomeric mixed-ligand complex of [Zn（bpbm）（npbm）] 1 and the other a dimer of [Zn2（npbm）4] 2 with their ratio of 2：1. Thus the overall formula for the title compound is 21.2. Adjacent 1 and 2 are connected to each other by intermolecular hydrogen bonding interactions in the lattice. The crystal data： monoclinic, space group P21/c, a = 15.0141（12）, b = 20.9941（17）, c = 18.4686（15） A, β = 97.445（2）°, V = 5772.4（8） A^3, Mr= 2429.68, Z = 2, Dc = 1.398 g/cm^3,μ = 1.579 -1 mm , F（000） = 2504, R = 0.0637 and wR = 0.1771 for 6464 observed reflections （I 〉 2σ（I））. The geometrical structure for 1 has also been theoretically optimized and compared with the experimental one.

关键词： zinc complex co-crystal structure 4-bromo-2-(1-butylbenzimidazol-2-yl)phenol 2-(1-butylbenzimidazol-2-yl)phenol

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A New Algorithm for Total Variation Based Image Denoising

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Acta Mathematicae Applicatae Sinica 2012年第4期28卷 721-730页

作者： yi-ping XU School of Science Southwest University of Science and Technology

We propose a new algorithm for the total variation based on image denoising problem. The split Bregman method is used to convert an unconstrained minimization denoising problem to a linear system in the outer iteration. An algebraic multi-grid method is applied to solve the linear system in the inner iteration. Furthermore, Krylov subspace acceleration is adopted to improve convergence in the outer iteration. Numerical experiments demonstrate that this algorithm is efficient even for images with large signal-to-noise ratio.

关键词： image denoising total variation split Bregman method algebraic multi-grid method,Krylov subspace acceleration

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COMPUTATION OF TURBULENT FLOW IN TWO-DIMENSIONAL IRREGULAR DOMAIN INCLUDING ROTATION EFFECTS

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Journal of Hydrodynamics 1991年第3期3卷 10-18页

作者： yin-yi, dang Xiang-lin, Fei Xi'an Jiaotong Univ Xi'an Shanxi China

A finite volume method is employed to predict the turbulent flow in irregular domains. In handling the irregular solution domain an algebraic nonorthogonal transformation along with the orthogonal body-surface coordinate is presented, which avoids the task of numerically generating the grid and also extends the scope of solution domain as compared with that of [1]. The modified K-Ε turbulence model is adopted to account for the Coriolis force caused by the system rotation. Three examples with or without rotation effects are presented.

关键词： Computers Applications Fluid Mechanics Hydrodynamics Mathematical Models Mechanical Variables Measurement Flow

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DRUG PRICING PATTERN IN CHINA： DILEMMA AND COUNTERMEASURE

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Journal of Systems Science and Systems Engineering 2018年第3期27卷 340-366页

作者： Mingxi Wang yi Hu Han Qiao Chuangyin dang School of International Trade and Economics University of International Business and Economics Beijing 100029 China School of Economics and Management University of Chinese Academy of Sciences Beijing 100190 China Department of Systems Engineering and Engineering Management City University of Hong Kong Kowloon Hong Kong

Maybe it is the most important medical reform for current China to adopt the bid-and-procurement scheme to correct the distortion of pharmaceutical resources allocation. Nevertheless, overpriced drugs often happen. This article aims to identify potential factors leading to the overpriced. Based on the mechanism rules of the scheme, it is found that unethical doctors are crucial to high price markup in the pricing pattern of drugs. Under China＇s actual conditions, asymmetric ownership is identified to be another cause of the overpriced by developing an asymmetric bidding model. How are the impacts of these two factors to be alleviated？ Upon examination, several reform measures cannot effectively avoid the occurrence of the overpriced. Yet, the issue is very urgent for China because it is facing with the problem of population aging. Therefore, alternative options - a regulation-penalty tool and an investment subsidy policy - are proposed to improve China＇s health care.

关键词： The bid-and-procurement scheme overpriced drug asymmetry health-care reform

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A Combination Model for Image Denoising

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Acta Mathematicae Applicatae Sinica 2016年第3期32卷 781-792页

作者： yi-ping XU School of Science Southwest University of Science and Technology

In this paper, we propose an efficient combination model of the second-order ROF model and a simple fourth-order partial differential equation （PDE） for image denoising. The split Bregman method is used to convert the nonlinear combination model into a linear system in the outer iteration, and an algebraic multigrid method is applied to solve the linear system in the inner iteration. Furthermore, Krylov subspace acceleration is adopted to improve convergence in the outer iteration. At the same time, we prove that the model is strictly convex and exists a unique global minimizer. We have also conducted a variety of numerical experiments to analyze the parameter selection criteria and discuss the performance of ~he fourth-order PDE in the combination model. The results show that our model can reduce blocky effects and our algorithm is efficient and robust to solve the proposed model.

关键词： image denoising partial differential equations split Bregman method algebraic multi-grid method Krylov subspace acceleration

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